ES2175217T3 - Preparados de capsulas blandas que contienen ciclosporina. - Google Patents

Preparados de capsulas blandas que contienen ciclosporina.

Info

Publication number
ES2175217T3
ES2175217T3 ES97109152T ES97109152T ES2175217T3 ES 2175217 T3 ES2175217 T3 ES 2175217T3 ES 97109152 T ES97109152 T ES 97109152T ES 97109152 T ES97109152 T ES 97109152T ES 2175217 T3 ES2175217 T3 ES 2175217T3
Authority
ES
Spain
Prior art keywords
fatty acid
cyclosporine
soft capsules
capsules containing
containing cyclosporine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97109152T
Other languages
English (en)
Inventor
Jong Soo Woo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2175217T3 publication Critical patent/ES2175217T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un preparado de cápsula blanda que contiene ciclosporina, caracterizado porque comprende: (1) ciclosporina como ingrediente activo; (2) carbonato de propileno o polietilenglicol o una mezcla de ambos como cosurfactante; (3) uno o una mezcla de dos o más compuestos seleccionados del grupo consistente en un compuesto esterificado de ácido graso y alcohol primario, un triglicérido de ácido graso de cadena media y un monoglicérido de ácido graso como componente oleoso; y (4) un surfactante que tiene un valor HLB (equilibrio hidrófilo-lipófilo) de 8 a 17.
ES97109152T 1996-06-19 1997-06-05 Preparados de capsulas blandas que contienen ciclosporina. Expired - Lifetime ES2175217T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960022417A KR0183449B1 (ko) 1996-06-19 1996-06-19 사이클로스포린-함유 연질캅셀제

Publications (1)

Publication Number Publication Date
ES2175217T3 true ES2175217T3 (es) 2002-11-16

Family

ID=19462548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97109152T Expired - Lifetime ES2175217T3 (es) 1996-06-19 1997-06-05 Preparados de capsulas blandas que contienen ciclosporina.

Country Status (16)

Country Link
EP (1) EP0813876B1 (es)
JP (2) JP2855135B2 (es)
KR (1) KR0183449B1 (es)
CN (1) CN1180840C (es)
AR (1) AR013586A1 (es)
AT (1) ATE214937T1 (es)
CO (1) CO4970826A1 (es)
DE (1) DE69711267T2 (es)
DK (1) DK0813876T3 (es)
ES (1) ES2175217T3 (es)
ID (1) ID18517A (es)
PE (1) PE97198A1 (es)
PL (1) PL188986B1 (es)
PT (1) PT813876E (es)
SI (1) SI0813876T1 (es)
ZA (1) ZA975448B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980073479A (ko) * 1997-03-14 1998-11-05 한스루돌프하우스, 니콜케르커 사이클로스포린-함유 연질캅셀제
KR19990047897A (ko) * 1997-12-05 1999-07-05 김충환 사이클로스포린 함유 약학적 조성물
CA2354233A1 (en) 1998-12-11 2000-06-15 Pharmasolutions, Inc. Self-emulsifying compositions for drugs poorly soluble in water
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
KR100533460B1 (ko) * 2002-07-20 2005-12-08 대화제약 주식회사 난용성 약물의 가용화용 점막흡착성 조성물, 이를 이용한난용성 약물의 가용화용 제형 및 이들의 제조 방법
GB2391473B (en) * 2002-08-02 2004-07-07 Satishchandra Punambhai Patel Pharmaceutical compositions
GB2391472B (en) 2002-08-02 2004-12-08 Satishchandra Punambhai Patel Pharmaceutical compositions
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
JP2006521366A (ja) * 2003-03-28 2006-09-21 シグモイド・バイオテクノロジーズ・リミテッド シームレスマイクロカプセルを含む固形経口剤形
CN100342856C (zh) * 2003-04-10 2007-10-17 上海医药工业研究院 达那唑半固体骨架制剂的组合物
EP2061440A2 (en) * 2007-04-04 2009-05-27 Sigmoid Pharma Limited A pharmaceutical composition of tacrolimus
ES2963291T3 (es) 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
TW200932240A (en) * 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
ES2530049T3 (es) 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
BR112012002963A2 (pt) 2009-08-12 2017-10-24 Sigmoid Pharma Ltd composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa
GB201020032D0 (en) * 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
AU2015258840B2 (en) * 2014-05-15 2018-03-15 Enzychem Lifesciences Corporation Methods for treating leukopenia and thrombocytopenia
EA036036B1 (ru) 2014-11-07 2020-09-16 Сигмойд Фарма Лимитед Композиции, содержащие циклоспорин

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU215966B (hu) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
KR0167613B1 (ko) * 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물

Also Published As

Publication number Publication date
ATE214937T1 (de) 2002-04-15
JP2923503B2 (ja) 1999-07-26
HK1006780A1 (en) 1999-03-19
CN1180840C (zh) 2004-12-22
ZA975448B (en) 1999-03-19
JP2855135B2 (ja) 1999-02-10
DK0813876T3 (da) 2002-07-22
PE97198A1 (es) 1999-01-13
KR0183449B1 (ko) 1999-05-01
JPH107550A (ja) 1998-01-13
PT813876E (pt) 2002-07-31
EP0813876A1 (en) 1997-12-29
AR013586A1 (es) 2001-01-10
PL188986B1 (pl) 2005-05-31
KR980000466A (ko) 1998-03-30
CN1178106A (zh) 1998-04-08
EP0813876B1 (en) 2002-03-27
DE69711267D1 (de) 2002-05-02
JPH11100326A (ja) 1999-04-13
ID18517A (id) 1998-04-16
SI0813876T1 (en) 2002-10-31
DE69711267T2 (de) 2002-11-21
CO4970826A1 (es) 2000-11-07

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