ES2171649T3 - Procedimiento para la preparacion de ciclosporina cromatograficamente pura utilizando un eluyente que consta esencialmente de dioxido de carbono a alta presion. - Google Patents

Procedimiento para la preparacion de ciclosporina cromatograficamente pura utilizando un eluyente que consta esencialmente de dioxido de carbono a alta presion.

Info

Publication number
ES2171649T3
ES2171649T3 ES96903038T ES96903038T ES2171649T3 ES 2171649 T3 ES2171649 T3 ES 2171649T3 ES 96903038 T ES96903038 T ES 96903038T ES 96903038 T ES96903038 T ES 96903038T ES 2171649 T3 ES2171649 T3 ES 2171649T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
chromatographicly
eluyent
high pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96903038T
Other languages
English (en)
Inventor
Juhani Lundell
Jarkko Ruohonen
Olli Aaltonen
Martti Alkio
Anneli Hase
Tapani Suortti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2171649T3 publication Critical patent/ES2171649T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO CROMATOGRAFICO DE PREPARACION DE CICLOSPORINA PURA, A PARTIR DE UNA MEZCLA DE VARIAS FORMAS DE CICLOSPORINA Y OTRAS SUSTANCIAS PREPARADAS MEDIANTE FERMENTACION, UTILIZANDO UN ELUYENTE CONSISTENTE BASICAMENTE EN DIOXIDO DE CARBONO A ALTA PRESION.
ES96903038T 1995-03-03 1996-03-01 Procedimiento para la preparacion de ciclosporina cromatograficamente pura utilizando un eluyente que consta esencialmente de dioxido de carbono a alta presion. Expired - Lifetime ES2171649T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI950983A FI102758B1 (fi) 1995-03-03 1995-03-03 Menetelmä puhtaan syklosporiinimuodon valmistamiseksi

Publications (1)

Publication Number Publication Date
ES2171649T3 true ES2171649T3 (es) 2002-09-16

Family

ID=8542963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96903038T Expired - Lifetime ES2171649T3 (es) 1995-03-03 1996-03-01 Procedimiento para la preparacion de ciclosporina cromatograficamente pura utilizando un eluyente que consta esencialmente de dioxido de carbono a alta presion.

Country Status (10)

Country Link
US (1) US5976381A (es)
EP (1) EP0815122B1 (es)
JP (1) JPH11501042A (es)
AT (1) ATE212353T1 (es)
DE (1) DE69618772T2 (es)
DK (1) DK0815122T3 (es)
ES (1) ES2171649T3 (es)
FI (1) FI102758B1 (es)
PT (1) PT815122E (es)
WO (1) WO1996027607A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
JP2008515886A (ja) 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
FR2889077B1 (fr) * 2005-07-26 2007-10-12 Novasep Soc Par Actions Simpli Procede et dispositif de separation chromatographique de fractions d'un melange
EP4145125B1 (en) * 2014-08-19 2025-10-01 Supercritical Fluid Technologies, Inc. Supercritical fluid chromatography system
US10765968B2 (en) 2014-08-19 2020-09-08 Supercritical Fluid Technologies, Inc. Systems and methods for supercritical fluid chromatography
US11913685B2 (en) 2014-08-19 2024-02-27 Supercritical Fluid Technologies, Inc. Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive Joule Thomson coefficient
CN105566381A (zh) * 2015-12-29 2016-05-11 成都普思生物科技股份有限公司 一种注射用磷脂酰胆碱的制备方法
WO2018071884A1 (en) 2016-10-14 2018-04-19 Supercritical Fluid Technologies, Inc. Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive joule-thomson coefficient
WO2020142753A1 (en) 2019-01-04 2020-07-09 Supercritical Fluid Technologies, Inc. Interchangeable chromatography cartridge adapter system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2729462A1 (de) * 1977-06-30 1979-01-18 Wolfgang Dr Hartmann Vorrichtung und verfahren zur chromatographischen trennung von substanzen geringen dampfdrucks
FR2527934A1 (fr) * 1982-06-03 1983-12-09 Elf Aquitaine Procede de fractionnement de melanges par chromatographie d'elution avec fluide en etat supercritique et installation pour sa mise en oeuvre
DE3318194C2 (de) * 1983-05-19 1987-01-22 Fried. Krupp Gmbh, 4300 Essen Verfahren zur Isolierung und Reinigung von Antibiotika
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.
FI93833C (fi) * 1992-05-14 1995-06-12 Orion Yhtymae Oy Menetelmä propionihappojohdosten valmistamiseksi
CA2108655A1 (en) * 1993-10-18 1995-04-19 Argyrios Margaritis Supercritical co2 extraction of cyclosporin a

Also Published As

Publication number Publication date
JPH11501042A (ja) 1999-01-26
US5976381A (en) 1999-11-02
DK0815122T3 (da) 2002-04-22
FI950983A0 (fi) 1995-03-03
FI950983L (fi) 1996-09-04
WO1996027607A1 (en) 1996-09-12
EP0815122B1 (en) 2002-01-23
ATE212353T1 (de) 2002-02-15
FI102758B (fi) 1999-02-15
PT815122E (pt) 2002-06-28
DE69618772D1 (de) 2002-03-14
HK1007882A1 (en) 1999-04-30
DE69618772T2 (de) 2002-08-29
FI102758B1 (fi) 1999-02-15
EP0815122A1 (en) 1998-01-07

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