ES2174570T3 - Procedimiento para la preparacion de acido 2- y 4-hidroxi mandelico. - Google Patents

Procedimiento para la preparacion de acido 2- y 4-hidroxi mandelico.

Info

Publication number
ES2174570T3
ES2174570T3 ES99202931T ES99202931T ES2174570T3 ES 2174570 T3 ES2174570 T3 ES 2174570T3 ES 99202931 T ES99202931 T ES 99202931T ES 99202931 T ES99202931 T ES 99202931T ES 2174570 T3 ES2174570 T3 ES 2174570T3
Authority
ES
Spain
Prior art keywords
acid
phenol
mandelic
hydroxy
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99202931T
Other languages
English (en)
Inventor
Raoul Kessels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gerard Kessels S A
Original Assignee
Gerard Kessels S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerard Kessels S A filed Critical Gerard Kessels S A
Application granted granted Critical
Publication of ES2174570T3 publication Critical patent/ES2174570T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedimiento para la preparación del ácido 2- y del ácido 4-hidroximandélico por condensación de ácido glioxílico con fenol, caracterizado porque se hace reaccionar el ácido glioxílico con fenol, después de lo cual, el fenol, el ácido 2- y el ácido 4-hidroximandélico, respectivamente, son separados por elución en una columna que comprende una resina de intercambio aniónico, en la cual se separa primero el exceso de fenol, seguido de la separación del ácido 4-hidroximandélico en forma de ácido o de sal y, finalmente, del ácido 2-hidroximandélico, también en forma de ácido o de sal, en función de los desorbentes.
ES99202931T 1998-09-15 1999-09-09 Procedimiento para la preparacion de acido 2- y 4-hidroxi mandelico. Expired - Lifetime ES2174570T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1010090A NL1010090C2 (nl) 1998-09-15 1998-09-15 Werkwijze voor de bereiding van 2- en 4-hydroxyamandelzuur.

Publications (1)

Publication Number Publication Date
ES2174570T3 true ES2174570T3 (es) 2002-11-01

Family

ID=19767815

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99202931T Expired - Lifetime ES2174570T3 (es) 1998-09-15 1999-09-09 Procedimiento para la preparacion de acido 2- y 4-hidroxi mandelico.

Country Status (9)

Country Link
US (1) US6359172B1 (es)
EP (1) EP0987245B1 (es)
JP (1) JP4416877B2 (es)
AT (1) ATE214359T1 (es)
DE (1) DE69901015T2 (es)
ES (1) ES2174570T3 (es)
IL (1) IL131770A (es)
IN (1) IN189269B (es)
NL (1) NL1010090C2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200514826A (en) * 2003-09-19 2005-05-01 Kyung In Synthetic Corp Alpha-hydroxy-benzeneacetic acid derivatives, and compounds having two 5-membered lactone rings fused to central cyclohexa-1, 4-diene nucleus using the same, and uses of the compounds
FR2901553B1 (fr) * 2006-05-24 2011-08-26 Clariant Specialty Fine Chem F Complexes metalliques comprenant un ligand derive d'acide 2-aryl-2-hydroxyacetique et un cation metallique divalent ou trivalent, et leur utilisation
FR2931476B1 (fr) * 2008-05-22 2012-12-28 Rhodia Operations Procede de separation d'un compose phenolique sous forme solifiee
FR2950886B1 (fr) * 2009-10-02 2011-10-28 Rhodia Operations Procede de separation de composes phenoliques sous forme salifiee
FR3013351B1 (fr) 2013-11-15 2016-01-01 Rhodia Operations Procede de preparation de compose aromatique mandelique et de compose aldehyde aromatique
CN108911970A (zh) * 2018-05-25 2018-11-30 江苏道博化工有限公司 一种扁桃酸的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868926A (en) * 1956-06-28 1961-05-25 Benckiser Gmbh Joh A A method for the purification and concentration of carboxylic acids
SE441524B (sv) * 1978-05-19 1985-10-14 Ici Ltd Fast natrium- eller kalium-p-hydroximandelat-monohydrat och sett for dess framstellning
US4368334A (en) * 1979-08-09 1983-01-11 Beecham Group Limited p-Hydroxymandelic acid
FR2638740B1 (fr) * 1988-11-08 1991-07-12 Hoechst France Nouveau procede de fabrication industrielle du parahydroxymandelate de sodium
EP0377430A1 (de) * 1989-01-05 1990-07-11 Jungbunzlauer Aktiengesellschaft Verfahren zur Abtrennung von Säuren aus salz- und kohlenhydrathaltigen Substraten
GB9121656D0 (en) * 1991-10-11 1991-11-27 Ici Plc Chemical process
FR2687143B1 (fr) * 1992-02-12 1995-06-23 Hoechst France Procede d'obtention de l'acide orthohydroxymandelique et de ses sels.
KR950005766B1 (ko) * 1992-03-05 1995-05-30 한국화약주식회사 4-히드록시 만델산의 제조방법
NL9202248A (nl) * 1992-12-23 1994-07-18 Univ Delft Tech Werkwijze voor het scheiden van de ortho- en para-isomeer van hydroxyamandelzuur of een zout daarvan, de volgens deze werkwijze verkregen ortho- en para-isomeer van hydroxyamandelzuur, alsmede de toepassing van de ortho-isomeer in de bereiding van EDDHA.
KR950005766A (ko) * 1993-08-21 1995-03-20 한무용 경량세라믹 판넬 및 그 제조방법

Also Published As

Publication number Publication date
JP2000109447A (ja) 2000-04-18
EP0987245B1 (en) 2002-03-13
IL131770A (en) 2006-12-10
NL1010090C2 (nl) 2000-03-17
JP4416877B2 (ja) 2010-02-17
IN189269B (es) 2003-01-25
DE69901015T2 (de) 2002-11-07
DE69901015D1 (de) 2002-04-18
ATE214359T1 (de) 2002-03-15
US6359172B1 (en) 2002-03-19
EP0987245A1 (en) 2000-03-22
IL131770A0 (en) 2001-03-19

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