ES2178496T3 - Preparado con espectro terapeutico mejorado, con contenido en inhibidores de la sintesis de nucleoticos. - Google Patents
Preparado con espectro terapeutico mejorado, con contenido en inhibidores de la sintesis de nucleoticos.Info
- Publication number
- ES2178496T3 ES2178496T3 ES99961041T ES99961041T ES2178496T3 ES 2178496 T3 ES2178496 T3 ES 2178496T3 ES 99961041 T ES99961041 T ES 99961041T ES 99961041 T ES99961041 T ES 99961041T ES 2178496 T3 ES2178496 T3 ES 2178496T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- group
- halogen
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 238000001228 spectrum Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229920001268 Cholestyramine Polymers 0.000 abstract 1
- 229920002911 Colestipol Polymers 0.000 abstract 1
- HZQDCMWJEBCWBR-UUOKFMHZSA-N Mizoribine Chemical compound OC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 HZQDCMWJEBCWBR-UUOKFMHZSA-N 0.000 abstract 1
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical group O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 abstract 1
- 229960002604 colestipol Drugs 0.000 abstract 1
- 230000010235 enterohepatic circulation Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229950000844 mizoribine Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002213 purine nucleotide Substances 0.000 abstract 1
- 150000003212 purines Chemical class 0.000 abstract 1
- 239000002719 pyrimidine nucleotide Substances 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Surgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Preparado que contiene 1) al menos un compuesto que reduce esencialmente la circulación enterohepática de los inhibidores de la síntesis de nucleótidos, del grupo colestipol, colestiramina y carbón activo, o un compuesto que, de modo desplazado en el tiempo, antagoniza el efecto de los inhibidores de la síntesis de nucleótidos, del grupo uridina, purina, nucleótidos de purina o nucleótidos de pirimidina, y 2) al menos un inhibidores de la síntesis de nucleótidos del grupo 4-hexenoato de 2-morfolinoetil-(E)-6(1, 3-dihidro-4-hidroxi-6-metoxi-7-metil-3-oxoisobenzofuran-5-il)-4-metilo, mizoribina y compuestos de la fórmula I o II **(Fórmulas)** y/o una forma eventualmente estereoisómera del compuesto de la fórmula I o II y/o una sal fisiológicamente tolerable del compuesto de la fórmula II, en la cual R1 representa a) alquilo(C1-C4), b) cicloalquilo(C3-C5), c) alquenilo(C2-C6), o d) alquinilo(C2-C6), R2 representa a) -CF3, b) -O-CF3, c) -S-CF3, d) -OH, e) -NO2, f) halógeno, g) bencilo, h) fenilo, i) -O-fenilo, k) -CN, o l) -O-fenilo sustituido, una o varias veces, con 1) alquilo(C1-C4), 2) halógeno, 3) -O-CF3, o 4) -O-CH3, R3 representa a) alquilo(C1-C4), b) halógeno, o c) un átomo de hidrógeno, y X representa a) un grupo -CH, o b) un átomo de nitrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19857009A DE19857009A1 (de) | 1998-12-10 | 1998-12-10 | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2178496T3 true ES2178496T3 (es) | 2002-12-16 |
Family
ID=7890633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99961041T Expired - Lifetime ES2178496T3 (es) | 1998-12-10 | 1999-12-01 | Preparado con espectro terapeutico mejorado, con contenido en inhibidores de la sintesis de nucleoticos. |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1137438B1 (es) |
| JP (1) | JP2002531525A (es) |
| KR (1) | KR20010080729A (es) |
| CN (1) | CN1189214C (es) |
| AR (1) | AR021577A1 (es) |
| AT (1) | ATE218370T1 (es) |
| AU (1) | AU766810B2 (es) |
| BG (1) | BG105548A (es) |
| BR (1) | BR9916006A (es) |
| CA (1) | CA2354266A1 (es) |
| CZ (1) | CZ20012029A3 (es) |
| DE (2) | DE19857009A1 (es) |
| DK (1) | DK1137438T3 (es) |
| EA (1) | EA005136B1 (es) |
| EE (1) | EE200100305A (es) |
| ES (1) | ES2178496T3 (es) |
| HK (1) | HK1041598B (es) |
| HR (1) | HRP20010429A2 (es) |
| HU (1) | HUP0104624A3 (es) |
| IL (1) | IL143586A0 (es) |
| MX (1) | MXPA01005861A (es) |
| NO (1) | NO20012719D0 (es) |
| NZ (1) | NZ511882A (es) |
| PL (1) | PL349336A1 (es) |
| PT (1) | PT1137438E (es) |
| SI (1) | SI1137438T1 (es) |
| SK (1) | SK284842B6 (es) |
| WO (1) | WO2000033876A1 (es) |
| YU (1) | YU39901A (es) |
| ZA (1) | ZA200104815B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10112924A1 (de) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | 1-Butansäurederivate, pharmazeutische Zusammensetzungen enthaltend solche Derivate und Verwendungen solcher Derivate |
| US20040152772A1 (en) * | 2001-03-13 | 2004-08-05 | Erich Eigenbrodt | 1-butyric acid derivatives and the use thereof |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| WO2004012746A2 (en) * | 2002-08-02 | 2004-02-12 | The Regents Of The University Of California | New uses for inhibitors of inosine monophosphate dehydrogenase |
| EP1534666A1 (de) | 2002-09-06 | 2005-06-01 | Schebo Biotech AG | Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes |
| WO2005060980A1 (ja) * | 2003-12-24 | 2005-07-07 | Masaakira Shonago | 疾患治療用医薬及び糖尿病治療用医薬 |
| DE102005017592A1 (de) * | 2005-04-16 | 2006-10-19 | Lindner, Jürgen, Dr. med. | Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem |
| EA015952B1 (ru) | 2007-05-03 | 2011-12-30 | Пфайзер Лимитед | 2-пиридинкарбоксамидные производные в качестве модуляторов натриевых каналов |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
| EP0538783B1 (de) * | 1991-10-23 | 1995-09-27 | Hoechst Aktiengesellschaft | N-phenyl-2-cyano-3-hydroxycrotonsäureamidderivate und deren Verwendung als Arzneimittel mit immunmodulatorischer Eigenschaft |
| IT1254519B (it) * | 1992-03-16 | 1995-09-25 | Chiesi Farma Spa | Associazioni di composti ad attivita' antivirale |
| DE19539638A1 (de) * | 1995-10-25 | 1997-04-30 | Hoechst Ag | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
| WO1998013047A1 (en) * | 1996-09-26 | 1998-04-02 | Williams, James, W. | Improved therapeutic uses of 4-quinoline-carboxylic acid derivatives |
-
1998
- 1998-12-10 DE DE19857009A patent/DE19857009A1/de not_active Withdrawn
-
1999
- 1999-12-01 MX MXPA01005861A patent/MXPA01005861A/es active IP Right Grant
- 1999-12-01 DK DK99961041T patent/DK1137438T3/da active
- 1999-12-01 NZ NZ511882A patent/NZ511882A/en unknown
- 1999-12-01 SI SI9930063T patent/SI1137438T1/xx unknown
- 1999-12-01 YU YU39901A patent/YU39901A/sh unknown
- 1999-12-01 ES ES99961041T patent/ES2178496T3/es not_active Expired - Lifetime
- 1999-12-01 IL IL14358699A patent/IL143586A0/xx unknown
- 1999-12-01 KR KR1020017007176A patent/KR20010080729A/ko not_active Ceased
- 1999-12-01 JP JP2000586366A patent/JP2002531525A/ja not_active Withdrawn
- 1999-12-01 PL PL99349336A patent/PL349336A1/xx not_active Application Discontinuation
- 1999-12-01 AU AU17793/00A patent/AU766810B2/en not_active Ceased
- 1999-12-01 HU HU0104624A patent/HUP0104624A3/hu unknown
- 1999-12-01 SK SK788-2001A patent/SK284842B6/sk unknown
- 1999-12-01 BR BR9916006-4A patent/BR9916006A/pt not_active IP Right Cessation
- 1999-12-01 CZ CZ20012029A patent/CZ20012029A3/cs unknown
- 1999-12-01 WO PCT/EP1999/009380 patent/WO2000033876A1/de not_active Ceased
- 1999-12-01 DE DE59901681T patent/DE59901681D1/de not_active Expired - Fee Related
- 1999-12-01 EE EEP200100305A patent/EE200100305A/xx unknown
- 1999-12-01 EA EA200100647A patent/EA005136B1/ru not_active IP Right Cessation
- 1999-12-01 PT PT99961041T patent/PT1137438E/pt unknown
- 1999-12-01 CA CA002354266A patent/CA2354266A1/en not_active Abandoned
- 1999-12-01 EP EP99961041A patent/EP1137438B1/de not_active Expired - Lifetime
- 1999-12-01 AT AT99961041T patent/ATE218370T1/de not_active IP Right Cessation
- 1999-12-01 CN CNB998142433A patent/CN1189214C/zh not_active Expired - Fee Related
- 1999-12-01 HK HK02103282.9A patent/HK1041598B/zh not_active IP Right Cessation
- 1999-12-01 HR HR20010429A patent/HRP20010429A2/hr not_active Application Discontinuation
- 1999-12-07 AR ARP990106239A patent/AR021577A1/es not_active Application Discontinuation
-
2001
- 2001-05-30 BG BG105548A patent/BG105548A/xx unknown
- 2001-06-01 NO NO20012719A patent/NO20012719D0/no not_active Application Discontinuation
- 2001-06-13 ZA ZA200104815A patent/ZA200104815B/en unknown
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