ES2175386T3 - Derivados de 2,3-benzodiazepina y su utilizacion como inhibidores de receptores de ampa. - Google Patents
Derivados de 2,3-benzodiazepina y su utilizacion como inhibidores de receptores de ampa.Info
- Publication number
- ES2175386T3 ES2175386T3 ES97915277T ES97915277T ES2175386T3 ES 2175386 T3 ES2175386 T3 ES 2175386T3 ES 97915277 T ES97915277 T ES 97915277T ES 97915277 T ES97915277 T ES 97915277T ES 2175386 T3 ES2175386 T3 ES 2175386T3
- Authority
- ES
- Spain
- Prior art keywords
- benzodiazepin
- inhibitors
- derivatives
- hydrogen
- rent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
- RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000006959 non-competitive inhibition Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION TRATA DE COMPOSICIONES DE FORMULA (I), EN LA CUAL X SIGNIFICA HIDROGENO O HALOGENO; Y SIGNIFICA NR 3 O N-; R 1 , R 2 Y R 3 SIGNIFICAN HIDROGENO O DIF ERENTES SUSTITUYENTES; R 4 SIGNIFICA OPCIONALMENTE ALQUILO C 1 C 6 SUSTITUIDO; R 5 SIGNIFICA HIDROGENO; O R 4 Y R 5 SIGNIFICAN JUNTOS OXIGENO; R 6 SIGNIFICA ALQUILO C 1 C 4 ; Y (A) SIGNIFICA UN ENLACE DOBLE O ENLACES SIMPLES. DEBIDO A LA INHIBICION NO COMPETITIVA DE LOS RECEPTORES DE AMPA, ESTAS COMPOSICIONES PUEDEN EMPLEARSE COMO MEDICAMENTOS PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19604920A DE19604920A1 (de) | 1996-02-01 | 1996-02-01 | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2175386T3 true ES2175386T3 (es) | 2002-11-16 |
Family
ID=7785065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97915277T Expired - Lifetime ES2175386T3 (es) | 1996-02-01 | 1997-01-29 | Derivados de 2,3-benzodiazepina y su utilizacion como inhibidores de receptores de ampa. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6200970B1 (es) |
| EP (1) | EP0888313B1 (es) |
| JP (1) | JP2000505793A (es) |
| AT (1) | ATE216373T1 (es) |
| AU (1) | AU2285997A (es) |
| CA (1) | CA2244777C (es) |
| DE (2) | DE19604920A1 (es) |
| DK (1) | DK0888313T3 (es) |
| ES (1) | ES2175386T3 (es) |
| HU (1) | HUP9901473A3 (es) |
| MX (1) | MX9806171A (es) |
| PT (1) | PT888313E (es) |
| WO (1) | WO1997028135A1 (es) |
| ZA (1) | ZA97850B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891871A (en) * | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
| PT1300396E (pt) | 2000-06-12 | 2009-04-20 | Eisai R&D Man Co Ltd | Compostos de 1,2-di-hidropiridina, processos para a sua preparação e sua utilização |
| US6887867B2 (en) * | 2000-06-16 | 2005-05-03 | Transgenomic, Inc. | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
| HU225100B1 (hu) * | 2000-12-21 | 2006-06-28 | Egyt Gyogyszervegyeszeti Gyar | 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk |
| EP1392663A2 (fr) * | 2001-06-07 | 2004-03-03 | Neuro3D | Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| PT1545546E (pt) * | 2002-09-13 | 2007-07-02 | Motac Neuroscience Ltd | Tratamento da discinesia com 2, 3-benzodiazepinas |
| JP2006502234A (ja) * | 2002-09-17 | 2006-01-19 | モタック・ニューロサイエンス・リミテッド | ジスキネジーの治療 |
| US20040141152A1 (en) * | 2002-09-27 | 2004-07-22 | Marino Joseph A. | Apparatus and method for conducting vision screening |
| US6858605B2 (en) | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
| HUP0302449A3 (en) * | 2003-08-04 | 2005-06-28 | Egis Gyogyszergyar Nyilvanosan | 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| EP1979308A1 (en) * | 2005-12-30 | 2008-10-15 | EGIS Gyógyszergyár Nyrt | Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis |
| TW200902024A (en) * | 2007-04-02 | 2009-01-16 | Teva Pharma | Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents |
| PE20150729A1 (es) | 2012-08-16 | 2015-06-14 | Bayer Pharma AG | 2,3-benzodiazepines |
| CA2901352A1 (en) | 2013-02-19 | 2014-08-28 | Bayer Pharma Aktiengesellschaft | Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines |
| WO2015121268A1 (de) * | 2014-02-14 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | 1-phenyl-3h-2,3-benzodiazepine und ihre verwendung als bromodomänen-inhibitoren |
| CN113226286B (zh) | 2018-12-14 | 2024-08-20 | 卫材R&D管理有限公司 | 1,2-二氢吡啶化合物的水基药物制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU179018B (en) | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
| HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
| HU191698B (en) | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
| HU208429B (en) | 1991-05-03 | 1993-10-28 | Gyogyszerkutato Intezet | Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity |
| US5891871A (en) * | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
-
1996
- 1996-02-01 DE DE19604920A patent/DE19604920A1/de not_active Withdrawn
-
1997
- 1997-01-29 DK DK97915277T patent/DK0888313T3/da active
- 1997-01-29 JP JP9527247A patent/JP2000505793A/ja not_active Ceased
- 1997-01-29 ES ES97915277T patent/ES2175386T3/es not_active Expired - Lifetime
- 1997-01-29 HU HU9901473A patent/HUP9901473A3/hu unknown
- 1997-01-29 EP EP97915277A patent/EP0888313B1/de not_active Expired - Lifetime
- 1997-01-29 AT AT97915277T patent/ATE216373T1/de not_active IP Right Cessation
- 1997-01-29 AU AU22859/97A patent/AU2285997A/en not_active Abandoned
- 1997-01-29 PT PT97915277T patent/PT888313E/pt unknown
- 1997-01-29 US US09/125,008 patent/US6200970B1/en not_active Expired - Fee Related
- 1997-01-29 CA CA002244777A patent/CA2244777C/en not_active Expired - Fee Related
- 1997-01-29 WO PCT/DE1997/000225 patent/WO1997028135A1/de not_active Ceased
- 1997-01-29 DE DE59707062T patent/DE59707062D1/de not_active Expired - Fee Related
- 1997-01-31 ZA ZA9700850A patent/ZA97850B/xx unknown
-
1998
- 1998-07-31 MX MX9806171A patent/MX9806171A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2285997A (en) | 1997-08-22 |
| WO1997028135A1 (de) | 1997-08-07 |
| DE19604920A1 (de) | 1997-08-07 |
| PT888313E (pt) | 2002-09-30 |
| HUP9901473A2 (hu) | 1999-09-28 |
| DE59707062D1 (de) | 2002-05-23 |
| DK0888313T3 (da) | 2002-07-15 |
| JP2000505793A (ja) | 2000-05-16 |
| CA2244777A1 (en) | 1997-08-07 |
| EP0888313A1 (de) | 1999-01-07 |
| ZA97850B (en) | 1997-08-04 |
| EP0888313B1 (de) | 2002-04-17 |
| CA2244777C (en) | 2006-11-07 |
| ATE216373T1 (de) | 2002-05-15 |
| MX9806171A (es) | 1998-10-31 |
| HUP9901473A3 (en) | 2001-07-30 |
| US6200970B1 (en) | 2001-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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