ES2168757T3 - Tetrahidroisoquinolin-tiofenocarboximidamidas. - Google Patents

Tetrahidroisoquinolin-tiofenocarboximidamidas.

Info

Publication number
ES2168757T3
ES2168757T3 ES98921953T ES98921953T ES2168757T3 ES 2168757 T3 ES2168757 T3 ES 2168757T3 ES 98921953 T ES98921953 T ES 98921953T ES 98921953 T ES98921953 T ES 98921953T ES 2168757 T3 ES2168757 T3 ES 2168757T3
Authority
ES
Spain
Prior art keywords
thiophenocarboximidamids
tetrahydroisoquinolin
thienyl
racemates
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98921953T
Other languages
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2168757T3 publication Critical patent/ES2168757T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de fórmula (I) en la cual: R 1 representa un anillo 2-tienilo o 3-tienilo; y R 2 representa un alquilo C 1 a 4; y sus isómeros ópticos y racematos y sus sales farmacéuticamente aceptables.
ES98921953T 1997-05-05 1998-04-28 Tetrahidroisoquinolin-tiofenocarboximidamidas. Expired - Lifetime ES2168757T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9701682A SE9701682D0 (sv) 1997-05-05 1997-05-05 Compounds

Publications (1)

Publication Number Publication Date
ES2168757T3 true ES2168757T3 (es) 2002-06-16

Family

ID=20406836

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98921953T Expired - Lifetime ES2168757T3 (es) 1997-05-05 1998-04-28 Tetrahidroisoquinolin-tiofenocarboximidamidas.

Country Status (28)

Country Link
US (1) US6166030A (es)
EP (1) EP0983266B1 (es)
JP (1) JP2001523263A (es)
KR (1) KR20010012227A (es)
CN (1) CN1255130A (es)
AR (1) AR012602A1 (es)
AT (1) ATE210661T1 (es)
AU (1) AU734394B2 (es)
BR (1) BR9808725A (es)
CA (1) CA2287999A1 (es)
DE (1) DE69802923T2 (es)
DK (1) DK0983266T3 (es)
EE (1) EE9900475A (es)
ES (1) ES2168757T3 (es)
HU (1) HUP0003766A3 (es)
ID (1) ID23156A (es)
IL (1) IL132677A0 (es)
IS (1) IS5237A (es)
MX (1) MXPA99009874A (es)
NO (1) NO995404L (es)
NZ (1) NZ500676A (es)
PL (1) PL336854A1 (es)
PT (1) PT983266E (es)
SE (1) SE9701682D0 (es)
SK (1) SK140699A3 (es)
TR (1) TR199902719T2 (es)
WO (1) WO1998050380A1 (es)
ZA (1) ZA983740B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024826A2 (en) * 1999-10-06 2001-04-12 The Brigham And Women's Hospital, Inc. Inrease of enos activity through activation of the pi3-kinase/akt pathway by estrogens
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) * 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US20050154229A1 (en) * 2002-03-22 2005-07-14 Aeri Kim Maleic acid salt of(2s)-n-{5-[amino(imino)methy]-2-thienyl}methyl-1-{(2r)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl}-2-pyrrolidine carboxamide and a process for
ES2357129T3 (es) 2005-04-13 2011-04-19 Neuraxon Inc. Compuestos indólicos sustituidos que tienen actividad inhibidora de nos.
US8173813B2 (en) * 2007-03-23 2012-05-08 Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
KR20100103799A (ko) 2007-11-16 2010-09-28 네우렉슨 인코포레이티드 내장통을 치료하기 위한 인돌 화합물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
WO1995005363A1 (en) * 1993-08-12 1995-02-23 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
EP0724570B1 (en) * 1993-10-21 1999-03-03 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
EP0759027B1 (en) * 1994-05-07 1999-08-04 Astra Aktiebolag Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
KR970706272A (ko) * 1995-08-10 1997-11-03 클래스 빌헬름슨 치료에 유용한 바이시클릭 아미딘 유도체(Bicyclic Amidine Derivatives Useful in Therapy)

Also Published As

Publication number Publication date
EP0983266B1 (en) 2001-12-12
DE69802923D1 (de) 2002-01-24
NO995404D0 (no) 1999-11-04
KR20010012227A (ko) 2001-02-15
AR012602A1 (es) 2000-11-08
EE9900475A (et) 2000-06-15
SK140699A3 (en) 2000-06-12
CN1255130A (zh) 2000-05-31
HUP0003766A2 (en) 2001-03-28
JP2001523263A (ja) 2001-11-20
AU7460098A (en) 1998-11-27
PT983266E (pt) 2002-05-31
ZA983740B (en) 1999-02-19
DK0983266T3 (da) 2002-03-11
BR9808725A (pt) 2000-07-11
TR199902719T2 (xx) 2000-02-21
DE69802923T2 (de) 2002-07-04
IS5237A (is) 1999-11-01
NO995404L (no) 2000-01-05
ATE210661T1 (de) 2001-12-15
MXPA99009874A (es) 2004-09-30
EP0983266A1 (en) 2000-03-08
SE9701682D0 (sv) 1997-05-05
IL132677A0 (en) 2001-03-19
HUP0003766A3 (en) 2001-09-28
NZ500676A (en) 2001-05-25
CA2287999A1 (en) 1998-11-12
AU734394B2 (en) 2001-06-14
WO1998050380A1 (en) 1998-11-12
US6166030A (en) 2000-12-26
ID23156A (id) 2000-03-23
PL336854A1 (en) 2000-07-17

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