ES2176452T3 - Composicion para la liberacion controlada de ingredientes activos dependiente de ph y procedimientos para su fabricacion. - Google Patents

Composicion para la liberacion controlada de ingredientes activos dependiente de ph y procedimientos para su fabricacion.

Info

Publication number
ES2176452T3
ES2176452T3 ES96912051T ES96912051T ES2176452T3 ES 2176452 T3 ES2176452 T3 ES 2176452T3 ES 96912051 T ES96912051 T ES 96912051T ES 96912051 T ES96912051 T ES 96912051T ES 2176452 T3 ES2176452 T3 ES 2176452T3
Authority
ES
Spain
Prior art keywords
almidon
dicarboxylate
acetate
composition
controlled release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96912051T
Other languages
English (en)
Inventor
Arto Olavi Urtti
Soili Hellevi Peltonen
Timo Petteri Paronen
Leena Johanna Nakari
Jani-Emanuel Vuorenpaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polymer Corex Kuopio Oy Ltd
Original Assignee
Polymer Corex Kuopio Oy Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polymer Corex Kuopio Oy Ltd filed Critical Polymer Corex Kuopio Oy Ltd
Application granted granted Critical
Publication of ES2176452T3 publication Critical patent/ES2176452T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/02—Esters
    • C08B31/04—Esters of organic acids, e.g. alkenyl-succinated starch

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

LA PRESENTE INVENCION ESTA RELACIONADA CON UNA COMPOSICION PARA LA LIBERACION CONTROLADA DEPENDIENTE DEL PH O REGULADA POR EL PH DE PRINCIPIOS ACTIVOS, EN ESPECIAL FARMACOS. LA COMPOSICION CONSISTE EN UNA MEZCLA COMPACTABLE DEL PRINCIPIO ACTIVO Y MOLECULAS DE ALMIDON SUSTITUIDO CON RESTOS ACETATO Y DICARBOXILATO. EL DICARBOXILATO DE ACIDO PREFERIDO ES EL SUCCINATO. EL GRADO DE SUSTITUCION MEDIO DEL RESTO ACETATO ES DE AL MENOS 1, Y DE 0,2 - 1,2 PARA EL RESTO DICARBOXILATO. LAS MOLECULAS DE ALMIDON PUEDEN LLEVAR LOS RESTOS ACETATO Y DICARBOXILATO UNIDOS AL MISMO ESQUELETO MOLECULAR DEL ALMIDON, O UNIDOS A OTROS ESQUELETOS MOLECULARES DEL ALMIDON. LA PRESENTE INVENCION TAMBIEN DESCRIBE PROCEDIMIENTOS PARA PREPARAR DICHOS ACETATO DICARBOXILATO DE ALMIDON MEDIANTE LA TRANSESTERIFICACION O LA MEZCLA DE ACETATOS DE ALMIDON Y DICARBOXILATOS DE ALMIDON, RESPECTIVAMENTE.
ES96912051T 1995-07-05 1996-04-29 Composicion para la liberacion controlada de ingredientes activos dependiente de ph y procedimientos para su fabricacion. Expired - Lifetime ES2176452T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/498,341 US5656292A (en) 1994-06-07 1995-07-05 Composition for pH dependent controlled release of active ingredients and methods for producing it

Publications (1)

Publication Number Publication Date
ES2176452T3 true ES2176452T3 (es) 2002-12-01

Family

ID=23980671

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96912051T Expired - Lifetime ES2176452T3 (es) 1995-07-05 1996-04-29 Composicion para la liberacion controlada de ingredientes activos dependiente de ph y procedimientos para su fabricacion.

Country Status (12)

Country Link
US (1) US5656292A (es)
EP (1) EP0850049B1 (es)
JP (1) JPH11508581A (es)
AT (1) ATE219663T1 (es)
AU (1) AU703085B2 (es)
CA (1) CA2222372A1 (es)
DE (1) DE69622038T2 (es)
DK (1) DK0850049T3 (es)
ES (1) ES2176452T3 (es)
HU (1) HUP9900304A3 (es)
PT (1) PT850049E (es)
WO (1) WO1997002018A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9724186D0 (en) 1997-11-14 1998-01-14 British Tech Group Low temperature coatings
US7182915B2 (en) * 2001-11-30 2007-02-27 Bristol-Myers Squibb Company Pipette configurations and arrays thereof for measuring cellular electrical properties
US20040062778A1 (en) * 2002-09-26 2004-04-01 Adi Shefer Surface dissolution and/or bulk erosion controlled release compositions and devices
US7670627B2 (en) * 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
US20080286253A1 (en) * 2004-02-09 2008-11-20 Transfert Plus Societe En Commandite Composition Comprising Polymeric Material And Uses Thereof
US20040224019A1 (en) * 2004-03-03 2004-11-11 Adi Shefer Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs
FR2951177B1 (fr) * 2009-10-09 2012-12-21 Roquette Freres Procede de preparation de derives acetyles de matiere amylacee
EP2386297A1 (en) * 2010-04-28 2011-11-16 Roquette Frères Indigestible polymer: starch acetate -based film coatings for colon targeting
TWI434706B (zh) 2011-12-15 2014-04-21 Ind Tech Res Inst 腸溶及腸酵素可分解材料及其製備方法
EP3055334B1 (en) 2013-10-10 2022-12-07 Cerdia International GmbH Acylation process

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011392A (en) * 1975-09-02 1977-03-08 The Sherwin-Williams Company Mixed starch esters and the use thereof
CH678920A5 (es) * 1989-11-14 1991-11-29 Gergely Gerhard
JPH0749378B2 (ja) * 1990-12-27 1995-05-31 ナショナル スターチ アンド ケミカル インベストメント ホールディング コーポレイション タブレット賦形剤としての酵素的に枝切りされたデンプン
DE4123001A1 (de) * 1991-07-11 1993-01-14 Laevosan Gmbh & Co Kg Pharmazeutische zusammensetzung fuer die peritonealdialyse
JPH07505433A (ja) * 1992-03-31 1995-06-15 ノボン・インターナショナル・インコーポレーテッド 生分解性ポリマー組成物
US5321132A (en) * 1992-12-23 1994-06-14 National Starch And Chemical Investment Holding Corporation Method of preparing intermediate DS starch esters in aqueous solution
EP0638609B1 (de) * 1993-08-04 2001-03-21 Buna Sow Leuna Olefinverbund GmbH Bioabbaubare, thermoplastisch verformbare Materialien aus Stärkeestern
FI942686A0 (fi) * 1994-06-07 1994-06-07 Alko Ab Oy Komposition innehaollande staerkelseacetat med varierande egenskaper, foerfarande foer dess framstaellning och anvaendning

Also Published As

Publication number Publication date
DK0850049T3 (da) 2002-10-21
DE69622038D1 (de) 2002-08-01
PT850049E (pt) 2002-10-31
CA2222372A1 (en) 1997-01-23
ATE219663T1 (de) 2002-07-15
AU703085B2 (en) 1999-03-18
WO1997002018A1 (en) 1997-01-23
AU5503296A (en) 1997-02-05
JPH11508581A (ja) 1999-07-27
HUP9900304A2 (hu) 1999-06-28
DE69622038T2 (de) 2003-02-13
EP0850049B1 (en) 2002-06-26
EP0850049A1 (en) 1998-07-01
HUP9900304A3 (en) 2001-04-28
US5656292A (en) 1997-08-12

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