ES2164328T3 - Derivados de 2,1,3-benzotia(oxa)diazol con efecto antagonista del receptor de endotelina. - Google Patents

Derivados de 2,1,3-benzotia(oxa)diazol con efecto antagonista del receptor de endotelina.

Info

Publication number
ES2164328T3
ES2164328T3 ES97905065T ES97905065T ES2164328T3 ES 2164328 T3 ES2164328 T3 ES 2164328T3 ES 97905065 T ES97905065 T ES 97905065T ES 97905065 T ES97905065 T ES 97905065T ES 2164328 T3 ES2164328 T3 ES 2164328T3
Authority
ES
Spain
Prior art keywords
endotheline
benzotia
diazol
oxa
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97905065T
Other languages
English (en)
Inventor
Dieter Dorsch
Mathias Osswald
Werner Mederski
Claudia Wilm
Claus Schmitges
Maria Christadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2164328T3 publication Critical patent/ES2164328T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION TRATA DE UNOS COMPUESTOS DE FORMULA (I) EN DONDE R ES (I), (II) O (III); N ES 0, 1 O 2; X ES 0 O S, TENIENDO R 1 , R 2 , R 3 Y R 4 DIFERENTES SIGNIFIC ADOS O TENER UNA FORMA TAUTOMERICA DE ANILLO CERRADO. LA INVENCION TRATA ADEMAS DE UNOS ISOMEROS (E) Y DE SUS SALES, MOSTRANDO ESTOS COMPUESTOS UNAS PROPIEDADES ANTAGONISTAS Y RECEPTORAS DE ENDOTELINA.
ES97905065T 1996-02-24 1997-02-20 Derivados de 2,1,3-benzotia(oxa)diazol con efecto antagonista del receptor de endotelina. Expired - Lifetime ES2164328T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19607096A DE19607096A1 (de) 1996-02-24 1996-02-24 Endothelin-Rezeptor-Antagonisten

Publications (1)

Publication Number Publication Date
ES2164328T3 true ES2164328T3 (es) 2002-02-16

Family

ID=7786418

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97905065T Expired - Lifetime ES2164328T3 (es) 1996-02-24 1997-02-20 Derivados de 2,1,3-benzotia(oxa)diazol con efecto antagonista del receptor de endotelina.

Country Status (14)

Country Link
US (1) US6017939A (es)
EP (1) EP0882030B1 (es)
CN (1) CN1072660C (es)
AR (1) AR005947A1 (es)
AT (1) ATE205486T1 (es)
AU (1) AU721203B2 (es)
DE (2) DE19607096A1 (es)
DK (1) DK0882030T3 (es)
ES (1) ES2164328T3 (es)
PT (1) PT882030E (es)
RU (1) RU2175320C2 (es)
UA (1) UA51696C2 (es)
WO (1) WO1997030982A1 (es)
ZA (1) ZA971466B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653037A1 (de) * 1996-12-19 1998-06-25 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE19710831A1 (de) * 1997-03-15 1998-09-17 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE19712141A1 (de) * 1997-03-22 1998-09-24 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE19731571A1 (de) * 1997-07-23 1999-01-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
WO2025219395A1 (en) 2024-04-16 2025-10-23 Chu D'angers Treatment of cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1039168A1 (ru) * 1981-12-05 1991-12-15 Физико-химический институт АН УССР Способ получени 5-оксибензо-2,1,3-тиадиазола
DE4206457A1 (de) * 1992-02-26 1993-09-02 Schering Ag Verfahren zur herstellung von aminoethyl-2,1,3-benzothiadiazolen
SK20396A3 (en) * 1993-08-19 1997-03-05 Warner Lambert Co Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base
DE19509950A1 (de) * 1995-03-18 1996-09-19 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten

Also Published As

Publication number Publication date
ZA971466B (en) 1997-08-28
ATE205486T1 (de) 2001-09-15
AU1875797A (en) 1997-09-10
DK0882030T3 (da) 2002-01-07
WO1997030982A1 (de) 1997-08-28
PT882030E (pt) 2002-03-28
EP0882030B1 (de) 2001-09-12
UA51696C2 (uk) 2002-12-16
AR005947A1 (es) 1999-07-21
CN1072660C (zh) 2001-10-10
CN1216540A (zh) 1999-05-12
DE19607096A1 (de) 1997-08-28
RU2175320C2 (ru) 2001-10-27
AU721203B2 (en) 2000-06-29
DE59704603D1 (de) 2001-10-18
US6017939A (en) 2000-01-25
EP0882030A1 (de) 1998-12-09

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