ES2180335T3 - Ligandos y complejos para la hidrogenacion enantioselectiva. - Google Patents

Ligandos y complejos para la hidrogenacion enantioselectiva.

Info

Publication number
ES2180335T3
ES2180335T3 ES99958031T ES99958031T ES2180335T3 ES 2180335 T3 ES2180335 T3 ES 2180335T3 ES 99958031 T ES99958031 T ES 99958031T ES 99958031 T ES99958031 T ES 99958031T ES 2180335 T3 ES2180335 T3 ES 2180335T3
Authority
ES
Spain
Prior art keywords
complexes
ligandos
enantioselective hydrogenation
ligand
ferroceneylphosphine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99958031T
Other languages
English (en)
Inventor
Paul Knochel
Tanja Ireland
Gabriele Grossheimann
Karlheinz Drauz
Ingo Klement
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2180335T3 publication Critical patent/ES2180335T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Ligandos enriquecidos en enantiómeros de fórmula general (I) y sus sales, en la que ** (Fórmula)** R1, R2 significan, independientemente uno de otro, R8, NR6R7, SR6, alquilo (C1-C18), alcoxi (C1C18), alcoxialquilo (C2-C18), aciloxi (C1-C18), arilo (C6-C18), aralquilo (C7-C19), heteroarilo (C3-C18), heteroaralquilo (C4-C19), alquil (C1-C8)-arilo (C6-C18), alquil (C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1-C8)-cicloalquilo (C3-C8), cicloalquil (C3-C8)-alquilo (C1-C8), o R1 y R2 están unidos mediante un carbociclo (C3-C7), que puede estar sustituido una o varias veces por alquilo (C1-C8), acilo (C1-C8), alcoxi (C1-C8), alcoxialquilo (C2-C8), lineales o ramificados y/o puede contener en el anillo heteroátomos tales como N, O, P, S, R3, R4 significan, independientemente uno de otro, H, alquilo (C1-C18), alcoxi (C1-C18), alcoxialquilo (C2-C18), aciloxi (C1-C18), arilo (C6-C18), aralquilo (C7-C19), heteroarilo (C3-C18), heteroaralquilo (C4C19), alquil (C1-C8)-arilo (C6-C18), alquil (C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1C8)-cicloalquilo (C3-C8), cicloalquil (C3-C8)-alquilo (C1-C8), o R3 y R4 están unidos mediante un puente (C3-C5), que puede contener uno o varios dobles enlaces y/o puede estar sustituido una o varias veces por alquilo (C1-C8), acilo (C1-C8), alcoxi (C1-C8), alcoxialquilo (C2-C8), lineales o ramificados, y/o puede contener en el anillo heteroátomos tales como N, O, P, S, R5 significa alquilo (C1-C18), arilo (C6-C18), heteroarilo (C3-C18), alquil (C1-C8)-arilo (C6-C18), alquil (C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1-C8)-cicloalquilo (C3-C8), en donde los restos R5 pueden ser diferentes en el mismo átomo de fósforo y/o en los dos átomos de fósforo, R6, R7 significan, independientemente uno de otro, H, alquilo (C1-C18), alcoxi (C1-C18), alcoxialquilo (C2-C18), acilo (C1-C18), arilo (C6-C18), aralquilo (C7-C19), heteroarilo (C3-C18), heteroaralquilo (C4-C19), alquil (C1-C8)arilo (C6-C18), alquil(C1-C8)-heteroalquilo (C3-C19), cicloalquilo (C3-C8), alquil (C1C8)-cicloalquilo (C3-C8), cicloalquil (C3-C6)-alquilo (C1-C8), o R6 y R7 están unidos mediante un carbociclo (C3-C7), que puede estar sustituido una o varias veces por alquilo (C1-C8), acilo (C1-C8), alcoxi (C1-C8), alcoxialquilo (C2-C8), lineales o ramificados y/o puede contener en el anillo heteroátomos tales como N, O, P, S, R8 significa H o un resto B-X-Z, siendo B un resto del grupo CR92, NR9, O, S, SiR92, X es un espaciador como, por ejemplo, 1, 4¿-bifenilo, 1-etileno, 2-etileno, 1-propileno, 3-propileno, PEG- (2-10) y Z representa un resto unido a un polímero mediante un grupo funcional, como por ejemplo, O-, NH-, COO-, CONH, etenil-, NHCONH-, OCONH- o NHCOO-, o los restos R8 de ambos anillos de ciclopentadienilo están unidos entre sí mediante un puente a, walquileno (C2-C4), R9 significa H, alquilo (C1-C18).
ES99958031T 1998-12-19 1999-11-12 Ligandos y complejos para la hidrogenacion enantioselectiva. Expired - Lifetime ES2180335T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19858865 1998-12-19
DE19952348A DE19952348A1 (de) 1998-12-19 1999-10-30 Liganden und Komplexe zur enantioselektiven Hydrierung

Publications (1)

Publication Number Publication Date
ES2180335T3 true ES2180335T3 (es) 2003-02-01

Family

ID=26050881

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99958031T Expired - Lifetime ES2180335T3 (es) 1998-12-19 1999-11-12 Ligandos y complejos para la hidrogenacion enantioselectiva.

Country Status (10)

Country Link
US (1) US6191284B1 (es)
EP (1) EP1140956B1 (es)
JP (1) JP4567201B2 (es)
AT (1) ATE222918T1 (es)
CA (1) CA2356154C (es)
DE (2) DE19952348A1 (es)
DK (1) DK1140956T3 (es)
ES (1) ES2180335T3 (es)
PT (1) PT1140956E (es)
WO (1) WO2000037478A1 (es)

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DE10017430A1 (de) * 2000-04-07 2001-10-11 Basf Ag Polymerisationskatalysator
JP5185485B2 (ja) * 2000-07-03 2013-04-17 ソルヴィーアス アクチェンゲゼルシャフト フェロセニルジホスフィンおよびその使用
US6562989B2 (en) 2000-08-07 2003-05-13 Yale University Catalyst for aromatic C—O, C—N, and C—C bond formation
US6919292B2 (en) * 2000-12-20 2005-07-19 Tosoh Corporation Transition metal compound, coordinative compound, catalyst for polymerization of olefin, and process for polymerization of olefin using the catalyst
AUPS044502A0 (en) * 2002-02-11 2002-03-07 Commonwealth Scientific And Industrial Research Organisation Novel catalysts and processes for their preparation
DE10211250A1 (de) * 2002-03-13 2003-10-23 Degussa Ferrocenylliganden und ihre Verwendung in der Katalyse
DE10219490A1 (de) * 2002-04-30 2003-11-13 Degussa Ferrocenylliganden und ein Verfahren zur Herstellung solcher Liganden
GB0228018D0 (en) * 2002-11-30 2003-01-08 Lucite Int Uk Ltd Carbonylation of ester
ES2429871T3 (es) * 2002-09-12 2013-11-18 Lucite International Uk Limited Un sistema catalizador que comprende un ligando de 1,2-bis-(fosfin)metaloceno
US7560136B2 (en) * 2003-01-13 2009-07-14 Nantero, Inc. Methods of using thin metal layers to make carbon nanotube films, layers, fabrics, ribbons, elements and articles
WO2005003070A1 (en) 2003-07-03 2005-01-13 Lucite International Uk Limited Process for the hydroformylation of ethylenically unsaturated compounds
JP2007516971A (ja) * 2003-12-12 2007-06-28 ソルヴィーアス　アクチェンゲゼルシャフト フェロセニル−１，２−ジホスフィン類、それらの製造および使用
EP1692149B1 (de) * 2003-12-12 2009-07-22 Solvias AG Verfahren zur herstellung von orthometallierten und orthosubstituierten aromatischen verbindungen
GB0400720D0 (en) 2004-01-14 2004-02-18 Stylacats Ltd Novel ferrocene-based phosphorus chiral phosphines
GB0403592D0 (en) * 2004-02-18 2004-03-24 Lucite Int Uk Ltd A catalyst system
DE102004012438A1 (de) * 2004-03-12 2005-09-29 Degussa Ag Verfahren zur Herstellung von enantiomerenangereicherten Ferrocenylliganden
US7671225B2 (en) * 2004-05-07 2010-03-02 Umicore Ag & Co. Kg Ferrocenyl ligands for homogeneous, enantioselective hydrogenation catalysts
GB0411951D0 (en) * 2004-05-28 2004-06-30 Lucite Int Uk Ltd Carbonylation of ester
JP5406524B2 (ja) * 2005-04-20 2014-02-05 ユミコア・アクチエンゲゼルシャフト・ウント・コムパニー・コマンディットゲゼルシャフト ジホスフィン類及び金属錯体
GB0516556D0 (en) * 2005-08-12 2005-09-21 Lucite Int Uk Ltd Improved catalyst system
US9334227B2 (en) 2005-11-17 2016-05-10 Lucite International Uk Limited Carbonylation of ethylenically unsaturated compounds
GB0607494D0 (en) 2006-04-13 2006-05-24 Lucite Int Uk Ltd Metal complexes
CN100465182C (zh) * 2006-08-11 2009-03-04 郑州大学 环钯化二茂铁亚胺-氨基膦配合物及其应用
BRPI0719344B1 (pt) * 2006-12-02 2017-05-02 Lucite Int Uk Ltd ligando bidentado, processo para a carbonilação de compostos etilenicamente insaturados, e, sistema de catalisador
GB0625518D0 (en) * 2006-12-21 2007-01-31 Lucite Int Uk Ltd Carbonylation of conjugated dienes
DE102007022389A1 (de) * 2007-05-10 2008-11-13 Umicore Ag & Co. Kg Ruthenium-Komplexe mit (P-P)-koordinierten Ferrocenyl-diphosphinliganden, Verfahren zu ihrer Herstellung sowie ihre Anwendung in der homogenen Katalyse
EP1995248A1 (en) 2007-05-23 2008-11-26 Evonik Degussa GmbH Process for the production of amino alcohols by asymmetric hydrogenation
WO2009086283A1 (en) * 2007-12-21 2009-07-09 Cambrex Charles City, Inc. Synthesis of enantiomerically pure 2-hydroxy-2-aryl-ethylamines
CA2708889C (en) 2007-12-28 2016-05-10 Actelion Pharmaceuticals Ltd Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative
WO2009083903A1 (en) 2007-12-28 2009-07-09 Actelion Pharmaceuticals Ltd Trisubstituted 3,4-dihydro-1h-isoquinolin compound, process for its preparation, and its use
EP2107065A1 (de) 2008-04-01 2009-10-07 Umicore AG & Co. KG Ruthenium-Komplexe mit (P-P)-koordinierten Di-Phosphor-Donorliganden sowie Verfahren zu ihrer Herstellung
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CN101885743B (zh) * 2010-06-25 2013-07-17 洛阳师范学院 含嘧啶基环钯金属配体及其制备方法
CN116023382B (zh) * 2023-02-22 2025-09-23 北京师范大学 一种合成手性四氢吡唑并[1,5-a]嘧啶的方法

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EP0564406B1 (de) * 1992-04-02 1999-05-06 Novartis AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
EP0612758B1 (de) * 1993-02-26 2003-04-09 Syngenta Participations AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
EP0646590B1 (de) * 1993-10-01 1999-08-25 Novartis AG Mit Fluoralkyl substituierte Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
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WO1996032400A1 (en) * 1995-04-11 1996-10-17 Novartis Ag Dihalogenated ferrocenes and processes for the preparation thereof
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Also Published As

Publication number Publication date
CA2356154A1 (en) 2000-06-29
PT1140956E (pt) 2003-01-31
JP4567201B2 (ja) 2010-10-20
US6191284B1 (en) 2001-02-20
JP2002533351A (ja) 2002-10-08
EP1140956A1 (de) 2001-10-10
DK1140956T3 (da) 2002-11-11
ATE222918T1 (de) 2002-09-15
DE19952348A1 (de) 2000-06-21
EP1140956B1 (de) 2002-08-28
CA2356154C (en) 2009-06-30
WO2000037478A1 (de) 2000-06-29
DE59902501D1 (de) 2002-10-02

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