ES2175449T3 - Procedimiento para la desactivacion de virus envueltos por lipidos, con lipopeptidos, y nuevos lipopeptidos antiviricos. - Google Patents
Procedimiento para la desactivacion de virus envueltos por lipidos, con lipopeptidos, y nuevos lipopeptidos antiviricos.Info
- Publication number
- ES2175449T3 ES2175449T3 ES97936699T ES97936699T ES2175449T3 ES 2175449 T3 ES2175449 T3 ES 2175449T3 ES 97936699 T ES97936699 T ES 97936699T ES 97936699 T ES97936699 T ES 97936699T ES 2175449 T3 ES2175449 T3 ES 2175449T3
- Authority
- ES
- Spain
- Prior art keywords
- lipopeptides
- new
- antivirical
- deactivation
- lipids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010028921 Lipopeptides Proteins 0.000 title abstract 6
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000009849 deactivation Effects 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 238000004113 cell culture Methods 0.000 abstract 2
- 230000000415 inactivating effect Effects 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 229940127557 pharmaceutical product Drugs 0.000 abstract 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA INVENCION TRATA DE UN PROCEDIMIENTO MUY EFICIENTE PARA LA INACTIVACION DE VIRUS CON ENVOLTURA LIPIDICA, COMO P. E. LOS HERPES O LOS RETROVIRUS BIOLOGICOS O BIOTECNOLOGICOS - EN PARTICULAR FARMACEUTICOS - Y EN CULTIVOS CELULARES, SE AÑADE UN LIPOPEPTIDO CICLICO O UNA MEZCLA DE LIPOPEPTIDOS O DE SUS SALES O ESTERES EN CONCENTRACIONES DETERMINADAS. SE HA DEMOSTRADO, QUE LOS LIPOPEPTIDOS TIENEN UN POTENCIAL DE INACTIVACION SORPRENDENTEMENTE ALTO PARA VIRUS CON ENVOLTURA LIPIDICA, Y ADEMAS TIENEN LA VENTAJA DE QUE TIENEN UNA TOXICIDAD IN VIVO MUY BAJA, POR LO QUE SE PUEDE SUPRIMIR LA ETAPA DE QUITAR EL AGENTE DE INACTIVACION DE LOS PRODUCTOS FARMACEUTICOS O DEL CULTIVO CELULAR. TAMBIEN SON OBJETO DE LA INVENCION LOS NUEVOS LIPOPEPTIDOS ANTIVIRALES, QUE PERTENECEN A LAS SURFACTINAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19633684A DE19633684A1 (de) | 1996-08-12 | 1996-08-12 | Verfahren zur Inaktivierung von lipidumhüllten Viren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2175449T3 true ES2175449T3 (es) | 2002-11-16 |
Family
ID=7803223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97936699T Expired - Lifetime ES2175449T3 (es) | 1996-08-12 | 1997-08-11 | Procedimiento para la desactivacion de virus envueltos por lipidos, con lipopeptidos, y nuevos lipopeptidos antiviricos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6787520B2 (es) |
| EP (1) | EP0918793B1 (es) |
| JP (1) | JP2000516600A (es) |
| AT (1) | ATE216399T1 (es) |
| AU (1) | AU726424B2 (es) |
| CA (1) | CA2265888A1 (es) |
| DE (2) | DE19633684A1 (es) |
| ES (1) | ES2175449T3 (es) |
| WO (1) | WO1998006744A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19633684A1 (de) | 1996-08-12 | 1998-02-19 | Dirk Dipl Ing Vollenbroich | Verfahren zur Inaktivierung von lipidumhüllten Viren |
| EP1528929A1 (en) * | 2002-06-28 | 2005-05-11 | Faculté Universitaire des Sciences Agronomiques de Gembloux | Novel use of lipopeptide preparations |
| WO2004073737A1 (en) | 2003-02-19 | 2004-09-02 | Merial Limited | Vaccination or immunization using a prime-boost regimen against brsv, bhv-1, bvdv, bpi-3 |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
| US9347065B2 (en) | 2012-03-29 | 2016-05-24 | International Aids Vaccine Initiative | Methods to improve vector expression and genetic stability |
| JP7432506B2 (ja) | 2017-10-30 | 2024-02-16 | 武田薬品工業株式会社 | 脂質エンベロープウイルスを不活化するための環境適合性の界面活性剤 |
| WO2022215495A1 (ja) * | 2021-04-08 | 2022-10-13 | 株式会社カネカ | 環状リポペプチド化合物のバイオバーデンの低減方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0050061B2 (en) | 1980-10-06 | 1990-06-20 | New York Blood Center, Inc. | Method of reducing undesirable activities of biological and pharmaceutical products |
| US4591505A (en) | 1982-04-14 | 1986-05-27 | New York Blood Center, Inc. | Process for inactivating hepatitis B virus |
| US4613501A (en) | 1984-12-21 | 1986-09-23 | New York Blood Center, Inc. | Inactivation of viruses in labile blood derivatives |
| US4841023A (en) | 1986-06-25 | 1989-06-20 | New York Blood Center, Inc. | Inactivation of viruses in labile protein-containing compositions using fatty acids |
| DE69519669T2 (de) * | 1994-05-26 | 2001-04-26 | Nisshin Flour Milling Co., Ltd. | Cyclodepsipeptide |
| DE19521938C2 (de) * | 1995-06-07 | 1999-11-11 | Dirk Vollenbroich | Verwendung von cyklischen Lipopeptiden zur Inaktivierung von oder zum Schutz vor Infektionen durch Mikroorganismen der Klasse Mollicutes |
| US6114108A (en) * | 1995-08-29 | 2000-09-05 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of viral nucleic acids |
| DE19633684A1 (de) | 1996-08-12 | 1998-02-19 | Dirk Dipl Ing Vollenbroich | Verfahren zur Inaktivierung von lipidumhüllten Viren |
-
1996
- 1996-08-12 DE DE19633684A patent/DE19633684A1/de not_active Withdrawn
-
1997
- 1997-08-11 AT AT97936699T patent/ATE216399T1/de not_active IP Right Cessation
- 1997-08-11 EP EP97936699A patent/EP0918793B1/de not_active Expired - Lifetime
- 1997-08-11 CA CA002265888A patent/CA2265888A1/en not_active Abandoned
- 1997-08-11 WO PCT/EP1997/004353 patent/WO1998006744A1/de not_active Ceased
- 1997-08-11 ES ES97936699T patent/ES2175449T3/es not_active Expired - Lifetime
- 1997-08-11 DE DE59707067T patent/DE59707067D1/de not_active Expired - Fee Related
- 1997-08-11 AU AU39433/97A patent/AU726424B2/en not_active Ceased
- 1997-08-11 US US09/242,343 patent/US6787520B2/en not_active Expired - Fee Related
- 1997-08-11 JP JP10509393A patent/JP2000516600A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ATE216399T1 (de) | 2002-05-15 |
| JP2000516600A (ja) | 2000-12-12 |
| US20020187929A1 (en) | 2002-12-12 |
| DE59707067D1 (de) | 2002-05-23 |
| AU3943397A (en) | 1998-03-06 |
| US6787520B2 (en) | 2004-09-07 |
| AU726424B2 (en) | 2000-11-09 |
| EP0918793A1 (de) | 1999-06-02 |
| WO1998006744A1 (de) | 1998-02-19 |
| DE19633684A1 (de) | 1998-02-19 |
| CA2265888A1 (en) | 1998-02-19 |
| EP0918793B1 (de) | 2002-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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