ES2178699T3 - Preparaciones antitumorales que contienen un acido lipoteicoico procedente de streptococcus. - Google Patents

Preparaciones antitumorales que contienen un acido lipoteicoico procedente de streptococcus.

Info

Publication number
ES2178699T3
ES2178699T3 ES96902922T ES96902922T ES2178699T3 ES 2178699 T3 ES2178699 T3 ES 2178699T3 ES 96902922 T ES96902922 T ES 96902922T ES 96902922 T ES96902922 T ES 96902922T ES 2178699 T3 ES2178699 T3 ES 2178699T3
Authority
ES
Spain
Prior art keywords
new
lta
streptococcus
grop
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96902922T
Other languages
English (en)
Inventor
Peter Truog
Peter Rothlisberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lunamed AG
Original Assignee
Lunamed AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lunamed AG filed Critical Lunamed AG
Application granted granted Critical
Publication of ES2178699T3 publication Critical patent/ES2178699T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO ACIDO LIPOTEICOICO QUE PUEDE AISLARSE A PARTIR DEL NUEVO STEPTOCOCCUS SP DSM8747. EL NUEVO LTA SE DENOMINA LTA-T. TIENE UN ANCLAJE DE LIPIDO, QUE ES UN GALACTOFURANOSIL-BETA-1,3-GLICEROL CON DIFERENTES RESTOS DE ACIDOS GRASOS ESTERIFICADOS A LOS DOS GRUPOS HIDROXI ADYACENTES EN LA UNIDAD GLICEROL Y UNA CADENA GROP NO RAMIFICADA, LINEAL Y NO GLICOSILADA CON UNA CADENA GROP CORTA HIDROFILA NO USUAL. LA CARACTERISTICA HIDROFILA CONSISTE EN 10 UNIDADES DE GLICEROFOSFATO ESTERIFICADAS CON D-ALANINA EN UNA EXTENSION DE UN 30%. LA INVENCION SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA CON EL NUEVO LTA-T, OPCIONALMENTE JUNTO CON UNA MENOQUINA Y/O UNA HALURONIDASA, A UN METODO PARA TRATAR EL CANCER QUE CONSISTE EN ADMINISTRAR UNA CANTIDAD ANTITUMORAL EFECTIVA DE ESTA COMPOSICION, A UN METODO PARA PRODUCIR EL NUEVO COMPUESTO Y LA NUEVA COMPOSICION FARMACEUTICA, A DOS PRODUCTOS DE DEGRADACION DEL NUEVO LTA-T Y SU USO, Y A LA NUEVA CEPA DE STEPTOCOCCUS A PARTIR DE LA CUAL SE AISLA EL NUEVO COMPUESTO.
ES96902922T 1995-01-30 1996-01-24 Preparaciones antitumorales que contienen un acido lipoteicoico procedente de streptococcus. Expired - Lifetime ES2178699T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95101208 1995-01-30

Publications (1)

Publication Number Publication Date
ES2178699T3 true ES2178699T3 (es) 2003-01-01

Family

ID=8218940

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96902922T Expired - Lifetime ES2178699T3 (es) 1995-01-30 1996-01-24 Preparaciones antitumorales que contienen un acido lipoteicoico procedente de streptococcus.

Country Status (11)

Country Link
US (2) US6114161A (es)
EP (1) EP0807185B9 (es)
JP (1) JP3638955B2 (es)
CN (1) CN1113102C (es)
AT (1) ATE219146T1 (es)
AU (1) AU4714196A (es)
CA (1) CA2208780C (es)
DE (1) DE69621776T2 (es)
DK (1) DK0807185T3 (es)
ES (1) ES2178699T3 (es)
WO (1) WO1996023896A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0807185B9 (en) * 1995-01-30 2002-12-11 Lunamed AG Antitumor preparations containing a lipoteichoic acid from steptococcus
US6610293B1 (en) 1997-06-16 2003-08-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
DE19728900A1 (de) * 1997-07-07 1999-01-14 Henkel Kgaa Hydrophile Glykoside
CA2326821C (en) * 1998-04-02 2010-09-28 The Board Of Regents Of The University Of Oklahoma Nucleic acid encoding hyaluronan synthase and methods of use
CA2455827C (en) * 2001-08-13 2015-06-09 University Of Florida Research Foundation, Inc. Materials and methods for nerve grafting comprising degrading chondroitin sulfate proteoglycan
AU2003220115A1 (en) * 2002-05-20 2003-12-12 Board Of Regents, The University Of Texas System Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
KR100443080B1 (ko) * 2002-07-11 2004-08-04 일동제약주식회사 콜레스테롤 저하능을 갖는 스트렙토코커스 페시움 균주
EP1567868A4 (en) * 2002-12-02 2008-02-06 Biosynexus Inc CELL WALL TEICHONSURE AS A GOAL F RANTI-STAPHYLOCOCCUS THERAPIES AND VACCINATES
GB0717442D0 (en) * 2007-09-07 2007-10-17 Isis Innovation Compositions and uses thereof
CN102666583B (zh) 2009-07-15 2015-11-25 Aimm医疗股份公司 革兰氏阳性细菌特异性结合化合物
JP2013502456A (ja) * 2009-08-26 2013-01-24 アールエヌエー アイエヌシー リポタイコ酸由来の糖脂質及びこれを含む組成物
EP2380565A1 (en) 2010-03-31 2011-10-26 Lunamed AG Compositions for dental treatment comprising Lipoteichoic acids or parts thereof like mono- or polyglycerphosphates
EP2500349B1 (en) * 2011-03-11 2015-05-06 Universitätsklinikum Freiburg Synthetic LTA mimetics and use thereof as vaccine component for therapy and/or prophylaxis against gram-positive infections
EP2545911A1 (en) 2011-07-12 2013-01-16 Lunamed AG Use of Lipoteichoic Acid in the Treatment of Non-Encapsulated Cancer Cells
EP2545910A1 (en) 2011-07-12 2013-01-16 Lunamed AG Use of Lipoteichoic Acid in the treatment of cancer in an inflammatory state
EP2545909A1 (en) 2011-07-12 2013-01-16 Lunamed AG Combination of D-Amino Acids and Lipoteichoic Acid
EP2574237A1 (en) 2011-09-30 2013-04-03 Lunamed AG Use of a lipoteichoic acid, mono- or polyglycerophosphate for antibacterial pre-treatment and especially in medical devices
EP2589387A1 (en) 2011-11-04 2013-05-08 Lunamed AG Use of a teichoic acid for the treatment of malignant liquor cerebrospinalis in the brain
EP2589388A1 (en) 2011-11-04 2013-05-08 Lunamed AG Use of a Teichoic acid for the treatment of malignant ascites
KR20190137397A (ko) * 2018-06-01 2019-12-11 경희대학교 산학협력단 리포테이코익산, TNF-α 및 IFN-γ를 유효성분으로 함유하는 항암용 조성물
KR102259799B1 (ko) * 2018-06-01 2021-06-02 경희대학교 산학협력단 리포테이코익산, TNF-α 및 IFN-γ를 유효성분으로 함유하는 항암용 조성물
CN115279380A (zh) 2019-12-27 2022-11-01 佰欧波利斯有限公司 来自双歧杆菌的脂磷壁酸的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3729461A (en) * 1970-12-23 1973-04-24 Us Agriculture Synthesis of glycosyl glycerides
SU787414A1 (ru) * 1978-10-05 1980-12-15 Московский Ордена Трудового Красного Знамени Институт Тонкой Химической Технологии Им. М.В. Ломоносова Способ получени 1,2-ди-0-пальмитоил- 3-0-/6-0-(1,2-ди-0-пальмитоил- - глицеро-3-0-фосфорил)- - глюкопиранозил/- -глицерина
US4678773A (en) * 1983-08-26 1987-07-07 Chugai Seiyaku Kabushiki Kaisha Antitumor agent
JPS61275217A (ja) * 1985-05-29 1986-12-05 Yakult Honsha Co Ltd グラム陰性桿菌感染症防御剤
JPS6456692A (en) * 1987-08-27 1989-03-03 Nisshin Oil Mills Ltd Production of sugar glycerol
JPS6467237A (en) * 1987-09-09 1989-03-13 Nisshin Oil Mills Ltd Novel surface active composition and emulsified composition combined therewith
NL9100510A (nl) * 1991-03-21 1992-10-16 Centraal Diergeneeskundig Inst Dna-sequenties die coderen voor kenmerken van virulentie van streptococcus suis en delen daarvan, daarvan afgeleide polypeptiden en antilichamen, alsmede toepassing daarvan bij de diagnose van en de bescherming tegen infectie met s. suis bij zoogdieren, waaronder de mens.
AU6362594A (en) * 1993-03-10 1994-09-26 Miles Inc. Hyaluronic acid used as a cancer treatment
EP0807185B9 (en) * 1995-01-30 2002-12-11 Lunamed AG Antitumor preparations containing a lipoteichoic acid from steptococcus

Also Published As

Publication number Publication date
DE69621776T2 (de) 2003-01-30
EP0807185A1 (en) 1997-11-19
US6214978B1 (en) 2001-04-10
JPH11500901A (ja) 1999-01-26
US6114161A (en) 2000-09-05
EP0807185B1 (en) 2002-06-12
AU4714196A (en) 1996-08-21
WO1996023896A1 (en) 1996-08-08
DE69621776D1 (de) 2002-07-18
CA2208780A1 (en) 1996-08-08
DK0807185T3 (da) 2002-10-07
CA2208780C (en) 2010-03-30
CN1173206A (zh) 1998-02-11
JP3638955B2 (ja) 2005-04-13
ATE219146T1 (de) 2002-06-15
EP0807185B9 (en) 2002-12-11
CN1113102C (zh) 2003-07-02

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