ES2170171T3 - Composicion de liberacion controlada que forma una estructura micelar inversa (l2) o una estructura micelar normal (l1). - Google Patents
Composicion de liberacion controlada que forma una estructura micelar inversa (l2) o una estructura micelar normal (l1).Info
- Publication number
- ES2170171T3 ES2170171T3 ES95941306T ES95941306T ES2170171T3 ES 2170171 T3 ES2170171 T3 ES 2170171T3 ES 95941306 T ES95941306 T ES 95941306T ES 95941306 T ES95941306 T ES 95941306T ES 2170171 T3 ES2170171 T3 ES 2170171T3
- Authority
- ES
- Spain
- Prior art keywords
- micelar
- composition
- mixture
- reverse
- normal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Detergent Compositions (AREA)
Abstract
COMPOSICION DE LKIBERACION CONTROLADA PARA UN MATERIAL ACTIVO BIOLOGICAMENTE, CARACTERIZADO EN QUE INCLUYE UNA MEZCLA DE: A) MONOCAPROINA, OPCIONALMENTE EN MEZCLA CON MONOCAPRILINA Y/O MONOCAPRINA, Y B) UN LIQUIDO POLAR SELECCIONADO ENTRE EL GRUPO INTEGRADO POR DICHOS LIQUIDOS POLARES QUE SON CAPACES DE FORMAR UNA FASE L2 CON A), Y C) UN MATERIAL ACTIVO BIOLOGICAMENTE DISUELTO O DISPERSO EN DICHA MEZCLA DE A) Y B), A) ESTANDO PRESENTE EN LA COMPOSICION, BASADO EN EL PESO TOTAL DE A)+B), EN UNA CANTIDAD QUE VA DEL LIMITE INFERIOR EN EL QUE LA MEZCLA DE A) Y B) FORMA UNA ESTRUCTURA MICELAR INVERSA (L2) Y HASTA UN 100% DE PESO DE A), CON LA CONDICION AÑADIDA DE QUE DICHA MEZCLA DE A) Y B) SE HALLA BASICAMENTE DENTRO DE ESE DOMINIO ESPECIFICO DE LA ESTRUCTURA L2, UN DIAGRAMA DE FASE, DONDE DICHA ESTRUCTURA L2 CAMBIARA A UNA ESTRUCTURA MICELAR NORMAL (L1) SI SE PONE EN CONTACTO CON UN LIQUIDO POLAR EXTERNO. ESTA COMPOSICION SE UTILIZA PREFERIBLEMENTE COMO UNA COMPOSICION MEDICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9404289A SE518619C2 (sv) | 1994-12-09 | 1994-12-09 | Komposition för reglerad frisättning innehållande monokaproin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2170171T3 true ES2170171T3 (es) | 2002-08-01 |
Family
ID=20396276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95941306T Expired - Lifetime ES2170171T3 (es) | 1994-12-09 | 1995-12-08 | Composicion de liberacion controlada que forma una estructura micelar inversa (l2) o una estructura micelar normal (l1). |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5906831A (es) |
| EP (1) | EP0790822B1 (es) |
| JP (1) | JP3487860B2 (es) |
| AT (1) | ATE213932T1 (es) |
| AU (1) | AU4276896A (es) |
| BR (1) | BR9509897A (es) |
| CA (1) | CA2207218C (es) |
| DE (1) | DE69525761T2 (es) |
| ES (1) | ES2170171T3 (es) |
| FI (1) | FI972415A7 (es) |
| NO (1) | NO972614D0 (es) |
| SE (1) | SE518619C2 (es) |
| WO (1) | WO1996017597A1 (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8765177B2 (en) * | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
| US7153845B2 (en) * | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
| US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
| US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
| US20020153508A1 (en) * | 2000-06-29 | 2002-10-24 | Lynch Matthew Lawrence | Cubic liquid crystalline compositions and methods for their preparation |
| DE60221287D1 (de) | 2001-11-08 | 2007-08-30 | Atrium Medical Corp | Intraluminale vorrichtung mit einer ein therapeutisches-mittel enthaltenden beschichtung |
| AU2002362039B2 (en) * | 2001-12-03 | 2007-07-26 | Soligenix, Inc | Stabilized reverse micelle compositions and uses thereof |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| US9592324B2 (en) | 2006-11-06 | 2017-03-14 | Atrium Medical Corporation | Tissue separating device with reinforced support for anchoring mechanisms |
| US8312836B2 (en) | 2004-09-28 | 2012-11-20 | Atrium Medical Corporation | Method and apparatus for application of a fresh coating on a medical device |
| US20060067977A1 (en) * | 2004-09-28 | 2006-03-30 | Atrium Medical Corporation | Pre-dried drug delivery coating for use with a stent |
| US20060083768A1 (en) * | 2004-09-28 | 2006-04-20 | Atrium Medical Corporation | Method of thickening a coating using a drug |
| US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US8367099B2 (en) | 2004-09-28 | 2013-02-05 | Atrium Medical Corporation | Perforated fatty acid films |
| US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US9801982B2 (en) | 2004-09-28 | 2017-10-31 | Atrium Medical Corporation | Implantable barrier device |
| EP1811935B1 (en) | 2004-09-28 | 2016-03-30 | Atrium Medical Corporation | Heat cured gel and method of making |
| US20060127437A1 (en) * | 2004-12-13 | 2006-06-15 | Misty Anderson Kennedy | Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids |
| US8535709B2 (en) * | 2004-12-13 | 2013-09-17 | Southeastern Medical Technologies, Llc | Agents for controlling biological fluids and methods of use thereof |
| US20070059350A1 (en) * | 2004-12-13 | 2007-03-15 | Kennedy John P | Agents for controlling biological fluids and methods of use thereof |
| US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
| US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
| AU2006304590A1 (en) | 2005-10-15 | 2007-04-26 | Atrium Medical Corporation | Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings |
| US7670997B2 (en) * | 2006-06-08 | 2010-03-02 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising a branched, glycerol monoalkyl compound and a fatty acid monoester |
| US9492596B2 (en) | 2006-11-06 | 2016-11-15 | Atrium Medical Corporation | Barrier layer with underlying medical device and one or more reinforcing support structures |
| AU2008283929B2 (en) | 2007-08-06 | 2013-10-10 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| PL2712622T3 (pl) * | 2008-05-21 | 2017-01-31 | Ferring B.V. | Ulegająca rozpadowi w ustach desmopresyna do zwiększania początkowego okresu snu niezakłócanego przez nokturię |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
| US10322213B2 (en) | 2010-07-16 | 2019-06-18 | Atrium Medical Corporation | Compositions and methods for altering the rate of hydrolysis of cured oil-based materials |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
| US9744542B2 (en) | 2013-07-29 | 2017-08-29 | Apeel Technology, Inc. | Agricultural skin grafting |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| WO2016187581A1 (en) | 2015-05-20 | 2016-11-24 | Apeel Technology, Inc. | Plant extract compositions and methods of preparation thereof |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| WO2017048951A1 (en) | 2015-09-16 | 2017-03-23 | Apeel Technology, Inc. | Precursor compounds for molecular coatings |
| JP6549326B2 (ja) | 2015-12-10 | 2019-07-24 | アピール テクノロジー，インコーポレイテッド | 保護コーティングを形成するための植物抽出物組成物 |
| CN109068627B (zh) | 2016-01-26 | 2022-03-18 | 阿比尔技术公司 | 用于制备和保存消毒产品的方法 |
| EP3541192B1 (en) | 2016-11-17 | 2025-06-25 | Apeel Technology, Inc. | Methods of preparing fatty acid esters from crosslinked polyesters |
| US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| WO2020018974A1 (en) | 2018-07-20 | 2020-01-23 | Lipocine Inc. | Liver disease |
| US12245605B2 (en) | 2018-09-05 | 2025-03-11 | Apeel Technology, Inc. | Compounds and formulations for protective coatings |
| US11641865B2 (en) | 2020-03-04 | 2023-05-09 | Apeel Technology, Inc. | Compounds and formulations for protective coatings |
| US11827591B2 (en) | 2020-10-30 | 2023-11-28 | Apeel Technology, Inc. | Compositions and methods of preparation thereof |
| WO2022098829A1 (en) * | 2020-11-04 | 2022-05-12 | Inolex Investment Corporation | Biobased glyceryl heptanoate ester compositions and methods of making and using the same |
| CN118159138A (zh) | 2021-09-08 | 2024-06-07 | 阿比尔技术公司 | 用于保护性涂层的化合物和制剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8206744D0 (sv) | 1982-11-26 | 1982-11-26 | Fluidcarbon International Ab | Preparat for kontrollerad avgivning av substanser |
| SE457693B (sv) * | 1986-07-01 | 1989-01-23 | Drilletten Ab | Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas |
-
1994
- 1994-12-09 SE SE9404289A patent/SE518619C2/sv not_active IP Right Cessation
-
1995
- 1995-12-08 CA CA002207218A patent/CA2207218C/en not_active Expired - Fee Related
- 1995-12-08 ES ES95941306T patent/ES2170171T3/es not_active Expired - Lifetime
- 1995-12-08 EP EP95941306A patent/EP0790822B1/en not_active Expired - Lifetime
- 1995-12-08 FI FI972415A patent/FI972415A7/fi unknown
- 1995-12-08 DE DE69525761T patent/DE69525761T2/de not_active Expired - Fee Related
- 1995-12-08 US US08/836,103 patent/US5906831A/en not_active Expired - Fee Related
- 1995-12-08 AT AT95941306T patent/ATE213932T1/de not_active IP Right Cessation
- 1995-12-08 BR BR9509897A patent/BR9509897A/pt not_active Application Discontinuation
- 1995-12-08 JP JP51754296A patent/JP3487860B2/ja not_active Expired - Fee Related
- 1995-12-08 WO PCT/SE1995/001479 patent/WO1996017597A1/en not_active Ceased
- 1995-12-08 AU AU42768/96A patent/AU4276896A/en not_active Abandoned
-
1997
- 1997-06-06 NO NO972614A patent/NO972614D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69525761D1 (de) | 2002-04-11 |
| JPH10510260A (ja) | 1998-10-06 |
| SE9404289L (sv) | 1996-06-10 |
| EP0790822B1 (en) | 2002-03-06 |
| CA2207218C (en) | 2002-02-12 |
| DE69525761T2 (de) | 2002-10-24 |
| SE9404289D0 (sv) | 1994-12-09 |
| NO972614L (no) | 1997-06-06 |
| FI972415A0 (fi) | 1997-06-06 |
| WO1996017597A1 (en) | 1996-06-13 |
| SE518619C2 (sv) | 2002-10-29 |
| NO972614D0 (no) | 1997-06-06 |
| CA2207218A1 (en) | 1996-06-13 |
| FI972415L (fi) | 1997-06-06 |
| JP3487860B2 (ja) | 2004-01-19 |
| FI972415A7 (fi) | 1997-06-06 |
| BR9509897A (pt) | 1997-12-30 |
| AU4276896A (en) | 1996-06-26 |
| EP0790822A1 (en) | 1997-08-27 |
| US5906831A (en) | 1999-05-25 |
| ATE213932T1 (de) | 2002-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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