ES2179049T3 - Oxepano-isomeros de rapamicina utiles como agentes inmunosupresores. - Google Patents

Oxepano-isomeros de rapamicina utiles como agentes inmunosupresores.

Info

Publication number: ES2179049T3
Authority: ES; Spain
Prior art keywords: useful; rapamicina; oxepano; isomeros; immunosuppressing agents
Prior art date: 1992-01-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES93300207T

Other languages

English (en)

Spanish (es)

Inventor

Philip Floyd Hughes

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee

Wyeth LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-16

Filing date

1993-01-14

Publication date

2003-01-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25235357&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2179049(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-01-14 Application filed by Wyeth LLC filed Critical Wyeth LLC

2003-01-16 Application granted granted Critical

2003-01-16 Publication of ES2179049T3 publication Critical patent/ES2179049T3/es

2013-01-14 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000001506 immunosuppresive effect Effects 0.000 title abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ES93300207T 1992-01-16 1993-01-14 Oxepano-isomeros de rapamicina utiles como agentes inmunosupresores. Expired - Lifetime ES2179049T3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/822,171 US5221740A (en)	1992-01-16	1992-01-16	Oxepane isomers of rapamycin useful as immunosuppressive agents

Publications (1)

Publication Number	Publication Date
ES2179049T3 true ES2179049T3 (es)	2003-01-16

Family

ID=25235357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES93300207T Expired - Lifetime ES2179049T3 (es)	1992-01-16	1993-01-14	Oxepano-isomeros de rapamicina utiles como agentes inmunosupresores.

Country Status (9)

Country	Link
US (2)	US5221740A (fr)
EP (1)	EP0552031B1 (fr)
JP (3)	JP3108557B2 (fr)
AT (1)	ATE219084T1 (fr)
CA (1)	CA2086643C (fr)
DE (1)	DE69332005T2 (fr)
DK (1)	DK0552031T3 (fr)
ES (1)	ES2179049T3 (fr)
PT (1)	PT552031E (fr)

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CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
ES2186956T5 (es)	1994-08-24	2009-07-24	Canon Kabushiki Kaisha	Contenedor de tinta para impresora por chorros de tinta, soporte para el contenedor, carro para el soporte y para la impresora por chorros de tinta.
GB9713730D0 (en)	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
US6790228B2 (en) *	1999-12-23	2004-09-14	Advanced Cardiovascular Systems, Inc.	Coating for implantable devices and a method of forming the same
US7807211B2 (en)	1999-09-03	2010-10-05	Advanced Cardiovascular Systems, Inc.	Thermal treatment of an implantable medical device
US20070032853A1 (en)	2002-03-27	2007-02-08	Hossainy Syed F	40-O-(2-hydroxy)ethyl-rapamycin coated stent
US6641611B2 (en)	2001-11-26	2003-11-04	Swaminathan Jayaraman	Therapeutic coating for an intravascular implant
US20040137066A1 (en) *	2001-11-26	2004-07-15	Swaminathan Jayaraman	Rationally designed therapeutic intravascular implant coating
US20050118344A1 (en)	2003-12-01	2005-06-02	Pacetti Stephen D.	Temperature controlled crimping
WO2006115509A2 (fr)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
US8313763B2 (en) *	2004-10-04	2012-11-20	Tolmar Therapeutics, Inc.	Sustained delivery formulations of rapamycin compounds
MX2007003789A (es) *	2004-10-04	2007-07-20	Qlt Usa Inc	Suministro ocular de formulaciones polimericas para suministro.
CA2602010A1 (fr) *	2005-03-07	2006-09-14	Wyeth	Isomere d'oxepane du 42-o-(2-hydroxy)ethyl-rapamycine
US7622477B2 (en) *	2006-02-28	2009-11-24	Cordis Corporation	Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same
US20070203168A1 (en) *	2006-02-28	2007-08-30	Zhao Jonathon Z	Isomers of rapamycin and 42-Epi-rapamycin, methods of making and using the same
US20070203171A1 (en) *	2006-02-28	2007-08-30	Zhao Jonathon Z	Combination of rapamycin and its tetrazole isomers and epimers, methods of making and using the same
JP4946751B2 (ja)	2006-11-06	2012-06-06	セイコーエプソン株式会社	容器ホルダ、液体消費装置及び液体収容容器
TW201738095A (zh)	2006-11-06	2017-11-01	Seiko Epson Corp	液體收容容器、容器夾持具、及液體消耗裝置
US9737640B2 (en)	2006-11-20	2017-08-22	Lutonix, Inc.	Drug releasing coatings for medical devices
US8414525B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8998846B2 (en)	2006-11-20	2015-04-07	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US8425459B2 (en)	2006-11-20	2013-04-23	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414526B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8430055B2 (en)	2008-08-29	2013-04-30	Lutonix, Inc.	Methods and apparatuses for coating balloon catheters
US8414909B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US9700704B2 (en)	2006-11-20	2017-07-11	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US8414910B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US20080276935A1 (en)	2006-11-20	2008-11-13	Lixiao Wang	Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
JP2008305262A (ja) *	2007-06-08	2008-12-18	Konica Minolta Business Technologies Inc	サーバ及びシンクライアント環境でのプリンタ紹介方法
ES2645692T3 (es)	2008-11-11	2017-12-07	The Board Of Regents,The University Of Texas System	Microcápsulas de rapamicina y su uso para el tratamiento del cáncer
WO2015161139A1 (fr)	2014-04-16	2015-10-22	Rapamycin Holdings, Llc	Préparation orale de rapamycine et utilisation pour une stomatite
US9283211B1 (en)	2009-11-11	2016-03-15	Rapamycin Holdings, Llc	Oral rapamycin preparation and use for stomatitis
RU2585489C2 (ru)	2010-04-27	2016-05-27	Рош Гликарт Аг	КОМБИНИРОВАННАЯ ТЕРАПИЯ АФУКОЗИЛИРОВАННЫМ АНТИТЕЛОМ CD20 И ИНГИБИТОРОМ mTOR
WO2012149014A1 (fr)	2011-04-25	2012-11-01	OSI Pharmaceuticals, LLC	Utilisation de signatures de gènes de tem dans la découverte de médicaments contre le cancer, diagnostics et traitement du cancer
WO2013013708A1 (fr)	2011-07-26	2013-01-31	Fundació Institut D'investigació Biomèdica De Bellvitge	Traitement du rejet aigu dans une transplantation rénale
CN103705925B (zh)	2012-09-29	2018-03-30	段磊	抑制PI3K/AKT/mTOR信号通路的药物组合
US9750728B2 (en)	2012-09-29	2017-09-05	Targeted Therapeutics, Llc	Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
WO2014059295A1 (fr)	2012-10-12	2014-04-17	The Board Of Regents Of The University Of Texas System	Utilisation d'inhibiteurs mtor pour traiter le déficit cognitif vasculaire
WO2014160328A1 (fr)	2013-03-13	2014-10-02	The Board Of Regents Of The University Of Texas System	Inhibiteurs de mtor pour la prévention de la croissance de polypes intestinaux
CN103739616B (zh) *	2013-12-27	2015-12-30	福建省微生物研究所	含噻唑基雷帕霉素类衍生物及其应用
EP3089737B1 (fr)	2013-12-31	2021-11-03	Rapamycin Holdings, LLC	Préparations orales de nanoparticules de rapamycine, et utilisation
US9700544B2 (en)	2013-12-31	2017-07-11	Neal K Vail	Oral rapamycin nanoparticle preparations
CA2943609A1 (fr)	2014-03-27	2015-10-01	The Brigham And Women's Hospital, Inc.	Conjugues de medicaments actives metaboliquement pour vaincre la resistance dans une therapie du cancer
EP3148564B1 (fr)	2014-06-02	2020-01-08	Children's Medical Center Corporation	Procédés et compositions pour une immunomodulation
WO2018204416A1 (fr)	2017-05-02	2018-11-08	Revolution Medicines, Inc.	Analogues de la rapamycine utilisés en tant qu'inhibiteurs de mtor
US20210154372A1 (en)	2017-05-15	2021-05-27	C.R. Bard, Inc.	Medical device with drug-eluting coating and intermediate layer
MX2020011565A (es)	2018-05-01	2021-01-29	Revolution Medicines Inc	Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor.
IL312291A (en)	2018-05-01	2024-06-01	Revolution Medicines Inc	C-26-linked rapamycin analogs as MTOR inhibitors
EP3880266B1 (fr)	2018-11-14	2025-05-07	Lutonix, Inc.	Dispositif médical avec revêtement à élution de médicament sur un dispositif à surface modifiée
EP3952937A1 (fr)	2019-04-08	2022-02-16	Bard Peripheral Vascular, Inc.	Dispositif médical portant un revêtement d'élution de médicament sur une surface modifiée de dispositif
WO2023288046A1 (fr)	2021-07-15	2023-01-19	President And Fellows Of Harvard College	Compositions et méthodes associées à des cellules comprenant des particules adhérées
CA3256390A1 (fr)	2022-05-25	2023-11-30	Revolution Medicines, Inc.	Méthodes de traitement du cancer au moyen d'un inhibiteur de mtor

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ZA737247B (en) *	1972-09-29	1975-04-30	Ayerst Mckenna & Harrison	Rapamycin and process of preparation
US5100899A (en) *	1989-06-06	1992-03-31	Roy Calne	Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
GB2246350A (en) *	1990-07-23	1992-01-29	Fujisawa Pharmaceutical Co	Tricyclo compounds
US5091389A (en) *	1991-04-23	1992-02-25	Merck & Co., Inc.	Lipophilic macrolide useful as an immunosuppressant

1992
- 1992-01-16 US US07/822,171 patent/US5221740A/en not_active Expired - Lifetime
1993
- 1993-01-04 CA CA002086643A patent/CA2086643C/fr not_active Expired - Fee Related
- 1993-01-14 JP JP05004754A patent/JP3108557B2/ja not_active Expired - Fee Related
- 1993-01-14 DK DK93300207T patent/DK0552031T3/da active
- 1993-01-14 PT PT93300207T patent/PT552031E/pt unknown
- 1993-01-14 ES ES93300207T patent/ES2179049T3/es not_active Expired - Lifetime
- 1993-01-14 AT AT93300207T patent/ATE219084T1/de not_active IP Right Cessation
- 1993-01-14 DE DE69332005T patent/DE69332005T2/de not_active Revoked
- 1993-01-14 EP EP93300207A patent/EP0552031B1/fr not_active Revoked
- 1993-03-18 US US08/032,910 patent/US5344833A/en not_active Expired - Lifetime
2002
- 2002-10-02 JP JP2002290288A patent/JP2003180385A/ja active Pending
2004
- 2004-05-26 JP JP2004156286A patent/JP2004313196A/ja active Pending

Also Published As

Publication number	Publication date
JP2004313196A (ja)	2004-11-11
DE69332005T2 (de)	2002-11-14
EP0552031A1 (fr)	1993-07-21
CA2086643A1 (fr)	1993-07-17
EP0552031B1 (fr)	2002-06-12
DE69332005D1 (de)	2002-07-18
JP2003180385A (ja)	2003-07-02
CA2086643C (fr)	2002-11-26
ATE219084T1 (de)	2002-06-15
DK0552031T3 (da)	2002-09-23
US5221740A (en)	1993-06-22
JP3108557B2 (ja)	2000-11-13
PT552031E (pt)	2002-09-30
JPH06312990A (ja)	1994-11-08
US5344833A (en)	1994-09-06

Publication	Publication Date	Title
ES2179049T3 (es)	2003-01-16	Oxepano-isomeros de rapamicina utiles como agentes inmunosupresores.
ATE163420T1 (de)	1998-03-15	C-22 ringstabilisierte rapamycin derivate
DE69724811D1 (de)	2003-10-16	Pentafluorobenzensulfonamide und analoge
ATE214379T1 (de)	2002-03-15	Cyclodepsipeptide
TR199801919T2 (xx)	1999-02-22	Rapamisin t�revlerinin damar hastal�klar� ve yabanc� doku naklinde kullan�m�.
PT920421E (pt)	2003-03-31	Derivados de isoxazolina uteis como agentes antimicrobianos
ES2119912T3 (es)	1998-10-16	Nuevos aminometilenpeptidos como inmunosupresores.
ES2116471T3 (es)	1998-07-16	Arilcarbonil y alcoxicarbonil carbamatos de rapamicina como agentes inmunosupresores y antifungicos.
DE69711996D1 (de)	2002-05-23	2-Aminobenzazepin-Derivate und ihre Verwendung für die Behandlung von Immunosuppression
ATE286055T1 (de)	2005-01-15	Kondensierte pyrrolocarbazole
SV1999000102A (es)	2000-07-06	Compuestos heterociclicos como inhibidores de enzimas de rotamasa. ref. pcs 9475 afae/bb.
ATE136900T1 (de)	1996-05-15	Prolinderivat von rapamycin, seine herstellung und verwendung
AR029214A1 (es)	2003-06-18	Compuestos inhibidores de fosfodiesterasa - 4: 8 - arilquinolinas sustituidas, composiciones farmaceuticas, metodo de tratamiento que las utiliza
ES2136887T3 (es)	1999-12-01	Derivados antifungicos de sordaridina.
BR9712081A (pt)	1999-08-24	Novos derivados de pept¡deos tendo res¡duo tiazolil-alanina
ATE172985T1 (de)	1998-11-15	Sulfonamidaminomethylenderivate als immunsuppressiva
MX9606494A (es)	1997-03-29	Compuestos organicos.
FI945164A7 (fi)	1994-11-02	Biologisesti aktiivisesti ureidojohdannaiset, jotka ovat käyttökelpoisia antimetastaattisina aineina
MX9304626A (es)	1994-02-28	Derivados heterociclicos utiles en el tratamiento de enfermedades cardiovasculares.
FI963222A0 (fi)	1996-08-16	6-substituoitu 4-amino-mykofenolihappo ja sen johdannaiset, joilla on immunosuppressiivista aktiivisuutta
DE69637641D1 (de)	2008-09-25	Auf rapamycin basierende regulation biologischer vorgänge
ES2062286T3 (es)	1994-12-16	Compuestos arilicos fenilacetonitriloalquilaminoalquil-orto-sustituidos de utilidad como agentes inmunosupresivos.
ATE197953T1 (de)	2000-12-15	Pyrrolo(4,3,2-de)chinolin-derivat
UA27752C2 (uk)	2000-10-16	Похідні рапаміцину, що мають індукуючу імунодепресію активність, спосіб індукування імунодепресії, фармацевтична композиція
ECSP972236A (es)	1998-09-22	Derivados de 6,6- heterobiciclicos sustituidos