ES2173085T3 - Celulas supresoras y progenitoras. - Google Patents

Celulas supresoras y progenitoras.

Info

Publication number
ES2173085T3
ES2173085T3 ES92925119T ES92925119T ES2173085T3 ES 2173085 T3 ES2173085 T3 ES 2173085T3 ES 92925119 T ES92925119 T ES 92925119T ES 92925119 T ES92925119 T ES 92925119T ES 2173085 T3 ES2173085 T3 ES 2173085T3
Authority
ES
Spain
Prior art keywords
cells
tcr
phenotype
beta
progenitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92925119T
Other languages
English (en)
Inventor
Samuel Strober
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2173085T3 publication Critical patent/ES2173085T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/59—Lectins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Cable Accessories (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)

Abstract

CELULAS SUPRESORAS NATURALES (NS) SECRETAN UN FACTOR SUPRESOR DE PROTEINA SOLUBLE (SF) QUE SUPRIME LA RESPUESTA DE LINFOCITOS MEZCLADOS. LAS CELULAS NS COMO LAS QUE SE DESCRIBEN AQUI, SON NULAS, ES DECIR, TIENEN EL FENOTIPO IL-2R+, CD3-, CD4-, CD8-, TCR (BETA)-, IG-, MAC-1, O SON SUPRESORAS NEGATIVAS DOBLES (DNS); ES DECIR, TIENEN EL FENOTIPO IL-2R-, CD3+, CD4-, CD8-, TCR (BETA)+. LOS DOS, NS Y SF, SON UTILES IN VIVO PARA CONFERIR INMUNOTOLERANCIA RESPECTO A TRASPLANTES ALOGENECOS Y A EFECTOS DE INMUNOSUPRESION. TAMBIEN REALZAN LA CAPACIDAD DE INJERTO DE LAS CELULAS TRASPLANTADAS. PUEDE SER PROPORCIONADA UNA POBLACION DE CELULAS USANDO TECNICAS DE SEPARACION DE GRADIENTES DE DENSIDAD LA CUAL ES ENRIQUECIDA EN CELULAS PROGENITORAS COMO IDENTIFICADAS POR LA PRESENCIA DE MARCADORES DE SUPERFICIE CD34.
ES92925119T 1991-11-05 1992-11-05 Celulas supresoras y progenitoras. Expired - Lifetime ES2173085T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78916991A 1991-11-05 1991-11-05
US93121092A 1992-08-17 1992-08-17

Publications (1)

Publication Number Publication Date
ES2173085T3 true ES2173085T3 (es) 2002-10-16

Family

ID=27120885

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92925119T Expired - Lifetime ES2173085T3 (es) 1991-11-05 1992-11-05 Celulas supresoras y progenitoras.

Country Status (9)

Country Link
EP (1) EP0667904B1 (es)
JP (1) JPH06510672A (es)
AT (1) ATE213505T1 (es)
AU (1) AU665042B2 (es)
CA (1) CA2124858A1 (es)
DE (1) DE69232427T2 (es)
DK (1) DK0667904T3 (es)
ES (1) ES2173085T3 (es)
WO (1) WO1993009234A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69334227D1 (de) * 1992-07-10 2008-08-14 Univ Pittsburgh Hämatopoetische "facilitatory"-zellen und ihre verwendung
WO1994027622A1 (en) * 1993-05-24 1994-12-08 The Johns Hopkins University Surrogate tolerogenesis for the development of tolerance to xenografts
US5772994A (en) * 1993-05-28 1998-06-30 The University Of Pittsburgh Hematopoietic facilitatory cells and their uses
WO1995003062A1 (en) * 1993-07-21 1995-02-02 Cellpro, Incorporated Methods and compositions for preventing immune rejection of solid organ grafts
CA2350692A1 (en) * 1998-10-29 2000-05-11 Cell Works Diagnostics, Inc. Multiple marker characterization of single cells
CA2316089A1 (en) * 1999-10-08 2001-04-08 Li Zhang Novel cells and molecules involved in immune regulation
US6685936B2 (en) * 1999-10-12 2004-02-03 Osiris Therapeutics, Inc. Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
US20030147865A1 (en) * 2002-02-07 2003-08-07 Benoit Salomon Cell therapy using immunoregulatory T-cells
GB0329449D0 (en) * 2003-12-19 2004-01-28 Omnicyte Ltd Stem cells
AU2005313857A1 (en) * 2004-12-10 2006-06-15 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Binding partners of antibodies specific for dendritic cell antigens
US20100111980A1 (en) 2004-12-10 2010-05-06 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Binding partners of antibodies specific for dendritic cell antigens
EP3622960A1 (en) * 2013-02-05 2020-03-18 Celularity, Inc. Natural killer cells from placenta

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7412987A (en) * 1986-06-12 1987-12-17 Board Of Trustees Of The Leland Stanford Junior University Immunosuppressive protein

Also Published As

Publication number Publication date
CA2124858A1 (en) 1993-05-13
DE69232427T2 (de) 2002-11-21
AU665042B2 (en) 1995-12-14
WO1993009234A2 (en) 1993-05-13
AU3130093A (en) 1993-06-07
JPH06510672A (ja) 1994-12-01
WO1993009234A3 (en) 1993-08-05
EP0667904A1 (en) 1995-08-23
EP0667904B1 (en) 2002-02-20
DE69232427D1 (en) 2002-03-28
ATE213505T1 (de) 2002-03-15
DK0667904T3 (da) 2002-06-03

Similar Documents

Publication Publication Date Title
DK1019493T3 (da) Fremstilling af hæmatopoietiske celler fra multipotente neurale stamceller
Lipps Plankton evolution
Gay et al. Serial sections for electron microscopy
IT7983329A0 (it) Dispositivo di legamento per almeno due persone ed in particolare per sci di fondo e di escursione.
WO2000006704A3 (en) Hematopoietic cell composition for use in transplantation
WO1993009234A3 (en) Suppressor and progenitor cells
FR2526034B1 (fr) Agents absorbant la lumiere ultraviolette, leur procede de preparation, compositions et articles en contenant
IT1116567B (it) Perfezionamento negli attacchi per sci
HU182393B (en) Harvesting adapter for land produces standing in rows first for meize
DK499580A (da) Faste formuleringer indeholdende pheromoner til anvendelse ved bekaempelse af insekter
Johnson Effect of mate loss on song performance in the Plain Titmouse
Lemke Distribution and status of the sheath-tailed bat (Emballonura semicaudata) in the Mariana Islands
Rugeles et al. EVIDENCE FOR THE PRESENCE OF MULTILINEAGE CHIMERISM AND PROGENITORS OF DONOR DENDRITIC CELLS IN THE PERIPHERAL BLOOD OF BONE MARROW-AUGMENTED ORGAN TRANSPLANT RECIPIENTS1
PT765398E (pt) Populacao de celulas enriquecedoras em progenitores mieloides e linfoides e metodos de as fazer e utilizar
Luedke et al. Map showing distribution, composition, and age of Late Cenozoic volcanic centers in Oregon and Washington
ZA84443B (en) Carbomate insecticidal compositions
EP0018443A1 (de) Pisten-Box
EP0249502A3 (en) Soluble immune suppressor factor and suppressor cells
VP et al. Karyomorphological studies in Chlorophytum Ker-Gawl
Bodiou COPÉPODES HARPACTICOÏDES (CRUSTACEA) DES SABLES FINS INFRALITTORAUX DE BANYULS-SUR-MER II. Variations saisonnières qualitatives du peuplement
DE69916302D1 (de) Verwendung von dendritischen zellen-depletierten zusammensetzungen zur verbesserung der transplantation von allogenen hämatopoietischen zellen
GB8311592D0 (en) Stable composition
Boscher et al. Characterisation of the wild Allium ampeloprasum complex in France: Interesting characters of Allium polyanthum ss for genetic resources
Monkolprasit Type specimens of Thai cyprinoid fishes
Bahn et al. Garrod and Glozel: the end of a fiasco

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 667904

Country of ref document: ES