ES2174132T3 - N-acil-a,omp-alquil-hidrazino-carboximidamidas. - Google Patents
N-acil-a,omp-alquil-hidrazino-carboximidamidas.Info
- Publication number
- ES2174132T3 ES2174132T3 ES96945113T ES96945113T ES2174132T3 ES 2174132 T3 ES2174132 T3 ES 2174132T3 ES 96945113 T ES96945113 T ES 96945113T ES 96945113 T ES96945113 T ES 96945113T ES 2174132 T3 ES2174132 T3 ES 2174132T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- composition
- group containing
- inhibiting
- hidrazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 230000032683 aging Effects 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108010005094 Advanced Glycation End Products Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Fats And Perfumes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPOSICIONES Y METODOS QUE INHIBEN LA RETICULACION NO ENZIMATICA (ENVEJECIMIENTO DE PROTEINAS) UTILIZANDO COMPUESTOS DE FORMULA (I), DONDE ALK ES UN GRUPO ALQUILENO DE CADENA LINEAL O RAMIFICADA QUE CONTIENE ENTRE 2 Y 8 ATOMOS DE CARBONO, Y R ES UN GRUPO ALQUILO INFERIOR QUE CONTIENE ENTRE 1 Y 6 ATOMOS DE CARBONO; ASI COMO SUS SALES DE ADICION BIOLOGICA O FARMACEUTICAMENTE ACEPTABLES. CONSECUENTEMENTE, SE DESCRIBE UNA COMPOSICION QUE COMPRENDE DICHAS N ACILAMINOALQUILHIDRAZINCARBOXIMIDAMIDAS, QUE SON CAPACES DE INHIBIR LA FORMACION DE PRODUCTOS FINALES DE GLICOSILACION AVANZADA DE PROTEINAS DIANA. DICHO METODO CONSISTE EN PONER EN CONTACTO LA PROTEINA DIANA CON DICHA COMPOSICION. SE PREVEN APLICACIONES TANTO INDUSTRIALES COMO TERAPEUTICAS PARA LA INVENCION, COMO EL TRATAMIENTO DE LA DEGRADACION DE ALIMENTOS Y EL ENVEJECIMIENTO DE PROTEINAS ANIMALES.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US922095P | 1995-12-26 | 1995-12-26 | |
| US61840796A | 1996-03-19 | 1996-03-19 | |
| US08/771,959 US5877217A (en) | 1995-12-26 | 1996-12-23 | N-acylaminoalkyl-hydrazinecarboximidamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2174132T3 true ES2174132T3 (es) | 2002-11-01 |
Family
ID=27358809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96945113T Expired - Lifetime ES2174132T3 (es) | 1995-12-26 | 1996-12-26 | N-acil-a,omp-alquil-hidrazino-carboximidamidas. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0888293B1 (es) |
| JP (1) | JP2000502684A (es) |
| CN (1) | CN1209117A (es) |
| AT (1) | ATE215068T1 (es) |
| AU (1) | AU720796B2 (es) |
| BR (1) | BR9612304A (es) |
| CA (1) | CA2241746A1 (es) |
| DE (1) | DE69620253T2 (es) |
| DK (1) | DK0888293T3 (es) |
| ES (1) | ES2174132T3 (es) |
| NO (1) | NO982976L (es) |
| NZ (1) | NZ326238A (es) |
| PT (1) | PT888293E (es) |
| TW (1) | TW502012B (es) |
| WO (1) | WO1997023447A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| BRPI0711558A2 (pt) | 2006-05-04 | 2011-11-08 | Boeringer Ingelheim Internat Gmbh | polimorfos |
| PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| AU2009290911A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EP2382216A1 (en) | 2008-12-23 | 2011-11-02 | Boehringer Ingelheim International GmbH | Salt forms of organic compound |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| EA034869B1 (ru) | 2009-11-27 | 2020-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин |
| MX341025B (es) | 2010-05-05 | 2016-08-04 | Boehringer Ingelheim Int Gmbh * | Terapia de combinacion. |
| PH12012502524A1 (en) | 2010-06-24 | 2014-02-10 | Boehringer Ingelheim Int | Diabetes therapy |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| EP3517539B1 (en) | 2011-07-15 | 2022-12-14 | Boehringer Ingelheim International GmbH | Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US20130303554A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in sirs and/or sepsis |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
| CN109310697A (zh) | 2016-06-10 | 2019-02-05 | 勃林格殷格翰国际有限公司 | 利格列汀和二甲双胍的组合 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758583A (en) * | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
-
1996
- 1996-12-26 CN CN96199999A patent/CN1209117A/zh active Pending
- 1996-12-26 ES ES96945113T patent/ES2174132T3/es not_active Expired - Lifetime
- 1996-12-26 CA CA002241746A patent/CA2241746A1/en not_active Abandoned
- 1996-12-26 JP JP09523883A patent/JP2000502684A/ja active Pending
- 1996-12-26 DE DE69620253T patent/DE69620253T2/de not_active Expired - Fee Related
- 1996-12-26 NZ NZ326238A patent/NZ326238A/xx unknown
- 1996-12-26 PT PT96945113T patent/PT888293E/pt unknown
- 1996-12-26 AT AT96945113T patent/ATE215068T1/de not_active IP Right Cessation
- 1996-12-26 BR BR9612304A patent/BR9612304A/pt unknown
- 1996-12-26 DK DK96945113T patent/DK0888293T3/da active
- 1996-12-26 WO PCT/US1996/020810 patent/WO1997023447A1/en not_active Ceased
- 1996-12-26 EP EP96945113A patent/EP0888293B1/en not_active Expired - Lifetime
- 1996-12-26 AU AU13560/97A patent/AU720796B2/en not_active Ceased
-
1997
- 1997-01-09 TW TW086100168A patent/TW502012B/zh active
-
1998
- 1998-06-26 NO NO982976A patent/NO982976L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997023447A1 (en) | 1997-07-03 |
| CN1209117A (zh) | 1999-02-24 |
| NO982976L (no) | 1998-08-26 |
| DE69620253T2 (de) | 2002-09-19 |
| TW502012B (en) | 2002-09-11 |
| BR9612304A (pt) | 1999-07-13 |
| CA2241746A1 (en) | 1997-07-03 |
| PT888293E (pt) | 2002-07-31 |
| DE69620253D1 (en) | 2002-05-02 |
| EP0888293B1 (en) | 2002-03-27 |
| DK0888293T3 (da) | 2002-04-22 |
| ATE215068T1 (de) | 2002-04-15 |
| NO982976D0 (no) | 1998-06-26 |
| AU1356097A (en) | 1997-07-17 |
| NZ326238A (en) | 1999-11-29 |
| EP0888293A1 (en) | 1999-01-07 |
| AU720796B2 (en) | 2000-06-15 |
| JP2000502684A (ja) | 2000-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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