ES2157539T3 - Derivados del benzopirano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Derivados del benzopirano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2157539T3
ES2157539T3 ES97402821T ES97402821T ES2157539T3 ES 2157539 T3 ES2157539 T3 ES 2157539T3 ES 97402821 T ES97402821 T ES 97402821T ES 97402821 T ES97402821 T ES 97402821T ES 2157539 T3 ES2157539 T3 ES 2157539T3
Authority
ES
Spain
Prior art keywords
sub
group
benzopirane
derivatives
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97402821T
Other languages
English (en)
Inventor
Timothee Muller
Claudie Moulin
Muriel Duflos
Sylvie Robert-Piessard
Baut Guillaume Le
Alain Tonnerre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2157539T3 publication Critical patent/ES2157539T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION ESTA RELACIONADA CON LOS COMPUESTOS QUE RESPONDEN A LA FORMULA GENERAL (I): DONDE: R SUB,1} REPRESENTA UN GRUPO ALQUIL; R SUB,2}, R SUB,4} Y R SUB,5}, IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALQUIL; R SUB,3} REPRESENTA UNO CUALQUIERA DE LOS GRUPOS DEFINIDOS EN LA DESCRIPCION; X REPRESENTA UN GRUPO CARBONIL O UN GRUPO METILENO; Y REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUIL O ARIL; A REPRESENTA UN ENLACE SIMPLE O UN GRUPO ALQUILFENIL; R SUB,6} REPRESENTA UNO CUALQUIERA DE LOS GRUPOS DEFINIDOS EN LA DESCRIPCION, SUS ISOMEROS Y TAMBIEN SUS SALES DE ADICION A UN ACIDO O UNA BASE FARMACEUTICAMENTE ACEPTABLE. DE APLICACION EN LA FABRICACION DE MEDICAMENTOS.
ES97402821T 1996-11-26 1997-11-24 Derivados del benzopirano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2157539T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9614470A FR2756284B1 (fr) 1996-11-26 1996-11-26 Nouveaux derives du benzopyrane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2157539T3 true ES2157539T3 (es) 2001-08-16

Family

ID=9498038

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97402821T Expired - Lifetime ES2157539T3 (es) 1996-11-26 1997-11-24 Derivados del benzopirano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (19)

Country Link
US (1) US5889045A (es)
EP (1) EP0844245B1 (es)
JP (1) JPH10158260A (es)
CN (1) CN1183412A (es)
AT (1) ATE201020T1 (es)
AU (1) AU720479B2 (es)
BR (1) BR9705064A (es)
CA (1) CA2222467C (es)
DE (1) DE69704755T2 (es)
DK (1) DK0844245T3 (es)
ES (1) ES2157539T3 (es)
FR (1) FR2756284B1 (es)
GR (1) GR3036242T3 (es)
HU (1) HUP9702227A3 (es)
NO (1) NO975402L (es)
NZ (1) NZ329264A (es)
PL (1) PL323339A1 (es)
PT (1) PT844245E (es)
ZA (1) ZA9710649B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000372A1 (fr) 1997-06-27 1999-01-07 Fujisawa Pharmaceutical Co., Ltd. Sulfamides et leur utilisation medicale
WO1999043315A1 (en) * 1998-02-25 1999-09-02 Shionogi & Co., Ltd. Therapeutic agent for complication of diabetes
KR100352986B1 (ko) * 2000-04-28 2002-09-18 주식회사 태평양 세라미드 유사 화합물 및 이의 제조방법, 및 이를함유하는 화장료 조성물
WO2004076437A1 (en) * 2003-02-26 2004-09-10 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Benzopyran compounds, process for preparing the same and their use
EP3725324A1 (en) * 2005-09-16 2020-10-21 Cornell Research Foundation, Inc. Aromatic-cationic peptide for use in a method for reducing cd36 expression
PL2220030T3 (pl) * 2007-11-06 2016-07-29 Bioelectron Tech Corp Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych
CA2986300C (en) 2015-05-22 2024-02-20 Sulfateq B.V. Compound for the prophylaxis or treatment of organ damage
TW201831471A (zh) 2017-02-24 2018-09-01 盧森堡商艾伯維公司 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2087423A1 (en) * 1990-07-25 1992-01-26 Tatsuki Shiota Benzopyran derivative, process for producing the same and pharmaceutical composition containing the same
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
KR950009863B1 (ko) * 1991-05-22 1995-08-29 재단법인한국화학연구소 벤조피란 유도체와 그의 제조방법
TW244350B (es) * 1991-12-14 1995-04-01 Hoechst Ag
ZA93436B (en) * 1992-01-24 1993-08-25 Chugai Pharmaceutical Co Ltd Benzopyran derivatives
US5236935A (en) * 1992-05-21 1993-08-17 Korea Research Institute Of Chemical Technology Benzopyran derivatives and processes for the preparation thereof
US5516917A (en) * 1994-06-08 1996-05-14 G. D. Searle & Co. Leukotriene B4 antagonists
ES2169102T3 (es) * 1994-10-14 2002-07-01 Merck Patent Gmbh (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central.
FR2733685B1 (fr) * 1995-05-05 1997-05-30 Adir Utilisation des derives du benzopyrane pour l'obtention de compositions pharmaceutiques destinees au traitement des pathologies liees a l'echangeur c1-/hc03-, na+ independant
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate

Also Published As

Publication number Publication date
HU9702227D0 (en) 1998-01-28
HUP9702227A3 (en) 1999-03-01
EP0844245A1 (fr) 1998-05-27
ATE201020T1 (de) 2001-05-15
DE69704755T2 (de) 2002-02-28
HUP9702227A2 (hu) 1998-12-28
DK0844245T3 (da) 2001-06-11
EP0844245B1 (fr) 2001-05-09
GR3036242T3 (en) 2001-10-31
CN1183412A (zh) 1998-06-03
FR2756284B1 (fr) 2000-04-28
AU4538397A (en) 1998-05-28
JPH10158260A (ja) 1998-06-16
NO975402D0 (no) 1997-11-25
DE69704755D1 (de) 2001-06-13
FR2756284A1 (fr) 1998-05-29
NZ329264A (en) 1998-04-27
US5889045A (en) 1999-03-30
PL323339A1 (en) 1998-06-08
BR9705064A (pt) 1999-07-20
PT844245E (pt) 2001-09-28
AU720479B2 (en) 2000-06-01
CA2222467A1 (fr) 1998-05-26
CA2222467C (fr) 2002-05-28
ZA9710649B (en) 1998-06-12
NO975402L (no) 1998-05-27

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