ES2159632T3 - Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo. - Google Patents

Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo.

Info

Publication number
ES2159632T3
ES2159632T3 ES95913940T ES95913940T ES2159632T3 ES 2159632 T3 ES2159632 T3 ES 2159632T3 ES 95913940 T ES95913940 T ES 95913940T ES 95913940 T ES95913940 T ES 95913940T ES 2159632 T3 ES2159632 T3 ES 2159632T3
Authority
ES
Spain
Prior art keywords
active ingredient
controlled release
solid forms
preparation
gotitas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95913940T
Other languages
English (en)
Inventor
Lorenzo Rodriguez
Maurizio Cini
Cristina Cavallari
Giuseppe Motta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saitec SRL
Original Assignee
Saitec SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saitec SRL filed Critical Saitec SRL
Application granted granted Critical
Publication of ES2159632T3 publication Critical patent/ES2159632T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
  • Nozzles (AREA)

Abstract

SE SUMINISTRA UN APARATO Y UN METODO MEJORADOS PARA PREPARAR FORMAS SOLIDAS CON LIBERACION CONTROLADA DEL INGREDIENTE ACTIVO DE ACUERDO CON TECNICAS DE SECADO POR ROCIADO Y CONGELACION POR ROCIADO. LA MEJORA COMPRENDE EL USO DE UN ATOMIZADOR QUE UTILIZA VIBRACIONES MECANICAS DE ELEMENTOS RESONANTES DE METAL O BOQUILLAS DE MANERA QUE SE OBTENGAN GOTITAS MUY PEQUEÑAS CON MUY POCA LONGITUD DE ROCIADO (25-30 CM). LAS GOTITAS CAEN PARA DAR PARTICULAS DE POLVO ESFERICAS QUE SE DEBEN A LA EVAPORACION DE LOS SOLVENTES CONTENIDOS O A LA SOLIDIFICACION DE LOS COMPONENTES CEROSOS FUNDIDOS.
ES95913940T 1994-08-03 1995-04-06 Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo. Expired - Lifetime ES2159632T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO940379A IT1274879B (it) 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.

Publications (1)

Publication Number Publication Date
ES2159632T3 true ES2159632T3 (es) 2001-10-16

Family

ID=11339983

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95913940T Expired - Lifetime ES2159632T3 (es) 1994-08-03 1995-04-06 Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo.

Country Status (19)

Country Link
US (1) US5707636A (es)
EP (1) EP0726765B1 (es)
JP (1) JPH09503441A (es)
KR (1) KR100348935B1 (es)
CN (1) CN1213735C (es)
AT (1) ATE202279T1 (es)
AU (1) AU693539B2 (es)
BR (1) BR9506305A (es)
CA (1) CA2173221A1 (es)
DE (1) DE69521406T2 (es)
DK (1) DK0726765T3 (es)
ES (1) ES2159632T3 (es)
GR (1) GR3036548T3 (es)
IT (1) IT1274879B (es)
MX (1) MX9601279A (es)
PT (1) PT726765E (es)
RU (1) RU2142792C1 (es)
TW (1) TW343149B (es)
WO (1) WO1996003979A1 (es)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
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US8012136B2 (en) * 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
PT1842533E (pt) * 2003-08-06 2013-05-17 Gruenenthal Gmbh Forma de dosagem protegida contra abuso
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
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DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) * 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
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DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
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CN102215821B (zh) * 2007-10-23 2013-05-08 皇家飞利浦电子股份有限公司 用于制备聚合物微颗粒的方法
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US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
ES2599031T3 (es) * 2008-05-09 2017-01-31 Grünenthal GmbH Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización
ES2534908T3 (es) * 2009-07-22 2015-04-30 Grünenthal GmbH Forma de dosificación de liberación controlada extruida por fusión en caliente
BR112012001466A2 (pt) * 2009-07-22 2020-08-11 Grünenthal GmbH forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem
US9579285B2 (en) 2010-02-03 2017-02-28 Gruenenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
MX2013000604A (es) 2010-07-15 2013-07-05 Corinthian Ophthalmic Inc Suministro oftálmico de fármaco.
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WO2012009702A1 (en) 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
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RU2449777C1 (ru) * 2010-12-20 2012-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Способ получения высокодисперсного парацетамола
JP6063462B2 (ja) 2011-07-29 2017-01-18 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時薬剤放出を提供するタンパーレジスタント錠剤
BR112014002022A2 (pt) 2011-07-29 2017-02-21 Gruenenthal Gmbh comprimido resistente à violação proporcionando liberação de fármaco imediata
CN104487028A (zh) 2011-12-12 2015-04-01 艾诺维亚股份有限公司 高模量聚合物喷射器机构、喷射器装置及其使用方法
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
LT2838512T (lt) 2012-04-18 2018-11-12 GrĆ¼nenthal GmbH Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX2015016254A (es) 2013-05-29 2016-04-20 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
US9452271B2 (en) 2013-05-29 2016-09-27 General Electric Company Nebulizer systems and methods
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Also Published As

Publication number Publication date
ITBO940379A1 (it) 1996-02-03
AU2113795A (en) 1996-03-04
PT726765E (pt) 2001-12-28
GR3036548T3 (en) 2001-12-31
DE69521406D1 (de) 2001-07-26
CA2173221A1 (en) 1996-02-15
CN1213735C (zh) 2005-08-10
EP0726765A1 (en) 1996-08-21
RU2142792C1 (ru) 1999-12-20
DE69521406T2 (de) 2002-05-02
DK0726765T3 (da) 2001-10-15
ATE202279T1 (de) 2001-07-15
WO1996003979A1 (en) 1996-02-15
MX9601279A (es) 1998-11-30
EP0726765B1 (en) 2001-06-20
TW343149B (en) 1998-10-21
KR100348935B1 (ko) 2002-12-28
BR9506305A (pt) 1997-08-05
KR960704529A (ko) 1996-10-09
US5707636A (en) 1998-01-13
IT1274879B (it) 1997-07-25
ITBO940379A0 (it) 1994-08-03
AU693539B2 (en) 1998-07-02
CN1135175A (zh) 1996-11-06
JPH09503441A (ja) 1997-04-08

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