ES2174132T3 - N-acil-a,omp-alquil-hidrazino-carboximidamidas. - Google Patents
N-acil-a,omp-alquil-hidrazino-carboximidamidas.Info
- Publication number
- ES2174132T3 ES2174132T3 ES96945113T ES96945113T ES2174132T3 ES 2174132 T3 ES2174132 T3 ES 2174132T3 ES 96945113 T ES96945113 T ES 96945113T ES 96945113 T ES96945113 T ES 96945113T ES 2174132 T3 ES2174132 T3 ES 2174132T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- composition
- group containing
- inhibiting
- hidrazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 230000032683 aging Effects 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108010005094 Advanced Glycation End Products Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Fats And Perfumes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPOSICIONES Y METODOS QUE INHIBEN LA RETICULACION NO ENZIMATICA (ENVEJECIMIENTO DE PROTEINAS) UTILIZANDO COMPUESTOS DE FORMULA (I), DONDE ALK ES UN GRUPO ALQUILENO DE CADENA LINEAL O RAMIFICADA QUE CONTIENE ENTRE 2 Y 8 ATOMOS DE CARBONO, Y R ES UN GRUPO ALQUILO INFERIOR QUE CONTIENE ENTRE 1 Y 6 ATOMOS DE CARBONO; ASI COMO SUS SALES DE ADICION BIOLOGICA O FARMACEUTICAMENTE ACEPTABLES. CONSECUENTEMENTE, SE DESCRIBE UNA COMPOSICION QUE COMPRENDE DICHAS N ACILAMINOALQUILHIDRAZINCARBOXIMIDAMIDAS, QUE SON CAPACES DE INHIBIR LA FORMACION DE PRODUCTOS FINALES DE GLICOSILACION AVANZADA DE PROTEINAS DIANA. DICHO METODO CONSISTE EN PONER EN CONTACTO LA PROTEINA DIANA CON DICHA COMPOSICION. SE PREVEN APLICACIONES TANTO INDUSTRIALES COMO TERAPEUTICAS PARA LA INVENCION, COMO EL TRATAMIENTO DE LA DEGRADACION DE ALIMENTOS Y EL ENVEJECIMIENTO DE PROTEINAS ANIMALES.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US922095P | 1995-12-26 | 1995-12-26 | |
| US61840796A | 1996-03-19 | 1996-03-19 | |
| US08/771,959 US5877217A (en) | 1995-12-26 | 1996-12-23 | N-acylaminoalkyl-hydrazinecarboximidamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2174132T3 true ES2174132T3 (es) | 2002-11-01 |
Family
ID=27358809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96945113T Expired - Lifetime ES2174132T3 (es) | 1995-12-26 | 1996-12-26 | N-acil-a,omp-alquil-hidrazino-carboximidamidas. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0888293B1 (es) |
| JP (1) | JP2000502684A (es) |
| CN (1) | CN1209117A (es) |
| AT (1) | ATE215068T1 (es) |
| AU (1) | AU720796B2 (es) |
| BR (1) | BR9612304A (es) |
| CA (1) | CA2241746A1 (es) |
| DE (1) | DE69620253T2 (es) |
| DK (1) | DK0888293T3 (es) |
| ES (1) | ES2174132T3 (es) |
| NO (1) | NO982976L (es) |
| NZ (1) | NZ326238A (es) |
| PT (1) | PT888293E (es) |
| TW (1) | TW502012B (es) |
| WO (1) | WO1997023447A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| KR101452915B1 (ko) | 2006-05-04 | 2014-10-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| CA2736421A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CA3070513C (en) | 2010-05-05 | 2023-01-03 | Boehringer Ingelheim International Gmbh | A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis |
| KR20130093012A (ko) | 2010-06-24 | 2013-08-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| DK2731947T3 (en) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013171166A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| EP4233840A3 (en) | 2016-06-10 | 2023-10-18 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758583A (en) * | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
-
1996
- 1996-12-26 CN CN96199999A patent/CN1209117A/zh active Pending
- 1996-12-26 ES ES96945113T patent/ES2174132T3/es not_active Expired - Lifetime
- 1996-12-26 PT PT96945113T patent/PT888293E/pt unknown
- 1996-12-26 JP JP09523883A patent/JP2000502684A/ja active Pending
- 1996-12-26 AT AT96945113T patent/ATE215068T1/de not_active IP Right Cessation
- 1996-12-26 CA CA002241746A patent/CA2241746A1/en not_active Abandoned
- 1996-12-26 EP EP96945113A patent/EP0888293B1/en not_active Expired - Lifetime
- 1996-12-26 BR BR9612304A patent/BR9612304A/pt unknown
- 1996-12-26 WO PCT/US1996/020810 patent/WO1997023447A1/en not_active Ceased
- 1996-12-26 DK DK96945113T patent/DK0888293T3/da active
- 1996-12-26 DE DE69620253T patent/DE69620253T2/de not_active Expired - Fee Related
- 1996-12-26 AU AU13560/97A patent/AU720796B2/en not_active Ceased
- 1996-12-26 NZ NZ326238A patent/NZ326238A/xx unknown
-
1997
- 1997-01-09 TW TW086100168A patent/TW502012B/zh active
-
1998
- 1998-06-26 NO NO982976A patent/NO982976L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0888293B1 (en) | 2002-03-27 |
| NZ326238A (en) | 1999-11-29 |
| AU720796B2 (en) | 2000-06-15 |
| DK0888293T3 (da) | 2002-04-22 |
| DE69620253T2 (de) | 2002-09-19 |
| BR9612304A (pt) | 1999-07-13 |
| ATE215068T1 (de) | 2002-04-15 |
| TW502012B (en) | 2002-09-11 |
| CA2241746A1 (en) | 1997-07-03 |
| NO982976D0 (no) | 1998-06-26 |
| AU1356097A (en) | 1997-07-17 |
| DE69620253D1 (en) | 2002-05-02 |
| CN1209117A (zh) | 1999-02-24 |
| WO1997023447A1 (en) | 1997-07-03 |
| EP0888293A1 (en) | 1999-01-07 |
| NO982976L (no) | 1998-08-26 |
| PT888293E (pt) | 2002-07-31 |
| JP2000502684A (ja) | 2000-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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