ES2159773T3 - Procedimiento para la obtencion de acidos l-alfa-amino-carboxilicos opticamente activos a partir de correspondientes acidos d,l-alfa-aminocarboxilicos racemicos. - Google Patents

Procedimiento para la obtencion de acidos l-alfa-amino-carboxilicos opticamente activos a partir de correspondientes acidos d,l-alfa-aminocarboxilicos racemicos.

Info

Publication number
ES2159773T3
ES2159773T3 ES96943040T ES96943040T ES2159773T3 ES 2159773 T3 ES2159773 T3 ES 2159773T3 ES 96943040 T ES96943040 T ES 96943040T ES 96943040 T ES96943040 T ES 96943040T ES 2159773 T3 ES2159773 T3 ES 2159773T3
Authority
ES
Spain
Prior art keywords
alpha
aminocarboxylic
acetyl
acid
aminocarboxylic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96943040T
Other languages
English (en)
Inventor
Karlheinz Drauz
Andreas Bommarius
Michael Karrenbauer
Gunter Knaup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2159773T3 publication Critical patent/ES2159773T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/36—Racemisation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DA A CONOCER UN PROCEDIMIENTO PARA OBTENER L AL ACIDOS AMINOCARBOXILICOS OPTICAMENTE ACTIVOS A PARTIR DE LOS CORRESPONDIENTES D,L AL ACIDOS AMINOCARBOXILICOS RACEMICOS, EN EL CUAL (A) LOS D,L AL ACIDOS AMINOCARBOXILICOS SON ACETILADOS; (B) LOS N ACETIL L AL ACIDOS AMINOCARBOXILICOS PRESENTES EN LA MEZCLA DE LOS N ACETIL D,L AL ACIDOS AMINOCARBOXILICOS OBTENIDOS SE DISOCIAN ENZIMATICAMENTE EN EL L AL ACIDO AMINOCA RBOXILICO; (C) EL L AL ACIDO AMINOCARBOXILICO SE SEPARA DE LA MEZCLA, RETENIENDOSE UNA CANTIDAD DE SOLUCION DE N ACETIL D(L) AL ACIDO AMINOCARBOXILICO Y UNA CANTIDAD DE ACETATO EQUIVALENTE DE LOS L AL ACIDOS AMINOCARBOXILICOS FORMADOS; Y (D) SE RACEMIZAN LOS N ACETIL D,L AL ACIDOS AMINOCARBOXILICOS CONTENIDOS EN LA SOLUCION Y SON RECICLADOS PARA SU DISOCIACION ENZIMATICA. LOS PROCEDIMIENTOS DE OBTENCION AL USO, EN LOS QUE SE LLEVAN A CABO LOS PASOS DE LA (A) A LA (D), TIENEN LA DESVENTAJA DE QUE PRODUCEN UNA GRAN CARGA DE SAL. ESTOS PROCEDIMIENTOS ESTAN ESPECIALMENTE ALEJADOS DELA ECUACION IDEAL, SEGUN LA CUAL UN CIEN POR CIEN DE ANHIDRIDO ACETICO Y DE D(L) AL ACIDO AMINOCARBOXILICO SE CONVIERTEN EN L AL ACIDO AMINOCARBOXILICO Y ACIDO ACETICO. AJUSTANDO LA SOLUCION CONSERVADA DEL PASO (C) HASTA OBTENER UNA SOLUCION QUE CONSISTE BASICAMENTE EN UNA N ACETIL D(L) AL SAL DE ACIDO AMINOCARBOXILICO Y ACIDO ACETICO LIBRE EN EQUILIBRIO CON ACETATO Y N ACETIL D(L) AL ACIDO AMINOCARBOXILICO LIBRE, DE DONDE SE EXTRAE ACIDO ACETICO POR DESTILACION, SE CONSIGUE DE FORMA SORPRENDENTEMENTE FACIL INTRODUCIR EN EL CIRCUITO LA SOLUCION FORMADA COMO LEJIA MADRE DESPUES DE LA SEPARACION DE LOS L AL ACIDOS AMINOCARBOXILICOS Y HACER REALIDAD UN BALANCE DE MATERIAS QUE SE ACERCA LO MAS POSIBLE AL IDEAL.
ES96943040T 1995-12-13 1996-12-05 Procedimiento para la obtencion de acidos l-alfa-amino-carboxilicos opticamente activos a partir de correspondientes acidos d,l-alfa-aminocarboxilicos racemicos. Expired - Lifetime ES2159773T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19546532A DE19546532C2 (de) 1995-12-13 1995-12-13 Verfahren zur Gewinnung von optisch aktiven L-alpha-Aminocarbonsäuren aus entsprechenden racemischen D,L-alpha-Aminocarbonsäuren

Publications (1)

Publication Number Publication Date
ES2159773T3 true ES2159773T3 (es) 2001-10-16

Family

ID=7780007

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96943040T Expired - Lifetime ES2159773T3 (es) 1995-12-13 1996-12-05 Procedimiento para la obtencion de acidos l-alfa-amino-carboxilicos opticamente activos a partir de correspondientes acidos d,l-alfa-aminocarboxilicos racemicos.

Country Status (9)

Country Link
EP (1) EP0874801B1 (es)
JP (1) JP3639599B2 (es)
AT (1) ATE202074T1 (es)
AU (1) AU1190897A (es)
DE (2) DE19546532C2 (es)
DK (1) DK0874801T3 (es)
ES (1) ES2159773T3 (es)
PT (1) PT874801E (es)
WO (1) WO1997021663A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4079748A1 (en) * 2021-04-23 2022-10-26 Insusense ApS Modulators of sortilin activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5037277B2 (es) * 1972-08-31 1975-12-01
JPS5233194B2 (es) * 1973-04-24 1977-08-26
DE3435095C2 (de) * 1984-09-25 1986-07-24 Degussa Ag, 6000 Frankfurt Verfahren zur Racemisierung von N-Acetyl-D(L)-α-aminocarbonsäuren
DE3438189A1 (de) * 1984-10-18 1986-04-24 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung aromatisch substituierter l-aminosaeuren
DE3603986A1 (de) * 1986-02-08 1987-08-13 Degussa Verfahren zur aufarbeitung der nach abtrennung des enzysm verbleibenden loesung aus der enzymatischen racematspaltung einer n-acetyl-dl-aminocarbonsaeure in gegenwart einer l-aminosaeureacylase
DE3702689A1 (de) * 1987-01-30 1988-08-11 Degussa Verfahren zur isolierung von l-aminosaeuren
SU1685924A1 (ru) * 1988-03-22 1991-10-23 Армянский филиал Всесоюзного научно-исследовательского института химических реактивов и особо чистых химических веществ Способ получени оптически активных L-аминокислот

Also Published As

Publication number Publication date
ATE202074T1 (de) 2001-06-15
DE59607102D1 (de) 2001-07-19
JP3639599B2 (ja) 2005-04-20
WO1997021663A1 (de) 1997-06-19
AU1190897A (en) 1997-07-03
DE19546532C2 (de) 2000-04-20
JP2000501938A (ja) 2000-02-22
EP0874801A1 (de) 1998-11-04
PT874801E (pt) 2001-10-30
EP0874801B1 (de) 2001-06-13
DK0874801T3 (da) 2001-07-23
DE19546532A1 (de) 1997-06-19

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