ES2179929T3 - Procedimiento que trata de inhibir la osteolisis y las metastasis. - Google Patents

Procedimiento que trata de inhibir la osteolisis y las metastasis.

Info

Publication number
ES2179929T3
ES2179929T3 ES96903630T ES96903630T ES2179929T3 ES 2179929 T3 ES2179929 T3 ES 2179929T3 ES 96903630 T ES96903630 T ES 96903630T ES 96903630 T ES96903630 T ES 96903630T ES 2179929 T3 ES2179929 T3 ES 2179929T3
Authority
ES
Spain
Prior art keywords
antibody
bone
pthrp
bisphosphonate
sequelae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96903630T
Other languages
English (en)
Inventor
Gregory R Mundy
Toshiyuki Yoneda
Theresa A Guise
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenotech Inc
Original Assignee
Xenotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/376,359 external-priority patent/US5626845A/en
Priority claimed from US08/386,361 external-priority patent/US5993817A/en
Application filed by Xenotech Inc filed Critical Xenotech Inc
Application granted granted Critical
Publication of ES2179929T3 publication Critical patent/ES2179929T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN ANTICUERPO PARA UN COMPUESTO SELECCIONADO A PARTIR DEL GRUPO QUE CONSTA DE PTHRP, TGF{AL}, IL PGE; 1,25 DIHIDROXI VITAMINA D{SUB,3} Y UN FRAGMENTO ANTIGENICO DE LA MISMA UTILIZADOS EN EL TRATAMIENTO DE METASTASIS CANCEROSA EN HUESO Y DEL CRECIMIENTO CELULAR CANCEROSO EN HUESOS ASI COMO DE OSTEOLISIS Y DE LAS SECUELAS SINTOMATICAS DE LA MISMA. ES PARTICULARMENTE PREFERIDO UN ANTICUERPO INMUNORREACTIVO FRENTE A PROTEINA RELACIONADA CON LA HORMONA PARATIROIDEA (PTHRP). LOS ANTICUERPOS CON CARACTERISTICAS HUMANAS ESTAN INCLUIDOS EN LA INVENCION PARA LA APLICACION DEL METODO DE LA INVENCION A SUJETOS HUMANOS. ASIMISMO, EL ANTICUERPO PUEDE ADMINISTRARSE EN UNA FORMULACION INYECTABLE EN COMBINACION CON UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN BISFOSFONATO O UN PIROFOSFATO QUE PRESENTEN UNA FORMULA ESTRUCTURAL GENERAL (I), EN LA QUE X ES UNA PORCION DE ENLACE QUE PERMITE LA INTERCONEXION DE LOS GRUPOS FOSFONATO Y SALES, HIDRATOS E HIDRATOS PARCIALES DE LOS MISMOS FARMACEUTICAMENTE ACEPTABLES. EL ANTICUERPO Y EL BISFOSFONATO ACTUAN SINERGICAMENTE EN EL TRATAMIENTO DE METASTASIS CANCEROSAS EN HUESO Y SECUELAS SINTOMATICAS DE LAS MISMAS Y PARTICULARMENTE EN CUANTO A RESORCION DEL HUESO.
ES96903630T 1995-01-23 1996-01-23 Procedimiento que trata de inhibir la osteolisis y las metastasis. Expired - Lifetime ES2179929T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/376,359 US5626845A (en) 1995-01-23 1995-01-23 Method to ameliorate osteolysis and metastasis
US08/386,361 US5993817A (en) 1995-01-23 1995-02-09 Method to ameliorate osteolysis and metastasis
US48108895A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
ES2179929T3 true ES2179929T3 (es) 2003-02-01

Family

ID=27409296

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96903630T Expired - Lifetime ES2179929T3 (es) 1995-01-23 1996-01-23 Procedimiento que trata de inhibir la osteolisis y las metastasis.

Country Status (12)

Country Link
US (1) US20050244414A1 (es)
EP (1) EP0813423B1 (es)
JP (1) JP4231106B2 (es)
KR (1) KR100528604B1 (es)
AT (1) ATE219945T1 (es)
AU (1) AU703222B2 (es)
CA (1) CA2210484C (es)
DE (1) DE69622157T2 (es)
DK (1) DK0813423T3 (es)
ES (1) ES2179929T3 (es)
PT (1) PT813423E (es)
WO (1) WO1996022790A1 (es)

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US5914233A (en) * 1996-08-23 1999-06-22 Osteo Screen Screening assay for the identification of agents which alter expression of PTH-rP
CZ106299A3 (cs) * 1996-09-26 1999-08-11 Chugai Seiyaku Kabushiki Kaisha Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
CN1817906B (zh) * 1996-09-26 2011-08-10 中外制药株式会社 抗人副甲状腺激素相关蛋白的抗体
AU2003203622B2 (en) * 1997-05-15 2006-12-21 Chugai Seiyaku Kabushiki Kaisha Cachexia remedy
WO1998051329A1 (en) 1997-05-15 1998-11-19 Chugai Seiyaku Kabushiki Kaisha Cachexia remedy
DE19828450A1 (de) * 1998-06-26 1999-12-30 Hassan Jomaa Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien
JP5232818B2 (ja) * 1998-08-06 2013-07-10 達也 沢村 酸化ｌｄｌ受容体に対する抗体を含んでなる医薬組成物
TWI255718B (en) 1999-07-02 2006-06-01 Chugai Pharmaceutical Co Ltd Ameliorative agent for low vasopressin concentration
JP4516711B2 (ja) * 1999-12-28 2010-08-04 中外製薬株式会社 安定な抗体組成物及び注射製剤
WO2001054725A1 (en) * 2000-01-25 2001-08-02 Chugai Seiyaku Kabushiki Kaisha Remedies and preventives for dental diseases
WO2001082968A1 (fr) 2000-04-28 2001-11-08 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de proliferation cellulaire
JP2003021631A (ja) * 2001-05-10 2003-01-24 Chugai Pharmaceut Co Ltd 骨転移抑制剤のスクリーニング方法
FR2841788B1 (fr) 2002-07-05 2006-01-27 Univ Pasteur Utilisation d'antagonistes de la pthrp pour traiter le carcinome a cellules renales
US20060127953A1 (en) * 2002-09-18 2006-06-15 London Health Sciences Centre Research Inc. Method of diagnosing osteolysis
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
EP1557176A1 (en) * 2004-01-26 2005-07-27 Ferring B.V. Treatment of bone metastases by means of PTH receptor agonists
US8907061B2 (en) 2008-01-11 2014-12-09 Lawrence Livermore National Security, Llc. Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
WO2009100201A2 (en) * 2008-02-07 2009-08-13 Lawrence Livermore National Security, Llc Functionalized platform for arrays configured for optical detection of targets and related arrays, methods and systems
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US10151037B2 (en) 2009-01-12 2018-12-11 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide dependent target reduction, and related methods and systems
US20120294868A1 (en) * 2009-04-24 2012-11-22 Edwards James R Anti-tgf-beta induction of bone cell function and bone growth
US8906610B2 (en) * 2010-02-08 2014-12-09 The Regents Of The University Of California Using phylogenetic probes for quantification of stable isotope labeling and microbial community analysis
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
US20150023920A1 (en) * 2012-03-29 2015-01-22 Drexel University Novel compositions and methods for preventing or treating cancer metastasis
RU2609871C1 (ru) * 2015-08-10 2017-02-06 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Противоопухолевое средство
US12226529B2 (en) 2015-08-25 2025-02-18 Lawrence Livermore National Security, Llc Stable nanolipoprotein particles and related compositions methods and systems
US11279749B2 (en) 2015-09-11 2022-03-22 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
US12083223B2 (en) 2017-05-02 2024-09-10 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions methods and systems for loading RNA
US11207422B2 (en) 2017-05-02 2021-12-28 Lawrence Livermore National Security, Llc MOMP telonanoparticles, and related compositions, methods and systems

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FR2556739A1 (fr) * 1983-12-19 1985-06-21 Pasteur Institut Lignees cellulaires secretant des anticorps monoclonaux contre la pg e2, leur preparation, les anticorps obtenus et leur application
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US5626845A (en) * 1995-01-23 1997-05-06 Xenotech Incorporated Method to ameliorate osteolysis and metastasis

Also Published As

Publication number Publication date
EP0813423B1 (en) 2002-07-03
CA2210484C (en) 2012-12-04
JP4231106B2 (ja) 2009-02-25
KR19980701585A (ko) 1998-05-15
PT813423E (pt) 2002-11-29
AU4764596A (en) 1996-08-14
DE69622157T2 (de) 2003-03-13
ATE219945T1 (de) 2002-07-15
US20050244414A1 (en) 2005-11-03
CA2210484A1 (en) 1996-08-01
AU703222B2 (en) 1999-03-18
DE69622157D1 (de) 2002-08-08
JPH10512885A (ja) 1998-12-08
WO1996022790A1 (en) 1996-08-01
EP0813423A4 (en) 1998-04-22
KR100528604B1 (ko) 2006-03-16
DK0813423T3 (da) 2002-07-22
EP0813423A1 (en) 1997-12-29

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