BR0212277A - Composto, processo para preparar um composto, uso de um composto, método para produzir um efeito inibidor do ibat, e, composição farmacêutica - Google Patents

Composto, processo para preparar um composto, uso de um composto, método para produzir um efeito inibidor do ibat, e, composição farmacêutica

Info

Publication number
BR0212277A
BR0212277A BR0212277-4A BR0212277A BR0212277A BR 0212277 A BR0212277 A BR 0212277A BR 0212277 A BR0212277 A BR 0212277A BR 0212277 A BR0212277 A BR 0212277A
Authority
BR
Brazil
Prior art keywords
compound
preparing
producing
pharmaceutical composition
inhibitory effect
Prior art date
Application number
BR0212277-4A
Other languages
English (en)
Inventor
Ingemar Starke
Mikael Ulf Johan Dahlstrom
David Blomberg
Suzanne Alenfalk
Peter Nordberg
Andreas Christer Wallberg
Stig Jonas Bostrom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0212277A publication Critical patent/BR0212277A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARAR UM COMPOSTO, USO DE UM COMPOSTO, MéTODO PARA PRODUZIR UM EFEITO INIBIDOR DO IBAT, E, COMPOSIçãO FARMACêUTICA". A presente invenção diz respeito a compostos de fórmula (I) em que os grupos variáveis são como definidos interiormente; sais, solvatos de tais sais e seus pró-medicamentos farmaceuticamente aceitáveis e seu uso como inibidores do transporte do ácido biliar ileal (IBAT) para o tratamento da hiperlipidemia. Também são descritos processos para sua fabricação e composições farmacêuticas contendo-os.
BR0212277-4A 2001-09-04 2002-08-30 Composto, processo para preparar um composto, uso de um composto, método para produzir um efeito inibidor do ibat, e, composição farmacêutica BR0212277A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0121337.0A GB0121337D0 (en) 2001-09-04 2001-09-04 Chemical compounds
PCT/GB2002/003983 WO2003020710A1 (en) 2001-09-04 2002-08-30 Benzothiazepine derivatives

Publications (1)

Publication Number Publication Date
BR0212277A true BR0212277A (pt) 2004-10-19

Family

ID=9921450

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212277-4A BR0212277A (pt) 2001-09-04 2002-08-30 Composto, processo para preparar um composto, uso de um composto, método para produzir um efeito inibidor do ibat, e, composição farmacêutica

Country Status (18)

Country Link
US (1) US7192946B2 (pt)
EP (1) EP1430040B1 (pt)
JP (1) JP4441261B2 (pt)
KR (1) KR20040029147A (pt)
CN (1) CN1599731A (pt)
AT (1) ATE438634T1 (pt)
BR (1) BR0212277A (pt)
CA (1) CA2459346A1 (pt)
DE (1) DE60233239D1 (pt)
ES (1) ES2329226T3 (pt)
GB (1) GB0121337D0 (pt)
IL (1) IL160503A0 (pt)
MX (1) MXPA04002032A (pt)
NO (1) NO20040924L (pt)
NZ (1) NZ531512A (pt)
UY (1) UY27431A1 (pt)
WO (1) WO2003020710A1 (pt)
ZA (1) ZA200401551B (pt)

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GB0201850D0 (en) 2002-01-26 2002-03-13 Astrazeneca Ab Therapeutic treatment
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
GB0216321D0 (en) 2002-07-13 2002-08-21 Astrazeneca Ab Therapeutic treatment
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use

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EP1430040A1 (en) 2004-06-23
CN1599731A (zh) 2005-03-23
US20040254160A1 (en) 2004-12-16
EP1430040B1 (en) 2009-08-05
JP4441261B2 (ja) 2010-03-31
ATE438634T1 (de) 2009-08-15
ZA200401551B (en) 2004-11-24
UY27431A1 (es) 2003-03-31
MXPA04002032A (es) 2004-06-07
DE60233239D1 (de) 2009-09-17
NZ531512A (en) 2005-10-28
US7192946B2 (en) 2007-03-20
WO2003020710A1 (en) 2003-03-13
ES2329226T3 (es) 2009-11-24
GB0121337D0 (en) 2001-10-24
IL160503A0 (en) 2004-07-25
CA2459346A1 (en) 2003-03-13
JP2005505554A (ja) 2005-02-24
NO20040924L (no) 2004-04-21

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