NO319558B1 - Fremgangsmate for stor-skala produksjon av astaxanthin fra haematococcus - Google Patents

Fremgangsmate for stor-skala produksjon av astaxanthin fra haematococcus Download PDF

Info

Publication number: NO319558B1
Authority: NO; Norway
Prior art keywords: cells; haematococcus; astaxanthin; conditions; cultivation
Prior art date: 1996-02-01

Application number

NO19983423A

Other languages

English (en)

Norwegian (no)

Other versions

NO983423D0 (no

NO983423L (no

Inventor

Sammy Boussiba

Avigad Vonshak

Zvi Cohen

Amos Richmond

Original Assignee

Univ Ben Gurion

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-01

Filing date

1998-07-24

Publication date

2005-08-29

1998-07-24 Application filed by Univ Ben Gurion filed Critical Univ Ben Gurion

1998-07-24 Publication of NO983423D0 publication Critical patent/NO983423D0/no

1998-10-01 Publication of NO983423L publication Critical patent/NO983423L/no

2005-08-29 Publication of NO319558B1 publication Critical patent/NO319558B1/no

Links

241000168525 Haematococcus Species 0.000 title claims description 79
238000000034 method Methods 0.000 title claims description 75
JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 title claims description 67
235000013793 astaxanthin Nutrition 0.000 title claims description 67
MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 title claims description 67
229940022405 astaxanthin Drugs 0.000 title claims description 67
239000001168 astaxanthin Substances 0.000 title claims description 67
230000008569 process Effects 0.000 title claims description 26
238000011031 large-scale manufacturing process Methods 0.000 title claims description 14
230000012010 growth Effects 0.000 claims description 35
238000009825 accumulation Methods 0.000 claims description 14
239000008399 tap water Substances 0.000 claims description 14
235000020679 tap water Nutrition 0.000 claims description 14
238000012258 culturing Methods 0.000 claims description 13
230000006698 induction Effects 0.000 claims description 12
241000168517 Haematococcus lacustris Species 0.000 claims description 11
239000003963 antioxidant agent Substances 0.000 claims description 9
230000003078 antioxidant effect Effects 0.000 claims description 9
235000006708 antioxidants Nutrition 0.000 claims description 9
238000005119 centrifugation Methods 0.000 claims description 8
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
229910052799 carbon Inorganic materials 0.000 claims description 7
238000003306 harvesting Methods 0.000 claims description 7
238000000227 grinding Methods 0.000 claims description 6
238000012545 processing Methods 0.000 claims description 6
238000004062 sedimentation Methods 0.000 claims description 6
239000004322 Butylated hydroxytoluene Substances 0.000 claims description 5
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 5
235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 5
229940095259 butylated hydroxytoluene Drugs 0.000 claims description 5
238000001035 drying Methods 0.000 claims description 5
230000007613 environmental effect Effects 0.000 claims description 5
238000012423 maintenance Methods 0.000 claims description 5
239000000203 mixture Substances 0.000 claims description 5
230000009105 vegetative growth Effects 0.000 claims description 5
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 4
230000001105 regulatory effect Effects 0.000 claims description 4
QWQNFXDYOCUEER-UHFFFAOYSA-N 2,3-ditert-butyl-4-methylphenol Chemical compound CC1=CC=C(O)C(C(C)(C)C)=C1C(C)(C)C QWQNFXDYOCUEER-UHFFFAOYSA-N 0.000 claims description 2
239000004255 Butylated hydroxyanisole Substances 0.000 claims description 2
239000004258 Ethoxyquin Substances 0.000 claims description 2
235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 2
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 2
229940043253 butylated hydroxyanisole Drugs 0.000 claims description 2
235000019285 ethoxyquin Nutrition 0.000 claims description 2
DECIPOUIJURFOJ-UHFFFAOYSA-N ethoxyquin Chemical compound N1C(C)(C)C=C(C)C2=CC(OCC)=CC=C21 DECIPOUIJURFOJ-UHFFFAOYSA-N 0.000 claims description 2
229940093500 ethoxyquin Drugs 0.000 claims description 2
238000001914 filtration Methods 0.000 claims description 2
238000004108 freeze drying Methods 0.000 claims description 2
238000007710 freezing Methods 0.000 claims description 2
230000008014 freezing Effects 0.000 claims description 2
239000000473 propyl gallate Substances 0.000 claims description 2
235000010388 propyl gallate Nutrition 0.000 claims description 2
229940075579 propyl gallate Drugs 0.000 claims description 2
238000001694 spray drying Methods 0.000 claims description 2
229930003799 tocopherol Natural products 0.000 claims description 2
239000011732 tocopherol Substances 0.000 claims description 2
235000019149 tocopherols Nutrition 0.000 claims description 2
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 claims description 2
210000004027 cell Anatomy 0.000 description 126
238000004519 manufacturing process Methods 0.000 description 12
239000002609 medium Substances 0.000 description 10
238000012786 cultivation procedure Methods 0.000 description 9
241000251468 Actinopterygii Species 0.000 description 8
238000011109 contamination Methods 0.000 description 8
235000019688 fish Nutrition 0.000 description 8
244000005700 microbiome Species 0.000 description 8
235000015097 nutrients Nutrition 0.000 description 8
239000000047 product Substances 0.000 description 8
229930002875 chlorophyll Natural products 0.000 description 7
235000019804 chlorophyll Nutrition 0.000 description 7
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 7
238000011081 inoculation Methods 0.000 description 7
239000002028 Biomass Substances 0.000 description 6
230000010261 cell growth Effects 0.000 description 6
239000001963 growth medium Substances 0.000 description 6
229920001817 Agar Polymers 0.000 description 5
241000195493 Cryptophyta Species 0.000 description 5
210000000712 G cell Anatomy 0.000 description 5
239000000654 additive Substances 0.000 description 5
239000008272 agar Substances 0.000 description 5
230000008901 benefit Effects 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
230000000996 additive effect Effects 0.000 description 4
239000007640 basal medium Substances 0.000 description 4
239000010432 diamond Substances 0.000 description 4
230000003647 oxidation Effects 0.000 description 4
238000007254 oxidation reaction Methods 0.000 description 4
239000000843 powder Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
241000894006 Bacteria Species 0.000 description 3
241000233866 Fungi Species 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
229940088710 antibiotic agent Drugs 0.000 description 3
239000004599 antimicrobial Substances 0.000 description 3
238000004113 cell culture Methods 0.000 description 3
230000032823 cell division Effects 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
235000015073 liquid stocks Nutrition 0.000 description 3
235000016709 nutrition Nutrition 0.000 description 3
239000002245 particle Substances 0.000 description 3
239000008188 pellet Substances 0.000 description 3
239000000049 pigment Substances 0.000 description 3
239000013049 sediment Substances 0.000 description 3
238000003828 vacuum filtration Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
241000238557 Decapoda Species 0.000 description 2
241000277331 Salmonidae Species 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
238000013461 design Methods 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
230000000284 resting effect Effects 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
241000972773 Aulopiformes Species 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
206010011732 Cyst Diseases 0.000 description 1
241000316144 Macrodon ancylodon Species 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920005372 Plexiglas® Polymers 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
238000005273 aeration Methods 0.000 description 1
230000001998 anti-microbiological effect Effects 0.000 description 1
238000009360 aquaculture Methods 0.000 description 1
244000144974 aquaculture Species 0.000 description 1
150000001514 astaxanthins Chemical class 0.000 description 1
238000010923 batch production Methods 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
150000001747 carotenoids Chemical group 0.000 description 1
150000001749 carotenones Chemical class 0.000 description 1
235000005472 carotenones Nutrition 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
238000004040 coloring Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
210000004748 cultured cell Anatomy 0.000 description 1
208000031513 cyst Diseases 0.000 description 1
230000037416 cystogenesis Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
239000008157 edible vegetable oil Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000009630 liquid culture Methods 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
230000035764 nutrition Effects 0.000 description 1
238000005457 optimization Methods 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
238000004321 preservation Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000007704 transition Effects 0.000 description 1
238000009461 vacuum packaging Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19983423A 1996-02-01 1998-07-24 Fremgangsmate for stor-skala produksjon av astaxanthin fra haematococcus NO319558B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL11699596A IL116995A (en)	1996-02-01	1996-02-01	Procedure for large-scale production of astaxanthin from haematococcus
PCT/IL1997/000042 WO1997028274A1 (en)	1996-02-01	1997-01-30	A procedure for large-scale production of astaxanthin from haematococcus

Publications (3)

Publication Number	Publication Date
NO983423D0 NO983423D0 (no)	1998-07-24
NO983423L NO983423L (no)	1998-10-01
NO319558B1 true NO319558B1 (no)	2005-08-29

Family

ID=11068504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19983423A NO319558B1 (no)	1996-02-01	1998-07-24	Fremgangsmate for stor-skala produksjon av astaxanthin fra haematococcus

Country Status (9)

Country	Link
US (1)	US6022701A (es)
EP (1)	EP0877817B1 (es)
CA (1)	CA2246048C (es)
DK (1)	DK0877817T3 (es)
ES (1)	ES2178749T3 (es)
IL (1)	IL116995A (es)
NO (1)	NO319558B1 (es)
WO (1)	WO1997028274A1 (es)
ZA (1)	ZA97830B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8507253B2 (en)	2002-05-13	2013-08-13	Algae Systems, LLC	Photobioreactor cell culture systems, methods for preconditioning photosynthetic organisms, and cultures of photosynthetic organisms produced thereby
US20050064577A1 (en) *	2002-05-13	2005-03-24	Isaac Berzin	Hydrogen production with photosynthetic organisms and from biomass derived therefrom
US20050239182A1 (en) *	2002-05-13	2005-10-27	Isaac Berzin	Synthetic and biologically-derived products produced using biomass produced by photobioreactors configured for mitigation of pollutants in flue gases
US20050260553A1 (en) *	2002-05-13	2005-11-24	Isaac Berzin	Photobioreactor and process for biomass production and mitigation of pollutants in flue gases
US9072311B2 (en) *	2003-06-19	2015-07-07	Advanced Bionutrition Corporation	Absorption of fat-soluble nutrients
KR101009000B1 (ko)	2003-07-01	2011-01-17	학교법인 포항공과대학교	아스타잔틴의 생산 방법
KR100490641B1 (ko) *	2003-12-16	2005-05-19	인하대학교 산학협력단	다중 광생물반응기 및 이를 이용한 광합성 미생물 배양방법
DE102004004925A1 (de) *	2004-01-31	2005-08-18	Cognis Deutschland Gmbh & Co. Kg	Verfahren zur Stabilisierung carotinoidhaltiger Biomasse
ATE468124T1 (de) *	2005-01-15	2010-06-15	Cognis Ip Man Gmbh	Verbessertes verfahren zur herstellung von karotene und karotenoiden aus algen und cyanobakterien
GB0501365D0 (en) *	2005-01-21	2005-03-02	Promar As	Compositions
EP1866428A2 (en)	2005-03-18	2007-12-19	Microbia, Inc.	Production of carotenoids in oleaginous yeast and fungi
US20060275863A1 (en) *	2005-05-17	2006-12-07	Yamaha Hatsudoki Kabushiki Kaisha	Method for preserving xanthophyll in algal cell
US20070054351A1 (en) *	2005-09-06	2007-03-08	Yamaha Hatsudoki Kabushiki Kaisha	Green algae having a high astaxanthin content and method for producing the same
US8110395B2 (en)	2006-07-10	2012-02-07	Algae Systems, LLC	Photobioreactor systems and methods for treating CO2-enriched gas and producing biomass
WO2008134010A2 (en)	2007-04-27	2008-11-06	Greenfuel Technologies Corp.	Photobioreactor systems positioned on bodies of water
TW200934872A (en)	2008-02-05	2009-08-16	Echem Hightech Co Ltd	A strain of genetically reengineered escherichia coli for biosynthesis of high yield carotenoids after mutation screening
MY159248A (en) *	2009-07-28	2016-12-30	Joule Unlimited Tech Inc	Photobioreactors, solar energy gathering systems, and thermal control methods
US8889400B2 (en)	2010-05-20	2014-11-18	Pond Biofuels Inc.	Diluting exhaust gas being supplied to bioreactor
US8940520B2 (en)	2010-05-20	2015-01-27	Pond Biofuels Inc.	Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply
US20120156669A1 (en)	2010-05-20	2012-06-21	Pond Biofuels Inc.	Biomass Production
US11512278B2 (en)	2010-05-20	2022-11-29	Pond Technologies Inc.	Biomass production
US8969067B2 (en)	2010-05-20	2015-03-03	Pond Biofuels Inc.	Process for growing biomass by modulating supply of gas to reaction zone
US20120276633A1 (en)	2011-04-27	2012-11-01	Pond Biofuels Inc.	Supplying treated exhaust gases for effecting growth of phototrophic biomass
PT105809B (pt) *	2011-07-13	2013-10-25	Algicel Biotecnologia E Investigacao Lda	Processo de produção à escala industrial de astaxantina a partir de microalgas produtoras de astaxantina
US9534261B2 (en)	2012-10-24	2017-01-03	Pond Biofuels Inc.	Recovering off-gas from photobioreactor
WO2014074770A2 (en)	2012-11-09	2014-05-15	Heliae Development, Llc	Balanced mixotrophy methods
WO2014074772A1 (en)	2012-11-09	2014-05-15	Heliae Development, Llc	Mixotrophic, phototrophic, and heterotrophic combination methods and systems
US10227557B2 (en)	2014-09-15	2019-03-12	Sustainable Nutrition, Inc.	Method and apparatus for producing astaxanthin
RU2573944C1 (ru) *	2014-12-18	2016-01-27	Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова", (МГУ)	Штамм микроводоросли haematococcus pluvialis - продуцент натурального астаксантина
JP7549444B2 (ja)	2016-06-30	2024-09-11	クーンルアグロシステムズ，インコーポレイテッド	微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品
US20180066288A1 (en)	2016-08-05	2018-03-08	Kuehnle Agrosystems, Inc.	Producing and altering microbial fermentation products using non-commonly used lignocellulosic hydrolysates
US20190141924A1 (en) *	2017-11-13	2019-05-16	Arevik Minasyan	Relatively inexpensive process to turn green cells of Haematococcus pluvialis into astaxanthin accumulating red cysts
US11497758B2 (en)	2018-11-15	2022-11-15	Samuel L. Shepherd	Method of treating oxidative stress due to radiation exposure
US11065269B1 (en)	2018-11-15	2021-07-20	Samuel L. Shepherd	Method of using astaxanthin for the treatment of diseases, and more particularly, the treatment of cancer
US11377675B2 (en)	2019-01-16	2022-07-05	Kuehnle Agrosystems, Inc.	Subterranean microalgae for production of microbial biomass, substances, and compositions
US20220356504A1 (en) *	2019-09-23	2022-11-10	Bioalgo (Wf) Co., Ltd.	Method for producing astaxanthin by heterotrophic culture of haematococcus pluvialis
IT202000032396A1 (it)	2020-12-24	2022-06-24	Innobio S R L	Composizione di combinazione contenente un principio attivo derivato da alghe e suoi usi in ambito medico e nutrizionale
IT202000032402A1 (it)	2020-12-24	2022-06-24	Innobio S R L	Composizione immunostimolante per indurre una risposta immunitaria
AU2022204064A1 (en)	2021-07-16	2023-02-02	Samuel L. Shepherd	Method of treating oxidative stress due to radiation exposure
AU2022224703A1 (en)	2021-09-28	2023-04-13	Samuel L. Shepherd	Tetraterpenes for use in cancer therapy
IT202200010115A1 (it)	2022-05-16	2023-11-16	Safi Medical Care S R L	Composizione per la prevenzione e il trattamento di malattie cutanee su base infiammatoria in particolare associate ad invecchiamento cutaneo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4871551A (en) *	1988-02-08	1989-10-03	Microbio Resources, Inc.	Pigmentation supplements for animal feed compositions
JP3163127B2 (ja) *	1991-09-11	2001-05-08	ヒガシマル醤油株式会社	アスタキサンチンの製造方法
JP3499259B2 (ja) *	1993-07-30	2004-02-23	ヒガシマル醤油株式会社	アスタキサンチンの製造方法

1996
- 1996-02-01 IL IL11699596A patent/IL116995A/xx not_active IP Right Cessation
1997
- 1997-01-30 US US09/117,497 patent/US6022701A/en not_active Expired - Lifetime
- 1997-01-30 WO PCT/IL1997/000042 patent/WO1997028274A1/en not_active Ceased
- 1997-01-30 EP EP97901245A patent/EP0877817B1/en not_active Expired - Lifetime
- 1997-01-30 CA CA002246048A patent/CA2246048C/en not_active Expired - Lifetime
- 1997-01-30 DK DK97901245T patent/DK0877817T3/da active
- 1997-01-30 ES ES97901245T patent/ES2178749T3/es not_active Expired - Lifetime
- 1997-01-31 ZA ZA97830A patent/ZA97830B/xx unknown
1998
- 1998-07-24 NO NO19983423A patent/NO319558B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL116995A (en)	2000-08-31
EP0877817B1 (en)	2002-07-03
NO983423D0 (no)	1998-07-24
EP0877817A1 (en)	1998-11-18
IL116995A0 (en)	1996-06-18
CA2246048A1 (en)	1997-08-07
NO983423L (no)	1998-10-01
DK0877817T3 (da)	2002-07-22
ZA97830B (en)	1997-07-30
AU1455697A (en)	1997-08-22
CA2246048C (en)	2008-07-29
AU734157B2 (en)	2001-06-07
ES2178749T3 (es)	2003-01-01
US6022701A (en)	2000-02-08
WO1997028274A1 (en)	1997-08-07

Legal Events

Date	Code	Title	Description
2017-02-06	MK1K	Patent expired

Publication	Publication Date	Title
NO319558B1 (no)	2005-08-29	Fremgangsmate for stor-skala produksjon av astaxanthin fra haematococcus
Iwamoto	2003	Industrial production of microalgal cell‐mass and secondary products‐major industrial species: chlorella
CN103571906B (zh)	2018-12-11	一种利用微藻高效生产虾青素的新方法
US8357510B2 (en)	2013-01-22	Process for obtaining lutein from algae
Mirón et al.	2002	Growth and biochemical characterization of microalgal biomass produced in bubble column and airlift photobioreactors: studies in fed-batch culture
AU2008264771B2 (en)	2014-09-18	Golden yellow algae and method of producing the same
US20040077036A1 (en)	2004-04-22	Process to produce astaxanthin from haematococcus biomass
IE890389L (en)	1989-08-08	Pigmentation supplements for animal feeds
Fagiri et al.	2013	Influence of chemical and environmental factors on the growth performance of Spirulina platensis strain SZ100
US20220340950A1 (en)	2022-10-27	Method for culturing haematococcus pluvialis to produce astaxanthin
US20220356504A1 (en)	2022-11-10	Method for producing astaxanthin by heterotrophic culture of haematococcus pluvialis
KR102813779B1 (ko)	2025-05-27	헤마토코쿠스 플루비알리스 돌연변이 균주, 아스타잔틴 추출물의 제조 방법 및 이를 위한 일체형 생산 시스템
Borowitzka	1998	Algae as food
Fagiri et al.	2013	Impact of physico-chemical parameters on the physiological growth of Arthrospira (Spirulina platensis) exogenous strain UTEXLB2340
EP1681060B1 (en)	2010-05-19	Improved process for obtaining carotene and carotenoids from algae or cyanobacteria
JP4045663B2 (ja)	2008-02-13	アスタキサンチン含有ヘマトコッカスの製造方法
KR101283149B1 (ko)	2013-07-05	만가닥버섯 느타리버섯 팽이버섯 새송이 버섯과 파피아 로도자이마 효모의 혼합배양기술 개발과 아스타잔틴이 함유된 항산화효과가 있는 사료첨가용 생균제의 개발
EP1806411B1 (en)	2008-12-17	Process for obtaining zeaxanthin from algae
KR100582792B1 (ko)	2006-05-23	클로렐라의 발효 가공방법과 이에 의한 발효클로렐라음료의 제조 방법 및 발효클로렐라 식품첨가물
AU734157C (en)	2002-01-17	A procedure for large-scale production of astaxanthin from haematococcus
RU2529715C2 (ru)	2014-09-27	Способ культивирования дрожжей phaffia rhodozyma для получения кормовой добавки, содержащей астаксантин
CN113462575A (zh)	2021-10-01	一种雨生红球藻培养基及其制备方法和雨生红球藻培养方法
US20260061015A1 (en)	2026-03-05	Cordyceps Militaris Designated as Strain M2-116-04 Compositions, Methods of Making, Methods of Using, and Methods for Treating a Mammal
Sujarit et al.	2017	Astaxanthin production from sewage of traditional Thai rice vermicelli
Singhal et al.	2017	Growth of Spirulina maxima in different physical conditions