ES2156287T3 - Derivados de difenilmetilen piperidina. - Google Patents

Derivados de difenilmetilen piperidina.

Info

Publication number
ES2156287T3
ES2156287T3 ES96927006T ES96927006T ES2156287T3 ES 2156287 T3 ES2156287 T3 ES 2156287T3 ES 96927006 T ES96927006 T ES 96927006T ES 96927006 T ES96927006 T ES 96927006T ES 2156287 T3 ES2156287 T3 ES 2156287T3
Authority
ES
Spain
Prior art keywords
difenilmetilen
piperidina
derivatives
difenylmethylenipiperidine
prophylaxis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96927006T
Other languages
English (en)
Inventor
Duncan Robertson Cleghorn Rae
David Robert Jaap
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2156287T3 publication Critical patent/ES2156287T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION TRATA DE UN DERIVADO DE DIFENILMETILENPIPERIDINA DE FORMULA (I), EN LA CUAL N ES 1 O 2; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, PARA SU USO EN TERAPIA, EN PARTICULAR PARA SU USO COMO UN ANTAGONISTA DE LA DOPAMINA PARA EL TRATAMIENTO O LA PROFILAXIS DE TRASTORNOS PSICOTICOS.
ES96927006T 1995-07-12 1996-07-09 Derivados de difenilmetilen piperidina. Expired - Lifetime ES2156287T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95201910 1995-07-12

Publications (1)

Publication Number Publication Date
ES2156287T3 true ES2156287T3 (es) 2001-06-16

Family

ID=8220478

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96927006T Expired - Lifetime ES2156287T3 (es) 1995-07-12 1996-07-09 Derivados de difenilmetilen piperidina.

Country Status (26)

Country Link
US (1) US5935974A (es)
EP (1) EP0842170B1 (es)
JP (1) JPH11508907A (es)
KR (1) KR19990028807A (es)
CN (1) CN1091108C (es)
AR (1) AR003966A1 (es)
AT (1) ATE199150T1 (es)
AU (1) AU699370B2 (es)
BR (1) BR9609330A (es)
CA (1) CA2226851A1 (es)
CZ (1) CZ288909B6 (es)
DE (1) DE69611788T2 (es)
DK (1) DK0842170T3 (es)
ES (1) ES2156287T3 (es)
GR (1) GR3035849T3 (es)
HU (1) HUP9802762A3 (es)
IL (1) IL118768A (es)
NO (1) NO309765B1 (es)
NZ (1) NZ315318A (es)
PL (1) PL183837B1 (es)
PT (1) PT842170E (es)
RU (1) RU2162846C2 (es)
TR (1) TR199800027T1 (es)
TW (1) TW419477B (es)
WO (1) WO1997003065A1 (es)
ZA (1) ZA965691B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019324A2 (en) * 1997-10-07 1999-04-22 Akzo Nobel N.V. Antipsychotic substituted piperidine derivatives
AU2279099A (en) * 1998-01-09 1999-07-26 Akzo Nobel N.V. Use of diphenylmethylene piperidine derivatives in the manufacture of a medicament for the treatment of depression
AU2517499A (en) * 1998-01-09 1999-07-26 Akzo Nobel N.V. Use of diphenylmethylene piperidine derivatives in the manufacture of a medicament for the treatment of movement disorders
AU5600100A (en) 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2000076513A1 (en) 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2000076511A1 (en) 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US6358979B1 (en) 1999-06-11 2002-03-19 Merck & Co., Inc. N-cyclopentyl modulators of chemokine receptor activity
US6500844B1 (en) 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US6472410B1 (en) 1999-06-11 2002-10-29 Merck & Co., Inc. N-cyclopentyl modulators of chemokine receptor activity
KR20010113007A (ko) * 2000-06-15 2001-12-24 주정호 항암제로서 유용한 ｎ-치환된 피페리디닐우레아 유도체 및그의 제조방법
TW200303304A (en) * 2002-02-18 2003-09-01 Astrazeneca Ab Chemical compounds
US6770659B2 (en) * 2002-08-26 2004-08-03 Sk Corporation Benzoyl piperidine compounds
KR20050085673A (ko) * 2002-12-18 2005-08-29 에프엠씨 코포레이션 Ｎ-(치환된 아릴메틸)-4-(이치환된 메틸)피페리딘 및피페라진
SE0400208D0 (sv) * 2004-02-02 2004-02-02 Astrazeneca Ab Chemical compounds
TW200812582A (en) * 2006-04-06 2008-03-16 Astrazeneca Ab Medicaments
MX381417B (es) 2014-08-28 2025-03-12 Asceneuron Sa Inhibidores de glucosidasa.
WO2017106254A1 (en) * 2015-12-18 2017-06-22 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
JP2019506430A (ja) 2016-02-25 2019-03-07 エースニューロン・ソシエテ・アノニム グリコシダーゼ阻害剤
CN108884077A (zh) 2016-02-25 2018-11-23 阿森纽荣股份公司 糖苷酶抑制剂
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
JP6971999B2 (ja) 2016-02-25 2021-11-24 エースニューロン・ソシエテ・アノニム ピペラジン誘導体の酸付加塩
US11213525B2 (en) 2017-08-24 2022-01-04 Asceneuron Sa Linear glycosidase inhibitors
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors
CA3110032A1 (en) 2018-08-22 2020-02-27 Asceneuron S.A. Succinate and fumarate acid addition salts of piperazine derivatives
US11795165B2 (en) 2018-08-22 2023-10-24 Asceneuron Sa Tetrahydro-benzoazepine glycosidase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US450780A (en) * 1891-04-21 Steam-engine
US4180583A (en) * 1972-01-28 1979-12-25 Richardson-Merrell Inc. Olefinic 4-substituted piperidino derivatives as therapeutics
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US4666905A (en) * 1983-06-02 1987-05-19 Warner-Lambert Company Diphenylmethylene piperidines compositions and methods for their use
US4540780A (en) * 1983-06-02 1985-09-10 Warner-Lambert Company Diphenylmethylene piperidines
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion

Also Published As

Publication number Publication date
CN1190965A (zh) 1998-08-19
HK1010818A1 (en) 1999-07-02
IL118768A0 (en) 1996-10-31
MX9800368A (es) 1998-03-31
IL118768A (en) 2000-10-31
EP0842170A1 (en) 1998-05-20
NO980109L (no) 1998-01-09
CN1091108C (zh) 2002-09-18
US5935974A (en) 1999-08-10
ATE199150T1 (de) 2001-02-15
DE69611788D1 (de) 2001-03-22
WO1997003065A1 (en) 1997-01-30
PL183837B1 (pl) 2002-07-31
CA2226851A1 (en) 1997-01-30
AU699370B2 (en) 1998-12-03
NO309765B1 (no) 2001-03-26
KR19990028807A (ko) 1999-04-15
DE69611788T2 (de) 2001-08-02
NZ315318A (en) 1999-10-28
EP0842170B1 (en) 2001-02-14
PL324451A1 (en) 1998-05-25
AU6699396A (en) 1997-02-10
HUP9802762A2 (hu) 1999-10-28
HUP9802762A3 (en) 2002-10-28
CZ8398A3 (cs) 1998-06-17
ZA965691B (en) 1997-01-24
RU2162846C2 (ru) 2001-02-10
PT842170E (pt) 2001-06-29
BR9609330A (pt) 1999-05-25
GR3035849T3 (en) 2001-08-31
CZ288909B6 (cs) 2001-09-12
DK0842170T3 (da) 2001-06-18
TR199800027T1 (xx) 1998-05-21
TW419477B (en) 2001-01-21
JPH11508907A (ja) 1999-08-03
AR003966A1 (es) 1998-09-30
NO980109D0 (no) 1998-01-09

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