ES2176800T3 - Derivados hetero-biaril-piridoquinazolinona como agentes anticancerosos. - Google Patents
Derivados hetero-biaril-piridoquinazolinona como agentes anticancerosos.Info
- Publication number
- ES2176800T3 ES2176800T3 ES97948622T ES97948622T ES2176800T3 ES 2176800 T3 ES2176800 T3 ES 2176800T3 ES 97948622 T ES97948622 T ES 97948622T ES 97948622 T ES97948622 T ES 97948622T ES 2176800 T3 ES2176800 T3 ES 2176800T3
- Authority
- ES
- Spain
- Prior art keywords
- ch2ch2nh2
- group
- alkyl
- piridoquinazolinona
- biaril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- -1 -CO2R4 Chemical group 0.000 abstract 1
- QZGXKHLZLRKTOV-UHFFFAOYSA-N 1h-pyrido[2,3-h]quinazolin-2-one Chemical group N1=CC=CC2=C(NC(=O)N=C3)C3=CC=C21 QZGXKHLZLRKTOV-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION PROPORCIONA UN COMPUESTO DE FORMULA (1), EN LA QUE (A) N = 2 - 4; (B) R 1 Y R 2 SON IGUALES O DIFERENTES, Y SE ELIGEN ENTRE EL GRUPO FORMADO POR H, ALQUILO (C1 - C 3 ), - CH 2 CH 2 OH, CH 2 CH 2 NH 2 Y CH 2 CH 2 N(CH 3 ) 2 O R 1 Y R 2 SON MITADES ALQUILO QUE SE TOMAN CONJUNTAMENTE PARA FORMAR UN ANILLO DE 4 A 7 MIEMBROS, (C) R 3 SE SELECCIONA ENTRE EL GRUPO FORMADO POR H, - CH 3 , - CH 2 CH 3 Y - CH 2 CH 2 NH 2 ; (D) Y ES UN RADICAL HETEROCICLICO QUE TIENE DE 5 A 14 ATOMOS, SITUADOS EN LAS POSICIONES 2 O 3 DEL NUCLEO DE PIRIDOQUINAZOLINONA, EN EL QUE 1 - 3 DE LOS ATOMOS DEL ANILLO HETEROCICLICO SON, INDEPENDIENTEMENTE, NITROGENO, OXIGENO O AZUFRE; CARACTERIZADO PORQUE Y PUEDE SER OPTATIVAMENTE MONO -, DI - O TRI - SUSTITUIDO CON - OR 4 , - NR 5 R 6 , - CO 2 H, - CO 2 R 4 , O FENILO; R 4 ES H O ALQUILO (C 1 - C 4 DE CADENA RECTA; R 5 Y R 6 SON IGUALES O DIFERENTES Y SE SELECCIONAN ENTRE EL GRUPO FORMADO POR H, ALQUILO DE CADENA RECTA C 1 C 4 ), - CH 2 CH 2 OH, - CH 2 CH 2 NH 2 YCH 2 CH 2 N(CH 3 ) 2 O R 5 Y R 6 SON MITADES ALQUILO QUE SE TOMAN CONJUNTAMENTE PARA FORMAR UN ANILLO DE 4 A 7 MIEMBROS, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS QUE ES UTIL COMO AGENTE NEOPLASICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75584596A | 1996-11-26 | 1996-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2176800T3 true ES2176800T3 (es) | 2002-12-01 |
Family
ID=25040889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97948622T Expired - Lifetime ES2176800T3 (es) | 1996-11-26 | 1997-11-24 | Derivados hetero-biaril-piridoquinazolinona como agentes anticancerosos. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0944628B1 (es) |
| JP (1) | JP2001507341A (es) |
| AT (1) | ATE218568T1 (es) |
| AU (1) | AU5465198A (es) |
| CA (1) | CA2272915A1 (es) |
| DE (1) | DE69713139T2 (es) |
| DK (1) | DK0944628T3 (es) |
| ES (1) | ES2176800T3 (es) |
| PT (1) | PT944628E (es) |
| WO (1) | WO1998023617A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101315628B1 (ko) * | 2008-08-12 | 2013-10-08 | 닛뽕소다 가부시키가이샤 | 함질소 헤테로고리 유도체 및 농원예용 살균제 |
| EP2484672B1 (en) | 2009-09-28 | 2015-07-15 | Nippon Soda Co., Ltd. | Nitrogen-containing heterocyclic compound and salt thereof, and herbicide for agricultural and horticultural use |
| CA3066009A1 (en) * | 2017-06-01 | 2018-12-06 | Oncostellae, S.L. | Pyridoquinazoline derivatives useful as protein kinase inhibitors |
| ES2692433A1 (es) * | 2017-06-01 | 2018-12-03 | Oncostellae, S.L. | Derivados de ácidos carboxílicos como inhibidores de proteinas quinasa |
| JP2023542930A (ja) | 2020-09-23 | 2023-10-12 | セント ジュード チルドレンズ リサーチ ホスピタル インコーポレイテッド | セレブロンタンパク質のモジュレータとしての置換ｎ－（２－（２，６－ジオキソピペリジン－３－イル）－１，３－ジオキソイソインドリン－５－イル）アリールスルホンアミド類似体 |
-
1997
- 1997-11-24 ES ES97948622T patent/ES2176800T3/es not_active Expired - Lifetime
- 1997-11-24 DK DK97948622T patent/DK0944628T3/da active
- 1997-11-24 JP JP52492998A patent/JP2001507341A/ja active Pending
- 1997-11-24 CA CA002272915A patent/CA2272915A1/en not_active Abandoned
- 1997-11-24 PT PT97948622T patent/PT944628E/pt unknown
- 1997-11-24 DE DE69713139T patent/DE69713139T2/de not_active Expired - Fee Related
- 1997-11-24 AU AU54651/98A patent/AU5465198A/en not_active Abandoned
- 1997-11-24 AT AT97948622T patent/ATE218568T1/de not_active IP Right Cessation
- 1997-11-24 EP EP97948622A patent/EP0944628B1/en not_active Expired - Lifetime
- 1997-11-24 WO PCT/US1997/022502 patent/WO1998023617A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69713139T2 (de) | 2002-12-19 |
| DK0944628T3 (da) | 2002-08-26 |
| HK1021373A1 (en) | 2000-06-09 |
| CA2272915A1 (en) | 1998-06-04 |
| DE69713139D1 (de) | 2002-07-11 |
| EP0944628A1 (en) | 1999-09-29 |
| AU5465198A (en) | 1998-06-22 |
| EP0944628B1 (en) | 2002-06-05 |
| ATE218568T1 (de) | 2002-06-15 |
| JP2001507341A (ja) | 2001-06-05 |
| PT944628E (pt) | 2002-09-30 |
| WO1998023617A1 (en) | 1998-06-04 |
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