ES2177448A1 - "oxima de eritromicina a." - Google Patents

"oxima de eritromicina a."

Info

Publication number
ES2177448A1
ES2177448A1 ES200050046A ES200050046A ES2177448A1 ES 2177448 A1 ES2177448 A1 ES 2177448A1 ES 200050046 A ES200050046 A ES 200050046A ES 200050046 A ES200050046 A ES 200050046A ES 2177448 A1 ES2177448 A1 ES 2177448A1
Authority
ES
Spain
Prior art keywords
production
intermediates
erythromycin
oxime
macrolide production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200050046A
Other languages
English (en)
Other versions
ES2177448B1 (es
Inventor
Inmaculada Bosch
Victor Centellas
Jose Diago
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Biochemie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9726992.2A external-priority patent/GB9726992D0/en
Priority claimed from GBGB9726991.4A external-priority patent/GB9726991D0/en
Application filed by Biochemie SA filed Critical Biochemie SA
Publication of ES2177448A1 publication Critical patent/ES2177448A1/es
Application granted granted Critical
Publication of ES2177448B1 publication Critical patent/ES2177448B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oxima de eritromicina A, en la que el grupo hidroxilo del grupo oxima está en forma que ha reaccionado resultante de la reacción con una base orgánica fuerte con un agente de sililación; un procedimiento para su produccion y su uso como un producto intermedio en la producción de macrólidos del tipo de eritromicina, tales como roxitromicina, azitromicina y compuestos similares.
ES200050046A 1997-12-22 1998-12-18 "oxima de eritromicina a.". Expired - Fee Related ES2177448B1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9726992.2A GB9726992D0 (en) 1997-12-22 1997-12-22 Organic compounds
GB9726992 1997-12-22
GB9726991 1997-12-22
GBGB9726991.4A GB9726991D0 (en) 1997-12-22 1997-12-22 Organic compounds

Publications (2)

Publication Number Publication Date
ES2177448A1 true ES2177448A1 (es) 2002-12-01
ES2177448B1 ES2177448B1 (es) 2004-08-01

Family

ID=26312817

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200050046A Expired - Fee Related ES2177448B1 (es) 1997-12-22 1998-12-18 "oxima de eritromicina a.".

Country Status (3)

Country Link
AU (1) AU2274799A (es)
ES (1) ES2177448B1 (es)
WO (1) WO1999032500A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
KR100361397B1 (ko) * 2000-03-15 2002-11-23 한미약품공업 주식회사 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222353A2 (en) * 1985-11-12 1987-05-20 Abbott Laboratories Macrolide antibiotic derivatives
EP0503932A1 (en) * 1991-03-15 1992-09-16 Merck & Co. Inc. 9-Deoxo-9(z)-hydroxy-iminoerythromycin A and O-derivatives thereof
WO1997036913A1 (en) * 1996-04-02 1997-10-09 Abbott Laboratories 9-oximesilyl erythromycin a derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534588B2 (fr) * 1982-10-15 1985-09-20 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222353A2 (en) * 1985-11-12 1987-05-20 Abbott Laboratories Macrolide antibiotic derivatives
EP0503932A1 (en) * 1991-03-15 1992-09-16 Merck & Co. Inc. 9-Deoxo-9(z)-hydroxy-iminoerythromycin A and O-derivatives thereof
WO1997036913A1 (en) * 1996-04-02 1997-10-09 Abbott Laboratories 9-oximesilyl erythromycin a derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Y. WATANABE et al., Journal Antibiotics, Vol. 46 (7), 1993, paginas 1163-1167. "Chemical modifications of erythromycins. A facile synthesis of clarithromycin (6-O-methylerythromycin A)". Todo el documento. *

Also Published As

Publication number Publication date
ES2177448B1 (es) 2004-08-01
AU2274799A (en) 1999-07-12
WO1999032500A3 (en) 1999-09-02
WO1999032500A2 (en) 1999-07-01

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