ES2164907T3 - Secuencias reguladoras del gen cd4 y su expresion especifica en los linfocitos t maduros. - Google Patents

Secuencias reguladoras del gen cd4 y su expresion especifica en los linfocitos t maduros.

Info

Publication number
ES2164907T3
ES2164907T3 ES96925809T ES96925809T ES2164907T3 ES 2164907 T3 ES2164907 T3 ES 2164907T3 ES 96925809 T ES96925809 T ES 96925809T ES 96925809 T ES96925809 T ES 96925809T ES 2164907 T3 ES2164907 T3 ES 2164907T3
Authority
ES
Spain
Prior art keywords
gen
lymphocytes
mature
regulatory sequences
specific expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96925809T
Other languages
English (en)
Inventor
David Klatzmann
Patrick Salmon
Olivier Boyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Pierre et Marie Curie
Original Assignee
Universite Pierre et Marie Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Pierre et Marie Curie filed Critical Universite Pierre et Marie Curie
Application granted granted Critical
Publication of ES2164907T3 publication Critical patent/ES2164907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C12N9/1211—Thymidine kinase (2.7.1.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SISTEMA DE EXPRESION DE UNA PROTEINA O UN GEN HETEROLOGO QUE INCLUYE UN VECTOR RECOMBINANTE, UTILIZABLE PARA LA TRANSDUCCION DE CELULAS DE LA SERIE HEMATOPOYETICA, PRINCIPALMENTE DE CELULAS MADRE, DE TAL MANERA QUE LA CELULA ASI TRANSDUCIDA EXPRESARA LA PROTEINA O EL GEN HETEROLOGO SOLO EN LOS LINFOCITOS T MADUROS PREVIA SELECCION DEL REPERTORIO. EL VECTOR RECOMBINANTE ESTA PROVISTO DE TODAS LAS SECUENCIAS QUE NECESITA PARA EXPRESARSE Y SE CARACTERIZA POR EL HECHO DE QUE CONTIENE POR LO MENOS UN AMPLIFICADOR DE UN GEN CD4 DE LA MISMA ESPECIE O DE UNA ESPECIE DIFERENTE.
ES96925809T 1995-07-17 1996-07-17 Secuencias reguladoras del gen cd4 y su expresion especifica en los linfocitos t maduros. Expired - Lifetime ES2164907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9508616A FR2736931B1 (fr) 1995-07-17 1995-07-17 Sequences regulatrices issues du gene cd4 et a expression specifique dans les lymphocytes t matures

Publications (1)

Publication Number Publication Date
ES2164907T3 true ES2164907T3 (es) 2002-03-01

Family

ID=9481044

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96925809T Expired - Lifetime ES2164907T3 (es) 1995-07-17 1996-07-17 Secuencias reguladoras del gen cd4 y su expresion especifica en los linfocitos t maduros.

Country Status (9)

Country Link
US (1) US6333171B1 (es)
EP (1) EP0839206B1 (es)
JP (1) JPH11509415A (es)
AT (1) ATE205538T1 (es)
CA (1) CA2227035A1 (es)
DE (1) DE69615201T2 (es)
ES (1) ES2164907T3 (es)
FR (1) FR2736931B1 (es)
WO (1) WO1997004118A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9807935D0 (en) 1998-04-14 1998-06-10 Univ Edinburgh Lineage specific cells and progenitor cells
US7462485B2 (en) * 2005-10-07 2008-12-09 Glaser Lawrence F Modified erythrocytes and uses thereof
EP4154903A1 (en) * 2008-04-22 2023-03-29 Vib Vzw Liver-specific nucleic acid regulatory elements and methods and use thereof
JP6273653B2 (ja) * 2015-10-23 2018-02-07 学校法人北里研究所 大腸炎又は大腸癌モデル非ヒト動物及びその利用
JP2022521486A (ja) * 2019-02-08 2022-04-08 ディーエヌエイ ツーポイント インコーポレイテッド トランスポゾンに基づく免疫細胞の改変
US12419913B2 (en) 2019-02-08 2025-09-23 Dna Twopointo, Inc. Modification of CAR-T cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2099247A1 (fr) 1991-10-30 1993-05-01 David Klatzmann Cellules transformees pour la prevention ou le traitement de maladies induites par des virus, notamment retrovirus pathogenes
FR2683226B1 (fr) 1991-10-30 1995-06-09 Univ Paris Curie Cellules piegees a l'egard d'antigenes provoquant le dysfonctionnement du systeme immunitaire, medicaments pour la prevention ou le traitement de maladies induites par ces dysfonctionnements.
FR2699191B1 (fr) 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.
FR2716459B1 (fr) 1994-02-22 1996-05-10 Univ Paris Curie Système hôte-vecteur utilisable en thérapie génique.
US5877010A (en) * 1994-05-02 1999-03-02 University Of Washington Thymidine kinase mutants

Also Published As

Publication number Publication date
DE69615201T2 (de) 2002-05-02
WO1997004118A1 (fr) 1997-02-06
DE69615201D1 (de) 2001-10-18
EP0839206A1 (fr) 1998-05-06
EP0839206B1 (fr) 2001-09-12
ATE205538T1 (de) 2001-09-15
US6333171B1 (en) 2001-12-25
FR2736931B1 (fr) 1997-09-19
FR2736931A1 (fr) 1997-01-24
JPH11509415A (ja) 1999-08-24
CA2227035A1 (fr) 1997-02-06

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