ES2180274T3 - Disoluciones nasales. - Google Patents

Disoluciones nasales.

Info

Publication number
ES2180274T3
ES2180274T3 ES99904823T ES99904823T ES2180274T3 ES 2180274 T3 ES2180274 T3 ES 2180274T3 ES 99904823 T ES99904823 T ES 99904823T ES 99904823 T ES99904823 T ES 99904823T ES 2180274 T3 ES2180274 T3 ES 2180274T3
Authority
ES
Spain
Prior art keywords
water
nasal
glycerol
mixtures
propylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99904823T
Other languages
English (en)
Inventor
Matthias Seidel
Christopher Buckley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Haleon CH SARL
Original Assignee
Haleon CH SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haleon CH SARL filed Critical Haleon CH SARL
Application granted granted Critical
Publication of ES2180274T3 publication Critical patent/ES2180274T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Una composición farmacéutica líquida nasal que comprende (a) uno o más principios activos adecuados para la administración nasal y seleccionados del grupo que consiste en vasoconstrictores, agentes antialérgicos y corticosteroides; (b) sorbitol; (c) un derivado de la alquil celulosa con 1 a 4 átomos de carbono soluble en agua; (d) un vehículo que está presente en una cantidad de al menos el 90% (m/V) de la composición total, y que se selecciona de agua y mezclas de agua con propilén glicol, agua con glicerol y agua con propilén glicol y glicerol, por lo que en todas estas mezclas está presente el agua en una cantidad de al menos el 95% (m/V); y (e) opcionalmente uno o más excipientes nasalmente aceptables.
ES99904823T 1998-01-30 1999-01-28 Disoluciones nasales. Expired - Lifetime ES2180274T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98810069 1998-01-30

Publications (1)

Publication Number Publication Date
ES2180274T3 true ES2180274T3 (es) 2003-02-01

Family

ID=8235913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99904823T Expired - Lifetime ES2180274T3 (es) 1998-01-30 1999-01-28 Disoluciones nasales.

Country Status (12)

Country Link
EP (1) EP1051155B1 (es)
JP (1) JP4603687B2 (es)
AT (1) ATE219657T1 (es)
AU (1) AU741364B2 (es)
CA (1) CA2311530C (es)
DE (1) DE69901936T2 (es)
DK (1) DK1051155T3 (es)
ES (1) ES2180274T3 (es)
IL (1) IL136591A (es)
NZ (1) NZ505919A (es)
PT (1) PT1051155E (es)
WO (1) WO1999038492A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059440A1 (en) * 1998-09-01 2003-03-27 Tim Clarot Composition and method for moisturizing nasal tissue
TR200103694T2 (tr) * 1999-06-22 2002-04-22 Boehringer Ingelheim International Gmbh Sabit ksilometazolin ve oksimetazolin çözeltisi
HU226527B1 (hu) * 2001-09-18 2009-03-30 Nycomed Danmark Aps Készítmények nátha kezelésére
BG65734B1 (bg) * 2002-02-22 2009-09-30 Био Терапютикс - Еоод Течен мукоадхезивен фармацевтичен състав
JP2005533076A (ja) * 2002-06-20 2005-11-04 ノバルテイス・コンシユーマー・ヘルス・エス・アー ムコ多糖及びプロピレングリコールを含む鼻用組成物
WO2004024187A2 (en) * 2002-09-13 2004-03-25 Zicam, Llc. Compositions to reduce congestion and methods for application thereof to the nasal membrane
US20040235807A1 (en) * 2003-05-21 2004-11-25 Weinrich Karl P. Formulations including a topical decongestant and a topical corticosteroid suitable for nasal administration and method for treating obstructive sleep apnea
MXPA06000281A (es) 2003-06-30 2006-07-03 Johnson & Johnson Formulaciones para microproyecciones revestidas que contienen contraiones no volatiles.
DE10337186A1 (de) * 2003-08-13 2005-03-17 Merck Patent Gmbh Wässrige Wirkstoff-Lösung
JP4956981B2 (ja) * 2005-01-05 2012-06-20 大正製薬株式会社 オキシメタゾリン含有水性組成物
GB2423711B (en) 2005-10-24 2007-02-14 Fortune Apex Dev Ltd Method for preparing a pharmaceutical composition with enhanced mucoadhesion
US8940796B2 (en) * 2006-02-21 2015-01-27 Wyeth Llc Phenylephrine liquid formulations
US20070249727A1 (en) 2006-04-21 2007-10-25 The Proctor & Gamble Company Compositions and kits useful for treatment of respiratory illness
US10022339B2 (en) 2006-04-21 2018-07-17 The Procter & Gamble Company Compositions and methods useful for treatment of respiratory illness
DE102008007198A1 (de) * 2008-02-01 2009-08-13 Infectopharm Arzneimittel Und Consilium Gmbh Oral oder nasal applizierbare Epinephrin- haltige Zubereitungen mit verbesserten Eigenschaften
JP2012505236A (ja) * 2008-10-10 2012-03-01 シェーリング コーポレイション コルチコステロイド組成物およびそれの治療方法
DE202013000748U1 (de) 2013-01-24 2013-02-19 Merz Pharma Gmbh & Co. Kgaa Sprühbare flüssige Zubereitung zur insbesondere nasalen Anwendung mit erhöhter lokaler Verweilzeit
PL2759290T3 (pl) 2013-01-24 2020-03-31 Merz Pharma Gmbh & Co. Kgaa Płynny preparat w aerozolu do stosowania donosowego z wydłużonym miejscowym czasem działania
DE102013001151A1 (de) 2013-01-24 2014-07-24 Merz Pharma Gmbh & Co. Kgaa Sprühbare flüssige Zubereitung zur insbesondere nasalen Anwendung mit erhöhter lokaler Verweilzeit
WO2014158119A1 (en) * 2013-03-29 2014-10-02 Santa Farma İlaç Sanayi̇ A.Ş Aqueous solution composition containing ipratropium and oxymetazoline
WO2014158118A1 (en) * 2013-03-29 2014-10-02 Santa Farma İlaç Sanayi̇ A.Ş. Suspension composition containing ipratropium and oxymetazoline
US20160120990A1 (en) * 2013-07-17 2016-05-05 Dow Global Technologies Llc Composition for application to a mucosa comprising a hydroxyalkyl methylcellulose
WO2015047762A1 (en) * 2013-09-25 2015-04-02 Dow Global Technologies Llc Composition for application to a mucosa comprising a cellulose ether
PL3236933T3 (pl) * 2014-12-24 2019-05-31 Jadran Galenski Laboratorij D D Kompozycja do podawania donosowego zawierająca wodę morską jako zaróbkę poprawiającą trwałość
WO2018195029A1 (en) * 2017-04-17 2018-10-25 Insys Development Company, Inc. Epinephrine spray formulations
CN112512506A (zh) * 2018-06-13 2021-03-16 希克玛药物美国股份有限公司 肾上腺素喷雾制剂
US12036329B2 (en) 2018-09-11 2024-07-16 Lead Biotherapeutics Ltd Mucoadhesive dispersion nanoparticle system and method for production the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62292719A (ja) * 1986-06-12 1987-12-19 Kaken Pharmaceut Co Ltd 外用澄明水溶性製剤
MY102411A (en) * 1986-12-23 1992-06-17 Ciba Geigy Ag Nasal solutions
JPH04327533A (ja) * 1991-04-23 1992-11-17 Lion Corp 抗アレルギー用粘膜局所投与剤
DE69222295T2 (de) * 1992-05-26 1998-04-09 The Procter & Gamble Co., Cincinnati, Ohio Pulverförmige pharmazeutische Zusammensetzung
CA2101126A1 (en) * 1992-08-03 1994-02-04 Yasushi Morita Preparation for local treatment
DE69434304T2 (de) * 1993-03-26 2005-12-29 Merkus, Franciscus Wilhelmus H.M. Pharmazeutische Zusammensetzungen zur intranasalen Verabreichung von Dihydroergotamin
JPH07109228A (ja) * 1993-10-08 1995-04-25 Earth Chem Corp Ltd リゾチーム配合口腔用組成物
JP3537440B2 (ja) * 1993-12-17 2004-06-14 持田製薬株式会社 可溶性トロンボモジュリンを長期保存安定化させる方法
JP3269770B2 (ja) * 1995-03-02 2002-04-02 参天製薬株式会社 再分散性の優れたイオン性高分子配合水性懸濁点眼剤
DE19549421C2 (de) * 1995-11-10 1999-11-18 Klosterfrau Mcm Vetrieb Gmbh Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden
EP1020194A4 (en) * 1997-10-01 2003-05-21 Wakamoto Pharma Co Ltd AQUEOUS TYPE EMULSION COMPOSITIONS

Also Published As

Publication number Publication date
DE69901936T2 (de) 2002-11-28
NZ505919A (en) 2002-10-25
JP4603687B2 (ja) 2010-12-22
JP2002501884A (ja) 2002-01-22
AU2519899A (en) 1999-08-16
IL136591A (en) 2005-08-31
WO1999038492A1 (en) 1999-08-05
CA2311530C (en) 2008-06-10
PT1051155E (pt) 2002-10-31
AU741364B2 (en) 2001-11-29
DK1051155T3 (da) 2002-09-16
EP1051155A1 (en) 2000-11-15
DE69901936D1 (de) 2002-08-01
EP1051155B1 (en) 2002-06-26
CA2311530A1 (en) 1999-08-05
IL136591A0 (en) 2001-06-14
ATE219657T1 (de) 2002-07-15

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