ES2177533T3 - Compuestos analogos a oligonucleotidos derivatizados en 3', con agrupaciones no nucleotidicas, su preparacion y utilizacion. - Google Patents

Compuestos analogos a oligonucleotidos derivatizados en 3', con agrupaciones no nucleotidicas, su preparacion y utilizacion.

Info

Publication number
ES2177533T3
ES2177533T3 ES93100893T ES93100893T ES2177533T3 ES 2177533 T3 ES2177533 T3 ES 2177533T3 ES 93100893 T ES93100893 T ES 93100893T ES 93100893 T ES93100893 T ES 93100893T ES 2177533 T3 ES2177533 T3 ES 2177533T3
Authority
ES
Spain
Prior art keywords
oligonucleotidos
nucleotidic
derivatized
clusters
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93100893T
Other languages
English (en)
Inventor
Eugen Dr Uhlmann
Anuschirwan Dr Peyman
Gerard Dr O'malley
Matthias Dr Helsberg
Irvin Dr Winkler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2177533T3 publication Critical patent/ES2177533T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Graft Or Block Polymers (AREA)

Abstract

ANALOGOS A LOS OLIGONUCLEOTIDOS 2'' DERIVADOS, CON AGRUPACIONES NO NUCLEOTIDAS, SU OBTENCION Y UTILIZACION. LA PRESENTE INVENCION CONCIERNE A NUEVOS ANALOGOS A LOS OLIGONUCLEOTIDOS, CON PROPIEDADES VALIOSAS FISICAS, BIOLOGICAS Y FARMACOLOGICAS, ASI COMO UN PROCEDIMIENTO PARA SU OBTENCION.
ES93100893T 1992-01-22 1993-01-21 Compuestos analogos a oligonucleotidos derivatizados en 3', con agrupaciones no nucleotidicas, su preparacion y utilizacion. Expired - Lifetime ES2177533T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4201663 1992-01-22

Publications (1)

Publication Number Publication Date
ES2177533T3 true ES2177533T3 (es) 2002-12-16

Family

ID=6450031

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01116471T Expired - Lifetime ES2250268T3 (es) 1992-01-22 1993-01-21 Analogos de oligonucleotidos 3'-derivatizados con agrupaciones no nucleotidicas, su preparacion y utilizacion.
ES93100893T Expired - Lifetime ES2177533T3 (es) 1992-01-22 1993-01-21 Compuestos analogos a oligonucleotidos derivatizados en 3', con agrupaciones no nucleotidicas, su preparacion y utilizacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01116471T Expired - Lifetime ES2250268T3 (es) 1992-01-22 1993-01-21 Analogos de oligonucleotidos 3'-derivatizados con agrupaciones no nucleotidicas, su preparacion y utilizacion.

Country Status (18)

Country Link
US (1) US5646261A (es)
EP (2) EP0552767B1 (es)
JP (1) JP3676388B2 (es)
KR (1) KR100273824B1 (es)
AT (2) ATE307821T1 (es)
AU (1) AU657191B2 (es)
CA (1) CA2087817C (es)
DE (2) DE59310287D1 (es)
DK (2) DK0552767T3 (es)
ES (2) ES2250268T3 (es)
FI (1) FI115215B (es)
HU (1) HUT63172A (es)
IL (1) IL104460A (es)
NO (1) NO308609B1 (es)
NZ (1) NZ245721A (es)
PL (1) PL172245B1 (es)
PT (1) PT552767E (es)
ZA (1) ZA93423B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2966849B2 (ja) * 1987-12-03 1999-10-25 三井化学株式会社 黄色系昇華転写用色材
ES2103408T3 (es) * 1992-09-24 1997-09-16 Hoechst Ag Analogos de oligorribonucleotidos y ribozimas con uniones terminales en 3'-3' o 5'-5' respectivamente.
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5532130A (en) * 1993-07-20 1996-07-02 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
US6358689B1 (en) * 1994-05-11 2002-03-19 Boston University Detection of markers in nascent proteins
DE4418691A1 (de) * 1994-05-28 1996-02-22 Boehringer Mannheim Gmbh 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
ATE188479T1 (de) 1994-06-01 2000-01-15 Hybridon Inc Verzweigte oligonukleotide als pathogenhemmende mittel
US5696248A (en) * 1994-06-15 1997-12-09 Hoechst Aktiengesellschaft 3'-modified oligonucleotide derivatives
US6326487B1 (en) 1995-06-05 2001-12-04 Aventis Pharma Deutschland Gmbh 3 modified oligonucleotide derivatives
US6274313B1 (en) 1996-03-21 2001-08-14 Pioneer-Hybrid International, Inc. Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US6331617B1 (en) 1996-03-21 2001-12-18 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US20040082774A1 (en) * 1999-03-16 2004-04-29 Guzaev Andrei P. Novel phosphate and thiophosphate protecting groups
US6121437A (en) 1999-03-16 2000-09-19 Isis Pharmaceuticals, Inc. Phosphate and thiophosphate protecting groups
US20040023367A1 (en) * 2002-07-31 2004-02-05 Affymetrix, Inc. Method of photolithographic production of polymer arrays
US8084589B2 (en) * 2007-08-31 2011-12-27 University Of Massachusetts Phosphoramidite nucleoside analogs
WO2012040524A1 (en) * 2010-09-24 2012-03-29 Mallinckrodt Llc Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
DE3751468T2 (de) * 1986-10-30 1996-02-29 Daicel Chem Verfahren zur herstellung von oligonukleotiden und verbindungen zur bildung hochmolekularer schutzgruppen.
US4816571A (en) * 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
DK0942000T3 (da) * 1989-10-24 2004-11-01 Isis Pharmaceuticals Inc 2'-modificerede oligonukleotider
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides
IL104461A (en) * 1992-01-22 2001-05-20 Hoechst Ag Oligonucleotide analogs, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE217881T1 (de) 2002-06-15
CA2087817A1 (en) 1993-07-23
ZA93423B (en) 1993-09-09
NO308609B1 (no) 2000-10-02
NZ245721A (en) 1995-09-26
HU9300161D0 (en) 1993-04-28
EP1142902B1 (de) 2005-10-26
ES2250268T3 (es) 2006-04-16
CA2087817C (en) 2010-03-16
ATE307821T1 (de) 2005-11-15
EP1142902A2 (de) 2001-10-10
NO930200D0 (no) 1993-01-21
DK1142902T3 (da) 2006-03-06
EP1142902A3 (de) 2001-10-17
DE59310380D1 (de) 2005-12-01
PL297516A1 (en) 1993-09-06
EP0552767B1 (de) 2002-05-22
FI930221L (fi) 1993-07-23
PT552767E (pt) 2002-10-31
KR100273824B1 (ko) 2000-12-15
JPH05310778A (ja) 1993-11-22
AU657191B2 (en) 1995-03-02
FI930221A0 (fi) 1993-01-20
FI115215B (fi) 2005-03-31
JP3676388B2 (ja) 2005-07-27
DE59310287D1 (de) 2002-06-27
DK0552767T3 (da) 2002-08-19
PL172245B1 (pl) 1997-08-29
IL104460A (en) 2003-03-12
US5646261A (en) 1997-07-08
AU3191193A (en) 1993-07-29
KR930016438A (ko) 1993-08-26
IL104460A0 (en) 1993-05-13
EP0552767A2 (de) 1993-07-28
EP0552767A3 (en) 1994-09-07
HUT63172A (en) 1993-07-28
NO930200L (no) 1993-07-23

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