PT552767E - Analogos de oligonucleotidos 3'-derivatisados com agrupamentos nao nucleotidicos, sua preparacao e utilizacao - Google Patents

Analogos de oligonucleotidos 3'-derivatisados com agrupamentos nao nucleotidicos, sua preparacao e utilizacao

Info

Publication number: PT552767E
Authority: PT; Portugal
Prior art keywords: oxy; alpha; sulfandiyl; alkyl; formula
Prior art date: 1992-01-22

Application number

PT93100893T

Other languages

English (en)

Inventor

Matthias Helsberg

Irvin Winkler

Peyman Dr Anuschirwan

Uhlmann Dr Eugen

Gerard O'malley

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-22

Filing date

1993-01-21

Publication date

2002-10-31

1993-01-21 Application filed by Hoechst Ag filed Critical Hoechst Ag

2002-10-31 Publication of PT552767E publication Critical patent/PT552767E/pt

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 3
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
-1 oxy, sulfandiyl Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 4
125000001841 imino group Chemical group [H]N=* 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000732 arylene group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical group 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000005731 phosphitylation reaction Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000000464 thioxo group Chemical group S=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Graft Or Block Polymers (AREA)
Macromonomer-Based Addition Polymer (AREA)

PT93100893T 1992-01-22 1993-01-21 Analogos de oligonucleotidos 3'-derivatisados com agrupamentos nao nucleotidicos, sua preparacao e utilizacao PT552767E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4201663		1992-01-22

Publications (1)

Publication Number	Publication Date
PT552767E true PT552767E (pt)	2002-10-31

Family

ID=6450031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93100893T PT552767E (pt)	1992-01-22	1993-01-21	Analogos de oligonucleotidos 3'-derivatisados com agrupamentos nao nucleotidicos, sua preparacao e utilizacao

Country Status (18)

Country	Link
US (1)	US5646261A (pt)
EP (2)	EP1142902B1 (pt)
JP (1)	JP3676388B2 (pt)
KR (1)	KR100273824B1 (pt)
AT (2)	ATE307821T1 (pt)
AU (1)	AU657191B2 (pt)
CA (1)	CA2087817C (pt)
DE (2)	DE59310287D1 (pt)
DK (2)	DK0552767T3 (pt)
ES (2)	ES2250268T3 (pt)
FI (1)	FI115215B (pt)
HU (1)	HUT63172A (pt)
IL (1)	IL104460A (pt)
NO (1)	NO308609B1 (pt)
NZ (1)	NZ245721A (pt)
PL (1)	PL172245B1 (pt)
PT (1)	PT552767E (pt)
ZA (1)	ZA93423B (pt)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2966849B2 (ja) *	1987-12-03	1999-10-25	三井化学株式会社	黄色系昇華転写用色材
ES2103408T3 (es)	1992-09-24	1997-09-16	Hoechst Ag	Analogos de oligorribonucleotidos y ribozimas con uniones terminales en 3'-3' o 5'-5' respectivamente.
EP0602524A1 (de) *	1992-12-15	1994-06-22	Hoechst Aktiengesellschaft	Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
CA2114355A1 (en) *	1993-01-29	1994-07-30	Hidehiko Furukawa	Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5532130A (en) *	1993-07-20	1996-07-02	Dyad Pharmaceutical Corporation	Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
US6919441B2 (en)	1994-03-14	2005-07-19	Aventis Pharma Deutschland Gmbh	Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (de) *	1994-03-14	1995-09-28	Hoechst Ag	Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
US6358689B1 (en) *	1994-05-11	2002-03-19	Boston University	Detection of markers in nascent proteins
DE4418691A1 (de) *	1994-05-28	1996-02-22	Boehringer Mannheim Gmbh	3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
KR970703357A (ko)	1994-06-01	1997-07-03	다알렌 반스톤	병원체-저해제로서의, 측쇄를 가지는 올리고누클레오티드(branched oligonu-cleotides as pathogen-inhibitory agents)
US5696248A (en) *	1994-06-15	1997-12-09	Hoechst Aktiengesellschaft	3'-modified oligonucleotide derivatives
US6326487B1 (en)	1995-06-05	2001-12-04	Aventis Pharma Deutschland Gmbh	3 modified oligonucleotide derivatives
US6274313B1 (en)	1996-03-21	2001-08-14	Pioneer-Hybrid International, Inc.	Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US6331617B1 (en)	1996-03-21	2001-12-18	University Of Iowa Research Foundation	Positively charged oligonucleotides as regulators of gene expression
US20040082774A1 (en) *	1999-03-16	2004-04-29	Guzaev Andrei P.	Novel phosphate and thiophosphate protecting groups
US6121437A (en)	1999-03-16	2000-09-19	Isis Pharmaceuticals, Inc.	Phosphate and thiophosphate protecting groups
US20040023367A1 (en) *	2002-07-31	2004-02-05	Affymetrix, Inc.	Method of photolithographic production of polymer arrays
WO2009029868A1 (en) *	2007-08-31	2009-03-05	University Of Massachusetts	Phosphoramidite nucleoside analogs
EP2618846A1 (en) *	2010-09-24	2013-07-31	Mallinckrodt LLC	Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3239888A1 (de) *	1982-10-28	1984-05-03	Hubert Prof. Dr. 2000 Hamburg Köster	Verfahren zur herstellung von oligonucleosidphosphonaten
US4739044A (en) *	1985-06-13	1988-04-19	Amgen	Method for derivitization of polynucleotides
WO1988003149A1 (fr) *	1986-10-30	1988-05-05	Daicel Chemical Industries, Ltd.	Procede de synthese d'oligonucleotides et composes servant a former des groupes protecteurs a poids moleculaire eleve
US4816571A (en) *	1987-06-04	1989-03-28	Applied Biosystems, Inc.	Chemical capping by phosphitylation during oligonucleotide synthesis
US5216141A (en) *	1988-06-06	1993-06-01	Benner Steven A	Oligonucleotide analogs containing sulfur linkages
US5399676A (en) *	1989-10-23	1995-03-21	Gilead Sciences	Oligonucleotides with inverted polarity
ATE269870T1 (de) *	1989-10-24	2004-07-15	Isis Pharmaceuticals Inc	2'-modifizierte oligonukleotide
US5210015A (en) *	1990-08-06	1993-05-11	Hoffman-La Roche Inc.	Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
GB9021625D0 (en) *	1990-10-04	1990-11-21	Ici Plc	Synthesis of oligonucleotides
FI115214B (fi) *	1992-01-22	2005-03-31	Hoechst Ag	Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö

1993
- 1993-01-19 US US08/005,283 patent/US5646261A/en not_active Expired - Lifetime
- 1993-01-20 NZ NZ245721A patent/NZ245721A/en not_active IP Right Cessation
- 1993-01-20 FI FI930221A patent/FI115215B/fi not_active IP Right Cessation
- 1993-01-20 IL IL10446093A patent/IL104460A/xx not_active IP Right Cessation
- 1993-01-20 KR KR1019930000676A patent/KR100273824B1/ko not_active Expired - Lifetime
- 1993-01-21 DK DK93100893T patent/DK0552767T3/da active
- 1993-01-21 DE DE59310287T patent/DE59310287D1/de not_active Expired - Lifetime
- 1993-01-21 ES ES01116471T patent/ES2250268T3/es not_active Expired - Lifetime
- 1993-01-21 HU HU9300161A patent/HUT63172A/hu unknown
- 1993-01-21 DK DK01116471T patent/DK1142902T3/da active
- 1993-01-21 PT PT93100893T patent/PT552767E/pt unknown
- 1993-01-21 AU AU31911/93A patent/AU657191B2/en not_active Expired
- 1993-01-21 DE DE59310380T patent/DE59310380D1/de not_active Expired - Lifetime
- 1993-01-21 ES ES93100893T patent/ES2177533T3/es not_active Expired - Lifetime
- 1993-01-21 EP EP01116471A patent/EP1142902B1/de not_active Expired - Lifetime
- 1993-01-21 EP EP93100893A patent/EP0552767B1/de not_active Expired - Lifetime
- 1993-01-21 CA CA2087817A patent/CA2087817C/en not_active Expired - Lifetime
- 1993-01-21 AT AT01116471T patent/ATE307821T1/de active
- 1993-01-21 ZA ZA93423A patent/ZA93423B/xx unknown
- 1993-01-21 NO NO930200A patent/NO308609B1/no not_active IP Right Cessation
- 1993-01-21 AT AT93100893T patent/ATE217881T1/de active
- 1993-01-21 JP JP00825693A patent/JP3676388B2/ja not_active Expired - Lifetime
- 1993-01-22 PL PL93297516A patent/PL172245B1/pl unknown

Also Published As

Publication number	Publication date
ES2250268T3 (es)	2006-04-16
ES2177533T3 (es)	2002-12-16
IL104460A0 (en)	1993-05-13
NZ245721A (en)	1995-09-26
EP0552767A3 (en)	1994-09-07
JP3676388B2 (ja)	2005-07-27
PL172245B1 (pl)	1997-08-29
DE59310380D1 (de)	2005-12-01
EP1142902B1 (de)	2005-10-26
ATE217881T1 (de)	2002-06-15
FI930221L (fi)	1993-07-23
JPH05310778A (ja)	1993-11-22
ZA93423B (en)	1993-09-09
NO930200L (no)	1993-07-23
KR100273824B1 (ko)	2000-12-15
HUT63172A (en)	1993-07-28
NO308609B1 (no)	2000-10-02
AU3191193A (en)	1993-07-29
DK0552767T3 (da)	2002-08-19
ATE307821T1 (de)	2005-11-15
US5646261A (en)	1997-07-08
AU657191B2 (en)	1995-03-02
FI930221A0 (fi)	1993-01-20
EP0552767A2 (de)	1993-07-28
PL297516A1 (en)	1993-09-06
KR930016438A (ko)	1993-08-26
IL104460A (en)	2003-03-12
HU9300161D0 (en)	1993-04-28
NO930200D0 (no)	1993-01-21
EP1142902A3 (de)	2001-10-17
EP0552767B1 (de)	2002-05-22
CA2087817A1 (en)	1993-07-23
DK1142902T3 (da)	2006-03-06
FI115215B (fi)	2005-03-31
EP1142902A2 (de)	2001-10-10
DE59310287D1 (de)	2002-06-27
CA2087817C (en)	2010-03-16

Publication	Publication Date	Title
PT552767E (pt)	2002-10-31	Analogos de oligonucleotidos 3'-derivatisados com agrupamentos nao nucleotidicos, sua preparacao e utilizacao
KR930016437A (ko)	1993-08-26	올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
FI104176B1 (fi)	1999-11-30	Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi
PT820461E (pt)	2005-09-30	Derivados de aril-ester de fosforamidato de 2',3'-didesidronucleosidos
NZ243153A (en)	1994-08-26	4a-substituted avermectin derivatives and anti-parasitic compositions thereof
WO2001026629A3 (en)	2002-05-10	Neutral-cationic lipid for nucleic acid and drug delivery
ATE156829T1 (de)	1997-08-15	Substituierte aminophosphonatderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE71526T1 (de)	1992-02-15	Stabilisierte anthracyclin-zubereitung.
DE69010795D1 (de)	1994-08-25	Zyklische Äther von Diaryläther.
FR2787109B1 (fr)	2001-01-19	Nouveaux derives de 1,2-dithiolane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL94980A0 (en)	1991-06-10	Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain,their preparation and pharmaceutical compositions containing them
IE831349L (en)	1983-12-10	4-aminopiperidine derivatives
DE69019786D1 (de)	1995-07-06	Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.
EP0182633A3 (en)	1987-09-02	Cephalosporin derivatives
ATE87926T1 (de)	1993-04-15	Ethylierte avermectine.
PT76834B (en)	1986-01-15	Process for the preparation of a pesticidal namely insecticidal acaricidal and/or nematocidal composition containing organophosphate pesticides
FR2699536B1 (fr)	1995-03-03	Nouveaux dérivés de p-[di(2-chloroéthyl)amino]phénylalanine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JPS6442499A (en)	1989-02-14	Cytosine derivative of racemic type
BR8005659A (pt)	1981-03-17	Composicoes pesticidas,sua aplicacao e preparacao e processo de preparacao de metanofosfonatos de propargilo
CA2019006A1 (en)	1991-12-14	Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
FR2332286A1 (fr)	1977-06-17	Nouveaux esters et amides d'esters de pyrimidinyle substitue d'acide (thiono)phosphorique (phosphonique), leur procede de preparation et leur application comme insecticides, acaricides et nematicides