ES2158115T3 - Derivados de histidina y homohistidina como inhibidores de la farnesiltransferasa de proteinas. - Google Patents

Derivados de histidina y homohistidina como inhibidores de la farnesiltransferasa de proteinas.

Info

Publication number
ES2158115T3
ES2158115T3 ES95921421T ES95921421T ES2158115T3 ES 2158115 T3 ES2158115 T3 ES 2158115T3 ES 95921421 T ES95921421 T ES 95921421T ES 95921421 T ES95921421 T ES 95921421T ES 2158115 T3 ES2158115 T3 ES 2158115T3
Authority
ES
Spain
Prior art keywords
protein
inhibitors
farnesiltransferasa
homohistidine
histidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921421T
Other languages
English (en)
Inventor
Gary Louis Bolton
John Cooke Hodges
Michael William Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2158115T3 publication Critical patent/ES2158115T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBEN NUEVOS INHIBIDORES DE ENZIMA FARNESILTRANSFERASA DE PROTEINA, ASI COMO METODOS PARA LA PREPARACION Y COMPOSICIONES FARMACEUTICAS DE LOS MISMOS, LOS CUALES SON UTILES EN EL CONTROL DE TRASTORNOS PROLIFERATIVOS DE TEJIDO, INCLUYENDO CANCER Y RESTENOSIS.
ES95921421T 1994-06-30 1995-05-30 Derivados de histidina y homohistidina como inhibidores de la farnesiltransferasa de proteinas. Expired - Lifetime ES2158115T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/268,364 US5571792A (en) 1994-06-30 1994-06-30 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Publications (1)

Publication Number Publication Date
ES2158115T3 true ES2158115T3 (es) 2001-09-01

Family

ID=23022659

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921421T Expired - Lifetime ES2158115T3 (es) 1994-06-30 1995-05-30 Derivados de histidina y homohistidina como inhibidores de la farnesiltransferasa de proteinas.

Country Status (17)

Country Link
US (1) US5571792A (es)
EP (1) EP0767800B1 (es)
JP (1) JPH10502078A (es)
AT (1) ATE200085T1 (es)
AU (1) AU699629B2 (es)
CA (1) CA2190977A1 (es)
DE (1) DE69520499T2 (es)
DK (1) DK0767800T3 (es)
ES (1) ES2158115T3 (es)
GR (1) GR3035936T3 (es)
HR (1) HRP950337B1 (es)
MX (1) MX9605945A (es)
NO (1) NO315427B1 (es)
NZ (1) NZ287696A (es)
PT (1) PT767800E (es)
WO (1) WO1996000736A1 (es)
ZA (1) ZA955411B (es)

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US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0840605A4 (en) * 1995-07-13 2000-05-10 Univ Cincinnati COMPOUNDS FOR USE IN THE TREATMENT OF NEUROFIBROMATOSE
AU1529997A (en) * 1996-01-16 1997-08-11 Warner-Lambert Company Substituted histidine inhibitors of protein farnesyltransferase
WO1997027852A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US5981562A (en) * 1996-01-30 1999-11-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6090948A (en) * 1996-01-30 2000-07-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2250937A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5922883A (en) * 1996-04-03 1999-07-13 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6300501B1 (en) * 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
WO1997044350A1 (en) * 1996-05-22 1997-11-27 Warner-Lambert Company Inhibitors of protein farnesyl transferase
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
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US5972966A (en) * 1996-12-05 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6015817A (en) * 1996-12-05 2000-01-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5932590A (en) * 1996-12-05 1999-08-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0951471B1 (en) 1996-12-17 2004-03-17 Warner-Lambert Company Llc Cycloalkyl inhibitors of protein farnesyltransferase
US6737410B1 (en) 1997-04-11 2004-05-18 Warner-Lambert Company Inhibitors of protein farnesyl transferase
WO1998046625A1 (en) * 1997-04-11 1998-10-22 Warner-Lambert Company Dipeptide inhibitors of protein farnesyltransferase
US6060038A (en) * 1997-05-15 2000-05-09 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
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NZ507165A (en) 1998-04-27 2003-06-30 Warner Lambert Co Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
ID27933A (id) 1998-05-12 2001-05-03 Warner Lambert Co Gabungan protein farnesiltransferase dan inhibitor hmg-coa reduktase serta penggunaannya untuk mengobati kanker
US6458935B1 (en) 1999-06-23 2002-10-01 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
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JP2001158799A (ja) 1999-09-28 2001-06-12 Rijksuniv Leiden プレニル化ピロリン酸消費酵素の新規な阻害剤
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Also Published As

Publication number Publication date
AU699629B2 (en) 1998-12-10
DE69520499D1 (de) 2001-05-03
ZA955411B (en) 1996-02-05
HRP950337A2 (en) 1997-08-31
DE69520499T2 (de) 2001-07-26
US5571792A (en) 1996-11-05
EP0767800A1 (en) 1997-04-16
NZ287696A (en) 1997-12-19
HRP950337B1 (en) 2001-12-31
GR3035936T3 (en) 2001-08-31
NO315427B1 (no) 2003-09-01
ATE200085T1 (de) 2001-04-15
NO965604D0 (no) 1996-12-27
WO1996000736A1 (en) 1996-01-11
CA2190977A1 (en) 1996-01-11
DK0767800T3 (da) 2001-06-18
PT767800E (pt) 2001-08-30
AU2650495A (en) 1996-01-25
MX9605945A (es) 1997-12-31
JPH10502078A (ja) 1998-02-24
NO965604L (no) 1997-02-25
EP0767800B1 (en) 2001-03-28

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