DK0652773T3 - Anvendelse af nor- og homo-galdesyrederivater somabsorptionsfremmende bestanddele i lægemidler - Google Patents
Anvendelse af nor- og homo-galdesyrederivater somabsorptionsfremmende bestanddele i lægemidlerInfo
- Publication number
- DK0652773T3 DK0652773T3 DK93912975T DK93912975T DK0652773T3 DK 0652773 T3 DK0652773 T3 DK 0652773T3 DK 93912975 T DK93912975 T DK 93912975T DK 93912975 T DK93912975 T DK 93912975T DK 0652773 T3 DK0652773 T3 DK 0652773T3
- Authority
- DK
- Denmark
- Prior art keywords
- homo
- pct
- northern
- medicines
- acid derivatives
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 230000002745 absorbent Effects 0.000 title 1
- 239000002250 absorbent Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 239000003613 bile acid Substances 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000029142 excretion Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921601A IT1255449B (it) | 1992-06-30 | 1992-06-30 | Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. |
| PCT/EP1993/001508 WO1994000155A1 (en) | 1992-06-30 | 1993-06-15 | The use of nor- and homo- bile acids derivatives as absorption enhancers for medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0652773T3 true DK0652773T3 (da) | 1998-09-07 |
Family
ID=11363597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93912975T DK0652773T3 (da) | 1992-06-30 | 1993-06-15 | Anvendelse af nor- og homo-galdesyrederivater somabsorptionsfremmende bestanddele i lægemidler |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5656277A (da) |
| EP (1) | EP0652773B1 (da) |
| JP (1) | JPH07508013A (da) |
| AT (1) | ATE161731T1 (da) |
| DE (1) | DE69316217T2 (da) |
| DK (1) | DK0652773T3 (da) |
| ES (1) | ES2114056T3 (da) |
| IT (1) | IT1255449B (da) |
| WO (1) | WO1994000155A1 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0821970A1 (en) * | 1996-08-02 | 1998-02-04 | Edward Henri Charles Verhaeren | Carrier composition for influencing the tight junction permeability |
| DE69834038D1 (de) | 1997-07-01 | 2006-05-18 | Isis Pharmaceutical Inc | Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre |
| US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| AU759016B2 (en) | 1998-10-05 | 2003-04-03 | Penn State Research Foundation, The | Compositions and methods for enhancing receptor-mediated cellular internalization |
| US6451286B1 (en) | 1998-12-21 | 2002-09-17 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds |
| US7087215B2 (en) * | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
| US6849263B2 (en) * | 1998-12-21 | 2005-02-01 | Generex Pharmaceutical Incorporated | Pharmaceutical compositions for buccal delivery of pain relief medications |
| US6375975B1 (en) | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
| US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
| US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| US20030118547A1 (en) * | 2000-01-27 | 2003-06-26 | Vandenberg Grant William | Composition for intestinal delivery |
| JP4452970B2 (ja) * | 2002-03-27 | 2010-04-21 | 日本臓器製薬株式会社 | ジクロフェナクナトリウム経口製剤 |
| US7674778B2 (en) | 2004-04-30 | 2010-03-09 | Alnylam Pharmaceuticals | Oligonucleotides comprising a conjugate group linked through a C5-modified pyrimidine |
| HUE025409T2 (en) | 2005-05-12 | 2016-02-29 | Medizinische Universität Graz | Application of 24-norUDCA |
| SI2182954T1 (sl) * | 2007-07-25 | 2019-04-30 | Medizinische Universitat Graz | Uporaba nor-žolčnih kislin pri zdravljenju arterioskleroze |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| SG11201703717SA (en) | 2014-11-06 | 2017-06-29 | Enanta Pharm Inc | Bile acid analogs an fxr/tgr5 agonists and methods of use thereof |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| EP3223823A4 (en) * | 2014-11-26 | 2018-10-17 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| US11578097B2 (en) | 2014-11-26 | 2023-02-14 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof |
| EP3256134A4 (en) | 2015-02-11 | 2018-10-03 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| WO2016161003A1 (en) | 2015-03-31 | 2016-10-06 | Enanta Phamraceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| WO2017147174A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| US10323060B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof |
| WO2017147159A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Deuterated bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| CN110121347A (zh) | 2016-11-29 | 2019-08-13 | 英安塔制药有限公司 | 制备磺酰脲胆汁酸衍生物的方法 |
| US10472386B2 (en) | 2017-02-14 | 2019-11-12 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR agonists and methods of use thereof |
| BR112019020780A2 (pt) | 2017-04-07 | 2020-04-28 | Enanta Pharm Inc | processo para preparação de derivados de ácido biliar de carbamato de sulfonila |
| AU2019308326B2 (en) | 2018-07-20 | 2025-07-31 | Lipocine Inc. | Liver disease |
| GB201911821D0 (en) | 2019-08-16 | 2019-10-02 | Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid | Compounds for use in the treatment of liver disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746508A (en) * | 1983-06-06 | 1988-05-24 | Beth Israel Hospital Assn. | Drug administration |
| IT1212835B (it) * | 1983-08-18 | 1989-11-30 | Lehner Ag | Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche. |
-
1992
- 1992-06-30 IT ITMI921601A patent/IT1255449B/it active IP Right Grant
-
1993
- 1993-06-15 EP EP93912975A patent/EP0652773B1/en not_active Expired - Lifetime
- 1993-06-15 AT AT93912975T patent/ATE161731T1/de not_active IP Right Cessation
- 1993-06-15 WO PCT/EP1993/001508 patent/WO1994000155A1/en not_active Ceased
- 1993-06-15 US US08/360,833 patent/US5656277A/en not_active Expired - Fee Related
- 1993-06-15 JP JP6501998A patent/JPH07508013A/ja active Pending
- 1993-06-15 ES ES93912975T patent/ES2114056T3/es not_active Expired - Lifetime
- 1993-06-15 DE DE69316217T patent/DE69316217T2/de not_active Expired - Fee Related
- 1993-06-15 DK DK93912975T patent/DK0652773T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2114056T3 (es) | 1998-05-16 |
| DE69316217D1 (de) | 1998-02-12 |
| ITMI921601A1 (it) | 1993-12-30 |
| US5656277A (en) | 1997-08-12 |
| ITMI921601A0 (it) | 1992-06-30 |
| EP0652773B1 (en) | 1998-01-07 |
| DE69316217T2 (de) | 1998-08-20 |
| EP0652773A1 (en) | 1995-05-17 |
| IT1255449B (it) | 1995-10-31 |
| ATE161731T1 (de) | 1998-01-15 |
| WO1994000155A1 (en) | 1994-01-06 |
| JPH07508013A (ja) | 1995-09-07 |
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