ES2170443T3 - Procedimiento de obtencion de trans-(r,r)-actinol. - Google Patents

Procedimiento de obtencion de trans-(r,r)-actinol.

Info

Publication number
ES2170443T3
ES2170443T3 ES98120544T ES98120544T ES2170443T3 ES 2170443 T3 ES2170443 T3 ES 2170443T3 ES 98120544 T ES98120544 T ES 98120544T ES 98120544 T ES98120544 T ES 98120544T ES 2170443 T3 ES2170443 T3 ES 2170443T3
Authority
ES
Spain
Prior art keywords
actinol
procedure
trans
complex
levodiona
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98120544T
Other languages
English (en)
Inventor
Yvo Crameri
Kurt Puentener
Michelangelo Scalone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2170443T3 publication Critical patent/ES2170443T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/497—Saturated compounds containing a keto group being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • B01J31/121—Metal hydrides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCEDIMIENTO PARA LA OBTENCION DE TRANS - (R, R) ACTINOL MEDIANTE LA HIDROGENACION DE TRANSFERENCIA DIASTEREOSELECTIVA DE LEVODIONA QUE CONSISTE EN QUE, LA (R) LEVODIONA SE HIDROGENA EN PRESENCIA DE UN DONADOR DE HIDROGENO, QUE SE PUEDE UTILIZAR SIMULTANEAMENTE COMO DISOLVENTE, Y DE UN COMPLEJO DE AMINO - AMIDA - RUTENIO, EN PARTICULAR DE FORMULA RUH(L - H )(Y), EN DONDE Y ES UN LIGANDO NEUTRO Y L ES UN LIGANDO DE DIAMINA MONOSULFONADO QUE PUEDE SER OPTICAMENTE ACTIVO, COMO EL QUE ESTA DEFINIDO EN LA DESCRIPCION. LA INVENCION TRATA ADEMAS DE UNA PARTE DETERMINADA DEL COMPLEJO AMINO - AMIDA - RUTENIO, ASI COMO LAS PREETAPAS CORRESPONDIENTES PARA FORMAR ESTE COMPLEJO, LOS CUALES TIENEN HALOGENO EN LUGAR DE H. EL PRODUCTO DEL PROCEDIMIENTO DE LA INVENCION, TRANS - (R, R) - ACTINOL, SE CONOCE COMO ELEMENTO IMPORTANTE PARA LA SINTESIS DE LOS CAROTENOIDES, P. E. ZEAXANTINA. MEDIANTE EL PROCEDIMIENTO SE OBTIENE TRANS - (R, R) - ACTINOL CON UNA PUREZA ESPECIALMENTE ENANTIOMERICA Y DIASTEREOMERICA.
ES98120544T 1997-11-06 1998-10-30 Procedimiento de obtencion de trans-(r,r)-actinol. Expired - Lifetime ES2170443T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97119381 1997-11-06
EP98116697 1998-09-03

Publications (1)

Publication Number Publication Date
ES2170443T3 true ES2170443T3 (es) 2002-08-01

Family

ID=26145874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98120544T Expired - Lifetime ES2170443T3 (es) 1997-11-06 1998-10-30 Procedimiento de obtencion de trans-(r,r)-actinol.

Country Status (10)

Country Link
US (2) US6187961B1 (es)
EP (1) EP0915076B1 (es)
JP (1) JP4422808B2 (es)
KR (1) KR100678794B1 (es)
CN (2) CN1269828C (es)
BR (1) BR9804565A (es)
CA (1) CA2253888C (es)
DE (1) DE59802620D1 (es)
DK (1) DK0915076T3 (es)
ES (1) ES2170443T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5041501B2 (ja) * 2000-08-01 2012-10-03 塩野義製薬株式会社 アミド化合物を配位子とする遷移金属錯体を用いたアルコールの製造方法
GB0204129D0 (en) * 2002-02-21 2002-04-10 Novartis Ag Process for the manufacture of organic compounds
ES2331911T3 (es) * 2002-06-17 2010-01-20 Saltigo Gmbh Procedimiento para la preparacion de diaminas mono-n-sulfoniladas.
GB0425320D0 (en) * 2004-11-17 2004-12-22 Johnson Matthey Plc Diamines
SI2805765T1 (sl) * 2009-03-17 2021-04-30 Johnson Matthey Public Limited Company Postopek za hidrogeniranje ketonov v prisotnosti katalizatorjev Ru(II)
HRP20150617T1 (hr) * 2011-03-10 2015-07-03 Zach System S.P.A. Asimetriäśni postupak redukcije

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072715A (en) 1974-08-21 1978-02-07 Hoffmann-La Roche Inc. Optically active cyclohexane derivatives
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
US5543559A (en) * 1994-07-07 1996-08-06 Hoffman-La Roche Inc. Process for the enantioselective hydrogenation of ketosiophorone derivatives
DE19543619A1 (de) 1995-11-23 1997-05-28 Basf Ag Verfahren zur Reindarstellung von trans- und cis-4-Hydroxy-2,2,6-trimethyl-cyclohexan-l-on aus Isomerengemischen
WO1997020789A1 (en) 1995-12-06 1997-06-12 Japan Science And Technology Corporation Process for preparating optically active compounds
GB9706321D0 (en) 1997-03-26 1997-05-14 Zeneca Ltd Catalytic hydrogenation

Also Published As

Publication number Publication date
JP4422808B2 (ja) 2010-02-24
US6187961B1 (en) 2001-02-13
US6300509B1 (en) 2001-10-09
CN1223998A (zh) 1999-07-28
JPH11236345A (ja) 1999-08-31
CA2253888C (en) 2008-09-09
CN1550482A (zh) 2004-12-01
EP0915076A1 (de) 1999-05-12
CN1269828C (zh) 2006-08-16
DE59802620D1 (de) 2002-02-21
KR100678794B1 (ko) 2007-06-04
BR9804565A (pt) 2000-04-11
CA2253888A1 (en) 1999-05-06
EP0915076B1 (de) 2002-01-16
KR19990045041A (ko) 1999-06-25
DK0915076T3 (da) 2002-04-22
CN1142130C (zh) 2004-03-17

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