DK1121145T3 - Insulinpræparater til indgivelse via lungerne, som indeholder mentol - Google Patents

Insulinpræparater til indgivelse via lungerne, som indeholder mentol

Info

Publication number: DK1121145T3
Authority: DK; Denmark
Prior art keywords: insulin; formulation; administration via; insulin preparations; menthol
Prior art date: 1998-10-16

Application number

DK99948726T

Other languages

English (en)

Inventor

Svend Havelund

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-15

Publication date

2002-08-12

1999-10-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2002-08-12 Application granted granted Critical

2002-08-12 Publication of DK1121145T3 publication Critical patent/DK1121145T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
102000004877 Insulin Human genes 0.000 title abstract 4
108090001061 Insulin Proteins 0.000 title abstract 4
229940125396 insulin Drugs 0.000 title abstract 4
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 title abstract 3
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 title abstract 3
229940041616 menthol Drugs 0.000 title abstract 3
210000004072 lung Anatomy 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000009472 formulation Methods 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
150000002500 ions Chemical class 0.000 abstract 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
150000002989 phenols Chemical class 0.000 abstract 1
230000002685 pulmonary effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

DK99948726T 1998-10-16 1999-10-15 Insulinpræparater til indgivelse via lungerne, som indeholder mentol DK1121145T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA199801326		1998-10-16
PCT/DK1999/000557 WO2000023099A1 (en)	1998-10-16	1999-10-15	Insulin preparations for pulmonary delivery containing menthol

Publications (1)

Publication Number	Publication Date
DK1121145T3 true DK1121145T3 (da)	2002-08-12

Family

ID=8103609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99948726T DK1121145T3 (da)	1998-10-16	1999-10-15	Insulinpræparater til indgivelse via lungerne, som indeholder mentol

Country Status (20)

Country	Link
EP (1)	EP1121145B1 (da)
JP (1)	JP2002527488A (da)
KR (1)	KR20010080132A (da)
CN (1)	CN1323220A (da)
AT (1)	ATE216258T1 (da)
AU (1)	AU758108B2 (da)
BR (1)	BR9914568A (da)
CA (1)	CA2346884A1 (da)
CZ (1)	CZ20011133A3 (da)
DE (1)	DE69901314T2 (da)
DK (1)	DK1121145T3 (da)
ES (1)	ES2177324T3 (da)
HU (1)	HUP0103606A3 (da)
IL (1)	IL142002A0 (da)
NO (1)	NO20011841L (da)
PL (1)	PL347171A1 (da)
PT (1)	PT1121145E (da)
UA (1)	UA67798C2 (da)
WO (1)	WO2000023099A1 (da)
ZA (1)	ZA200102068B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE354376T1 (de)	1999-10-14	2007-03-15	Pola Chem Ind Inc	Zusammensetzungen für die elektroporation
EP1222931B1 (en) *	1999-10-15	2006-06-07	Pola Chemical Industries Inc.	Percutaneous absorption promoters for electroporation
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
DK2498802T3 (da)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Farmaceutisk præparat omfattende en glp-1-agonist, et insulin og en methionin
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
GB201906917D0 (en) *	2019-05-16	2019-07-03	Intract Pharma Ltd	Novel compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5635161A (en) *	1995-06-07	1997-06-03	Abbott Laboratories	Aerosol drug formulations containing vegetable oils
ATE369146T1 (de) *	1996-06-20	2007-08-15	Novo Nordisk As	Insulinpreparation mit mannitol
ATE219942T1 (de) *	1997-03-20	2002-07-15	Novo Nordisk As	Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

1999
- 1999-10-15 UA UA2001042149A patent/UA67798C2/uk unknown
- 1999-10-15 DK DK99948726T patent/DK1121145T3/da active
- 1999-10-15 PT PT99948726T patent/PT1121145E/pt unknown
- 1999-10-15 CZ CZ20011133A patent/CZ20011133A3/cs unknown
- 1999-10-15 JP JP2000576872A patent/JP2002527488A/ja not_active Withdrawn
- 1999-10-15 AU AU61890/99A patent/AU758108B2/en not_active Ceased
- 1999-10-15 EP EP99948726A patent/EP1121145B1/en not_active Expired - Lifetime
- 1999-10-15 ES ES99948726T patent/ES2177324T3/es not_active Expired - Lifetime
- 1999-10-15 KR KR1020017004638A patent/KR20010080132A/ko not_active Withdrawn
- 1999-10-15 HU HU0103606A patent/HUP0103606A3/hu unknown
- 1999-10-15 PL PL99347171A patent/PL347171A1/xx unknown
- 1999-10-15 BR BR9914568-5A patent/BR9914568A/pt not_active IP Right Cessation
- 1999-10-15 CA CA002346884A patent/CA2346884A1/en not_active Abandoned
- 1999-10-15 AT AT99948726T patent/ATE216258T1/de not_active IP Right Cessation
- 1999-10-15 CN CN99812209A patent/CN1323220A/zh active Pending
- 1999-10-15 WO PCT/DK1999/000557 patent/WO2000023099A1/en not_active Ceased
- 1999-10-15 DE DE69901314T patent/DE69901314T2/de not_active Expired - Fee Related
- 1999-10-15 IL IL14200299A patent/IL142002A0/xx unknown
2001
- 2001-03-13 ZA ZA200102068A patent/ZA200102068B/en unknown
- 2001-04-10 NO NO20011841A patent/NO20011841L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0103606A2 (hu)	2002-02-28
CZ20011133A3 (cs)	2001-08-15
KR20010080132A (ko)	2001-08-22
NO20011841L (no)	2001-06-15
AU758108B2 (en)	2003-03-13
PT1121145E (pt)	2002-09-30
EP1121145A1 (en)	2001-08-08
JP2002527488A (ja)	2002-08-27
BR9914568A (pt)	2001-07-03
CA2346884A1 (en)	2000-04-27
DE69901314D1 (de)	2002-05-23
HUP0103606A3 (en)	2002-05-28
PL347171A1 (en)	2002-03-25
WO2000023099A1 (en)	2000-04-27
ATE216258T1 (de)	2002-05-15
IL142002A0 (en)	2002-03-10
NO20011841D0 (no)	2001-04-10
UA67798C2 (uk)	2004-07-15
CN1323220A (zh)	2001-11-21
ES2177324T3 (es)	2002-12-01
DE69901314T2 (de)	2002-11-21
EP1121145B1 (en)	2002-04-17
ZA200102068B (en)	2001-10-12
AU6189099A (en)	2000-05-08

Publication	Publication Date	Title
PT1121145E (pt)	2002-09-30	Preparacoes de insulina contendo mentol e destinadas a administracao via pulmonar
CO5271759A1 (es)	2003-04-30	Formulacion en solucion que contiene una mezcla de disolventes
DE69901726D1 (de)	2002-07-11	Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
GEP20043258B (en)	2004-06-25	Systems and Methods for Aerosolizing Pharmaceutical Formulations
YU59092A (sh)	1994-12-28	Formulacije aerosola koji ne sadrže hlorofluorougljenična jedinjenja
PT1309503E (pt)	2005-02-28	Dispositivo medico de pulverizacao
TR200002692T2 (tr)	2001-02-21	Aerosol haline getirilen aktif maddenin verilmesi.
CO4410203A1 (es)	1997-01-09	Formulaciones de analogos de insulina
HRP20000867B1 (en)	2010-10-31	Pharmaceutical formulations for aerosols with two or more active substances
BR9917089A (pt)	2001-10-16	Composições e métodos para distribuição mucosal
RU94040387A (ru)	1996-10-20	Композиция, способствующая прекращению курения, никотиносодержащий распыляемый раствор, способ снижения потребности в курении табака, способ замены курения табака
BR0108435A (pt)	2004-06-15	Formulação e uso de entecavir de baixa dose
DK1091729T3 (da)	2008-07-21	Mikropartikelformulering til inhalation
MY129112A (en)	2007-03-30	Flow resistance modulated aerosolized active agent delivery
YU54499A (sh)	2002-06-19	Farmaceutski preparat za primenu na mukozu
DK1146896T3 (da)	2002-09-02	Formuleringer, som indeholder monodisperse hexamere acylerede insulin-analoger
ATE253928T1 (de)	2003-11-15	Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung enthaltend desmopressin
Morris	1997	Uptake of acetaldehyde vapor and aldehyde dehydrogenase levels in the upper respiratory tracts of the mouse, rat, hamster, and guinea pig
BRPI0014878B8 (pt)	2021-05-25	composição farmacêutica contendo ciclosonida para aplicação à mucosa
ATE350024T1 (de)	2007-01-15	Flüssige zubereitung enthaltend tobramycin
MY136546A (en)	2008-10-31	A pharmaceutical component based on human parathyroid harmone and a pharmaceutical composition for intranasal administration comprising the component
TR199900523T2 (xx)	1999-05-21	Vir�s k�kenli hastal�klar�n tedavisi i�in farmas�tik bile�imler.
EP1297838A4 (en)	2003-07-09	PRALMORELIN-CONTAINED NOSE DROP PREPARATIONS
BR0006237A (pt)	2001-11-27	Inalador em aerossol, e, processo de tratamentode um sujeito com um agente farmacêutico