ES2166487T3 - Benzoil-guanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

Benzoil-guanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
ES2166487T3
ES2166487T3 ES97108258T ES97108258T ES2166487T3 ES 2166487 T3 ES2166487 T3 ES 2166487T3 ES 97108258 T ES97108258 T ES 97108258T ES 97108258 T ES97108258 T ES 97108258T ES 2166487 T3 ES2166487 T3 ES 2166487T3
Authority
ES
Spain
Prior art keywords
medicinal
well
guanidinas
benzoil
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97108258T
Other languages
English (en)
Inventor
Andreas Dr Weichert
Joachim Dr Brendel
Heinz-Werner Dr Kleemann
Hans Jochen Dr Lang
Jan-Robert Dr Schwark
Udo Dr Albus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2166487T3 publication Critical patent/ES2166487T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA INVENCION TRATA DE BENZOILGUANIDINAS ORTO INDICADOS EN LAS REIVINDICACIONES, Y QUE, COMO MEDICAMENTOS ANTIARRITMICOS CON COMPONENTE CARDIOPROTECTOR, SON IDONEAS PARA LA PROFILAXIS DEL INFARTO Y EL TRATAMIENTO DEL MISMO, ASI COMO PARA EL TRATAMIENTO DE LA ANGINA DE PECHO. TAMBIEN INHIBEN DE FORMA PREVENTIVA LOS PROCESOS PATOFISIOLOGICOS EN CASO DE QUE EXISTIERAN DAÑOS INDUCIDOS ISQUEMICAMENTE, EN PARTICULAR SI SE PRODUJERAN ARRITMIAS CARDIACAS INDUCIDAS ISQUEMICAMENTE.
ES97108258T 1996-06-04 1997-05-22 Benzoil-guanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. Expired - Lifetime ES2166487T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19622370A DE19622370A1 (de) 1996-06-04 1996-06-04 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
ES2166487T3 true ES2166487T3 (es) 2002-04-16

Family

ID=7796095

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97108258T Expired - Lifetime ES2166487T3 (es) 1996-06-04 1997-05-22 Benzoil-guanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Country Status (29)

Country Link
US (1) US6011063A (es)
EP (1) EP0811610B1 (es)
JP (1) JP4101904B2 (es)
KR (1) KR980002019A (es)
CN (1) CN1064956C (es)
AR (1) AR008761A1 (es)
AT (1) ATE209630T1 (es)
AU (1) AU723665B2 (es)
BR (1) BR9703440A (es)
CA (1) CA2206758C (es)
CZ (1) CZ289411B6 (es)
DE (2) DE19622370A1 (es)
DK (1) DK0811610T3 (es)
ES (1) ES2166487T3 (es)
HR (1) HRP970304B1 (es)
HU (1) HUP9700989A3 (es)
ID (1) ID17038A (es)
IL (1) IL120988A0 (es)
MX (1) MX9704094A (es)
NO (1) NO310188B1 (es)
NZ (1) NZ314973A (es)
PL (1) PL185757B1 (es)
PT (1) PT811610E (es)
RU (1) RU2214397C2 (es)
SI (1) SI0811610T1 (es)
SK (1) SK282628B6 (es)
TR (1) TR199700453A2 (es)
TW (1) TW429243B (es)
ZA (1) ZA974869B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410563B1 (en) 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
EP1289961A1 (en) 2000-05-25 2003-03-12 Merck Frosst Canada & Co. Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
US6740666B2 (en) 2000-12-20 2004-05-25 Merck & Co., Inc. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
CA2447765C (en) 2001-05-24 2011-01-25 Merck Frosst Canada & Co./Merck Frosst Canada & Cie 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors
JO2311B1 (en) 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyl inhibitors Ariel phosphodiesterase-4
EP1485093B1 (en) 2002-03-12 2010-11-03 Merck Sharp & Dohme Corp. Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DK0612723T3 (da) * 1993-02-20 1998-03-30 Hoechst Ag Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4327244A1 (de) * 1993-08-13 1995-02-16 Hoechst Ag Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CZ169697A3 (en) 1997-12-17
CA2206758A1 (en) 1997-12-04
JPH1067731A (ja) 1998-03-10
ATE209630T1 (de) 2001-12-15
AU723665B2 (en) 2000-08-31
SK282628B6 (sk) 2002-10-08
PL320327A1 (en) 1997-12-08
DE19622370A1 (de) 1997-12-11
DE59705495D1 (de) 2002-01-10
HRP970304A2 (en) 1998-04-30
NO972527L (no) 1997-12-05
HUP9700989A2 (en) 1997-12-29
CN1064956C (zh) 2001-04-25
KR980002019A (ko) 1998-03-30
BR9703440A (pt) 1998-09-29
HU9700989D0 (en) 1997-07-28
HRP970304B1 (en) 2002-10-31
EP0811610A1 (de) 1997-12-10
SK69697A3 (en) 1998-01-14
JP4101904B2 (ja) 2008-06-18
EP0811610B1 (de) 2001-11-28
CN1175572A (zh) 1998-03-11
SI0811610T1 (en) 2002-04-30
AU2465097A (en) 1997-12-11
RU2214397C2 (ru) 2003-10-20
CA2206758C (en) 2007-08-14
IL120988A0 (en) 1997-11-20
MX9704094A (es) 1997-12-31
TW429243B (en) 2001-04-11
CZ289411B6 (cs) 2002-01-16
HUP9700989A3 (en) 1998-04-28
PL185757B1 (pl) 2003-07-31
NZ314973A (en) 1998-09-24
ZA974869B (en) 1997-12-04
ID17038A (id) 1997-12-04
US6011063A (en) 2000-01-04
NO310188B1 (no) 2001-06-05
DK0811610T3 (da) 2002-03-25
PT811610E (pt) 2002-05-31
AR008761A1 (es) 2000-02-23
NO972527D0 (no) 1997-06-03
TR199700453A2 (xx) 1997-12-21

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