ES2173912T3 - Desbloqueo de las vias comunes de sintesis de aminoacidos aromaticos. - Google Patents

Desbloqueo de las vias comunes de sintesis de aminoacidos aromaticos.

Info

Publication number
ES2173912T3
ES2173912T3 ES94905362T ES94905362T ES2173912T3 ES 2173912 T3 ES2173912 T3 ES 2173912T3 ES 94905362 T ES94905362 T ES 94905362T ES 94905362 T ES94905362 T ES 94905362T ES 2173912 T3 ES2173912 T3 ES 2173912T3
Authority
ES
Spain
Prior art keywords
unlock
synthesis
amino acids
aromatic amino
common roads
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94905362T
Other languages
English (en)
Inventor
John W Frost
Kristi A Dell
Karen M Draths
Alan Berry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Danisco US Inc
Original Assignee
Purdue Research Foundation
Genencor International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25540381&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2173912(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Purdue Research Foundation, Genencor International Inc filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of ES2173912T3 publication Critical patent/ES2173912T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1092—3-Phosphoshikimate 1-carboxyvinyltransferase (2.5.1.19), i.e. 5-enolpyruvylshikimate-3-phosphate synthase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA MEJORA DE LA EFICIENCIA DE LA PRODUCCION DE COMPUESTOS AROMATICOS POR MEDIO DEL CAMINO COMUN, SEGUN SE MUESTRA EN LA FIGURA, DE UNA CELULA ANFITRIONA SE REALIZA INCREMENTANDO LA EXPRESION DE ESPECIES DE ENZIMAS QUE ACTUAN SOBRE PRODUCTOS INTERMEDIOS EN FORMA DE SUBSTRATOS EN PASOS DE REACCION IDENTIFICADOS, LIMITADORES DE LA VELOCIDAD EN LA SENDA. LAS CELULAS ANFITRIONAS SE TRANSFORMAN CON DNA RECOMBINANTE QUE CODIFICA LAS ENZIMAS LIMITADORAS DE LA VELOCIDAD PARA SUMINISTRAR TRANSFORMANTES CELULARES QUE SE CARACTERIZAN POR LA CAPACIDAD DE PRODUCIR ALTAS CONCENTRACIONES DE METABOLITOS AROMATICOS CUANDO CRECEN EN UN CULTIVO CELULAR CON UNA FUENTE DE CARBONO METABOLIZABLE.
ES94905362T 1992-12-21 1993-12-09 Desbloqueo de las vias comunes de sintesis de aminoacidos aromaticos. Expired - Lifetime ES2173912T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99419492A 1992-12-21 1992-12-21

Publications (1)

Publication Number Publication Date
ES2173912T3 true ES2173912T3 (es) 2002-11-01

Family

ID=25540381

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94905362T Expired - Lifetime ES2173912T3 (es) 1992-12-21 1993-12-09 Desbloqueo de las vias comunes de sintesis de aminoacidos aromaticos.

Country Status (11)

Country Link
EP (1) EP0675954B1 (es)
JP (1) JP3429765B2 (es)
KR (2) KR950704500A (es)
AT (1) ATE214426T1 (es)
CA (1) CA2148482C (es)
DE (1) DE69331707T2 (es)
DK (1) DK0675954T3 (es)
ES (1) ES2173912T3 (es)
FI (1) FI953045A0 (es)
MX (1) MX232452B (es)
WO (1) WO1994014955A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59406283D1 (de) * 1994-08-17 1998-07-23 Asea Brown Boveri Verfahren zur Herstellung einer Turbinenschaufel aus einer (alpha-Beta)-Titan-Basislegierung
US6600077B1 (en) 1999-01-29 2003-07-29 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of quinic acid and conversion to hydroquinone
US6613552B1 (en) * 1999-01-29 2003-09-02 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of shikimic acid
JP2003159065A (ja) * 1999-07-19 2003-06-03 Ajinomoto Co Inc 発酵法による目的物質の製造法
KR100433134B1 (ko) * 2002-03-05 2004-05-27 김병기 신규한 호열성 미생물 및 이를 이용한 방향족ｌ-아미노산의 제조 방법
WO2005030949A1 (en) 2003-09-24 2005-04-07 Board Of Trustees Operating Michigan State University Methods and materials for the production of shikimic acid
WO2019030808A1 (ja) * 2017-08-07 2019-02-14 地方独立行政法人大阪産業技術研究所 芳香族化合物を産生する微生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57170184A (en) * 1980-07-18 1982-10-20 Unisearch Ltd Mutant of e. coli and production of phenylalanine
US5168056A (en) * 1991-02-08 1992-12-01 Purdue Research Foundation Enhanced production of common aromatic pathway compounds

Also Published As

Publication number Publication date
KR100359131B1 (ko) 2003-03-06
FI953045L (fi) 1995-06-20
JP3429765B2 (ja) 2003-07-22
FI953045A7 (fi) 1995-06-20
DK0675954T3 (da) 2002-05-27
MX232452B (es) 2005-11-30
CA2148482A1 (en) 1994-07-07
WO1994014955A1 (en) 1994-07-07
DE69331707D1 (de) 2002-04-18
EP0675954A4 (en) 1998-04-01
KR950704500A (ko) 1995-11-20
EP0675954A1 (en) 1995-10-11
JPH08504594A (ja) 1996-05-21
ATE214426T1 (de) 2002-03-15
EP0675954B1 (en) 2002-03-13
FI953045A0 (fi) 1995-06-20
DE69331707T2 (de) 2002-11-21
CA2148482C (en) 2006-10-31

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