ES2178496T3 - Preparado con espectro terapeutico mejorado, con contenido en inhibidores de la sintesis de nucleoticos. - Google Patents
Preparado con espectro terapeutico mejorado, con contenido en inhibidores de la sintesis de nucleoticos.Info
- Publication number
- ES2178496T3 ES2178496T3 ES99961041T ES99961041T ES2178496T3 ES 2178496 T3 ES2178496 T3 ES 2178496T3 ES 99961041 T ES99961041 T ES 99961041T ES 99961041 T ES99961041 T ES 99961041T ES 2178496 T3 ES2178496 T3 ES 2178496T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- group
- halogen
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 238000001228 spectrum Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229920001268 Cholestyramine Polymers 0.000 abstract 1
- 229920002911 Colestipol Polymers 0.000 abstract 1
- HZQDCMWJEBCWBR-UUOKFMHZSA-N Mizoribine Chemical compound OC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 HZQDCMWJEBCWBR-UUOKFMHZSA-N 0.000 abstract 1
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical group O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 abstract 1
- 229960002604 colestipol Drugs 0.000 abstract 1
- 230000010235 enterohepatic circulation Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229950000844 mizoribine Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002213 purine nucleotide Substances 0.000 abstract 1
- 150000003212 purines Chemical class 0.000 abstract 1
- 239000002719 pyrimidine nucleotide Substances 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
Preparado que contiene 1) al menos un compuesto que reduce esencialmente la circulación enterohepática de los inhibidores de la síntesis de nucleótidos, del grupo colestipol, colestiramina y carbón activo, o un compuesto que, de modo desplazado en el tiempo, antagoniza el efecto de los inhibidores de la síntesis de nucleótidos, del grupo uridina, purina, nucleótidos de purina o nucleótidos de pirimidina, y 2) al menos un inhibidores de la síntesis de nucleótidos del grupo 4-hexenoato de 2-morfolinoetil-(E)-6(1, 3-dihidro-4-hidroxi-6-metoxi-7-metil-3-oxoisobenzofuran-5-il)-4-metilo, mizoribina y compuestos de la fórmula I o II **(Fórmulas)** y/o una forma eventualmente estereoisómera del compuesto de la fórmula I o II y/o una sal fisiológicamente tolerable del compuesto de la fórmula II, en la cual R1 representa a) alquilo(C1-C4), b) cicloalquilo(C3-C5), c) alquenilo(C2-C6), o d) alquinilo(C2-C6), R2 representa a) -CF3, b) -O-CF3, c) -S-CF3, d) -OH, e) -NO2, f) halógeno, g) bencilo, h) fenilo, i) -O-fenilo, k) -CN, o l) -O-fenilo sustituido, una o varias veces, con 1) alquilo(C1-C4), 2) halógeno, 3) -O-CF3, o 4) -O-CH3, R3 representa a) alquilo(C1-C4), b) halógeno, o c) un átomo de hidrógeno, y X representa a) un grupo -CH, o b) un átomo de nitrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19857009A DE19857009A1 (de) | 1998-12-10 | 1998-12-10 | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2178496T3 true ES2178496T3 (es) | 2002-12-16 |
Family
ID=7890633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99961041T Expired - Lifetime ES2178496T3 (es) | 1998-12-10 | 1999-12-01 | Preparado con espectro terapeutico mejorado, con contenido en inhibidores de la sintesis de nucleoticos. |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1137438B1 (es) |
| JP (1) | JP2002531525A (es) |
| KR (1) | KR20010080729A (es) |
| CN (1) | CN1189214C (es) |
| AR (1) | AR021577A1 (es) |
| AT (1) | ATE218370T1 (es) |
| AU (1) | AU766810B2 (es) |
| BG (1) | BG105548A (es) |
| BR (1) | BR9916006A (es) |
| CA (1) | CA2354266A1 (es) |
| CZ (1) | CZ20012029A3 (es) |
| DE (2) | DE19857009A1 (es) |
| DK (1) | DK1137438T3 (es) |
| EA (1) | EA005136B1 (es) |
| EE (1) | EE200100305A (es) |
| ES (1) | ES2178496T3 (es) |
| HK (1) | HK1041598B (es) |
| HR (1) | HRP20010429A2 (es) |
| HU (1) | HUP0104624A3 (es) |
| IL (1) | IL143586A0 (es) |
| MX (1) | MXPA01005861A (es) |
| NO (1) | NO20012719D0 (es) |
| NZ (1) | NZ511882A (es) |
| PL (1) | PL349336A1 (es) |
| PT (1) | PT1137438E (es) |
| SI (1) | SI1137438T1 (es) |
| SK (1) | SK284842B6 (es) |
| WO (1) | WO2000033876A1 (es) |
| YU (1) | YU39901A (es) |
| ZA (1) | ZA200104815B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10112924A1 (de) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | 1-Butansäurederivate, pharmazeutische Zusammensetzungen enthaltend solche Derivate und Verwendungen solcher Derivate |
| EP1377291A2 (de) * | 2001-03-13 | 2004-01-07 | Protagen AG | 1-butansäuderivate wie z.b. carbomethoxypropionylcyanid oder leflunomidderivate und deren therapeutische anwendung |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| WO2004012746A2 (en) * | 2002-08-02 | 2004-02-12 | The Regents Of The University Of California | New uses for inhibitors of inosine monophosphate dehydrogenase |
| EP1534666A1 (de) | 2002-09-06 | 2005-06-01 | Schebo Biotech AG | Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes |
| JPWO2005060980A1 (ja) * | 2003-12-24 | 2007-12-13 | 正彬 少名子 | 疾患治療用医薬及び糖尿病治療用医薬 |
| DE102005017592A1 (de) * | 2005-04-16 | 2006-10-19 | Lindner, Jürgen, Dr. med. | Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem |
| WO2008135826A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Limited | 2 -pyridine carboxamide derivatives as sodium channel modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
| NZ244814A (en) * | 1991-10-23 | 1994-06-27 | Hoechst Ag | N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and pharmaceutical compositions |
| IT1254519B (it) * | 1992-03-16 | 1995-09-25 | Chiesi Farma Spa | Associazioni di composti ad attivita' antivirale |
| DE19539638A1 (de) * | 1995-10-25 | 1997-04-30 | Hoechst Ag | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
| AU4596097A (en) * | 1996-09-26 | 1998-04-17 | Williams, James W. | Improved therapeutic uses of 4-quinoline-carboxylic acid derivatives |
-
1998
- 1998-12-10 DE DE19857009A patent/DE19857009A1/de not_active Withdrawn
-
1999
- 1999-12-01 ES ES99961041T patent/ES2178496T3/es not_active Expired - Lifetime
- 1999-12-01 AT AT99961041T patent/ATE218370T1/de not_active IP Right Cessation
- 1999-12-01 HU HU0104624A patent/HUP0104624A3/hu unknown
- 1999-12-01 DE DE59901681T patent/DE59901681D1/de not_active Expired - Fee Related
- 1999-12-01 SK SK788-2001A patent/SK284842B6/sk unknown
- 1999-12-01 CZ CZ20012029A patent/CZ20012029A3/cs unknown
- 1999-12-01 WO PCT/EP1999/009380 patent/WO2000033876A1/de not_active Ceased
- 1999-12-01 BR BR9916006-4A patent/BR9916006A/pt not_active IP Right Cessation
- 1999-12-01 JP JP2000586366A patent/JP2002531525A/ja not_active Withdrawn
- 1999-12-01 MX MXPA01005861A patent/MXPA01005861A/es active IP Right Grant
- 1999-12-01 PT PT99961041T patent/PT1137438E/pt unknown
- 1999-12-01 EP EP99961041A patent/EP1137438B1/de not_active Expired - Lifetime
- 1999-12-01 HK HK02103282.9A patent/HK1041598B/zh not_active IP Right Cessation
- 1999-12-01 AU AU17793/00A patent/AU766810B2/en not_active Ceased
- 1999-12-01 CN CNB998142433A patent/CN1189214C/zh not_active Expired - Fee Related
- 1999-12-01 PL PL99349336A patent/PL349336A1/xx not_active Application Discontinuation
- 1999-12-01 SI SI9930063T patent/SI1137438T1/xx unknown
- 1999-12-01 YU YU39901A patent/YU39901A/sh unknown
- 1999-12-01 HR HR20010429A patent/HRP20010429A2/hr not_active Application Discontinuation
- 1999-12-01 EE EEP200100305A patent/EE200100305A/xx unknown
- 1999-12-01 CA CA002354266A patent/CA2354266A1/en not_active Abandoned
- 1999-12-01 EA EA200100647A patent/EA005136B1/ru not_active IP Right Cessation
- 1999-12-01 IL IL14358699A patent/IL143586A0/xx unknown
- 1999-12-01 DK DK99961041T patent/DK1137438T3/da active
- 1999-12-01 KR KR1020017007176A patent/KR20010080729A/ko not_active Ceased
- 1999-12-01 NZ NZ511882A patent/NZ511882A/en unknown
- 1999-12-07 AR ARP990106239A patent/AR021577A1/es not_active Application Discontinuation
-
2001
- 2001-05-30 BG BG105548A patent/BG105548A/xx unknown
- 2001-06-01 NO NO20012719A patent/NO20012719D0/no not_active Application Discontinuation
- 2001-06-13 ZA ZA200104815A patent/ZA200104815B/en unknown
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