ES2176502T3 - Derivados de hidroxilamina utiles para mejorar la pproduccion de chaperonas moleculares su su preparacion. - Google Patents

Derivados de hidroxilamina utiles para mejorar la pproduccion de chaperonas moleculares su su preparacion.

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Publication number
ES2176502T3
ES2176502T3 ES96935195T ES96935195T ES2176502T3 ES 2176502 T3 ES2176502 T3 ES 2176502T3 ES 96935195 T ES96935195 T ES 96935195T ES 96935195 T ES96935195 T ES 96935195T ES 2176502 T3 ES2176502 T3 ES 2176502T3
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ES
Spain
Prior art keywords
cell
hydroxylamine derivative
pproduction
preparation
improve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96935195T
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English (en)
Inventor
Laszlo Vigh
Nagy Peter Literati
Jeno Szilbereky
Laszlo Urogdi
Andrea Jednakovits
Laszlo Jaszlits
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biorex Kutato Fejleszto Kft
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Biorex Kutato Fejleszto Kft
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Application filed by Biorex Kutato Fejleszto Kft filed Critical Biorex Kutato Fejleszto Kft
Application granted granted Critical
Publication of ES2176502T3 publication Critical patent/ES2176502T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61P17/00—Drugs for dermatological disorders
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    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
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    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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  • Organic Chemistry (AREA)
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Abstract

SE PROPORCIONA UN METODO PARA AUMENTAR LA EXPRESION DE UNA CAPERUZA MOLECULAR POR UNA CELULA Y/O POTENCIANDO LA ACTIVIDAD DE UNA CAPERUZA MOLECULAR EN CELULAS. EL METODO CONSISTE EN TRATAR UNA CELULA EXPUESTA A UN ESTRES FISIOLOGICO QUE INDUCE LA EXPRESION DE UNA CAPERUZA MOLECULAR POR LA CELULA CON UNA CANTIDAD EFICAZ DE CIERTO DERIVADO DE HIDROXILAMINA PARA AUMENTAR EL ESTRES. ALTERNATIVAMENTE SE PUEDE ADMINISTRAR A UNA CELULA UN DERIVADO DE HIDROXILAMINA ANTES DE SU EXPOSICION A ESTRES FISIOLOGICO QUE INDUZCA LA EXPRESION DE UNA CAPERUZA MOLECULAR POR LA CELULA. PREFERIBLEMENTE, LA CELULA A LA QUE SE ADMINISTRA EL DERIVADO DE HIDROXILAMINA ES UNA CELULA EUCARIOTA. EL DERIVADO DE HIDROXILAMINA CORRESPONDE A LAS FORMULAS (I) O (II). LA INVENCION PROPORCIONA TAMBIEN NUEVOS DERIVADOS DE HIDROXILAMINA COMPRENDIDOS DENTRO DEL GRUPO DE FORMULAS (I) Y (II) ASI COMO COMPOSICIONES FARMACEUTICAS Y/O COSMETICAS QUE INCLUYEN DICHOS COMPONENTES.
ES96935195T 1995-11-02 1996-11-01 Derivados de hidroxilamina utiles para mejorar la pproduccion de chaperonas moleculares su su preparacion. Expired - Lifetime ES2176502T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU9503141A HU222994B1 (hu) 1995-11-02 1995-11-02 Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HU9603919 1996-02-09
HU9629820 1996-10-04
PCT/HU1996/000064 WO1997016439A1 (en) 1995-11-02 1996-11-01 Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof

Publications (1)

Publication Number Publication Date
ES2176502T3 true ES2176502T3 (es) 2002-12-01

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ES96935195T Expired - Lifetime ES2176502T3 (es) 1995-11-02 1996-11-01 Derivados de hidroxilamina utiles para mejorar la pproduccion de chaperonas moleculares su su preparacion.

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US (4) US6653326B1 (es)
EP (1) EP0801649B1 (es)
JP (2) JP4531865B2 (es)
KR (1) KR19980700976A (es)
CN (1) CN1152871C (es)
AT (1) ATE221880T1 (es)
AU (1) AU720195B2 (es)
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DE (1) DE69622840T2 (es)
DK (1) DK0801649T3 (es)
EE (1) EE04239B1 (es)
ES (1) ES2176502T3 (es)
HR (1) HRP960508B1 (es)
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IL (1) IL121126A (es)
MX (1) MX9704988A (es)
NO (1) NO321140B1 (es)
NZ (1) NZ320523A (es)
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