ES2173316T3 - Derivados de galantamina y proceso para su preparacion. - Google Patents

Derivados de galantamina y proceso para su preparacion.

Info

Publication number
ES2173316T3
ES2173316T3 ES96931169T ES96931169T ES2173316T3 ES 2173316 T3 ES2173316 T3 ES 2173316T3 ES 96931169 T ES96931169 T ES 96931169T ES 96931169 T ES96931169 T ES 96931169T ES 2173316 T3 ES2173316 T3 ES 2173316T3
Authority
ES
Spain
Prior art keywords
hydrogen
procedure
carbon atoms
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96931169T
Other languages
English (en)
Inventor
Peter David Tiffin
Neil Fraser
David Andrew Chaplin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2173316T3 publication Critical patent/ES2173316T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA (11), QUE INCLUYA LA CICLACION OXIDATIVA DE UNA AMINA TERCIARIA QUE PRESENTA LA FORMULA (12), EN LA CUAL X 1 ES UNA FUNCIONALIDAD ELIMINABLE, X 2 ES HIDROGENO O UN GRUPO SEGUN SE DEFINE ANTERIORMENTE PARA X 1 , Y R 1 SE SELECCIONA ENTRE HIDROGENO Y GRUPOS ALQUILO, ARILO, ALCARILO Y ARALQUILO QUE PRESENTAN HASTA 20 ATOMOS DE CARBONO, Y R 2 Y R 3 SE SELECCIONAN INDEPENDIENTEMENTE ENTRE HIDROGENO Y GRUPOS ALQUILO, ARILO, ALCARILO, ARALQUILO Y ACILO QUE PRESENTAN HASTA 20 ATOMOS DE CARBONO. MEDIANTE ESTE PROCEDIMIENTO SE UTILIZAN Y PRODUCEN NUEVOS COMPUESTOS.
ES96931169T 1995-09-21 1996-09-23 Derivados de galantamina y proceso para su preparacion. Expired - Lifetime ES2173316T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9519267.0A GB9519267D0 (en) 1995-09-21 1995-09-21 Preparation of alkaloids

Publications (1)

Publication Number Publication Date
ES2173316T3 true ES2173316T3 (es) 2002-10-16

Family

ID=10781038

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96931169T Expired - Lifetime ES2173316T3 (es) 1995-09-21 1996-09-23 Derivados de galantamina y proceso para su preparacion.

Country Status (13)

Country Link
US (1) US6093815A (es)
EP (1) EP0854873B1 (es)
AT (1) ATE214070T1 (es)
AU (1) AU714711B2 (es)
CA (1) CA2230826C (es)
CY (1) CY2301B1 (es)
DE (1) DE69619685T2 (es)
DK (1) DK0854873T3 (es)
ES (1) ES2173316T3 (es)
GB (1) GB9519267D0 (es)
PT (1) PT854873E (es)
WO (1) WO1997011077A1 (es)
ZA (1) ZA968028B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100648869B1 (ko) 1998-09-30 2007-02-28 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
JP2003136077A (ja) * 2001-10-31 2003-05-13 Nec Corp 半導体製造に用いる洗浄水又は浸漬水の製造装置
WO2005065662A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
CA2551946A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Immediate, controlled and sustained release formulations of galantamine
WO2006124585A2 (en) * 2005-05-13 2006-11-23 Alza Corporation Multilayer drug system for the delivery of galantamine
EP1937226A2 (en) * 2005-09-23 2008-07-02 Alza Corporation Transdermal galantamine delivery system
AT504663B1 (de) * 2007-02-22 2008-07-15 Sanochemia Pharmazeutika Ag Verfahren zum herstellen von hochreinen 4a,5,9,10,11,12,-hexahydro-6h-benzofuro(3a,3,2- f)(2) benzazepinen sowie dessen derivaten
EP2009015B1 (en) * 2007-06-18 2012-01-11 Aurobindo Pharma Limited Process for the preparation of galantamine hydrobromide
AT507039A1 (de) 2008-06-26 2010-01-15 Sanochemia Pharmazeutika Ag Verfahren zum herstellen von hochreinen benzazepinderivaten
CN106977412B (zh) * 2017-05-15 2019-08-02 张家港威胜生物医药有限公司 一种加兰他敏关键中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363415B1 (en) * 1987-05-04 2008-10-15 Davis, Bonnie Compounds for the treatment of alzheimer's disease
WO1996012692A1 (de) * 1994-10-21 1996-05-02 Waldheim Pharmazeutika Gesellschaft M.B.H. VERFAHREN ZUM HERSTELLEN VON DERIVATEN DES 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINS
AT401058B (de) * 1994-10-21 1996-06-25 Waldheim Pharmazeutika Gmbh Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins

Also Published As

Publication number Publication date
CY2301B1 (en) 2003-07-04
ATE214070T1 (de) 2002-03-15
US6093815A (en) 2000-07-25
WO1997011077A1 (en) 1997-03-27
DK0854873T3 (da) 2002-07-01
EP0854873B1 (en) 2002-03-06
EP0854873A1 (en) 1998-07-29
AU6996496A (en) 1997-04-09
CA2230826A1 (en) 1997-03-27
DE69619685T2 (de) 2002-10-17
ZA968028B (en) 1997-09-23
GB9519267D0 (en) 1995-11-22
AU714711B2 (en) 2000-01-06
PT854873E (pt) 2002-08-30
DE69619685D1 (de) 2002-04-11
CA2230826C (en) 2008-09-02

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