ES2117304T3 - Sintesis de esfingosinas. - Google Patents

Sintesis de esfingosinas.

Info

Publication number
ES2117304T3
ES2117304T3 ES94930717T ES94930717T ES2117304T3 ES 2117304 T3 ES2117304 T3 ES 2117304T3 ES 94930717 T ES94930717 T ES 94930717T ES 94930717 T ES94930717 T ES 94930717T ES 2117304 T3 ES2117304 T3 ES 2117304T3
Authority
ES
Spain
Prior art keywords
sphingosins
synthesis
chire
biocatalitical
aquiral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94930717T
Other languages
English (en)
Inventor
Tomas Hudlicky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Tech Intellectual Properties Inc
Original Assignee
Virginia Tech Intellectual Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties Inc filed Critical Virginia Tech Intellectual Properties Inc
Application granted granted Critical
Publication of ES2117304T3 publication Critical patent/ES2117304T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

MEDIANTE LA PRESENTE INVENCION SE PROPORCIONA UN PROCESO PARA LA SINTESIS BIOCATALITICA DE ESFINGOSINAS OPTICAMENTE PURAS A PARTIR DE MATERIAL DE INICIO AQUIRAL. LOS ESTEREOISOMEROS DE ESFINGOSINA SE PREPARAN A PARTIR DE DIOLES DE ARENO QUIRAL UTILIZANDO TECNICAS DE REACCION ESTEREOESPECIFICAS PARA OBTENER LA ESFINGOSINA DESEADA O UN DERIVADO DE LA MISMA.
ES94930717T 1993-10-18 1994-10-11 Sintesis de esfingosinas. Expired - Lifetime ES2117304T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13734693A 1993-10-18 1993-10-18

Publications (1)

Publication Number Publication Date
ES2117304T3 true ES2117304T3 (es) 1998-08-01

Family

ID=22476987

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94930717T Expired - Lifetime ES2117304T3 (es) 1993-10-18 1994-10-11 Sintesis de esfingosinas.

Country Status (7)

Country Link
US (2) US5488166A (es)
EP (1) EP0724562B1 (es)
JP (2) JP3783730B2 (es)
CA (1) CA2174431C (es)
DE (1) DE69410814T2 (es)
ES (1) ES2117304T3 (es)
WO (1) WO1995011222A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720184B1 (en) 1991-08-05 2004-04-13 Emory University Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination
FR2727407B1 (fr) * 1994-11-30 1996-12-27 Oreal Procede de preparation de 2-amino-alcane-1,3-diols
US6232299B1 (en) 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
DE69943314D1 (de) * 1998-02-12 2011-05-12 Kapil N Bhalla Sphingolipid-derivate und verfahren zu deren verwendung
AU4716299A (en) 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US8592368B2 (en) 2003-12-19 2013-11-26 University Of South Florida JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
PE20070435A1 (es) 2005-09-16 2007-06-13 Schering Corp Formulacion farmaceutica que comprende temozolomida y un inhibidor de la proteina quinasa
WO2008030840A2 (en) * 2006-09-06 2008-03-13 Emory University Synthesis of sphingosines and their derivatives
CN116747310A (zh) * 2018-03-29 2023-09-15 中国医学科学院基础医学研究所 植物来源“汤剂体”的提取和“本草体”的人工制备及其相关产品

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0651715B2 (ja) * 1985-06-07 1994-07-06 理化学研究所 シアロシルセレブロシド類及びその製造法
ATE71104T1 (de) * 1985-08-13 1992-01-15 Solco Basel Ag Neues verfahren zur herstellung von sphingosinderivaten.
DE3852526D1 (de) * 1987-06-26 1995-02-02 Solco Basel Ag Neue pharmazeutische Präparate sowie neue Lactosylverbindungen und ihre Herstellung.
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
US5110987A (en) * 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
US5012000A (en) * 1989-10-30 1991-04-30 Eastman Kodak Company Total synthesis of chiral 2-amino-1,3-diols
US5068345A (en) * 1989-10-30 1991-11-26 Eastman Kodak Company Oxazolidinone aldol adduct
US5200516A (en) * 1990-02-16 1993-04-06 Virginia Tech Intellectual Properties Synthesis of sugars from substituted and unsubstituted arene diols
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
US5137919A (en) * 1990-12-31 1992-08-11 Biomembrane Institute Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
US5220043A (en) * 1991-03-21 1993-06-15 Ohio University Synthesis of D-erythro-sphingomyelins

Also Published As

Publication number Publication date
US5488167A (en) 1996-01-30
JP4224049B2 (ja) 2009-02-12
JP3783730B2 (ja) 2006-06-07
US5488166A (en) 1996-01-30
EP0724562B1 (en) 1998-06-03
WO1995011222A1 (en) 1995-04-27
DE69410814D1 (de) 1998-07-09
JP2006028196A (ja) 2006-02-02
CA2174431C (en) 2005-12-06
DE69410814T2 (de) 1998-11-12
JPH09503786A (ja) 1997-04-15
EP0724562A1 (en) 1996-08-07
CA2174431A1 (en) 1995-04-27

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