ES2160675T3 - Dispositivo implantable debajo de la dermis. - Google Patents

Dispositivo implantable debajo de la dermis.

Info

Publication number
ES2160675T3
ES2160675T3 ES95307809T ES95307809T ES2160675T3 ES 2160675 T3 ES2160675 T3 ES 2160675T3 ES 95307809 T ES95307809 T ES 95307809T ES 95307809 T ES95307809 T ES 95307809T ES 2160675 T3 ES2160675 T3 ES 2160675T3
Authority
ES
Spain
Prior art keywords
layer
drug
central core
polymeric
intermediate layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95307809T
Other languages
English (en)
Inventor
Alfred J Moo-Young
Horacio B Croxatto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Population Council Inc
Original Assignee
Population Council Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Population Council Inc filed Critical Population Council Inc
Application granted granted Critical
Publication of ES2160675T3 publication Critical patent/ES2160675T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)

Abstract

LO DESCRITO ES UN DISPOSITIVO DE ADMINISTRACION DE FARMACOS SUBDERMICAMENTE IMPLANTABLE (10), QUE CONTIENE: UN NUCLEO CENTRAL (11) QUE SE EXTIENDE EN UNA DIRECCION AXIAL Y QUE TIENE UNA SUPERFICIE EXTERIOR (12) Y EXTREMOS OPUESTOS (13 Y 13''), DICHO NUCLEO INCLUYENDO UNA MATRIZ DE UNA CANTIDAD FARMACEUTICAMENTE EFECTIVA DE UN FARMACO SUBDERMICAMENTE ADMINISTRABLE (14) SUSTANCIALMENTE UNIFORMEMENTE DISPERSADO EN UN MATERIAL DE BASE POLIMERICA (15); UNA CAPA INTERMEDIA POLIMERICA (16) QUE YACE SOBRE LA SUPERFICIE EXTERIOR DEL NUCLEO CENTRAL; Y UNA CAPA POLIMERICA EXTERIOR (17) QUE YACE POR ENCIMA DE LA CAPA INTERMEDIA, CARACTERIZADA ADEMAS EN QUE LA CAPA INTERMEDIA CONTROLA LA FRECUENCIA DE DIFUSION DEL FARMACO DESDE EL NUCLEO CENTRAL A LA CAPA EXTERIOR. EN REALIZACIONES PREFERIDAS, EL FARMACO SUBDERMICAMENTE ADMINISTRABLE (14) ES UN AGENTE CONTRACEPTIVO COMO PROGESTINA NESTORONE{SUB,TM}; EL MATERIAL DE BASE POLIMERICA (15) Y LA CAPA POLIMERICA EXTERIOR (17) CONTIENE UN POLIDIMETISILOXANO COMOSILASTIC{SUB,R}; LA CAPA INTERMEDIA (16) CONTIENE UN MATERIAL POROSO COMO CELULOSA, Y EL DISPOSITIVO (10) CONTIENE ADEMAS ELEMENTOS DE SELLADO COMO UNA CAPA DE PLASTICO (21 Y 22) Y ADHESIVO (18, 18'') QUE COOPERAN CON LA CAPA BIOCOMPATIBLE PARA ENCAPSULAR COMPLETAMENTE EL NUCLEO CENTRAL Y LA CAPA INTERMEDIA. LOS DISPOSITIVOS PROPORCIONAN LA LIBERACION SUSTANCIALMENTE DE ORDEN CERO DEL FARMACO PARA SU DURACION ESTIMADA SIN SOBREDOSIFICACION INICIAL DEL FARMACO. TAMBIEN SE DESCRIBEN METODOS DE TRATAMIENTO DE SUJETOS CON LOS DISPOSITIVOS DE ADMINISTRACION DE FARMACO IMPLANTABLE DE LA INVENCION, Y METODOS DE CONTRACEPCION.
ES95307809T 1994-11-02 1995-11-01 Dispositivo implantable debajo de la dermis. Expired - Lifetime ES2160675T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/333,279 US5660848A (en) 1994-11-02 1994-11-02 Subdermally implantable device

Publications (1)

Publication Number Publication Date
ES2160675T3 true ES2160675T3 (es) 2001-11-16

Family

ID=23302115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95307809T Expired - Lifetime ES2160675T3 (es) 1994-11-02 1995-11-01 Dispositivo implantable debajo de la dermis.

Country Status (8)

Country Link
US (2) US5660848A (es)
EP (1) EP0710491B1 (es)
AT (1) ATE204773T1 (es)
CA (1) CA2161950C (es)
DE (1) DE69522409T2 (es)
DK (1) DK0710491T3 (es)
ES (1) ES2160675T3 (es)
PT (1) PT710491E (es)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960007947B1 (ko) 1993-09-17 1996-06-17 엘지전자 주식회사 가라오케-콤팩트 디스크(karaoke-cd) 및 이를 이용한 오디오 제어장치
US6309843B1 (en) 1994-10-25 2001-10-30 The Curators Of The University Of Missouri Glycoprotein for use in determining endometrial receptivity
US5733565A (en) * 1996-02-23 1998-03-31 The Population Council, Center For Biomedical Research Male contraceptive implant
US6472367B1 (en) 1998-05-05 2002-10-29 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin mediated cell adhesion
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
US6485972B1 (en) 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
WO2001043726A1 (en) * 1999-12-16 2001-06-21 Trident Technologies, Llc System and method for extended delivery of a therapeutic agent with its receptor loading dose
US6476079B1 (en) * 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
DE10107659B4 (de) 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin
US6694158B2 (en) 2001-04-11 2004-02-17 Motorola, Inc. System using a portable detection device for detection of an analyte through body tissue
US7521019B2 (en) * 2001-04-11 2009-04-21 Lifescan, Inc. Sensor device and methods for manufacture
US6454710B1 (en) 2001-04-11 2002-09-24 Motorola, Inc. Devices and methods for monitoring an analyte
US6379622B1 (en) 2001-04-11 2002-04-30 Motorola, Inc. Sensor incorporating a quantum dot as a reference
DE10136781B4 (de) * 2001-07-27 2008-03-06 Lts Lohmann Therapie-Systeme Ag Flache orale Darreichungsformen mit wirkstoffhaltigen Partikeln
CN1289064C (zh) * 2001-08-31 2006-12-13 先灵有限责任公司 药物输送体系
US20030118649A1 (en) * 2001-10-04 2003-06-26 Jinming Gao Drug delivery devices and methods
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
EP1643946A2 (en) * 2003-06-20 2006-04-12 Viral Genomix, Inc. Compositions for and methods for treating hiv
US7196061B2 (en) 2003-09-10 2007-03-27 Wyeth Compounds that modulate neuronal growth and their uses
US20050245905A1 (en) * 2004-04-30 2005-11-03 Schmidt Steven P Local drug-delivery system
EP3417895A1 (en) 2004-07-28 2018-12-26 Medtronic Ardian Luxembourg S.à.r.l. Methods and devices for renal nerve blocking
DE102004050457A1 (de) * 2004-10-12 2006-04-13 Capsulution Nanoscience Ag Segmentierte Vorrichtung für die verzögerte Freisetzung von Molekülen in tangentialer Richtung durch dünne Filme und Anwendungen derselben
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
CA2588295C (en) 2004-11-23 2013-10-22 Adamas Pharma, Llc Method and composition for administering an nmda receptor antagonist to a subject
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
CA2588296A1 (en) 2004-11-24 2006-06-01 Neuromolecular Pharmaceuticals, Inc. Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease
JP5155146B2 (ja) * 2005-03-15 2013-02-27 サーモディクス，インコーポレイティド 挿入可能な医療器具用の柔軟性ポリマー被膜
JP5666087B2 (ja) 2005-04-06 2015-02-12 アダマス・ファーマシューティカルズ・インコーポレーテッド Ｃｎｓ関連疾患の治療のための方法及び組成物
WO2007038619A2 (en) * 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
MX2010001684A (es) * 2007-08-15 2010-04-21 Amunix Inc Composiciones y metodos para modificar propiedades de polipeptidos biologicamente activos.
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
CN108530543B (zh) 2009-02-03 2023-06-23 阿穆尼克斯制药公司 延伸重组多肽和包含该延伸重组多肽的组合物
US8940701B2 (en) 2009-05-13 2015-01-27 The Regents Of The University Of Michigan Compounds for, and methods of, treating cancer and inhibiting invasion and metastases
DK2440241T3 (en) 2009-06-08 2017-10-02 Amunix Operating Inc GROWTH HORMON POLYPEPTIDES AND PROCEDURES FOR PREPARING AND USING THEREOF
JP5839597B2 (ja) 2009-06-08 2016-01-06 アムニクス オペレーティング インコーポレイテッド グルコース調節ポリペプチド並びにその作成及び使用方法
WO2011008897A2 (en) 2009-07-14 2011-01-20 Board Of Regents, The University Of Texas System Methods for making controlled delivery devices having zero order kinetics
CN102741275B (zh) 2009-08-24 2016-08-03 阿穆尼克斯运营公司 凝血因子ix组合物及其制备和使用方法
AU2010325960C1 (en) 2009-12-02 2015-08-06 Adamas Pharma, Llc Amantadine compositions and methods of use
EP4450523A3 (en) 2010-04-02 2025-03-12 Amunix Pharmaceuticals, Inc. Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
CN107007348B (zh) 2010-10-25 2019-05-31 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
EP2476409A1 (en) * 2011-01-14 2012-07-18 Université Catholique De Louvain Implant comprising a core and a tube encasing the core
EP2717813B1 (en) * 2011-06-06 2020-05-20 Auritec Pharmaceuticals Drug delivery device employing wicking release window
AR089765A1 (es) * 2012-01-23 2014-09-17 Bayer Oy Un sistema para el suministro de un farmaco
LT3564260T (lt) 2012-02-15 2023-01-10 Bioverativ Therapeutics Inc. Viii faktoriaus kompozicijos ir jų gamybos bei panaudojimo būdai
EP2822577B1 (en) 2012-02-15 2019-02-06 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
EP3348220B1 (en) 2012-03-08 2024-10-23 Medtronic Ardian Luxembourg S.à.r.l. Biomarker sampling in the context of neuromodulation devices and associated systems
AU2013230781B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
DK2859015T3 (en) 2012-06-08 2018-06-18 Alkermes Inc LIGANDS MODIFIED BY CIRCULAR MODIFICATION AS AGONISTS AND ANTAGONISTS
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US9907691B2 (en) 2013-03-13 2018-03-06 Hologic, Inc. Intrauterine contraceptive devices
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
TWI667255B (zh) 2013-08-14 2019-08-01 美商生物化學醫療公司 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
SG11201605242YA (en) 2014-01-10 2016-07-28 Biogen Ma Inc Factor viii chimeric proteins and uses thereof
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
WO2015184407A1 (en) * 2014-05-30 2015-12-03 Textile-Based Delivery, Inc. Drug delivery systems and related methods of use
US10226419B2 (en) 2014-09-08 2019-03-12 ProMed Pharma, LLC Methods for manufacturing implants
BR112017007942A2 (pt) 2014-10-30 2017-12-19 Textile Based Delivery Inc sistemas de liberação
IL257231B (en) 2015-08-03 2022-09-01 Bioverativ Therapeutics Inc Factor ix fusion proteins and methods of making and using same
WO2017027376A1 (en) 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Subcutaneous drug delivery device with manual activation and deactivation of drug release
AU2016319782A1 (en) 2015-09-09 2018-04-05 Micell Technologies, Inc. Biopharma application of micell technology
WO2018064556A1 (en) 2016-09-29 2018-04-05 Gesea Biosciences Inc. Bioerodible implant for long-term drug delivery and associated methods of manufacture and use
KR102637575B1 (ko) * 2016-10-05 2024-02-20 타이탄 파머슈티컬즈 인코퍼레이티드 버스트 방출이 감소된 약물 전달용 이식 가능한 장치
MX2019006444A (es) 2016-12-02 2019-10-30 Bioverativ Therapeutics Inc Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos.
WO2018200885A1 (en) 2017-04-26 2018-11-01 Neurocentria, Inc. Magnesium compositions and methods of use
GB201708224D0 (en) * 2017-05-23 2017-07-05 Juniper Pharmaceuticals Uk Ltd Device
US10494345B2 (en) 2017-10-03 2019-12-03 Zonula, Inc. Modulators of cell adhesion, methods and compositions therefor
BR102017023175A8 (pt) * 2017-10-26 2022-09-27 Rodrigo Otavio Sarraff Berger Implante com reservatório contendo microporos de liberação prolongada para aplicação subdérmica com propriedades termoelásticas e termostática e uso do dito implante
SI3793588T1 (sl) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc. Postopki zdravljenja hemofilije A
CA3130212A1 (en) * 2019-02-19 2020-08-27 Particle Sciences, Inc. Compartmentalized drug delivery devices
IL298815A (en) 2020-06-25 2023-02-01 Amunix Pharmaceuticals Inc Bispecific compositions targeting HER-2 and methods for their preparation and use
EP4314073A4 (en) 2021-03-24 2025-02-19 Alkermes, Inc. Upar antibodies and fusion proteins with the same
CN113398318B (zh) * 2021-06-11 2022-04-08 上海达华药业有限公司 一种医用粘合剂的制备方法及医用粘合剂

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US3832252A (en) * 1970-09-29 1974-08-27 T Higuchi Method of making a drug-delivery device
US3948254A (en) * 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
GB1412970A (en) * 1974-01-15 1975-11-05 Schering Ag Pharmaceutical preparations containing silicone rubber
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US3992518A (en) * 1974-10-24 1976-11-16 G. D. Searle & Co. Method for making a microsealed delivery device
US3926188A (en) * 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
US4053580A (en) * 1975-01-01 1977-10-11 G. D. Searle & Co. Microsealed pharmaceutical delivery device
GB2010676B (en) * 1977-12-27 1982-05-19 Alza Corp Diffusional drug delivery device with block copolymer as drug carrier
US4244949A (en) * 1978-04-06 1981-01-13 The Population Council, Inc. Manufacture of long term contraceptive implant
DK119884A (da) * 1983-03-18 1984-09-19 Lilly Co Eli Fast, cylindrisk, subkutan implantation og dens anvendelse
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
IE56979B1 (en) * 1984-02-14 1992-02-26 Drug Systems Res & Dev Subcutaneous implant
US4609374A (en) * 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
US5057317A (en) * 1987-03-24 1991-10-15 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
ES2054784T3 (es) * 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
US5035891A (en) * 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
FI81494C (fi) * 1987-12-30 1990-11-12 Huhtamaeki Oy Kasettsystem och anordning foer framstaellning av subkutan preventivkapsel.
US5141748A (en) * 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
US5326568A (en) * 1991-05-03 1994-07-05 Giampapa Vincent C Method of tissue-specific delivery
FR2695826B1 (fr) * 1992-09-21 1995-01-06 Theramex Nouvelles compositions pharmaceutiques à base de dérivés de nomégestrol et leurs procédés d'obtention.

Also Published As

Publication number Publication date
CA2161950A1 (en) 1996-05-03
EP0710491B1 (en) 2001-08-29
ATE204773T1 (de) 2001-09-15
DE69522409D1 (de) 2001-10-04
DK0710491T3 (da) 2001-10-08
PT710491E (pt) 2001-12-28
US5660848A (en) 1997-08-26
EP0710491A1 (en) 1996-05-08
DE69522409T2 (de) 2001-12-13
CA2161950C (en) 2000-10-24
US5756115A (en) 1998-05-26

Similar Documents

Publication Publication Date Title
DK0710491T3 (da) Subdermalt implanterbar anordning
US5694947A (en) Intravaginal delivery system
Mashak et al. Silicone polymers in controlled drug delivery systems: a review
US3710795A (en) Drug-delivery device with stretched, rate-controlling membrane
PT754032E (pt) Composicoes liquidas para difusao
JP4054114B2 (ja) 腟内薬物供給装置
CA2232635C (en) Intravaginal rings with insertable drug-containing core
US4186742A (en) Contraceptive-antivenereal disease tampon
PT863729E (pt) Dispositivo implantavel de libertacao controlada para distribuir farmacos directamente a uma porcao interna do corpo
NZ511216A (en) Drug delivery device having a membrane composed of a siloxane based elastomer having 3,3,3-trifluoropropyl groups for the delivery of progestins and estrogens
BR0007454A (pt) Dispositivos e métodos de implante comtransferência de droga biocompatìvel deliberação controlada no sistema ocular
US4649075A (en) Transdermal and transmucosal vortexed foam devices and the method of making
CA2301685A1 (en) Sustained release drug delivery devices
EP2806893B1 (en) A drug delivery system
US3796217A (en) Drug release system
CA2165282C (en) Intravaginal delivery system
ES2115735T3 (es) Elemento oftalmico postizo bioadhesivo.
CA2239089A1 (en) Implantable medical device
BRPI9607752B8 (pt) formulação farmacêutica de microcápsula de liberação controlada.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 710491

Country of ref document: ES