ES2159632T3 - Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo. - Google Patents

Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo.

Info

Publication number
ES2159632T3
ES2159632T3 ES95913940T ES95913940T ES2159632T3 ES 2159632 T3 ES2159632 T3 ES 2159632T3 ES 95913940 T ES95913940 T ES 95913940T ES 95913940 T ES95913940 T ES 95913940T ES 2159632 T3 ES2159632 T3 ES 2159632T3
Authority
ES
Spain
Prior art keywords
active ingredient
controlled release
solid forms
preparation
gotitas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95913940T
Other languages
English (en)
Inventor
Lorenzo Rodriguez
Maurizio Cini
Cristina Cavallari
Giuseppe Motta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saitec SRL
Original Assignee
Saitec SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saitec SRL filed Critical Saitec SRL
Application granted granted Critical
Publication of ES2159632T3 publication Critical patent/ES2159632T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nozzles (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)

Abstract

SE SUMINISTRA UN APARATO Y UN METODO MEJORADOS PARA PREPARAR FORMAS SOLIDAS CON LIBERACION CONTROLADA DEL INGREDIENTE ACTIVO DE ACUERDO CON TECNICAS DE SECADO POR ROCIADO Y CONGELACION POR ROCIADO. LA MEJORA COMPRENDE EL USO DE UN ATOMIZADOR QUE UTILIZA VIBRACIONES MECANICAS DE ELEMENTOS RESONANTES DE METAL O BOQUILLAS DE MANERA QUE SE OBTENGAN GOTITAS MUY PEQUEÑAS CON MUY POCA LONGITUD DE ROCIADO (25-30 CM). LAS GOTITAS CAEN PARA DAR PARTICULAS DE POLVO ESFERICAS QUE SE DEBEN A LA EVAPORACION DE LOS SOLVENTES CONTENIDOS O A LA SOLIDIFICACION DE LOS COMPONENTES CEROSOS FUNDIDOS.
ES95913940T 1994-08-03 1995-04-06 Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo. Expired - Lifetime ES2159632T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO940379A IT1274879B (it) 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.

Publications (1)

Publication Number Publication Date
ES2159632T3 true ES2159632T3 (es) 2001-10-16

Family

ID=11339983

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95913940T Expired - Lifetime ES2159632T3 (es) 1994-08-03 1995-04-06 Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo.

Country Status (19)

Country Link
US (1) US5707636A (es)
EP (1) EP0726765B1 (es)
JP (1) JPH09503441A (es)
KR (1) KR100348935B1 (es)
CN (1) CN1213735C (es)
AT (1) ATE202279T1 (es)
AU (1) AU693539B2 (es)
BR (1) BR9506305A (es)
CA (1) CA2173221A1 (es)
DE (1) DE69521406T2 (es)
DK (1) DK0726765T3 (es)
ES (1) ES2159632T3 (es)
GR (1) GR3036548T3 (es)
IT (1) IT1274879B (es)
MX (1) MX9601279A (es)
PT (1) PT726765E (es)
RU (1) RU2142792C1 (es)
TW (1) TW343149B (es)
WO (1) WO1996003979A1 (es)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
ATE501766T1 (de) * 2003-05-20 2011-04-15 James F Collins Ophthalmisches arzneimittelabgabesystem
US8545463B2 (en) * 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
NZ545202A (en) * 2003-08-06 2010-03-26 Gruenenthal Chemie Abuse-proofed dosage form comprising opiods and a high molecular weight polyethylene oxide
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) * 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
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DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
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DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
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KR101616246B1 (ko) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 약제학적 투여형
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
AU2009243681B2 (en) * 2008-05-09 2013-12-19 Grunenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
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WO2011009602A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Hot-melt extruded controlled release dosage form
US9579285B2 (en) * 2010-02-03 2017-02-28 Gruenenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
WO2012009696A2 (en) 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Ophthalmic drug delivery
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック，インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
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WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
RU2449777C1 (ru) * 2010-12-20 2012-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Способ получения высокодисперсного парацетамола
AU2012289764B2 (en) 2011-07-29 2017-03-02 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
ES2648129T3 (es) 2011-07-29 2017-12-28 Grünenthal GmbH Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
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PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
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Also Published As

Publication number Publication date
RU2142792C1 (ru) 1999-12-20
AU2113795A (en) 1996-03-04
BR9506305A (pt) 1997-08-05
MX9601279A (es) 1998-11-30
CA2173221A1 (en) 1996-02-15
EP0726765B1 (en) 2001-06-20
CN1135175A (zh) 1996-11-06
US5707636A (en) 1998-01-13
IT1274879B (it) 1997-07-25
AU693539B2 (en) 1998-07-02
TW343149B (en) 1998-10-21
ITBO940379A1 (it) 1996-02-03
GR3036548T3 (en) 2001-12-31
WO1996003979A1 (en) 1996-02-15
PT726765E (pt) 2001-12-28
ATE202279T1 (de) 2001-07-15
DE69521406D1 (de) 2001-07-26
KR960704529A (ko) 1996-10-09
JPH09503441A (ja) 1997-04-08
ITBO940379A0 (it) 1994-08-03
DE69521406T2 (de) 2002-05-02
KR100348935B1 (ko) 2002-12-28
EP0726765A1 (en) 1996-08-21
DK0726765T3 (da) 2001-10-15
CN1213735C (zh) 2005-08-10

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