ES2157166A1 - Procedimiento para la obtencion de licopeno. - Google Patents

Procedimiento para la obtencion de licopeno.

Info

Publication number
ES2157166A1
ES2157166A1 ES009901869A ES9901869A ES2157166A1 ES 2157166 A1 ES2157166 A1 ES 2157166A1 ES 009901869 A ES009901869 A ES 009901869A ES 9901869 A ES9901869 A ES 9901869A ES 2157166 A1 ES2157166 A1 ES 2157166A1
Authority
ES
Spain
Prior art keywords
lycopene
alcohol
biosynthesis
obtaining
purified biomass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009901869A
Other languages
English (en)
Other versions
ES2157166B1 (es
Inventor
Castro Antonio Estrella
De La Vieja Alfonso Collados
Ermanno Bernasconi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009901869A priority Critical patent/ES2157166B1/es
Application filed by Antibioticos SA filed Critical Antibioticos SA
Priority to EP00949493A priority patent/EP1201762B1/en
Priority to AU62826/00A priority patent/AU6282600A/en
Priority to CNB008116342A priority patent/CN1197972C/zh
Priority to AT00949493T priority patent/ATE290095T1/de
Priority to DE60018427T priority patent/DE60018427T2/de
Priority to ES00949493T priority patent/ES2237439T3/es
Priority to JP2001516919A priority patent/JP2003507021A/ja
Priority to PCT/ES2000/000266 priority patent/WO2001012832A1/es
Publication of ES2157166A1 publication Critical patent/ES2157166A1/es
Application granted granted Critical
Publication of ES2157166B1 publication Critical patent/ES2157166B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • External Artificial Organs (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento de obtención de licopeno. La presente invención se refiere a un nuevo procedimiento para la obtención de carotinoides, especialmente licopeno, a partir de fuentes naturales biosintéticas en general y, en concreto de cultivos sumergidos de hongos mucorales como Blakeslea, Choanephora o Phycomyces. El procedimiento descrito permite obtener una simplificación en el proceso de recuperación y un incremento en la purificación del producto. Consta de las siguientes etapas: 1) Tratamiento directo con alcohol sobre la fuente natural de biosíntesis (caldo de fermentación por ejemplo) y separación de una biomasa húmeda purificada. 2) Acondicionamiento de la biomasa purificada mediante secado más disgregación o ruptura de la misma. 3) Extracción sólido-líquido del licopeno con un disolvente orgánico. 4) Concentración del extracto enriquecido. 5) Precipitación/cristalización por adición de alcohol. 6) Filtración. 7) Secado.
ES009901869A 1999-08-12 1999-08-12 Procedimiento para la obtencion de licopeno. Expired - Fee Related ES2157166B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES009901869A ES2157166B1 (es) 1999-08-12 1999-08-12 Procedimiento para la obtencion de licopeno.
AU62826/00A AU6282600A (en) 1999-08-12 2000-07-21 Process for producing lycopen
CNB008116342A CN1197972C (zh) 1999-08-12 2000-07-21 一种生产番茄红素的方法
AT00949493T ATE290095T1 (de) 1999-08-12 2000-07-21 Verfahren zur herstellung von lykopen
EP00949493A EP1201762B1 (en) 1999-08-12 2000-07-21 Process for producing lycopen
DE60018427T DE60018427T2 (de) 1999-08-12 2000-07-21 Verfahren zur herstellung von lykopen
ES00949493T ES2237439T3 (es) 1999-08-12 2000-07-21 Procedimiento para producir licopeno.
JP2001516919A JP2003507021A (ja) 1999-08-12 2000-07-21 リコペンの製造方法
PCT/ES2000/000266 WO2001012832A1 (es) 1999-08-12 2000-07-21 Procedimiento para la obtencion de licopeno

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901869A ES2157166B1 (es) 1999-08-12 1999-08-12 Procedimiento para la obtencion de licopeno.

Publications (2)

Publication Number Publication Date
ES2157166A1 true ES2157166A1 (es) 2001-08-01
ES2157166B1 ES2157166B1 (es) 2002-02-16

Family

ID=8309661

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009901869A Expired - Fee Related ES2157166B1 (es) 1999-08-12 1999-08-12 Procedimiento para la obtencion de licopeno.
ES00949493T Expired - Lifetime ES2237439T3 (es) 1999-08-12 2000-07-21 Procedimiento para producir licopeno.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00949493T Expired - Lifetime ES2237439T3 (es) 1999-08-12 2000-07-21 Procedimiento para producir licopeno.

Country Status (8)

Country Link
EP (1) EP1201762B1 (es)
JP (1) JP2003507021A (es)
CN (1) CN1197972C (es)
AT (1) ATE290095T1 (es)
AU (1) AU6282600A (es)
DE (1) DE60018427T2 (es)
ES (2) ES2157166B1 (es)
WO (1) WO2001012832A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003056028A1 (es) 2001-12-31 2003-07-10 Vitatene, S.A. Procedimiento mejorado de produccion de licopeno mediante la fermentacion de cepas seleccionadas de blakeslea trispora, formulaciones y usos del licopeno obtenido
AU2011253728B2 (en) * 2001-12-31 2013-11-21 Dsm Ip Assets, B.V. Improved method of producing lycopene through the fermentation of selected strains of Blakeslea Trispora, formulations and uses of the lycopene thus obtained

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094772A1 (en) * 2001-05-18 2002-11-28 Aventis Animal Nutrition S.A. Process for the extraction of esters of xanthophyll and of carotenoids
ITMI20020632A1 (it) 2002-03-27 2003-09-29 Indena Spa Processo per la preparazione di estratti di pomodoro ad elevato contenuto di licopene
EP2371967B1 (en) 2005-03-18 2015-06-03 DSM IP Assets B.V. Production of carotenoids in oleaginous yeast and fungi
EP1886584A1 (en) * 2006-08-08 2008-02-13 Indena S.P.A. Stable and bioavailable compositions of isomers of lycopene for skin and hair
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
CN101085989B (zh) * 2007-07-10 2010-06-02 北京市农林科学院 一种利用细菌发酵生产番茄红素的方法
CN102140052B (zh) * 2010-12-30 2013-12-18 南京工业大学 一种连续提取番茄红素的方法
CN102787158B (zh) * 2011-05-20 2015-01-21 浙江医药股份有限公司新昌制药厂 一种发酵法生产天然β-胡萝卜素的方法和应用
PH12014500630A1 (en) 2011-09-19 2014-05-12 Omniactive Health Tech Limited An efficient process for the preparation of lycopene containing oleoresin and lycopene crystals for human consumption
CN103664462B (zh) * 2013-11-19 2015-06-17 新疆红帆生物科技有限公司 番茄油中番茄红素的二次回收方法
CN112479799B (zh) * 2020-12-07 2023-06-27 中国科学院天津工业生物技术研究所 一种从发酵液中分离提取番茄红素的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003480A1 (en) * 1996-07-19 1998-01-29 Gist-Brocade B.V. PROCESS FOR THE RECOVERY OF CRYSTALLINE β-CAROTENE FROM A NATURAL SOURCE
WO1998043620A1 (en) * 1997-04-03 1998-10-08 Kemin Foods, L.C. Process for the isolation and purification of lycopene crystals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003480A1 (en) * 1996-07-19 1998-01-29 Gist-Brocade B.V. PROCESS FOR THE RECOVERY OF CRYSTALLINE β-CAROTENE FROM A NATURAL SOURCE
WO1998043620A1 (en) * 1997-04-03 1998-10-08 Kemin Foods, L.C. Process for the isolation and purification of lycopene crystals

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003056028A1 (es) 2001-12-31 2003-07-10 Vitatene, S.A. Procedimiento mejorado de produccion de licopeno mediante la fermentacion de cepas seleccionadas de blakeslea trispora, formulaciones y usos del licopeno obtenido
ES2195758A1 (es) * 2001-12-31 2003-12-01 Antibioticos Sau Procedimiento mejorado de produccion de licopeno mediante la fermentacion de cepas seleccionadas de blakeslea trispora, formulaciones y usos del licopeno obtenido.
ES2195758B1 (es) * 2001-12-31 2005-03-01 Antibioticos, S.A.U. Procedimiento mejorado de produccion de licopeno mediante la fermentacion de cepas seleccionadas de blakeslea trispora, formulaciones y usos del licopeno obtenido.
US7799540B2 (en) 2001-12-31 2010-09-21 Vitatene, S.A. Method of producing lycopene through the fermentation of selected strains of Blackeslea trispora, formulations and uses of the lycopene thus obtained
AU2008264168B2 (en) * 2001-12-31 2011-11-24 Dsm Ip Assets B.V. Improved method of producing lycopene through the fermentation of selected strains of Blakeslea Trispora, formulations and uses of the lycopene thus obtained
AU2011253728B2 (en) * 2001-12-31 2013-11-21 Dsm Ip Assets, B.V. Improved method of producing lycopene through the fermentation of selected strains of Blakeslea Trispora, formulations and uses of the lycopene thus obtained

Also Published As

Publication number Publication date
ATE290095T1 (de) 2005-03-15
AU6282600A (en) 2001-03-13
ES2157166B1 (es) 2002-02-16
EP1201762A1 (en) 2002-05-02
WO2001012832A1 (es) 2001-02-22
DE60018427D1 (de) 2005-04-07
CN1370241A (zh) 2002-09-18
DE60018427T2 (de) 2006-04-06
EP1201762B1 (en) 2005-03-02
JP2003507021A (ja) 2003-02-25
ES2237439T3 (es) 2005-08-01
CN1197972C (zh) 2005-04-20

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