ES2178632T3 - Compuestos de benzoquinazolina farmaceuticamente activos. - Google Patents

Compuestos de benzoquinazolina farmaceuticamente activos.

Info

Publication number
ES2178632T3
ES2178632T3 ES91910823T ES91910823T ES2178632T3 ES 2178632 T3 ES2178632 T3 ES 2178632T3 ES 91910823 T ES91910823 T ES 91910823T ES 91910823 T ES91910823 T ES 91910823T ES 2178632 T3 ES2178632 T3 ES 2178632T3
Authority
ES
Spain
Prior art keywords
group
rent
hydrogen
compounds
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910823T
Other languages
English (en)
Inventor
William Pendergast
Scott Howard Dickerson
Julius Vass Johnson
Robert Ferone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2178632T3 publication Critical patent/ES2178632T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) O SALES DE LOS MISMOS, EN LA QUE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O DOBLE, R1 ES ALQUIL O AMINO OPCIONALMENTE SUBSTITUDO POR UN GRUPO ALQUIL, ALCANOIL O BENCIL; R2, R3, R4 Y R5 SON IGUALES O DIFERENTES Y CADA UNA DE ELLAS ESTA SELECCIONADA ENTRE HIDROGENO, FENIL, HALO, NITRO, UN GRUPO S(O)NR8 EN EL QUE N ES UN ENTERO QUE VALE 0, 1 O 2 Y R8 ES HALO O ALQUIL O UN GRUPO NR9R10 EN EL QUE R9 Y R10 SON AMBAS HIDROGENO, UN GRUPO NR11R12 EN DONDE R11 Y R12 SON IGUALES O DIFERENTES Y CADA UNA DE ELLAS ES HIDROGENO O ALQUIL, UN GRUPO OR13 EN DONDE R13 ES HIDROGENO O UN GRUPO ALQUIL C1-4 OPCIONALMENTE SUBSTITUIDO POR HALO; UN GRUPO ALIFATICO C1-C4 OPCIONALMENTE SUBSTITUIDO POR UN GRUPO OR14 O NR14R15 EN DONDE R14 O R15 SON IGUALES O DIFERENTES Y CADA UNA DE ELLAS ES HIDROGENO O ALQUIL; O DOS DE ENTRE R2 Y R5 SE ENCUENTRAN UNIDAS JUNTAS PARA FORMAR UN GRUPO BENZO, O UNA DE ENTRE R2 Y R5 ES UN GRUPO X-Y-R16 EN EL QUE X ES CH2, NR17, CO O S(O)M E Y ES CH2, NR17, O S(O)M, O X-Y ES O, NR17, -CH=CHN=N. LOS COMPUESTOS SON ADECUADOS COMO AGENTES FARMACOLOGICOS UTILES EN EL TRATAMIENTO DE TUMORES. TAMBIEN SE DESCRIBEN COMPOSICIONES FARMACEUTICAS Y METODOS PARA LA PREPARACION DE LOS COMPUESTOS DE LA FORMULA (I).
ES91910823T 1990-06-19 1991-06-18 Compuestos de benzoquinazolina farmaceuticamente activos. Expired - Lifetime ES2178632T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909013615A GB9013615D0 (en) 1990-06-19 1990-06-19 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ES2178632T3 true ES2178632T3 (es) 2003-01-01

Family

ID=10677828

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91910823T Expired - Lifetime ES2178632T3 (es) 1990-06-19 1991-06-18 Compuestos de benzoquinazolina farmaceuticamente activos.
ES02075192T Expired - Lifetime ES2211851T3 (es) 1990-06-19 1991-06-18 Compuesto de benzoquinozolina farmaceuticamente activos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02075192T Expired - Lifetime ES2211851T3 (es) 1990-06-19 1991-06-18 Compuesto de benzoquinozolina farmaceuticamente activos.

Country Status (26)

Country Link
US (4) US6090941A (es)
EP (2) EP0535034B1 (es)
JP (1) JP2966929B2 (es)
KR (1) KR0183042B1 (es)
CN (1) CN1049215C (es)
AP (1) AP218A (es)
AT (2) ATE222243T1 (es)
AU (1) AU639815B2 (es)
CA (1) CA2085589C (es)
CS (1) CS186391A3 (es)
DE (2) DE69133371T2 (es)
DK (2) DK0535034T3 (es)
ES (2) ES2178632T3 (es)
FI (1) FI925778A0 (es)
GB (1) GB9013615D0 (es)
HU (2) HUT62273A (es)
IE (1) IE912073A1 (es)
IL (1) IL98542A (es)
MC (1) MC2290A1 (es)
MY (1) MY107001A (es)
NO (1) NO924929D0 (es)
NZ (1) NZ238582A (es)
PL (1) PL169927B1 (es)
PT (1) PT98021B (es)
WO (1) WO1991019700A1 (es)
ZA (1) ZA914676B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9226842D0 (en) 1992-12-23 1993-02-17 Wellcome Found Pharmaceutical compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
US6420344B1 (en) 1999-03-16 2002-07-16 The Regents Of The University Of California Glycosylated polyamines
CN1446080A (zh) * 2000-06-09 2003-10-01 Osi药物公司 脂质体苯并喹唑啉胸苷酸合成酶抑制剂制剂
BR0212829A (pt) * 2001-09-26 2004-08-03 Bayer Pharmaceuticals Corp Derivados de 1,8-naftiridina e seu uso para tratar diabetes e distúrbios relacionados
CN100434425C (zh) * 2005-03-09 2008-11-19 首都师范大学 4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用
EP1754484A1 (en) 2005-08-17 2007-02-21 Dan Stoicescu Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes
JP5237821B2 (ja) 2005-12-05 2013-07-17 日東電工株式会社 ポリグルタミン酸−アミノ酸結合体および方法
GB0525069D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP1958632A1 (en) 2007-02-14 2008-08-20 Dan Stoicescu Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
EP2155253A2 (en) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
DK2155255T3 (da) * 2007-05-09 2013-09-02 Nitto Denko Corp Sammensætninger der omfatter en hydrofob forbindelse og et polyaminosyrekonjugat
US8146622B2 (en) 2007-08-20 2012-04-03 Ford Global Technologies, Llc Switch and hose-valve connection arrangement for vehicle temporary mobility kit
US8517760B2 (en) 2007-08-20 2013-08-27 Ford Global Technologies, Llc Cord wrap and power plug receptacle arrangement for inflator
US8501242B2 (en) 2009-05-29 2013-08-06 University Of Florida Research Foundation Methods and compositions for treating neoplasia
CN101580501B (zh) * 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
WO2011078226A1 (ja) * 2009-12-22 2011-06-30 協和発酵キリン株式会社 三環系化合物
CA3195150A1 (en) 2020-10-08 2022-04-14 Sven Weiler Benzo[h]quinazolin-4-amine and thieno[3,2-h]quinazolin-4-amine derivatives for the treatment of cancer
CN116547280A (zh) * 2020-10-08 2023-08-04 雷多纳治疗公司 用于治疗癌症的苯并[h]喹唑啉-4-胺和噻吩并[3,2-h]喹唑啉-4-胺衍生物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UST862021I4 (en) * 1969-01-27 1969-05-27 Defensive publication
DE2202847A1 (de) * 1971-02-05 1972-08-17 Apaw Sa Speiseeismaschine,insbesondere fuer Familiengebrauch,Kleinbetriebe od.dgl.
EP0031237B1 (en) * 1979-12-19 1984-10-17 National Research Development Corporation Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US4603186A (en) 1985-10-21 1986-07-29 The Standard Oil Company Tetrapolymers containing indene
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5405851A (en) * 1990-06-19 1995-04-11 Burroughs Wellcome Co. Pharmaceutical compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds

Also Published As

Publication number Publication date
US5661155A (en) 1997-08-26
IL98542A0 (en) 1992-07-15
DK0535034T3 (da) 2002-12-09
PT98021B (pt) 1998-11-30
HU211265A9 (en) 1995-11-28
FI925778A7 (fi) 1992-12-18
US6090941A (en) 2000-07-18
NZ238582A (en) 1993-12-23
FI925778A0 (fi) 1992-12-18
ES2211851T3 (es) 2004-07-16
HU9204011D0 (en) 1993-03-29
JPH05507704A (ja) 1993-11-04
CA2085589C (en) 2001-12-18
EP1199307B1 (en) 2004-02-25
KR930701415A (ko) 1993-06-11
DE69133088T2 (de) 2003-03-20
US6306865B1 (en) 2001-10-23
KR0183042B1 (ko) 1999-05-01
DE69133371D1 (de) 2004-04-01
MY107001A (en) 1995-08-30
IE912073A1 (en) 1992-01-01
DE69133088D1 (de) 2002-09-19
EP0535034A1 (en) 1993-04-07
JP2966929B2 (ja) 1999-10-25
CA2085589A1 (en) 1991-12-20
CN1049215C (zh) 2000-02-09
AU639815B2 (en) 1993-08-05
GB9013615D0 (en) 1990-08-08
HUT62273A (en) 1993-04-28
NO924929L (no) 1992-12-18
CS186391A3 (en) 1992-04-15
DE69133371T2 (de) 2005-01-27
AP218A (en) 1992-09-27
MC2290A1 (fr) 1993-07-14
AU8094391A (en) 1992-01-07
PL169927B1 (pl) 1996-09-30
EP1199307A1 (en) 2002-04-24
DK1199307T3 (da) 2004-06-14
WO1991019700A1 (en) 1991-12-26
IL98542A (en) 1995-05-26
ZA914676B (en) 1993-02-24
EP0535034B1 (en) 2002-08-14
ATE222243T1 (de) 2002-08-15
CN1058208A (zh) 1992-01-29
PT98021A (pt) 1992-04-30
AP9100283A0 (en) 1991-07-31
ATE260262T1 (de) 2004-03-15
US5663337A (en) 1997-09-02
NO924929D0 (no) 1992-12-18

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