ES2175073T3 - Procedimiento de preparacion de formas para la administracion oral de antibioticos beta-lactamicos de rapida dispersabilidad en agua. - Google Patents

Procedimiento de preparacion de formas para la administracion oral de antibioticos beta-lactamicos de rapida dispersabilidad en agua.

Info

Publication number
ES2175073T3
ES2175073T3 ES96904039T ES96904039T ES2175073T3 ES 2175073 T3 ES2175073 T3 ES 2175073T3 ES 96904039 T ES96904039 T ES 96904039T ES 96904039 T ES96904039 T ES 96904039T ES 2175073 T3 ES2175073 T3 ES 2175073T3
Authority
ES
Spain
Prior art keywords
preparation
forms
oral administration
dispersability
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96904039T
Other languages
English (en)
Inventor
Gerrit Jan Sijbrands
Koutrik Robertus Cornelis Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Europe BV
Original Assignee
Yamanouchi Europe BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Europe BV filed Critical Yamanouchi Europe BV
Application granted granted Critical
Publication of ES2175073T3 publication Critical patent/ES2175073T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE DESCRIBE UN GRANULADO QUE CONTIENE AL MENOS UN 50 % EN PESO DE UN ANTIBIOTICO {BE} PROCESO PARA PREPARAR UN GRANULADO QUE CONTIENE DICHO ANTIBIOTICO {BE} LACTAMICO EN EL QUE SE HUMEDECEN LOS COMPUESTOS QUE FORMAN EL GRANULADO CON UNA SOLUCION ACUOSA QUE NO CONTIENE UNA CANTIDAD SUSTANCIAL DE UN AGENTE AGLUTINANTE PARA GRANULACION HUMEDA. SE DESCRIBEN ASIMISMO FORMAS DE ADMINISTRACION ORAL QUE CONTIENEN DICHO ANTIBIOTICO EN FORMA GRANULAR, UN PRODUCTO DE CELULOSA Y UN DISGREGANTE QUE SE DISPERSAN RAPIDAMENTE CUANDO SE INTRODUCEN EN UN AMBIENTE ACUOSO, ASI COMO UN METODO PARA PREPARAR LAS FORMAS DE ADMINISTRACION.
ES96904039T 1995-02-08 1996-02-08 Procedimiento de preparacion de formas para la administracion oral de antibioticos beta-lactamicos de rapida dispersabilidad en agua. Expired - Lifetime ES2175073T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95200313 1995-02-08

Publications (1)

Publication Number Publication Date
ES2175073T3 true ES2175073T3 (es) 2002-11-16

Family

ID=8220003

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96904039T Expired - Lifetime ES2175073T3 (es) 1995-02-08 1996-02-08 Procedimiento de preparacion de formas para la administracion oral de antibioticos beta-lactamicos de rapida dispersabilidad en agua.

Country Status (19)

Country Link
US (1) US5948422A (es)
EP (1) EP0801559B1 (es)
CN (1) CN1125636C (es)
AT (1) ATE216576T1 (es)
AU (1) AU4789696A (es)
BG (1) BG63528B1 (es)
BR (1) BR9607189A (es)
CZ (1) CZ293718B6 (es)
DE (1) DE69620866T2 (es)
DK (1) DK0801559T3 (es)
EA (2) EA003736B1 (es)
ES (1) ES2175073T3 (es)
HU (1) HU227938B1 (es)
MX (1) MX9706062A (es)
NO (1) NO319993B1 (es)
PL (1) PL186386B1 (es)
PT (1) PT801559E (es)
WO (1) WO1996024337A1 (es)
ZA (1) ZA961018B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225402B (en) * 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
WO1998002145A2 (en) * 1996-07-16 1998-01-22 Gist-Brocades B.V. β-LACTAM GRANULES FREE OF ORGANIC SOLVENTS
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
DE69901938T3 (de) * 1998-03-06 2012-08-02 Aptalis Pharma S.R.L. Schnell zerfallende tablette
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
DE19922537A1 (de) * 1999-05-10 2000-11-16 Roland Bodmeier Darreichungsform zur Applikation in Körperöffnungen
EP1319409A4 (en) * 2000-09-22 2006-05-03 Takeda Pharmaceutical SOLID PREPARATIONS
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
BR0206979A (pt) * 2001-02-05 2004-04-20 Scherer Technologies Inc R P Métodos e composições para reduzir o paladar de agentes farmaceuticamente ativos
RU2190403C1 (ru) * 2001-09-27 2002-10-10 Нестерук Владимир Викторович Фармацевтическая композиция, обладающая антибактериальным действием, и способ ее получения
WO2003077842A2 (en) * 2002-03-12 2003-09-25 Bristol-Myers Squibb Company Palatable oral suspension and method
EP1555024B1 (en) * 2002-10-02 2010-09-29 Meiji Seika Kaisha Ltd. Antibacterial medicinal composition of enhanced oral absorptivity
DK1803443T3 (en) * 2002-12-20 2019-02-25 Niconovum Ab Nicotine-containing particulate material with a crystalline cellulose
CA2848954A1 (en) * 2003-07-03 2005-03-03 Sertoli Technologies, Llc Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
WO2005021056A1 (en) * 2003-08-21 2005-03-10 Cns, Inc. Effervescent delivery system
CN101309674A (zh) 2005-11-17 2008-11-19 诺瓦提斯公司 药物组合物
CA2646942C (en) 2006-03-16 2014-07-29 Modoral Brands Inc. Improved snuff composition
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
CA2658951A1 (en) * 2006-07-28 2008-01-31 Sertocell Biotechnology (Us) Corp. Adult sertoli cells and uses thereof
US8833378B2 (en) * 2008-09-17 2014-09-16 Niconovum Ab Process for preparing snuff composition
CA2746768A1 (en) * 2008-12-17 2010-07-08 Altheus Therapeutics, Inc. Enema formulations
WO2023204773A1 (en) * 2022-04-20 2023-10-26 Bilim Ilac Sanayii Ve Ticaret A.S. Tablet formulations for the treatment of urinary system infections and method for the preparation of such formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3344030A (en) * 1964-06-15 1967-09-26 American Home Prod Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables
DE2251250C3 (de) * 1972-10-19 1981-06-25 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten
DE2251249A1 (de) * 1972-10-19 1974-05-02 Hoechst Ag Verfahren zur herstellung von penicillin-verbindungen enthaltenden tabletten
DE3887179T2 (de) * 1987-03-02 1994-06-16 Brocades Pharma Bv Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung.
US5049394A (en) * 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same
EP0330284B1 (en) * 1988-02-25 1994-07-27 Yamanouchi Europe B.V. Process for the preparation of a pharmaceutical granulate
US5643591A (en) * 1991-01-16 1997-07-01 Fmc Corporation Solid dosage forms
EP0755258B1 (en) * 1994-04-13 2002-01-23 Research Corporation Technologies, Inc Methods of treating disease using sertoli cells and allografts or xenografts
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin

Also Published As

Publication number Publication date
PL321567A1 (en) 1997-12-08
HUP9801677A2 (hu) 1998-11-30
BG63528B1 (bg) 2002-04-30
HUP9801677A3 (en) 1999-05-28
PT801559E (pt) 2002-09-30
NO973646L (no) 1997-09-11
ATE216576T1 (de) 2002-05-15
EA000361B1 (ru) 1999-06-24
CZ230297A3 (en) 1997-11-12
WO1996024337A1 (en) 1996-08-15
DE69620866D1 (de) 2002-05-29
EP0801559B1 (en) 2002-04-24
HU227938B1 (en) 2012-06-28
CZ293718B6 (cs) 2004-07-14
NO319993B1 (no) 2005-10-10
PL186386B1 (pl) 2004-01-30
NO973646D0 (no) 1997-08-07
EA199900205A1 (ru) 2000-06-26
BG101822A (en) 1998-04-30
US5948422A (en) 1999-09-07
ZA961018B (en) 1997-08-08
CN1125636C (zh) 2003-10-29
EA199700093A1 (ru) 1998-02-26
MX9706062A (es) 1997-10-31
DK0801559T3 (da) 2002-06-17
EA003736B1 (ru) 2003-08-28
DE69620866T2 (de) 2003-02-27
CN1173816A (zh) 1998-02-18
EP0801559A1 (en) 1997-10-22
BR9607189A (pt) 1997-11-11
AU4789696A (en) 1996-08-27

Similar Documents

Publication Publication Date Title
UY23958A1 (es) Procedimiento para la preparación de formas de dosificación de liberación controlada de azitromicina
ES2148198T3 (es) Procedimiento de trituracion de sustancias farmaceuticas.
AR002754A1 (es) Composición farmacéutica que comprende bacterias lactobacillus viables micro-encapsuladas, y uso de la composición para preparar de un medicamento
MX9405217A (es) Proceso para la fabricacion de sal de magnesio de omeprazol, productoobtenido a partir del mismo y composicion farmaceutica que contiene dichoproducto.
NO175240C (no) Fremgangsmåte for fremstilling av et langsomt frigivende farmasöytisk preparat som omfatter sekundære granuler
MX9202407A (es) Composicion farmaceutica que contiene un compuesto de alilamina como el agente activo y proceso para su preparacion.
DE3772072D1 (de) Pharmazeutische zusammensetzung.
DE69904954D1 (de) Verfahren zur herstellung neuer fenofibrathaltiger arzneiformulierungen, dadurch hergestellte arzneiformulierungen und ihre verwendung
ES2178268T3 (es) Formulaciones de liberacion controlada.
HUP0000141A2 (hu) Eljárás legfeljebb 90 tömeg% gyógyhatású anyagot tartalmazó pelletek előállítására
ES2130638T3 (es) Sistema para la liberacion de sustancia activa, filmogeno, vaporizable, para utilizar en las plantas.
EA199900205A1 (ru) Лекарственные формы для перорального введения, содержащие бета-лактамный антибиотик
FI940696A0 (fi) Uudet pyratsiinijohdannaiset, niiden valmistus ja käyttö
KR880004805A (ko) 분무건조된 아세트아미노펜
PE20011100A1 (es) Combinacion de amoxicilina y clavulanato de potasio
ATE60711T1 (de) Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
ES2174054T3 (es) Composiciones farmaceuticas acuosas liquidas que comprenden alginato sodico y bicarbonato potasico.
BR9916304A (pt) Goma de mascar contendo agentes ativos demedicamentos
FI822441A0 (fi) Pao xantinderivat baserade, magen icke irriterande laekemedelsprodukter och foerfarande foer deras framstaellning
HUP9800512A2 (hu) Moenomicin csoportba tartozó antibiotikumok bizmutsói, eljárás előállításukra, ezek alkalmazása és ezeket tartalmazó gyógyszerkészítmények
CO4750645A1 (es) Metodo de preparacion de granulos que incorporan un medica- mento para uso farmaceutico
ES479854A1 (es) Un procedimiento para mejorar la solidez de un agregado ce- lular bacteriano conformado de streptomyces olivaceus.
ES500185A0 (es) Un metodo para la preparacion de una formulacion farmaceutica de un antibiotico glicosidico o similar.
SE7901203L (sv) O-substituerade oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra, sett for framstellning och anvendning derav som lekemedel samt farmaceutiska kompositioner innehallande dessa foreningar
IT1228130B (it) Derivati dell'1,1,2-trifenilpropano e dell'1,1,2-trifenilpropene, procedimento per la loro preparazione e composizioni farmaceutiche contenenti i composti

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 801559

Country of ref document: ES