NO995404L - Forbindelser - Google Patents

Forbindelser

Info

Publication number
NO995404L
NO995404L NO995404A NO995404A NO995404L NO 995404 L NO995404 L NO 995404L NO 995404 A NO995404 A NO 995404A NO 995404 A NO995404 A NO 995404A NO 995404 L NO995404 L NO 995404L
Authority
NO
Norway
Prior art keywords
compounds
thienyl
racemates
therapy
alkyl
Prior art date
Application number
NO995404A
Other languages
English (en)
Other versions
NO995404D0 (no
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO995404D0 publication Critical patent/NO995404D0/no
Publication of NO995404L publication Critical patent/NO995404L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye forbindelser av formel (I): HN d) hvor R1 representerer en 2-tienyl- eller 3-tienylring og R2 representerer C l-4 alkyl, og optiske isomerer og racemater derav og farmasøytisk akseptable salter derav, samt fremgangsmåter for deres fremstilling, preparater som inneholder forbindelsene og deres anvendelse i terapi. Forbindelsene er selektive inhibitorer av den neuronale isoformen av nitrogenoksydsyntase.
NO995404A 1997-05-05 1999-11-04 Forbindelser NO995404L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701682A SE9701682D0 (sv) 1997-05-05 1997-05-05 Compounds
PCT/SE1998/000792 WO1998050380A1 (en) 1997-05-05 1998-04-28 Compounds

Publications (2)

Publication Number Publication Date
NO995404D0 NO995404D0 (no) 1999-11-04
NO995404L true NO995404L (no) 2000-01-05

Family

ID=20406836

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995404A NO995404L (no) 1997-05-05 1999-11-04 Forbindelser

Country Status (28)

Country Link
US (1) US6166030A (no)
EP (1) EP0983266B1 (no)
JP (1) JP2001523263A (no)
KR (1) KR20010012227A (no)
CN (1) CN1255130A (no)
AR (1) AR012602A1 (no)
AT (1) ATE210661T1 (no)
AU (1) AU734394B2 (no)
BR (1) BR9808725A (no)
CA (1) CA2287999A1 (no)
DE (1) DE69802923T2 (no)
DK (1) DK0983266T3 (no)
EE (1) EE9900475A (no)
ES (1) ES2168757T3 (no)
HU (1) HUP0003766A3 (no)
ID (1) ID23156A (no)
IL (1) IL132677A0 (no)
IS (1) IS5237A (no)
MX (1) MXPA99009874A (no)
NO (1) NO995404L (no)
NZ (1) NZ500676A (no)
PL (1) PL336854A1 (no)
PT (1) PT983266E (no)
SE (1) SE9701682D0 (no)
SK (1) SK140699A3 (no)
TR (1) TR199902719T2 (no)
WO (1) WO1998050380A1 (no)
ZA (1) ZA983740B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1330901A (en) * 1999-10-06 2001-05-10 Brigham And Women's Hospital Compounds and methods for modulating non-transcriptional effects of steroid hormones
US6683108B1 (en) * 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
BR0308524A (pt) * 2002-03-22 2005-02-01 Lg Life Sciences Ltd Composto, e, processos para preparar o composto e a forma cristalina do composto
JP5833804B2 (ja) 2005-04-13 2015-12-16 ニューラクソン，インコーポレーテッド Ｎｏｓ阻害活性を有する置換インドール化合物
TWI417099B (zh) * 2007-03-23 2013-12-01 Neuraxon Inc 具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物
KR20100103799A (ko) 2007-11-16 2010-09-28 네우렉슨 인코포레이티드 내장통을 치료하기 위한 인돌 화합물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
US5807885A (en) * 1993-08-12 1998-09-15 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
KR100342275B1 (ko) * 1993-10-21 2002-12-05 지.디. 썰 엘엘씨 산화질소신타제저해제로서유용한아미디노유도체
WO1996001817A1 (en) * 1994-05-07 1996-01-25 Astra Aktiebolag Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
CZ287969B6 (cs) * 1995-08-10 2001-03-14 Astra Pharmaceuticals Limited Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití

Also Published As

Publication number Publication date
AU7460098A (en) 1998-11-27
PL336854A1 (en) 2000-07-17
IS5237A (is) 1999-11-01
NO995404D0 (no) 1999-11-04
KR20010012227A (ko) 2001-02-15
MXPA99009874A (es) 2004-09-30
AU734394B2 (en) 2001-06-14
WO1998050380A1 (en) 1998-11-12
IL132677A0 (en) 2001-03-19
HUP0003766A2 (en) 2001-03-28
PT983266E (pt) 2002-05-31
AR012602A1 (es) 2000-11-08
DE69802923T2 (de) 2002-07-04
EP0983266A1 (en) 2000-03-08
ES2168757T3 (es) 2002-06-16
DK0983266T3 (da) 2002-03-11
CN1255130A (zh) 2000-05-31
SE9701682D0 (sv) 1997-05-05
HUP0003766A3 (en) 2001-09-28
BR9808725A (pt) 2000-07-11
NZ500676A (en) 2001-05-25
TR199902719T2 (xx) 2000-02-21
EP0983266B1 (en) 2001-12-12
CA2287999A1 (en) 1998-11-12
ATE210661T1 (de) 2001-12-15
EE9900475A (et) 2000-06-15
US6166030A (en) 2000-12-26
ZA983740B (en) 1999-02-19
SK140699A3 (en) 2000-06-12
DE69802923D1 (de) 2002-01-24
JP2001523263A (ja) 2001-11-20
ID23156A (id) 2000-03-23

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application