ES2177324T3 - Preparaciones de insulina destinadas a la entrega pulmonar y que contiene mentol. - Google Patents
Preparaciones de insulina destinadas a la entrega pulmonar y que contiene mentol.Info
- Publication number
- ES2177324T3 ES2177324T3 ES99948726T ES99948726T ES2177324T3 ES 2177324 T3 ES2177324 T3 ES 2177324T3 ES 99948726 T ES99948726 T ES 99948726T ES 99948726 T ES99948726 T ES 99948726T ES 2177324 T3 ES2177324 T3 ES 2177324T3
- Authority
- ES
- Spain
- Prior art keywords
- mentol
- pulmonary delivery
- insulin preparations
- preparations intended
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
- 102000004877 Insulin Human genes 0.000 title abstract 4
- 108090001061 Insulin Proteins 0.000 title abstract 4
- 229940125396 insulin Drugs 0.000 title abstract 4
- NOOLISFMXDJSKH-ZDGBYWQASA-N (2s,5r)-5-methyl-2-propan-2-ylcyclohexan-1-ol Chemical compound CC(C)[C@@H]1CC[C@@H](C)CC1O NOOLISFMXDJSKH-ZDGBYWQASA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000002685 pulmonary effect Effects 0.000 title 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Formulación de la insulina acuosa que incluye una insulina humana o un análogo o un derivado, de 2 a 5 iones Zn2+ por cada seis moléculas de insulina, de 3 a 18 moléculas fenólicas por cada seis moléculas de insulina, y mentol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801326 | 1998-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2177324T3 true ES2177324T3 (es) | 2002-12-01 |
Family
ID=8103609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99948726T Expired - Lifetime ES2177324T3 (es) | 1998-10-16 | 1999-10-15 | Preparaciones de insulina destinadas a la entrega pulmonar y que contiene mentol. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1121145B1 (es) |
| JP (1) | JP2002527488A (es) |
| KR (1) | KR20010080132A (es) |
| CN (1) | CN1323220A (es) |
| AT (1) | ATE216258T1 (es) |
| AU (1) | AU758108B2 (es) |
| BR (1) | BR9914568A (es) |
| CA (1) | CA2346884A1 (es) |
| CZ (1) | CZ20011133A3 (es) |
| DE (1) | DE69901314T2 (es) |
| DK (1) | DK1121145T3 (es) |
| ES (1) | ES2177324T3 (es) |
| HU (1) | HUP0103606A3 (es) |
| IL (1) | IL142002A0 (es) |
| NO (1) | NO20011841L (es) |
| PL (1) | PL347171A1 (es) |
| PT (1) | PT1121145E (es) |
| UA (1) | UA67798C2 (es) |
| WO (1) | WO2000023099A1 (es) |
| ZA (1) | ZA200102068B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE354376T1 (de) | 1999-10-14 | 2007-03-15 | Pola Chem Ind Inc | Zusammensetzungen für die elektroporation |
| EP1222931B1 (en) * | 1999-10-15 | 2006-06-07 | Pola Chemical Industries Inc. | Percutaneous absorption promoters for electroporation |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
| KR101853606B1 (ko) | 2009-07-06 | 2018-05-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 메티오닌을 함유하는 수성 인슐린 제제 |
| KR101337322B1 (ko) | 2009-11-13 | 2013-12-06 | 사노피-아벤티스 도이칠란트 게엠베하 | Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
| DK2498802T3 (en) | 2009-11-13 | 2015-04-13 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine |
| ES2606554T3 (es) | 2010-08-30 | 2017-03-24 | Sanofi-Aventis Deutschland Gmbh | Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| PL2750699T3 (pl) | 2011-08-29 | 2015-12-31 | Sanofi Aventis Deutschland | Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| AU2015359376B2 (en) | 2014-12-12 | 2021-09-09 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| GB201906917D0 (en) * | 2019-05-16 | 2019-07-03 | Intract Pharma Ltd | Novel compositions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5635161A (en) * | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing vegetable oils |
| ATE369146T1 (de) * | 1996-06-20 | 2007-08-15 | Novo Nordisk As | Insulinpreparation mit mannitol |
| ATE219942T1 (de) * | 1997-03-20 | 2002-07-15 | Novo Nordisk As | Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält |
-
1999
- 1999-10-15 UA UA2001042149A patent/UA67798C2/uk unknown
- 1999-10-15 DK DK99948726T patent/DK1121145T3/da active
- 1999-10-15 PT PT99948726T patent/PT1121145E/pt unknown
- 1999-10-15 CZ CZ20011133A patent/CZ20011133A3/cs unknown
- 1999-10-15 JP JP2000576872A patent/JP2002527488A/ja not_active Withdrawn
- 1999-10-15 AU AU61890/99A patent/AU758108B2/en not_active Ceased
- 1999-10-15 EP EP99948726A patent/EP1121145B1/en not_active Expired - Lifetime
- 1999-10-15 ES ES99948726T patent/ES2177324T3/es not_active Expired - Lifetime
- 1999-10-15 KR KR1020017004638A patent/KR20010080132A/ko not_active Withdrawn
- 1999-10-15 HU HU0103606A patent/HUP0103606A3/hu unknown
- 1999-10-15 PL PL99347171A patent/PL347171A1/xx unknown
- 1999-10-15 BR BR9914568-5A patent/BR9914568A/pt not_active IP Right Cessation
- 1999-10-15 CA CA002346884A patent/CA2346884A1/en not_active Abandoned
- 1999-10-15 AT AT99948726T patent/ATE216258T1/de not_active IP Right Cessation
- 1999-10-15 CN CN99812209A patent/CN1323220A/zh active Pending
- 1999-10-15 WO PCT/DK1999/000557 patent/WO2000023099A1/en not_active Ceased
- 1999-10-15 DE DE69901314T patent/DE69901314T2/de not_active Expired - Fee Related
- 1999-10-15 IL IL14200299A patent/IL142002A0/xx unknown
-
2001
- 2001-03-13 ZA ZA200102068A patent/ZA200102068B/en unknown
- 2001-04-10 NO NO20011841A patent/NO20011841L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0103606A2 (hu) | 2002-02-28 |
| CZ20011133A3 (cs) | 2001-08-15 |
| KR20010080132A (ko) | 2001-08-22 |
| NO20011841L (no) | 2001-06-15 |
| AU758108B2 (en) | 2003-03-13 |
| PT1121145E (pt) | 2002-09-30 |
| EP1121145A1 (en) | 2001-08-08 |
| JP2002527488A (ja) | 2002-08-27 |
| BR9914568A (pt) | 2001-07-03 |
| CA2346884A1 (en) | 2000-04-27 |
| DE69901314D1 (de) | 2002-05-23 |
| HUP0103606A3 (en) | 2002-05-28 |
| PL347171A1 (en) | 2002-03-25 |
| WO2000023099A1 (en) | 2000-04-27 |
| ATE216258T1 (de) | 2002-05-15 |
| DK1121145T3 (da) | 2002-08-12 |
| IL142002A0 (en) | 2002-03-10 |
| NO20011841D0 (no) | 2001-04-10 |
| UA67798C2 (uk) | 2004-07-15 |
| CN1323220A (zh) | 2001-11-21 |
| DE69901314T2 (de) | 2002-11-21 |
| EP1121145B1 (en) | 2002-04-17 |
| ZA200102068B (en) | 2001-10-12 |
| AU6189099A (en) | 2000-05-08 |
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