PT815122E - Processo para a preparacao de ciclosporina pura por cromatografia utilizando um eluente que consiste essencialmente em dioxido de carbono de alta pressao - Google Patents

Processo para a preparacao de ciclosporina pura por cromatografia utilizando um eluente que consiste essencialmente em dioxido de carbono de alta pressao

Info

Publication number: PT815122E
Authority: PT; Portugal
Prior art keywords: pct; pure; cyclosporin; preparation; carbon dioxide
Prior art date: 1995-03-03

Application number

PT96903038T

Other languages

English (en)

Inventor

Olli Aaltonen

Anneli Hase

Martti Alkio

Jarkko Ruohonen

Juhani Lundell

Tapani Suortti

Original Assignee

Santen Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-03

Filing date

1996-03-01

Publication date

2002-06-28

1996-03-01 Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd

2002-06-28 Publication of PT815122E publication Critical patent/PT815122E/pt

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 5
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 title abstract 4
108010036949 Cyclosporine Proteins 0.000 title abstract 3
238000004587 chromatography analysis Methods 0.000 title abstract 3
229960001265 ciclosporin Drugs 0.000 title abstract 3
229930182912 cyclosporin Natural products 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
229910002092 carbon dioxide Inorganic materials 0.000 title abstract 2
239000001569 carbon dioxide Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
239000003480 eluent Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000002671 adjuvant Substances 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
239000000377 silicon dioxide Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Crystals, And After-Treatments Of Crystals (AREA)

PT96903038T 1995-03-03 1996-03-01 Processo para a preparacao de ciclosporina pura por cromatografia utilizando um eluente que consiste essencialmente em dioxido de carbono de alta pressao PT815122E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI950983A FI102758B (fi)	1995-03-03	1995-03-03	Menetelmä puhtaan syklosporiinimuodon valmistamiseksi

Publications (1)

Publication Number	Publication Date
PT815122E true PT815122E (pt)	2002-06-28

Family

ID=8542963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96903038T PT815122E (pt)	1995-03-03	1996-03-01	Processo para a preparacao de ciclosporina pura por cromatografia utilizando um eluente que consiste essencialmente em dioxido de carbono de alta pressao

Country Status (10)

Country	Link
US (1)	US5976381A (pt)
EP (1)	EP0815122B1 (pt)
JP (1)	JPH11501042A (pt)
AT (1)	ATE212353T1 (pt)
DE (1)	DE69618772T2 (pt)
DK (1)	DK0815122T3 (pt)
ES (1)	ES2171649T3 (pt)
FI (1)	FI102758B (pt)
PT (1)	PT815122E (pt)
WO (1)	WO1996027607A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL143604A0 (en)	1998-12-30	2002-04-21	Dexcel Ltd	Dispersable concentrate for the delivery of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
CA2518265A1 (en)	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en)	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
FR2889077B1 (fr) *	2005-07-26	2007-10-12	Novasep Soc Par Actions Simpli	Procede et dispositif de separation chromatographique de fractions d'un melange
US11913685B2 (en)	2014-08-19	2024-02-27	Supercritical Fluid Technologies, Inc.	Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive Joule Thomson coefficient
AU2015305892B2 (en) *	2014-08-19	2021-06-03	Supercritical Fluid Technologies, Inc.	Supercritical fluid chromatography system
US10765968B2 (en)	2014-08-19	2020-09-08	Supercritical Fluid Technologies, Inc.	Systems and methods for supercritical fluid chromatography
CN105566381A (zh) *	2015-12-29	2016-05-11	成都普思生物科技股份有限公司	一种注射用磷脂酰胆碱的制备方法
AU2017342549B2 (en)	2016-10-14	2022-02-17	Supercritical Fluid Technologies, Inc.	Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive joule-thomson coefficient
US11946915B2 (en)	2019-01-04	2024-04-02	Supercritical Fluid Technologies, Inc.	Interchangeable chromatography cartridgeadapter system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2729462A1 (de) *	1977-06-30	1979-01-18	Wolfgang Dr Hartmann	Vorrichtung und verfahren zur chromatographischen trennung von substanzen geringen dampfdrucks
FR2527934A1 (fr) *	1982-06-03	1983-12-09	Elf Aquitaine	Procede de fractionnement de melanges par chromatographie d'elution avec fluide en etat supercritique et installation pour sa mise en oeuvre
DE3318194C2 (de) *	1983-05-19	1987-01-22	Fried. Krupp Gmbh, 4300 Essen	Verfahren zur Isolierung und Reinigung von Antibiotika
DE59106428D1 (de) *	1991-04-06	1995-10-12	Dresden Arzneimittel	Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.
FI93833C (fi) *	1992-05-14	1995-06-12	Orion Yhtymae Oy	Menetelmä propionihappojohdosten valmistamiseksi
CA2108655A1 (en) *	1993-10-18	1995-04-19	Argyrios Margaritis	Supercritical co2 extraction of cyclosporin a

1995
- 1995-03-03 FI FI950983A patent/FI102758B/fi not_active IP Right Cessation
1996
- 1996-03-01 US US08/894,957 patent/US5976381A/en not_active Expired - Fee Related
- 1996-03-01 JP JP8526631A patent/JPH11501042A/ja not_active Ceased
- 1996-03-01 PT PT96903038T patent/PT815122E/pt unknown
- 1996-03-01 WO PCT/FI1996/000120 patent/WO1996027607A1/en not_active Ceased
- 1996-03-01 ES ES96903038T patent/ES2171649T3/es not_active Expired - Lifetime
- 1996-03-01 DK DK96903038T patent/DK0815122T3/da active
- 1996-03-01 DE DE69618772T patent/DE69618772T2/de not_active Expired - Fee Related
- 1996-03-01 AT AT96903038T patent/ATE212353T1/de not_active IP Right Cessation
- 1996-03-01 EP EP96903038A patent/EP0815122B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HK1007882A1 (en)	1999-04-30
DE69618772T2 (de)	2002-08-29
WO1996027607A1 (en)	1996-09-12
JPH11501042A (ja)	1999-01-26
FI950983L (fi)	1996-09-04
DE69618772D1 (de)	2002-03-14
DK0815122T3 (da)	2002-04-22
FI950983A0 (fi)	1995-03-03
ATE212353T1 (de)	2002-02-15
ES2171649T3 (es)	2002-09-16
FI102758B1 (fi)	1999-02-15
EP0815122B1 (en)	2002-01-23
EP0815122A1 (en)	1998-01-07
FI102758B (fi)	1999-02-15
US5976381A (en)	1999-11-02

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