ES2178749T3 - Procedimiento para la produccion a gran escala de astaxantina a partir de haematococcus. - Google Patents

Procedimiento para la produccion a gran escala de astaxantina a partir de haematococcus.

Info

Publication number
ES2178749T3
ES2178749T3 ES97901245T ES97901245T ES2178749T3 ES 2178749 T3 ES2178749 T3 ES 2178749T3 ES 97901245 T ES97901245 T ES 97901245T ES 97901245 T ES97901245 T ES 97901245T ES 2178749 T3 ES2178749 T3 ES 2178749T3
Authority
ES
Spain
Prior art keywords
cells
haematococcus
conditions
astaxantine
large scale
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97901245T
Other languages
English (en)
Inventor
Sammy Boussiba
Avigad Vonshak
Zvi Cohen
Amos Richmond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ben Gurion University of the Negev Research and Development Authority Ltd
Ben Gurion University of the Negev BGU
Original Assignee
Ben Gurion University of the Negev Research and Development Authority Ltd
Ben Gurion University of the Negev BGU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ben Gurion University of the Negev Research and Development Authority Ltd, Ben Gurion University of the Negev BGU filed Critical Ben Gurion University of the Negev Research and Development Authority Ltd
Application granted granted Critical
Publication of ES2178749T3 publication Critical patent/ES2178749T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE CULTIVO DE CELULAS DE HAEMATOCOCCUS, PARA LA PRODUCCION A GRAN ESCALA DE CELULAS DE HAEMATOCOCCUS ENRIQUECIDAS EN ASTAXANTINA, QUE CONSISTE EN: (A) CULTIVAR DICHAS CELULAS DE HAEMATOCOCCUS BAJO CONDICIONES ADECUADAS PARA UN CRECIMIENTO VEGETATIVO OPTIMO DE LAS MISMAS, CONSISTIENDO DICHAS CONDICIONES EN CULTIVAR LAS CELULAS BAJO UNA INTENSIDAD DE LUZ COMPRENDIDA ENTRE 30-140 MI MOLES DE FOTONES (POR) M -2 (POR) S -1 Y A UNA TEMPERAT URA COMPRENDIDA ENTRE 15 Y 28 (GRADOS) C; Y (B) RECOGER LAS CELULAS CULTIVADAS SEGUN (A) Y CULTIVARLAS NUEVAMENTE BAJO CONDICIONES ADECUADAS PARA UNA INDUCCION Y ACUMULACION OPTIMAS DE ASTAXANTINA EN DICHAS CELULAS, CONSISTIENDO DICHAS CONDICIONES EN INOCULAR DICHAS CELULAS PROCEDENTES DE LA FASE (A) EN UNA SOLUCION DE CULTIVO QUE CONTIENE FUNDAMENTALMENTE UNA FUENTE DE CARBONO Y HACIENDO CRECER DICHAS CELULAS A UNA TEMPERATURA INFERIOR A 35 (GRADOS) C.
ES97901245T 1996-02-01 1997-01-30 Procedimiento para la produccion a gran escala de astaxantina a partir de haematococcus. Expired - Lifetime ES2178749T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11699596A IL116995A (en) 1996-02-01 1996-02-01 Procedure for large-scale production of astaxanthin from haematococcus

Publications (1)

Publication Number Publication Date
ES2178749T3 true ES2178749T3 (es) 2003-01-01

Family

ID=11068504

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97901245T Expired - Lifetime ES2178749T3 (es) 1996-02-01 1997-01-30 Procedimiento para la produccion a gran escala de astaxantina a partir de haematococcus.

Country Status (9)

Country Link
US (1) US6022701A (es)
EP (1) EP0877817B1 (es)
CA (1) CA2246048C (es)
DK (1) DK0877817T3 (es)
ES (1) ES2178749T3 (es)
IL (1) IL116995A (es)
NO (1) NO319558B1 (es)
WO (1) WO1997028274A1 (es)
ZA (1) ZA97830B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200702294A1 (ru) * 2002-05-13 2008-02-28 Гринфьюел Текнолоджиз Корпорейшн Фотобиореактор и способ для производства биомассы и снижения уровня загрязняющих веществ в топочных газах
US20050239182A1 (en) * 2002-05-13 2005-10-27 Isaac Berzin Synthetic and biologically-derived products produced using biomass produced by photobioreactors configured for mitigation of pollutants in flue gases
US8507253B2 (en) 2002-05-13 2013-08-13 Algae Systems, LLC Photobioreactor cell culture systems, methods for preconditioning photosynthetic organisms, and cultures of photosynthetic organisms produced thereby
US20050064577A1 (en) * 2002-05-13 2005-03-24 Isaac Berzin Hydrogen production with photosynthetic organisms and from biomass derived therefrom
EP1633335A4 (en) * 2003-06-19 2009-08-19 Advanced Bionutrition Corp IMPROVED ABSORPTION OF FAT-SOLUBLE NUTRIENTS
KR101009000B1 (ko) 2003-07-01 2011-01-17 학교법인 포항공과대학교 아스타잔틴의 생산 방법
KR100490641B1 (ko) * 2003-12-16 2005-05-19 인하대학교 산학협력단 다중 광생물반응기 및 이를 이용한 광합성 미생물 배양방법
DE102004004925A1 (de) * 2004-01-31 2005-08-18 Cognis Deutschland Gmbh & Co. Kg Verfahren zur Stabilisierung carotinoidhaltiger Biomasse
EP1681060B1 (en) 2005-01-15 2010-05-19 Cognis IP Management GmbH Improved process for obtaining carotene and carotenoids from algae or cyanobacteria
GB0501365D0 (en) * 2005-01-21 2005-03-02 Promar As Compositions
CN101218352B (zh) 2005-03-18 2013-09-04 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
US20060275863A1 (en) * 2005-05-17 2006-12-07 Yamaha Hatsudoki Kabushiki Kaisha Method for preserving xanthophyll in algal cell
US20070054351A1 (en) * 2005-09-06 2007-03-08 Yamaha Hatsudoki Kabushiki Kaisha Green algae having a high astaxanthin content and method for producing the same
US8110395B2 (en) * 2006-07-10 2012-02-07 Algae Systems, LLC Photobioreactor systems and methods for treating CO2-enriched gas and producing biomass
EP2152848A2 (en) * 2007-04-27 2010-02-17 Greenfuel Technologies Corporation Photobioreactor systems positioned on bodies of water
TW200934872A (en) * 2008-02-05 2009-08-16 Echem Hightech Co Ltd A strain of genetically reengineered escherichia coli for biosynthesis of high yield carotenoids after mutation screening
WO2011017171A1 (en) * 2009-07-28 2011-02-10 Joule Unlimited, Inc. Photobioreactors, solar energy gathering systems, and thermal control methods
US8889400B2 (en) 2010-05-20 2014-11-18 Pond Biofuels Inc. Diluting exhaust gas being supplied to bioreactor
US8940520B2 (en) 2010-05-20 2015-01-27 Pond Biofuels Inc. Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply
US11512278B2 (en) 2010-05-20 2022-11-29 Pond Technologies Inc. Biomass production
US8969067B2 (en) 2010-05-20 2015-03-03 Pond Biofuels Inc. Process for growing biomass by modulating supply of gas to reaction zone
US20120156669A1 (en) 2010-05-20 2012-06-21 Pond Biofuels Inc. Biomass Production
US20120276633A1 (en) 2011-04-27 2012-11-01 Pond Biofuels Inc. Supplying treated exhaust gases for effecting growth of phototrophic biomass
PT105809B (pt) * 2011-07-13 2013-10-25 Algicel Biotecnologia E Investigacao Lda Processo de produção à escala industrial de astaxantina a partir de microalgas produtoras de astaxantina
US9534261B2 (en) 2012-10-24 2017-01-03 Pond Biofuels Inc. Recovering off-gas from photobioreactor
WO2014074770A2 (en) 2012-11-09 2014-05-15 Heliae Development, Llc Balanced mixotrophy methods
WO2014074772A1 (en) 2012-11-09 2014-05-15 Heliae Development, Llc Mixotrophic, phototrophic, and heterotrophic combination methods and systems
US10227557B2 (en) 2014-09-15 2019-03-12 Sustainable Nutrition, Inc. Method and apparatus for producing astaxanthin
RU2573944C1 (ru) * 2014-12-18 2016-01-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова", (МГУ) Штамм микроводоросли haematococcus pluvialis - продуцент натурального астаксантина
EP3478850A1 (en) 2016-06-30 2019-05-08 Kuehnle Agrosystems, Inc. Improved heterotrophic production methods for microbial biomass and bioproducts
US20180066288A1 (en) 2016-08-05 2018-03-08 Kuehnle Agrosystems, Inc. Producing and altering microbial fermentation products using non-commonly used lignocellulosic hydrolysates
US20190141924A1 (en) * 2017-11-13 2019-05-16 Arevik Minasyan Relatively inexpensive process to turn green cells of Haematococcus pluvialis into astaxanthin accumulating red cysts
US11497758B2 (en) 2018-11-15 2022-11-15 Samuel L. Shepherd Method of treating oxidative stress due to radiation exposure
US11065269B1 (en) 2018-11-15 2021-07-20 Samuel L. Shepherd Method of using astaxanthin for the treatment of diseases, and more particularly, the treatment of cancer
US11377675B2 (en) 2019-01-16 2022-07-05 Kuehnle Agrosystems, Inc. Subterranean microalgae for production of microbial biomass, substances, and compositions
US20220356504A1 (en) * 2019-09-23 2022-11-10 Bioalgo (Wf) Co., Ltd. Method for producing astaxanthin by heterotrophic culture of haematococcus pluvialis
IT202000032396A1 (it) 2020-12-24 2022-06-24 Innobio S R L Composizione di combinazione contenente un principio attivo derivato da alghe e suoi usi in ambito medico e nutrizionale
IT202000032402A1 (it) 2020-12-24 2022-06-24 Innobio S R L Composizione immunostimolante per indurre una risposta immunitaria
AU2022204064A1 (en) 2021-07-16 2023-02-02 Samuel L. Shepherd Method of treating oxidative stress due to radiation exposure
AU2022224703A1 (en) 2021-09-28 2023-04-13 Samuel L. Shepherd Tetraterpenes for use in cancer therapy
IT202200010115A1 (it) 2022-05-16 2023-11-16 Safi Medical Care S R L Composizione per la prevenzione e il trattamento di malattie cutanee su base infiammatoria in particolare associate ad invecchiamento cutaneo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871551A (en) * 1988-02-08 1989-10-03 Microbio Resources, Inc. Pigmentation supplements for animal feed compositions
JP3163127B2 (ja) * 1991-09-11 2001-05-08 ヒガシマル醤油株式会社 アスタキサンチンの製造方法
JP3499259B2 (ja) * 1993-07-30 2004-02-23 ヒガシマル醤油株式会社 アスタキサンチンの製造方法

Also Published As

Publication number Publication date
DK0877817T3 (da) 2002-07-22
EP0877817A1 (en) 1998-11-18
CA2246048C (en) 2008-07-29
NO983423D0 (no) 1998-07-24
CA2246048A1 (en) 1997-08-07
IL116995A0 (en) 1996-06-18
NO983423L (no) 1998-10-01
ZA97830B (en) 1997-07-30
EP0877817B1 (en) 2002-07-03
AU1455697A (en) 1997-08-22
NO319558B1 (no) 2005-08-29
AU734157B2 (en) 2001-06-07
US6022701A (en) 2000-02-08
WO1997028274A1 (en) 1997-08-07
IL116995A (en) 2000-08-31

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