ES2173921T3 - Derivados de hidroisoquinolina. - Google Patents
Derivados de hidroisoquinolina.Info
- Publication number
- ES2173921T3 ES2173921T3 ES94924764T ES94924764T ES2173921T3 ES 2173921 T3 ES2173921 T3 ES 2173921T3 ES 94924764 T ES94924764 T ES 94924764T ES 94924764 T ES94924764 T ES 94924764T ES 2173921 T3 ES2173921 T3 ES 2173921T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- sec
- nitrogen
- zero
- carbon atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000004800 hydroisoquinoline derivatives Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical class C* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- LRGZZEOWQURWFK-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7-octahydroisoquinoline Chemical class C1NCCC2CCCC=C21 LRGZZEOWQURWFK-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lubricants (AREA)
- Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE PRESENTAN DERIVADOS TRICICLICOS DE LA OCTOAHIDROISOQUINOLINA DE LA FORMULA (I), EN DONDE N ES 0 O 1 Y SI N ES 0, UNA DE ENTRE X O Y ES NH, OXIGENO O AZUFRE, Y LA OTRA ES NH, CH O UN ATOMO DE CARBONO SUSTITUIDO CON R4 O R5, SI N ES 1, ENTONCES X E Y SON AMBAS NITROGENO, O UNA DE ELLAS ES NITROGENO Y LA OTRA ES CH O UN ATOMOS DE CARBONO SUSTITUIDO CON R4 O R5, LOS DERIVADOS TIENEN ACTIVIDAD ANTAGONISTA DE RECEPTORES SELECTIVOS, Y SON DE POTENCIAL UTILIDAD TERAPEUTICA COMO ANALGESICOS O INMUNOMODULADORES Y/O AGENTES CARDIOVASCULARES.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001788A IT1265043B1 (it) | 1993-08-06 | 1993-08-06 | Derivati di idroisochinolina |
| ITMI940202A IT1274008B (it) | 1994-02-04 | 1994-02-04 | Derivati di idroisochinolina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2173921T3 true ES2173921T3 (es) | 2002-11-01 |
Family
ID=26331034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94924764T Expired - Lifetime ES2173921T3 (es) | 1993-08-06 | 1994-07-14 | Derivados de hidroisoquinolina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5731322A (es) |
| EP (1) | EP0712402B1 (es) |
| JP (1) | JPH09505030A (es) |
| CN (1) | CN1043641C (es) |
| AT (1) | ATE215949T1 (es) |
| AU (1) | AU690576B2 (es) |
| CA (1) | CA2168853A1 (es) |
| DE (1) | DE69430373T2 (es) |
| ES (1) | ES2173921T3 (es) |
| NZ (1) | NZ271338A (es) |
| WO (1) | WO1995004734A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| JP4417108B2 (ja) | 2001-10-15 | 2010-02-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新規な置換された４−フェニル−４−［１ｈ−イミダゾール−２−イル］−ピペリジン誘導体および選択的非ペプチドデルタオピオイドアゴニストとしてのそれらの使用 |
| KR20140015122A (ko) | 2003-10-01 | 2014-02-06 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
| US7087749B2 (en) * | 2004-03-11 | 2006-08-08 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| WO2008033299A2 (en) | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| US7645801B2 (en) * | 2007-01-29 | 2010-01-12 | Alaven Pharmaceutical Llc | Reduced irritant enema for treatment of inflammatory bowel disease (IBD) |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20100311782A1 (en) * | 2009-06-08 | 2010-12-09 | Adolor Corporation | Substituted piperidinylpropanoic acid compounds and methods of their use |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| WO2012094618A1 (en) | 2011-01-07 | 2012-07-12 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| ES2943542T3 (es) | 2013-11-25 | 2023-06-14 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides de azadecalina condensada con octahidro |
| AU2018244928B2 (en) | 2017-03-31 | 2023-10-19 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN113194931B (zh) | 2018-12-19 | 2023-11-10 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| NZ778399A (en) | 2019-02-22 | 2024-11-29 | Corcept Therapeutics Inc | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| CN110330465B (zh) * | 2019-06-28 | 2021-05-11 | 深圳市三启药物开发有限公司 | 腙酰胺类衍生物及其在制备防治脱发药物中的应用 |
| JP7569492B2 (ja) | 2019-12-11 | 2024-10-18 | コーセプト セラピューティクス， インコーポレイテッド | 抗精神病薬誘発性体重増加のミリコリラントによる治療方法 |
| EP4157276A4 (en) | 2020-05-27 | 2024-06-12 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of cyp2c8 and cyp3a4 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12616698B2 (en) | 2021-05-05 | 2026-05-05 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
| WO2024077169A1 (en) | 2022-10-06 | 2024-04-11 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260762A (en) * | 1979-09-10 | 1981-04-07 | Hoffmann-La Roche Inc. | Octahydro-1H-pyrrolo[2,3-g]isoquinolines |
| ES2173866T3 (es) * | 1991-07-05 | 2002-11-01 | Glaxosmithkline Spa | Derivados de hidroisoquinolina. |
-
1994
- 1994-07-14 DE DE69430373T patent/DE69430373T2/de not_active Expired - Fee Related
- 1994-07-14 EP EP94924764A patent/EP0712402B1/en not_active Expired - Lifetime
- 1994-07-14 ES ES94924764T patent/ES2173921T3/es not_active Expired - Lifetime
- 1994-07-14 WO PCT/EP1994/002325 patent/WO1995004734A1/en not_active Ceased
- 1994-07-14 CN CN94193633A patent/CN1043641C/zh not_active Expired - Fee Related
- 1994-07-14 AT AT94924764T patent/ATE215949T1/de not_active IP Right Cessation
- 1994-07-14 CA CA002168853A patent/CA2168853A1/en not_active Abandoned
- 1994-07-14 JP JP7506175A patent/JPH09505030A/ja not_active Ceased
- 1994-07-14 NZ NZ271338A patent/NZ271338A/en unknown
- 1994-07-14 AU AU74937/94A patent/AU690576B2/en not_active Ceased
- 1994-07-14 US US08/591,514 patent/US5731322A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69430373D1 (de) | 2002-05-16 |
| AU690576B2 (en) | 1998-04-30 |
| JPH09505030A (ja) | 1997-05-20 |
| CN1043641C (zh) | 1999-06-16 |
| AU7493794A (en) | 1995-02-28 |
| US5731322A (en) | 1998-03-24 |
| EP0712402A1 (en) | 1996-05-22 |
| CN1132510A (zh) | 1996-10-02 |
| ATE215949T1 (de) | 2002-04-15 |
| NZ271338A (en) | 1998-06-26 |
| DE69430373T2 (de) | 2002-12-12 |
| WO1995004734A1 (en) | 1995-02-16 |
| EP0712402B1 (en) | 2002-04-10 |
| CA2168853A1 (en) | 1995-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69430373D1 (de) | Hydroisochinolinderivate | |
| TW367327B (en) | Heterocyclic compounds having tachykinin receptor antagonist activity, their preparation and their use | |
| NZ331001A (en) | Use of an opiate K receptor agonist as an antipruritic | |
| DE69618231D1 (de) | TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER | |
| PL326159A1 (en) | Heterocyclic fungicides | |
| NO20003133D0 (no) | Anilidderivater, fremstilling og anvendelse derav | |
| MY102842A (en) | Calcium independent camp phosphodiesterase inhibitor antidepressant | |
| AU2003301020A8 (en) | Isoquinolinone derivatives and their use as therapeutic agents | |
| NZ233735A (en) | Heterocyclic substituted aminophenol derivatives | |
| YU231790A (sh) | Spirocikli koji sadrže azot | |
| ATE302606T1 (de) | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren | |
| PL346344A1 (en) | Arylpiperazines and their use as metalloproteinase inhibiting agents (mmp) | |
| KR950701911A (ko) | 피페리딘 유도체를 유효성분으로 하는 말초혈관확장제(peripheral vaso-dilating agent containing piperidine derivative as active ingredient) | |
| ATE175661T1 (de) | Benzamid-derivate als vasopressin-antagonisten | |
| MY117092A (en) | Chemotherapeutic pyrrolocarbazole derivatives | |
| DE69733843D1 (de) | Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel | |
| DK0960111T3 (da) | Morphinderivat med analgesisk aktivitet | |
| MXPA02012470A (es) | Inhibidores de fosfodiesterasa especificos para gmp ciclico. | |
| DE59510713D1 (de) | N-substituierte 3-azabicyclo(3.2.0)heptan-derivate als neuroleptika | |
| DE60121048D1 (de) | PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE | |
| DE69522332D1 (de) | 1,4-dihydropyridine als bradykinin antagonisten | |
| SG49910A1 (en) | Substituted 6,11-ethano-6,11-dihydroenzo(B)quinolizinium salts and composition and methods of use thereof | |
| ATE47135T1 (de) | Antikonvulsive mittel. | |
| DE69526097D1 (de) | Bicyclische carboxamide als 5-ht1a rezeptoren liganden | |
| FI962301A0 (fi) | Substituoidut aminoalkyyliaminopyridiinit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 712402 Country of ref document: ES |