NO965604L - Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferase - Google Patents

Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferase

Info

Publication number: NO965604L
Authority: NO; Norway
Prior art keywords: inhibitors; homohistidine; histidine; derivatives; farnesyl transferase
Prior art date: 1994-06-30

Application number

NO965604A

Other languages

English (en)

Other versions

NO315427B1 (no

NO965604D0 (no

Inventor

Gary Louis Bolton

John Cooke Hodges

Michael William Wilson

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-30

Filing date

1996-12-27

Publication date

1997-02-25

1996-12-27 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1996-12-27 Publication of NO965604D0 publication Critical patent/NO965604D0/no

1997-02-25 Publication of NO965604L publication Critical patent/NO965604L/no

2003-09-01 Publication of NO315427B1 publication Critical patent/NO315427B1/no

Links

239000003112 inhibitor Substances 0.000 title abstract 2
108010054353 p21(ras) farnesyl-protein transferase Proteins 0.000 title abstract 2
MSECZMWQBBVGEN-LURJTMIESA-N (2s)-2-azaniumyl-4-(1h-imidazol-5-yl)butanoate Chemical class OC(=O)[C@@H](N)CCC1=CN=CN1 MSECZMWQBBVGEN-LURJTMIESA-N 0.000 title 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 title 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO19965604A 1994-06-30 1996-12-27 Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferase, anvendelse derav, farmasöytisk preparat, opplösnings-syntesemetode samt fastfase-syntesemetode NO315427B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/268,364 US5571792A (en)	1994-06-30	1994-06-30	Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
PCT/US1995/006660 WO1996000736A1 (en)	1994-06-30	1995-05-30	Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Publications (3)

Publication Number	Publication Date
NO965604D0 NO965604D0 (no)	1996-12-27
NO965604L true NO965604L (no)	1997-02-25
NO315427B1 NO315427B1 (no)	2003-09-01

Family

ID=23022659

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19965604A NO315427B1 (no)	1994-06-30	1996-12-27	Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferase, anvendelse derav, farmasöytisk preparat, opplösnings-syntesemetode samt fastfase-syntesemetode

Country Status (17)

Country	Link
US (1)	US5571792A (no)
EP (1)	EP0767800B1 (no)
JP (1)	JPH10502078A (no)
AT (1)	ATE200085T1 (no)
AU (1)	AU699629B2 (no)
CA (1)	CA2190977A1 (no)
DE (1)	DE69520499T2 (no)
DK (1)	DK0767800T3 (no)
ES (1)	ES2158115T3 (no)
GR (1)	GR3035936T3 (no)
HR (1)	HRP950337B1 (no)
MX (1)	MX9605945A (no)
NO (1)	NO315427B1 (no)
NZ (1)	NZ287696A (no)
PT (1)	PT767800E (no)
WO (1)	WO1996000736A1 (no)
ZA (1)	ZA955411B (no)

Families Citing this family (94)

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JP2000504014A (ja) *	1996-01-30	2000-04-04	メルクエンドカンパニーインコーポレーテッド	ファルネシル―タンパク質転移酵素の阻害剤
EP1011669A4 (en) *	1996-01-30	2001-09-12	Merck & Co Inc	FARNESYL PROTEIN TRANSFERASE INHIBITORS
JP2000505797A (ja) *	1996-01-30	2000-05-16	メルクエンドカンパニーインコーポレーテッド	ファルネシル―タンパク質転移酵素の阻害剤
US5968965A (en) *	1996-01-30	1999-10-19	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5981562A (en) *	1996-01-30	1999-11-09	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
WO1997036584A1 (en) *	1996-04-03	1997-10-09	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5922883A (en) *	1996-04-03	1999-07-13	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
NZ332712A (en) *	1996-05-22	2000-07-28	Warner Lambert Co	Polypeptide inhibitors of protein farnesyl transferase
US6300501B1 (en) *	1996-05-22	2001-10-09	Warner-Lambert Company	Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
US6093816A (en) *	1996-06-27	2000-07-25	Isis Pharmaceuticals, Inc.	Cationic lipids
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US5932590A (en) *	1996-12-05	1999-08-03	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5972966A (en) *	1996-12-05	1999-10-26	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5977134A (en) *	1996-12-05	1999-11-02	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US6015817A (en) *	1996-12-05	2000-01-18	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
EP0951471B1 (en)	1996-12-17	2004-03-17	Warner-Lambert Company Llc	Cycloalkyl inhibitors of protein farnesyltransferase
AU6877998A (en) *	1997-04-11	1998-11-11	Warner-Lambert Company	Dipeptide inhibitors of protein farnesyltransferase
US6737410B1 (en)	1997-04-11	2004-05-18	Warner-Lambert Company	Inhibitors of protein farnesyl transferase
US6060038A (en) *	1997-05-15	2000-05-09	Merck & Co., Inc.	Radiolabeled farnesyl-protein transferase inhibitors
US6870909B2 (en) *	1997-09-08	2005-03-22	Mci, Inc.	Single telephone number access to multiple communications services
EP1076663B1 (en)	1998-04-27	2004-02-18	Warner-Lambert Company LLC	Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
YU68900A (sh)	1998-05-12	2002-12-10	Warner-Lambert Company	Kombinacije inhibitora protein farnesiltransferaze i hmg coa reduktaze i njihova upotreba u tretmanu raka
US6458935B1 (en)	1999-06-23	2002-10-01	Merck & Co., Inc.	Radiolabeled farnesyl-protein transferase inhibitors
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1994
- 1994-06-30 US US08/268,364 patent/US5571792A/en not_active Expired - Fee Related
1995
- 1995-05-30 AT AT95921421T patent/ATE200085T1/de not_active IP Right Cessation
- 1995-05-30 NZ NZ287696A patent/NZ287696A/en unknown
- 1995-05-30 DE DE69520499T patent/DE69520499T2/de not_active Expired - Fee Related
- 1995-05-30 MX MX9605945A patent/MX9605945A/es not_active IP Right Cessation
- 1995-05-30 PT PT95921421T patent/PT767800E/pt unknown
- 1995-05-30 EP EP95921421A patent/EP0767800B1/en not_active Expired - Lifetime
- 1995-05-30 JP JP8503154A patent/JPH10502078A/ja active Pending
- 1995-05-30 ES ES95921421T patent/ES2158115T3/es not_active Expired - Lifetime
- 1995-05-30 WO PCT/US1995/006660 patent/WO1996000736A1/en not_active Ceased
- 1995-05-30 AU AU26504/95A patent/AU699629B2/en not_active Ceased
- 1995-05-30 DK DK95921421T patent/DK0767800T3/da active
- 1995-05-30 CA CA002190977A patent/CA2190977A1/en not_active Abandoned
- 1995-06-14 HR HR950337A patent/HRP950337B1/xx not_active IP Right Cessation
- 1995-06-29 ZA ZA955411A patent/ZA955411B/xx unknown
1996
- 1996-12-27 NO NO19965604A patent/NO315427B1/no not_active IP Right Cessation
2001
- 2001-05-25 GR GR20010400790T patent/GR3035936T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE200085T1 (de)	2001-04-15
EP0767800B1 (en)	2001-03-28
PT767800E (pt)	2001-08-30
JPH10502078A (ja)	1998-02-24
EP0767800A1 (en)	1997-04-16
WO1996000736A1 (en)	1996-01-11
ZA955411B (en)	1996-02-05
CA2190977A1 (en)	1996-01-11
HRP950337A2 (en)	1997-08-31
DK0767800T3 (da)	2001-06-18
US5571792A (en)	1996-11-05
DE69520499D1 (de)	2001-05-03
HRP950337B1 (en)	2001-12-31
NZ287696A (en)	1997-12-19
AU699629B2 (en)	1998-12-10
GR3035936T3 (en)	2001-08-31
NO315427B1 (no)	2003-09-01
ES2158115T3 (es)	2001-09-01
MX9605945A (es)	1997-12-31
NO965604D0 (no)	1996-12-27
DE69520499T2 (de)	2001-07-26
AU2650495A (en)	1996-01-25

Legal Events

Date	Code	Title	Description
2005-01-03	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO965604D0 (no)	1996-12-27	Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferase
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IT1289154B1 (it)	1998-09-29	Derivati di isoflavone loro preparazione e loro impiego terapeutico
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AU2003209899A1 (en)	2003-10-08	Dithiolopyrrolone derivatives useful in the treatment of proliferative diseases
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