ES2176434T3 - Derivados de benzodiazepina, sales de los mismos, y farmacos que los contienen. - Google Patents

Derivados de benzodiazepina, sales de los mismos, y farmacos que los contienen.

Info

Publication number
ES2176434T3
ES2176434T3 ES96901983T ES96901983T ES2176434T3 ES 2176434 T3 ES2176434 T3 ES 2176434T3 ES 96901983 T ES96901983 T ES 96901983T ES 96901983 T ES96901983 T ES 96901983T ES 2176434 T3 ES2176434 T3 ES 2176434T3
Authority
ES
Spain
Prior art keywords
group
indicates
substituted
salts
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96901983T
Other languages
English (en)
Inventor
Toshio Tatsuoka
Katsuhide Kamei
Noriko Maeda
Teruyoshi Inoue
Mika Nishimura
Ichiro Hirotsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2176434T3 publication Critical patent/ES2176434T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN DERIVADO DE BENZOXACEPINA QUE TIENE LA FORMULA GENERAL (I) Y SUS SALES Y MEDICAMENTOS QUE LAS CONTIENEN COMO INGREDIENTES EFECTIVOS: EN DONDE, N ES UN NUMERO ENTERO DE 2 A 5, R1 INDICA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO INFERIOR DE C1 A C4, UN GRUPO ALCOXIALQUILO INFERIOR DE C1 A C4, UN GRUPO HALOGENOALQUIL DE C1 A C4, UN GRUPO CIANO, O UN GRUPO ESTER, R2 INDICA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO INFERIOR DE C1 A C4, UN GRUPO ALCOXI INFERIOR DE C1 A C4, O UN GRUPO HIDROXI, LA LINEA DE PUNTOS INDICA LA PRESENCIA O AUSENCIA DE UN ENLACE DE UNION, W INDICA C, CH, O CH2 O UN ATOMO DE NITROGENO, SIEMPRE QUE CUANDO W ES UN ATOMO DE NITROGENO, Z ESTA UNIDO A W Y LA LINEA DE PUNTOS INDICA LA AUSENCIA DE UN ENLACE, Y Z INDICA UN GRUPO DE ANILLO HIDROCARBURO AROMATICO SUSTITUIDO O NO-SUSTITUIDO O UN GRUPO HETEROCICLICO SUSTITUIDO O NO-SUSTITUIDO.
ES96901983T 1995-02-10 1996-02-09 Derivados de benzodiazepina, sales de los mismos, y farmacos que los contienen. Expired - Lifetime ES2176434T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5830795 1995-02-10
JP4183695 1995-03-01

Publications (1)

Publication Number Publication Date
ES2176434T3 true ES2176434T3 (es) 2002-12-01

Family

ID=26381494

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96901983T Expired - Lifetime ES2176434T3 (es) 1995-02-10 1996-02-09 Derivados de benzodiazepina, sales de los mismos, y farmacos que los contienen.

Country Status (10)

Country Link
US (2) US6187769B1 (es)
EP (1) EP0755930B1 (es)
JP (2) JP3164584B2 (es)
KR (1) KR100408379B1 (es)
AU (1) AU709133B2 (es)
CA (1) CA2187541C (es)
DE (1) DE69622648T2 (es)
ES (1) ES2176434T3 (es)
HU (1) HUP9602774A3 (es)
WO (1) WO1996024594A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096884A (en) * 1997-05-22 2000-08-01 Suntory Limited Method of production and method of separation of 2,4'-dipyridyl derivatives and methods of production of benzoxazepine derivatives and salts thereof
HU227478B1 (en) * 1997-07-14 2011-07-28 Asubio Pharma Co Process of production of 4-substituted-3-halogeno-1,4-benzoxazepine derivative and salts thereof
DE10031391A1 (de) * 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
JP5352449B2 (ja) 2007-04-18 2013-11-27 キッセイ薬品工業株式会社 縮合へテロ環誘導体、それを含有する医薬組成物及びその医薬用途
KR20100098491A (ko) 2007-11-30 2010-09-07 다이이찌 산쿄 가부시키가이샤 파킨슨병의 운동 합병증 또는 정신증상을 개선하는 약제
CA3254867A1 (en) * 2022-03-30 2023-10-05 University Of Florida Research Foundation, Incorported COMPOUNDS FOR THE TREATMENT OF PSYCHOSTIMULANT MISUSE
WO2024163956A2 (en) * 2023-02-03 2024-08-08 University Of Florida Research Foundation, Incorporated Sigma receptor ligand compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2865341B2 (ja) * 1988-12-28 1999-03-08 サントリー株式会社 ベンゾオキサゼピン誘導体
EP0376633B1 (en) * 1988-12-28 1994-10-12 Suntory Limited Benzoxazepine derivatives
JP2935541B2 (ja) * 1990-06-28 1999-08-16 サントリー株式会社 縮合複素環化合物
JP3112728B2 (ja) * 1991-08-21 2000-11-27 サントリー株式会社 ２，３，４，５−テトラヒドロ−１，４−ベンゾオキサゼピン−３，５−ジオンの製造法
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Also Published As

Publication number Publication date
AU4633796A (en) 1996-08-27
EP0755930B1 (en) 2002-07-31
DE69622648D1 (de) 2002-09-05
DE69622648T2 (de) 2003-02-27
KR970702272A (ko) 1997-05-13
WO1996024594A1 (en) 1996-08-15
JP3995404B2 (ja) 2007-10-24
AU709133B2 (en) 1999-08-19
HUP9602774A3 (en) 1998-12-28
JP3164584B2 (ja) 2001-05-08
US6187769B1 (en) 2001-02-13
CA2187541C (en) 2008-04-08
US6337397B1 (en) 2002-01-08
CA2187541A1 (en) 1996-08-15
HU9602774D0 (en) 1996-11-28
EP0755930A4 (en) 1998-06-10
HUP9602774A2 (en) 1997-11-28
EP0755930A1 (en) 1997-01-29
JP2001058989A (ja) 2001-03-06
KR100408379B1 (ko) 2004-04-03

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