ES2170876T3 - Productos intermedios para la hemisintesis de taxanos y sus procedimientos de preparacion. - Google Patents

Productos intermedios para la hemisintesis de taxanos y sus procedimientos de preparacion.

Info

Publication number
ES2170876T3
ES2170876T3 ES96934977T ES96934977T ES2170876T3 ES 2170876 T3 ES2170876 T3 ES 2170876T3 ES 96934977 T ES96934977 T ES 96934977T ES 96934977 T ES96934977 T ES 96934977T ES 2170876 T3 ES2170876 T3 ES 2170876T3
Authority
ES
Spain
Prior art keywords
taxanos
hemisintesis
preparation procedures
intermediate products
stages
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96934977T
Other languages
English (en)
Inventor
Luc Chanteloup
Bruno Chauveau
Christine Corbin
Robert Dhal
Guen Sonia Le
Arnaud Lamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM
Original Assignee
Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM filed Critical Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM
Application granted granted Critical
Publication of ES2170876T3 publication Critical patent/ES2170876T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS INTERMEDIARIOS PARA LA HEMISINTESIS DE TAXANOS Y LOS PROCEDIMIENTOS DE PREPARACION CORRESPONDIENTES. SE TRATA, EN PARTICULAR, DE DERIVADOS DE OXAZOLIDINAS U OXAZOLIDINONAS, ASI COMO DE NUEVOS DERIVADOS DE LA BACCATINA III. EL METODO GENERAL DE SINTESIS DE LOS TAXANOS PROPUESTO EN LA INVENCION PERMITE OBTENER UN PRODUCTO COMO EL PACLITAXEL TM EN SOLO CINCO ETAPAS A PARTIR DE PRODUCTOS DISP ONIBLES EN EL MERCADO, FRENTE A LAS NUEVE ETAPAS GENERALMENTE NECESARIAS EN LOS PROCEDIMIENTOS TECNICOS ACTUALES.
ES96934977T 1995-10-27 1996-10-25 Productos intermedios para la hemisintesis de taxanos y sus procedimientos de preparacion. Expired - Lifetime ES2170876T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9512739A FR2740451B1 (fr) 1995-10-27 1995-10-27 Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes

Publications (1)

Publication Number Publication Date
ES2170876T3 true ES2170876T3 (es) 2002-08-16

Family

ID=9484016

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96934977T Expired - Lifetime ES2170876T3 (es) 1995-10-27 1996-10-25 Productos intermedios para la hemisintesis de taxanos y sus procedimientos de preparacion.

Country Status (25)

Country Link
US (5) US6265587B1 (es)
EP (1) EP0863887B1 (es)
JP (1) JP2000500437A (es)
KR (1) KR100489865B1 (es)
CN (1) CN100374428C (es)
AT (1) ATE212342T1 (es)
AU (1) AU710314B2 (es)
BR (1) BR9610908A (es)
CZ (1) CZ125598A3 (es)
DE (1) DE69618812T2 (es)
DK (1) DK0863887T3 (es)
EE (1) EE03610B1 (es)
ES (1) ES2170876T3 (es)
FR (1) FR2740451B1 (es)
GE (1) GEP20001938B (es)
HU (1) HU225507B1 (es)
IL (1) IL155876A (es)
NO (1) NO981823L (es)
NZ (1) NZ320356A (es)
PL (1) PL327458A1 (es)
PT (1) PT863887E (es)
RU (1) RU2159237C2 (es)
SK (1) SK52398A3 (es)
TR (1) TR199800713T2 (es)
WO (1) WO1997015562A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US6150537A (en) 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
KR100267596B1 (ko) * 1998-04-17 2000-10-16 강재헌 베타-아미노-알파-하이드록시산과 균등한 옥사졸린 유도체의 입체선택적 합성방법
WO2001030770A1 (en) * 1999-10-26 2001-05-03 Dong Kook Pharmaceutical Co., Ltd. Stereoselective synthesis of oxazoline derivative
ES2178539B1 (es) * 2000-03-14 2004-08-01 Dong Kook Pharmaceutical Co., Ltd. Procedimiento para la preparacion de un compuesto de oxazolina.
WO2002066448A1 (en) * 2001-02-20 2002-08-29 Dabur India Limited Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid
FR2846327B1 (fr) * 2002-10-25 2006-03-24 Merck Sante Sas Derives de n-benzodioxolyl, n-benzodioxanyl et n-benzodioxepinyl arylcarboxamides utilisables dans le traitement de dyslipidemies et compositions pharmaceutiques les contenant.
AU2006258065A1 (en) * 2005-06-10 2006-12-21 Florida State University Research Foundation, Inc. Processes for the production of polycyclic fused ring compounds
US7550608B2 (en) * 2005-06-10 2009-06-23 Florida State University Research Foundation, Inc. Processes for the preparation of docetaxel
GB0701523D0 (en) * 2007-01-26 2007-03-07 Chatham Biotec Ltd Semi-synthetic process for the preparation of taxane derivatives
CN101468974B (zh) * 2007-12-28 2011-02-09 上海百灵医药科技有限公司 多烯紫杉醇的半合成方法
US9321715B2 (en) 2009-12-30 2016-04-26 Basf Pharma (Callanish) Limited Simulated moving bed chromatographic separation process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
CN103508918B (zh) * 2012-06-18 2015-09-09 上海医药工业研究院 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
JP6303017B2 (ja) 2014-01-07 2018-03-28 ノヴァセプ プロセスＮｏｖａｓｅｐ Ｐｒｏｃｅｓｓ 芳香族アミノ酸を精製する方法
CN107848990B (zh) * 2015-07-07 2021-06-11 万代忠胜 紫杉醇和多烯紫杉醇的侧链前体的制造方法
CN112876503B (zh) * 2021-03-18 2022-04-29 中国科学院兰州化学物理研究所 用于癌症硼中子俘获治疗药物的硼酸盐化合物及其制备
CN114195820B (zh) * 2021-12-17 2023-11-10 中山大学 异丝氨酸衍生物及其制备与在紫杉醇合成中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US5008411A (en) * 1988-05-24 1991-04-16 Hoffmann-La Roche Inc. Glycidic acid ester and process of preparation
US5274300A (en) * 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
CA2023645C (fr) * 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5304670A (en) 1989-08-23 1994-04-19 Centre National De La Recherche Scientifique Process for the enantioselective preparation of phenylisoserine derivatives
JPH088879B2 (ja) * 1989-09-13 1996-01-31 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
WO1993010076A1 (en) * 1991-11-22 1993-05-27 The University Of Mississippi Synthesis and optical resolution of the taxol side chain and related compounds
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
HU0203995D0 (en) * 1992-12-23 2003-04-28 Bristol Myers Squibb Co Oxazole derivatives for synthesis of sidechain-bearing taxanes and preparation thereof
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US6228955B1 (en) * 1996-04-19 2001-05-08 Chirotech Technology, Ltd. Asymmetric epoxides, their synthesis and use

Also Published As

Publication number Publication date
DK0863887T3 (da) 2002-04-22
ATE212342T1 (de) 2002-02-15
US7220871B2 (en) 2007-05-22
WO1997015562A1 (fr) 1997-05-01
DE69618812D1 (de) 2002-03-14
HUP9802487A2 (hu) 1999-09-28
KR100489865B1 (ko) 2006-01-27
US7279586B2 (en) 2007-10-09
CN100374428C (zh) 2008-03-12
JP2000500437A (ja) 2000-01-18
EP0863887B1 (fr) 2002-01-23
EE03610B1 (et) 2002-02-15
NZ320356A (en) 2000-01-28
US6265587B1 (en) 2001-07-24
IL155876A (en) 2008-07-08
HUP9802487A3 (en) 2000-07-28
US20020068833A1 (en) 2002-06-06
PL327458A1 (en) 1998-12-07
EE9800149A (et) 1998-12-15
AU710314B2 (en) 1999-09-16
NO981823D0 (no) 1998-04-23
RU2159237C2 (ru) 2000-11-20
FR2740451B1 (fr) 1998-01-16
US20050222089A1 (en) 2005-10-06
US6825365B2 (en) 2004-11-30
TR199800713T2 (xx) 1998-09-21
US7432383B2 (en) 2008-10-07
FR2740451A1 (fr) 1997-04-30
US20040220256A1 (en) 2004-11-04
SK52398A3 (en) 1998-09-09
US20070208185A1 (en) 2007-09-06
EP0863887A1 (fr) 1998-09-16
CN1200731A (zh) 1998-12-02
PT863887E (pt) 2002-07-31
AU7308696A (en) 1997-05-15
GEP20001938B (en) 2000-02-05
DE69618812T2 (de) 2002-08-29
BR9610908A (pt) 1999-07-13
CZ125598A3 (cs) 1998-08-12
NO981823L (no) 1998-04-23
HU225507B1 (en) 2007-01-29
KR19990067124A (ko) 1999-08-16

Similar Documents

Publication Publication Date Title
ES2163234T3 (es) Mejoras relacionadas con la teoflavina o con la produccion de la misma.
AR024554A1 (es) Enfriamiento mejorado del producto premezclado en maquinas expendedoras de alimentos semi-congelados
GT199900140A (es) Derivados de quinolin-2-ona alquinilsustituidos utiles como agentes anticancerosos.
DE60128179D1 (de) Nahrungsmittel enthaltend Vitamin k2
GR3036305T3 (en) Chiral methyl phenyl oxazolidinones
MX9605206A (es) 1alfa,26-dihidroxi-d-homo-vitamina d3.
IT1307928B1 (it) Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
ES2175247T3 (es) Recubrimiento jaspeado para confiteria.
ES2170785T3 (es) Procedimiento para la fabricacion de arilpirroles insecticidas a traves de productos intermedios de oxazolamina.
BR9814913A (pt) Nova substância kf-1040 e processo para produção da mesma
ES2167721T3 (es) Utilizacion de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica.
ES2117304T3 (es) Sintesis de esfingosinas.
ES2135168T3 (es) Preparacion de d4t a partir de 5-metiluridina.
ATE253069T1 (de) Optisch reine camptothecinanaloge, optisch reines synthese-zwischenprodukt und verfahren zu ihrer herstellung
ES2170140T3 (es) Procedimiento mejorado para la obtencion de un producto intermedio de d-(+)-biotina.
DE69617933D1 (de) Pflanzenöl, geeignet zur herstellung von backwaren
ES2141948T3 (es) Derivados de ciclohexanona, procedimiento para su preparacion y productos intermedios del procedimiento.
ES2170402T3 (es) Derivados de benzo(g)quinolina.
UY28574A1 (es) Derivados de bengamida, procedimiento para su preparación y su uso
CR8376A (es) Metodo para producir derivados de (3-oxo-2,3-dihidro-1 h-isoindol-1-il)-acetilguanidina
CA2510174A1 (en) A process for the preparation of (-)-epicatechin from a new natural source namely dichrostachys cinerea
MXPA04001856A (es) Indan-1-oles c2-sustituidos y sus derivados, metodo para su produccion y su uso como medicamentos.
MXPA04001852A (es) Uso de sistemas indan-1-ol c2-sustituidas para la produccion de medicamentos para la profilaxis o tratamiento de obesidad.
TW200407314A (en) Preparation of 4, 6-dichloro-5-fluoropyrimidine
MXPA02004864A (es) Producto para el blanqueamiento dental.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 863887

Country of ref document: ES