ES2171532T3 - Utilizacion de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. - Google Patents

Utilizacion de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Info

Publication number
ES2171532T3
ES2171532T3 ES95908286T ES95908286T ES2171532T3 ES 2171532 T3 ES2171532 T3 ES 2171532T3 ES 95908286 T ES95908286 T ES 95908286T ES 95908286 T ES95908286 T ES 95908286T ES 2171532 T3 ES2171532 T3 ES 2171532T3
Authority
ES
Spain
Prior art keywords
sub
acilo
sup
lipoxygenase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95908286T
Other languages
English (en)
Inventor
De Falgas Joaquin Bonal
Belmonte Lorenzo Lopez
Navarro Luis Vila
Pujol Antonio Maria Molins
Novales Luis Lacoma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bobel246 S L
Original Assignee
Bobel246 S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bobel246 S L filed Critical Bobel246 S L
Application granted granted Critical
Publication of ES2171532T3 publication Critical patent/ES2171532T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PRODUCTOS DE FORMULA (I) EN LOS QUE R 2 ES (C 1}C{SUB,4}-ALQUILO, C{SUB,1}-C{SUB,4}-ACILO, CF{SUB,3}, CL, BR O L; R{SUP,3} ES H, (C{SUB,1}-C{SUB,4}-ALQUIL, C{SUB,1}-{SUB,4}ACIL, (C{SUB,1}-C{SUB,4}-ALCOXIL, CF{SUB,3}, F, CL, BR, FENILO, OH, SH, NH2 O AMINO MONO O DISUSTITUIDO POR (C{SUB, 1}-C{SUB, 3}ALQUIL; R{SUP,4} ES C{SUB,1}-C{SUB,4}-ALQUILO, (C{SUB,1}C{SUB,4}-ACILO, CF{SUB,3}, F, CL, BR O L, CARBOXILO, C{SUB, 1}C{SUB,4} ALCOXICARBONILO, CIANO, NITRO O FENILO; Y R{SUP, 6} ES H, (C{SUB,1-C{SUB,4})-ALQUILO, (C{SUB,1}-C{SUB,4}) ACILO, CF{SUB, 3}, CL, BR O L, DICHOS PRODUCTOS OFRECEN, ADEMAS DE UNA BAJA TOXICIDAD, UNA ACTIVIDAD INHIBIDORA DE LA 5-LIPOXIGENASA MUCHO MAS ALTA QUE LA QUE OFRECE EL BENAPROFENO O KETOCONAZOL. ESTAS CARACTERISTICAS HACEN QUE LOS DERIVADOS DESCUBIERTOS SEAN EXTREMADAMENTE UTILES PARA LA PREPARACION DE MEDICAMENTOS CONTRA LAS ENFERMEDADES MEDIADAS POR LA LEUCOTRIENA, COMO LA ARTRITIS REUMATOIDE, LA COLITIS ULCEROSA, EL ASMA, LA PSORIASIS Y EL HERPES.
ES95908286T 1994-02-08 1995-02-06 Utilizacion de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. Expired - Lifetime ES2171532T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09400217A ES2087019B1 (es) 1994-02-08 1994-02-08 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Publications (1)

Publication Number Publication Date
ES2171532T3 true ES2171532T3 (es) 2002-09-16

Family

ID=8285128

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09400217A Expired - Fee Related ES2087019B1 (es) 1994-02-08 1994-02-08 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
ES95908286T Expired - Lifetime ES2171532T3 (es) 1994-02-08 1995-02-06 Utilizacion de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES09400217A Expired - Fee Related ES2087019B1 (es) 1994-02-08 1994-02-08 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Country Status (11)

Country Link
US (1) US5985937A (es)
EP (1) EP0707849B1 (es)
JP (1) JPH08511561A (es)
AT (1) ATE210974T1 (es)
AU (1) AU706305B2 (es)
BR (1) BR9505842A (es)
DE (1) DE69524709T2 (es)
ES (2) ES2087019B1 (es)
MX (1) MX9504248A (es)
NZ (1) NZ279509A (es)
WO (1) WO1995021610A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2134107C1 (ru) 1998-10-12 1999-08-10 Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН Препарат "гистохром" для лечения воспалительных заболеваний сетчатки и роговицы глаз
DE10040051A1 (de) * 2000-08-11 2002-02-21 Basf Ag Derivate des 4-(Trifluormethyl)-phenols sowie Derivate des 4-(Trifluormethylphenyl)-2-(tetrahydropyranyl)ethers und Verfahren zu ihre Herstellung
US6696466B1 (en) 2000-09-07 2004-02-24 Leslie Joe Dunaway Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines
WO2003075905A1 (es) * 2002-03-14 2003-09-18 Bobel 246, S.L. Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la expresion de l-selectinas y de la isoforma inductible de la sintasa del oxido nitrico
AU2006328198B2 (en) * 2005-12-19 2013-07-18 Medizinische Hochschule Hannover Substituted phenol derivatives as analgesics
EP2810927A1 (en) * 2007-05-09 2014-12-10 Sowood Healthcare LLC Therapeutic compounds
CA2685813A1 (en) * 2007-05-09 2008-11-20 Pharmacofore, Inc. Therapeutic compounds
ES2396360T3 (es) 2008-10-09 2013-02-21 Industrial Farmaceutica Cantabria, S.A. Composición micronizada de un derivado de fenol 2,4-di sustituido
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
NL2025295B1 (en) * 2020-04-07 2021-10-25 Zhi Lin Wen Use of phenol in treatment of microbially induced dyspnoea
WO2021206549A1 (en) 2020-04-07 2021-10-14 Lin wen zhi Use of phenol in treatment of microbially induced dyspnoea

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029816A (en) * 1975-11-25 1977-06-14 Merck & Co., Inc. Substituted 2-aminomethyl-6-iodophenols
US4677124A (en) * 1983-12-16 1987-06-30 Bislak, S.A. Process for preparing and therapeutical applications of the "2,4,6-triiodophenol"
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase
EP0334119B1 (en) * 1988-03-21 1993-06-16 Boehringer Ingelheim Pharmaceuticals Inc. Compounds for inhibiting the biosynthesis of lipoxygenase-derived metabolites of arachidonic acid

Also Published As

Publication number Publication date
EP0707849B1 (en) 2001-12-19
ES2087019A1 (es) 1996-07-01
EP0707849A1 (en) 1996-04-24
WO1995021610A1 (es) 1995-08-17
AU706305B2 (en) 1999-06-10
DE69524709D1 (de) 2002-01-31
MX9504248A (es) 1997-04-30
JPH08511561A (ja) 1996-12-03
ATE210974T1 (de) 2002-01-15
AU1666295A (en) 1995-08-29
US5985937A (en) 1999-11-16
BR9505842A (pt) 1996-02-13
DE69524709T2 (de) 2002-08-08
ES2087019B1 (es) 1997-03-16
NZ279509A (en) 1999-09-29

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